| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Riejanne Seigers, Jessica Timmermans, Hans J van der Horn, Erik F J de Vries, Rudi A Dierckx, Lydia Visser, Sanne B Schagen, Frits S A M van Dam, Jaap M Koolhaas, Bauke Buwald. Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release. Behavioural brain research. vol 207. issue 2. 2010-04-13. PMID:19840821. |
methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release. |
2010-04-13 |
2023-08-12 |
rat |
| Riejanne Seigers, Jessica Timmermans, Hans J van der Horn, Erik F J de Vries, Rudi A Dierckx, Lydia Visser, Sanne B Schagen, Frits S A M van Dam, Jaap M Koolhaas, Bauke Buwald. Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release. Behavioural brain research. vol 207. issue 2. 2010-04-13. PMID:19840821. |
neuroinflammatory processes were explored via a number of methods: a microglia immunohistochemical marker was applied to hippocampal sections, [(11)c]pk11195 pet was performed, and cytokine levels in plasma and homogenized hippocampal tissue were measured. |
2010-04-13 |
2023-08-12 |
rat |
| Riejanne Seigers, Jessica Timmermans, Hans J van der Horn, Erik F J de Vries, Rudi A Dierckx, Lydia Visser, Sanne B Schagen, Frits S A M van Dam, Jaap M Koolhaas, Bauke Buwald. Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release. Behavioural brain research. vol 207. issue 2. 2010-04-13. PMID:19840821. |
methotrexate activated microglia in the hippocampus 1 week and 3 weeks after treatment. |
2010-04-13 |
2023-08-12 |
rat |
| Riejanne Seigers, Jessica Timmermans, Hans J van der Horn, Erik F J de Vries, Rudi A Dierckx, Lydia Visser, Sanne B Schagen, Frits S A M van Dam, Jaap M Koolhaas, Bauke Buwald. Methotrexate reduces hippocampal blood vessel density and activates microglia in rats but does not elevate central cytokine release. Behavioural brain research. vol 207. issue 2. 2010-04-13. PMID:19840821. |
although methotrexate activates microglia activation in the hippocampus, no effects were seen in [(11)c]pk11195 tracer uptake or hippocampal cytokine levels. |
2010-04-13 |
2023-08-12 |
rat |
| Fang Yang, Zhi-Rong Liu, Jing Chen, Shi-Jun Zhang, Qing-Yun Quan, Yuan-Gui Huang, Wen Jian. Roles of astrocytes and microglia in seizure-induced aberrant neurogenesis in the hippocampus of adult rats. Journal of neuroscience research. vol 88. issue 3. 2010-03-30. PMID:19774666. |
roles of astrocytes and microglia in seizure-induced aberrant neurogenesis in the hippocampus of adult rats. |
2010-03-30 |
2023-08-12 |
human |
| Fang Yang, Zhi-Rong Liu, Jing Chen, Shi-Jun Zhang, Qing-Yun Quan, Yuan-Gui Huang, Wen Jian. Roles of astrocytes and microglia in seizure-induced aberrant neurogenesis in the hippocampus of adult rats. Journal of neuroscience research. vol 88. issue 3. 2010-03-30. PMID:19774666. |
in this study, we examined the role of activated astrocytes and microglia in the aberrant hippocampal neurogenesis induced by status epilepticus. |
2010-03-30 |
2023-08-12 |
human |
| Fang Yang, Zhi-Rong Liu, Jing Chen, Shi-Jun Zhang, Qing-Yun Quan, Yuan-Gui Huang, Wen Jian. Roles of astrocytes and microglia in seizure-induced aberrant neurogenesis in the hippocampus of adult rats. Journal of neuroscience research. vol 88. issue 3. 2010-03-30. PMID:19774666. |
furthermore, with stereotaxic injection of lipopolysaccharide into the intact dentate hilus to activate local microglia, we found that lipopolysaccharide promoted the development of ectopic hilar basal dendrites in the hippocampus. |
2010-03-30 |
2023-08-12 |
human |
| M-S Kwon, Y-J Seo, S-M Choi, M-H Won, J-K Lee, S-H Park, J-S Jung, Y-B Sim, H-W Su. The time-dependent effect of lipopolysaccharide on kainic acid-induced neuronal death in hippocampal CA3 region: possible involvement of cytokines via glucocorticoid. Neuroscience. vol 165. issue 4. 2010-03-12. PMID:19961903. |
in addition, ru38486 (glucocorticoid receptor antagonist) decreased the hippocampal il-1beta mrna level and abolished the aggravating effect of lps on ka-induced neuronal death at lps 90 min and 24 h. in the immunohistochemical study, we found activated and ramified microglia (ox-42) and astrocyte (gfap) at 24 h after lps treatment (lps 24 h) in the hippocampus. |
2010-03-12 |
2023-08-12 |
mouse |
| Bharathi Hattiangady, Ashok K Shett. Decreased neuronal differentiation of newly generated cells underlies reduced hippocampal neurogenesis in chronic temporal lobe epilepsy. Hippocampus. vol 20. issue 1. 2010-03-09. PMID:19309040. |
interestingly, the extent of proliferation of astrocytes and microglia (identified through ki-67 and s-100beta and ki-67 and ox-42 dual immunofluorescence) in the sgz-gcl was similar between the chronically epileptic hippocampus and the age-matched intact hippocampus, implying that the proliferation of neural stem/progenitor cells in the sgz-gcl of the chronically epileptic hippocampus was not obscured by an increased division of glia. |
2010-03-09 |
2023-08-12 |
rat |
| Shuei Sugam. Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders. Medical hypotheses. vol 73. issue 6. 2010-03-01. PMID:19556067. |
in particular, activated microglia have been reported in various brain regions, including the hippocampus, substantia nigra, striatum, and cerebral cortex, in which significant neurodegeneration occurs in various neurodegenerative disorders. |
2010-03-01 |
2023-08-12 |
Not clear |
| b' Pavle R Andjus, Danijela Batavelji\\xc4\\x87, Greetje Vanhoutte, Dinko Mitrecic, Fabrizio Pizzolante, Nevena Djogo, Charles Nicaise, Fabrice Gankam Kengne, Carlo Gangitano, Fabrizio Michetti, Annemie van der Linden, Roland Pochet, Goran Baci\\xc4\\x8. In vivo morphological changes in animal models of amyotrophic lateral sclerosis and Alzheimer\'s-like disease: MRI approach. Anatomical record (Hoboken, N.J. : 2007). vol 292. issue 12. 2010-02-26. PMID:19943341.' |
expected deterioration in the hippocampus was not observed by clinical mri, but immunocytochemistry could reveal significant redistribution of macro- and microglia in this structure. |
2010-02-26 |
2023-08-12 |
rat |
| Johanna Hung, Mathieu Chansard, Shalina S Ousman, Minh Dang Nguyen, Michael A Colico. Activation of microglia by neuronal activity: results from a new in vitro paradigm based on neuronal-silicon interfacing technology. Brain, behavior, and immunity. vol 24. issue 1. 2010-02-17. PMID:19559784. |
by using photoconductive stimulation to trigger localized regions of neuronal action potentials and astrocyte ca(2+) waves in dissociated rat hippocampal cultures, we can directly study microglia behavior in response to physiological and pathological levels of activity. |
2010-02-17 |
2023-08-12 |
rat |
| Matthew G Frank, Zurine D Miguel, Linda R Watkins, Steven F Maie. Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide. Brain, behavior, and immunity. vol 24. issue 1. 2010-02-17. PMID:19647070. |
prior exposure (24h) to gcs also potentiated the pro-inflammatory response of hippocampal microglia to lps ex vivo. |
2010-02-17 |
2023-08-12 |
Not clear |
| Fangfang Yin, Rebecca Banerjee, Bobby Thomas, Ping Zhou, Liping Qian, Ting Jia, Xiaojing Ma, Yao Ma, Costantino Iadecola, M Flint Beal, Carl Nathan, Aihao Din. Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. The Journal of experimental medicine. vol 207. issue 1. 2010-02-17. PMID:20026663. |
pgrn-deficient macrophages and microglia were cytotoxic to hippocampal cells in vitro, and pgrn-deficient hippocampal slices were hypersusceptible to deprivation of oxygen and glucose. |
2010-02-17 |
2023-08-12 |
mouse |
| Fangfang Yin, Rebecca Banerjee, Bobby Thomas, Ping Zhou, Liping Qian, Ting Jia, Xiaojing Ma, Yao Ma, Costantino Iadecola, M Flint Beal, Carl Nathan, Aihao Din. Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. The Journal of experimental medicine. vol 207. issue 1. 2010-02-17. PMID:20026663. |
with age, brains of pgrn-deficient mice displayed greater activation of microglia and astrocytes than wt, and their hippocampal and thalamic neurons accumulated cytosolic phosphorylated transactivation response element dna binding protein-43. |
2010-02-17 |
2023-08-12 |
mouse |
| Melissa Paulussen, Bart Landuyt, Liliane Schoofs, Walter Luyten, Lut Arcken. Thymosin beta 4 mRNA and peptide expression in phagocytic cells of different mouse tissues. Peptides. vol 30. issue 10. 2010-02-01. PMID:19631707. |
in the brain, tbeta4 was clearly present in neurons of the olfactory bulb, neocortex, hippocampus, striatum, amygdala, piriform cortex and cerebellum, and in microglia across the entire brain. |
2010-02-01 |
2023-08-12 |
mouse |
| Iwona Kurkowska-Jastrzebska, Małgorzata Zaremba, Anna Członkowska, Barbara Oderfeld-Nowa. Down-regulation of microglia and NG2-positive cells reaction in trimethyltin-injured hippocampus of rats treated with myelin basic protein-reactive T cells: possible contribution to the neuroprotective effect of T cells. Journal of neuroscience research. vol 88. issue 1. 2010-01-26. PMID:19610113. |
down-regulation of microglia and ng2-positive cells reaction in trimethyltin-injured hippocampus of rats treated with myelin basic protein-reactive t cells: possible contribution to the neuroprotective effect of t cells. |
2010-01-26 |
2023-08-12 |
rat |
| Honghua Zheng, Wei Zhu, Hu Zhao, Xiaojing Wang, Wei Wang, Zhengli L. Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta. Neuroimmunomodulation. vol 17. issue 1. 2010-01-26. PMID:19816055. |
kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta. |
2010-01-26 |
2023-08-12 |
rat |
| Honghua Zheng, Wei Zhu, Hu Zhao, Xiaojing Wang, Wei Wang, Zhengli L. Kainic acid-activated microglia mediate increased excitability of rat hippocampal neurons in vitro and in vivo: crucial role of interleukin-1beta. Neuroimmunomodulation. vol 17. issue 1. 2010-01-26. PMID:19816055. |
the present study was carried out to explore whether interleukin-1beta (il-1beta), a proinflammatory cytokine produced in abundance by activated microglia, mediates increased excitability of hippocampal neurons and the related molecular mechanisms. |
2010-01-26 |
2023-08-12 |
rat |
| Robert N Wine, Christopher A McPherson, G Jean Harr. IGF-1 and pAKT signaling promote hippocampal CA1 neuronal survival following injury to dentate granule cells. Neurotoxicity research. vol 16. issue 3. 2010-01-25. PMID:19526277. |
within 24 h of injection, igf-1 mrna levels were elevated in the hippocampus and igf-1 protein detected in both astrocytes and microglia. |
2010-01-25 |
2023-08-12 |
mouse |