| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yannick Marchalant, Francesca Cerbai, Holly M Brothers, Gary L Wen. Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17561311. |
stimulation of endocannabinoid receptors can reduce the number of activated microglia, particularly in the hippocampus, of young rats infused chronically with lipopolysaccharide (lps). |
2009-01-23 |
2023-08-12 |
rat |
| Yannick Marchalant, Francesca Cerbai, Holly M Brothers, Gary L Wen. Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17561311. |
in the current study we demonstrate that endocannabinoid receptor stimulation by administration of win-55212-2 (2mg/kg day) can reduce the number of activated microglia in hippocampus of aged rats and attenuate the spatial memory impairment in the water pool task. |
2009-01-23 |
2023-08-12 |
rat |
| Dong Hyun Kim, Sunho Kim, Su Jin Jeon, Kun Ho Son, Seungjoo Lee, Byung Hoon Yoon, Jae Hoon Cheong, Kwang Ho Ko, Jong Hoon Ry. The effects of acute and repeated oroxylin A treatments on Abeta(25-35)-induced memory impairment in mice. Neuropharmacology. vol 55. issue 5. 2009-01-15. PMID:18620712. |
moreover, abeta(25-35)-induced increases in gfap (an astroglia marker) and ox-42 (a microglia marker), and increases in inos positive cells in the hippocampus were found to be attenuated by subchronic oroxylin a (1 or 5mg/kg/day, i.p., p<0.05). |
2009-01-15 |
2023-08-12 |
mouse |
| Xuesong Chen, Xun Lan, Ian Roche, Rugao Liu, Jonathan D Geige. Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum. Journal of neurochemistry. vol 107. issue 4. 2009-01-15. PMID:18808450. |
striatum (and for some studies hippocampus and cerebral cortex as well) were evaluated for bbb leakage, tight junction protein expression levels, integrity of dopaminergic neurons, and activation of astrocytes and microglia using immunostaining, immunoblotting and real-time pcr techniques. |
2009-01-15 |
2023-08-12 |
mouse |
| Bin Zhang, Eric J West, Ken C Van, Gene G Gurkoff, Jia Zhou, Xiu-Mei Zhang, Alan P Kozikowski, Bruce G Lyet. HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain research. vol 1226. 2009-01-07. PMID:18582446. |
hippocampal ca2/3 tissue was processed for acetyl-histone h3 immunolocalization, ox-42 immunolocalization (for microglia), and fluoro-jade b histofluorescence (for degenerating neurons) at 24 h after injury. |
2009-01-07 |
2023-08-12 |
rat |
| Bin Zhang, Eric J West, Ken C Van, Gene G Gurkoff, Jia Zhou, Xiu-Mei Zhang, Alan P Kozikowski, Bruce G Lyet. HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats. Brain research. vol 1226. 2009-01-07. PMID:18582446. |
vehicle-treated tbi rats exhibited a high density of phagocytic microglia in the ipsilateral ca2/3 hippocampus compared to sham tbi in which none were observed. |
2009-01-07 |
2023-08-12 |
rat |
| Anna De Simoni, Nicola J Allen, David Attwel. Charge compensation for NADPH oxidase activity in microglia in rat brain slices does not involve a proton current. The European journal of neuroscience. vol 28. issue 6. 2008-12-15. PMID:18783372. |
here we show that in microglia, either in the resting state or when activated by the bacterial coat component lipopolysaccharide, both in acute and in cultured hippocampal slices, no significant h(+) current is detectable. |
2008-12-15 |
2023-08-12 |
rat |
| Ik-Hyun Cho, Jinpyo Hong, Eun Cheng Suh, Jae Hwan Kim, Hyunkyoung Lee, Jong Eun Lee, Soojin Lee, Chong-Hyun Kim, Dong Woon Kim, Eun-Kyeong Jo, Kyung Eun Lee, Michael Karin, Sung Joong Le. Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain : a journal of neurology. vol 131. issue Pt 11. 2008-12-12. PMID:18819987. |
based on these data, we concluded that ikk/nuclear factor-kappab dependent microglia activation contributes to ka-induced hippocampal neuronal cell death in vivo through induction of inflammatory mediators. |
2008-12-12 |
2023-08-12 |
mouse |
| M Pomponi, A Di Gioia, P Bria, M F L Pompon. Fatty aspirin: a new perspective in the prevention of dementia of Alzheimer's type? Current Alzheimer research. vol 5. issue 5. 2008-12-12. PMID:18855583. |
dha and newly identified dha-derived messenger, neuroprotecting d1 (npd1), protect synapses and decrease the number of activated microglia in the hippocampal system. |
2008-12-12 |
2023-08-12 |
Not clear |
| Gigliola Ramírez, Sergio Rey, Rommy von Bernhard. Proinflammatory stimuli are needed for induction of microglial cell-mediated AbetaPP_{244-C} and Abeta-neurotoxicity in hippocampal cultures. Journal of Alzheimer's disease : JAD. vol 15. issue 1. 2008-11-18. PMID:18780966. |
those effects were not observed in the absence of microglia or when hippocampal cells were co-cultured with microglia for one day. |
2008-11-18 |
2023-08-12 |
Not clear |
| Gigliola Ramírez, Sergio Rey, Rommy von Bernhard. Proinflammatory stimuli are needed for induction of microglial cell-mediated AbetaPP_{244-C} and Abeta-neurotoxicity in hippocampal cultures. Journal of Alzheimer's disease : JAD. vol 15. issue 1. 2008-11-18. PMID:18780966. |
in contrast, a 2-fold increase of transforming growth factor beta1 was observed in hippocampal cultures exposed to inflammatory stimuli for 4 days, whereas induction of transforming growth factor beta1 by inflammation plus amyloid-beta and amyloid-beta protein precursor was nearly abolished by microglia. |
2008-11-18 |
2023-08-12 |
Not clear |
| Wha-Sun Kang, Jeong-Sun Choi, Yoo-Jin Shin, Ha-Young Kim, Jung-Ho Cha, Ji-Yeon Lee, Myung-Hoon Chun, Mun-Yong Le. Differential regulation of osteopontin receptors, CD44 and the alpha(v) and beta(3) integrin subunits, in the rat hippocampus following transient forebrain ischemia. Brain research. vol 1228. 2008-11-03. PMID:18638458. |
in contrast, increased immunoreactivity for alpha(v) and beta(3), which shared overlapping expression patterns in the ischemic hippocampus, occurred in the majority of reactive astrocytes and only a few microglia at day 3 after reperfusion, and was sustained for more than 2 weeks. |
2008-11-03 |
2023-08-12 |
rat |
| Elena Avignone, Lauriane Ulmann, Françoise Levavasseur, François Rassendren, Etienne Audina. Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 37. 2008-11-03. PMID:18784294. |
se induced within 3 h an increased expression of inflammatory mediators in the hippocampus, followed by a modification of microglia morphology, a microglia proliferation, and a significant neurodegeneration in ca1. |
2008-11-03 |
2023-08-12 |
mouse |
| Elena Avignone, Lauriane Ulmann, Françoise Levavasseur, François Rassendren, Etienne Audina. Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 37. 2008-11-03. PMID:18784294. |
changes in electrophysiological intrinsic membrane properties of hippocampal microglia were detected at 24-48 h after se with, in particular, the appearance of new voltage-activated potassium currents. |
2008-11-03 |
2023-08-12 |
mouse |
| Elena Avignone, Lauriane Ulmann, Françoise Levavasseur, François Rassendren, Etienne Audina. Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 37. 2008-11-03. PMID:18784294. |
consistent with the observation of an upregulation of purinergic receptor mrnas in the hippocampus, we also provide pharmacological evidence that microglia membrane currents mediated by the activation of p2 receptors, including p2x(7), p2y(6), and p2y(12), were increased 48 h after se. |
2008-11-03 |
2023-08-12 |
mouse |
| Elena Avignone, Lauriane Ulmann, Françoise Levavasseur, François Rassendren, Etienne Audina. Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 37. 2008-11-03. PMID:18784294. |
as a functional consequence of this modification of purinergic signaling, motility of microglia processes toward a source of p2y(12) receptor agonist was twice as fast in the epileptic hippocampus. |
2008-11-03 |
2023-08-12 |
mouse |
| Maria Strassburger, Holger Braun, Klaus G Reyman. Anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. European journal of pharmacology. vol 592. issue 1-3. 2008-10-24. PMID:18638472. |
anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor sb239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. |
2008-10-24 |
2023-08-12 |
Not clear |
| Maria Strassburger, Holger Braun, Klaus G Reyman. Anti-inflammatory treatment with the p38 mitogen-activated protein kinase inhibitor SB239063 is neuroprotective, decreases the number of activated microglia and facilitates neurogenesis in oxygen-glucose-deprived hippocampal slice cultures. European journal of pharmacology. vol 592. issue 1-3. 2008-10-24. PMID:18638472. |
the p38 mapk phosphorylation returned to basal levels within 1 h after oxygen-glucose deprivation, whereas the erk1/2 phosphorylation reached the basal level only after 24 h. treatment with 20 microm and 100 microm sb239063 strikingly reduced cell death after oxygen-glucose deprivation and significantly diminished microglia activation in the cornu ammonis (ca-region), but not in the area dentata. |
2008-10-24 |
2023-08-12 |
Not clear |
| Rajat Sandhir, Gregory Onyszchuk, Nancy E J Berma. Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury. Experimental neurology. vol 213. issue 2. 2008-10-08. PMID:18692046. |
basal mrna expression of cd11b and iba1, markers of activated microglia, was higher in aged hippocampus as compared to the adult. |
2008-10-08 |
2023-08-12 |
mouse |
| Rajat Sandhir, Gregory Onyszchuk, Nancy E J Berma. Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury. Experimental neurology. vol 213. issue 2. 2008-10-08. PMID:18692046. |
the pronounced and prolonged activation of microglia and astrocytes in hippocampus may contribute to worse cognitive outcomes in the elderly following tbi. |
2008-10-08 |
2023-08-12 |
mouse |