| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asha Naidu, Qiang Xu, Rosanne Catalano, Barbara Cordel. Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain research. vol 958. issue 1. 2003-02-25. PMID:12468034. |
we determined that protein prenylation is required for apoe release from a continuous microglial cell line, primary mixed glia, and from organotypic hippocampal cultures. |
2003-02-25 |
2023-08-12 |
Not clear |
| Chun Shu Piao, Yongzhe Che, Pyung-Lim Han, Ja-Kyeong Le. Delayed and differential induction of p38 MAPK isoforms in microglia and astrocytes in the brain after transient global ischemia. Brain research. Molecular brain research. vol 107. issue 2. 2003-02-10. PMID:12425942. |
the induced p38alpha was concentrated in microglia in hippocampus as well as in frontal and parietal cortices of the brain, where significant neuronal damage was occurred. |
2003-02-10 |
2023-08-12 |
Not clear |
| A D Rogove, W Lu, Stella E Tsirk. Microglial activation and recruitment, but not proliferation, suffice to mediate neurodegeneration. Cell death and differentiation. vol 9. issue 8. 2003-01-31. PMID:12107823. |
we have reported that microglia can exhibit neurotoxic behaviors after injection of excitotoxins into the hippocampus. |
2003-01-31 |
2023-08-12 |
mouse |
| Sheila M Brooke, Robert M Sapolsk. Glucocorticoid exacerbation of gp120 neurotoxicity: role of microglia. Experimental neurology. vol 177. issue 1. 2002-12-09. PMID:12429218. |
there also appeared to be a component of gp120 neurotoxicity in hippocampal cultures that was exacerbated by gcs, independent of the amount of microglia present. |
2002-12-09 |
2023-08-12 |
Not clear |
| S Chirumamilla, D Sun, M R Bullock, R J Colell. Traumatic brain injury induced cell proliferation in the adult mammalian central nervous system. Journal of neurotrauma. vol 19. issue 6. 2002-09-13. PMID:12165131. |
in contrast, there was a significant increase in the number of immature astrocytes and activated microglia, but not neurons, at this early time point in the hippocampus. |
2002-09-13 |
2023-08-12 |
rat |
| O T Wolf, V Dyakin, A Patel, C Vadasz, M J de Leon, B S McEwen, K Bulloc. Volumetric structural magnetic resonance imaging (MRI) of the rat hippocampus following kainic acid (KA) treatment. Brain research. vol 934. issue 2. 2002-08-07. PMID:11955471. |
the histological observations supported the mri data showing neuronal loss and neuronal degeneration in ca1 and ca3 of the hippocampus, which was accompanied by strong microglia activation. |
2002-08-07 |
2023-08-12 |
rat |
| Valerie A M Vincent, Simon P Selwood, Greer M Murph. Proinflammatory effects of M-CSF and A beta in hippocampal organotypic cultures. Neurobiology of aging. vol 23. issue 3. 2002-06-14. PMID:11959396. |
induction of cytokines and inos was also observed after lipopolysaccharide treatment of organotypic hippocampal cultures, but inos expression was localized mainly to microglia rather than astrocytes. |
2002-06-14 |
2023-08-12 |
Not clear |
| G Jean Harry, Kelly Tyler, Christian Lefebvre d'Hellencourt, Hugh A Tilson, William E Maie. Morphological alterations and elevations in tumor necrosis factor-alpha, interleukin (IL)-1alpha, and IL-6 in mixed glia cultures following exposure to trimethyltin: modulation by proinflammatory cytokine recombinant proteins and neutralizing antibodies. Toxicology and applied pharmacology. vol 180. issue 3. 2002-06-11. PMID:12009860. |
trimethyltin (tmt), is a hippocampal neurotoxicant characterized by neuronal degeneration, astrogliosis, and microglia reactivity with an associated elevation in proinflammatory cytokine mrna levels. |
2002-06-11 |
2023-08-12 |
Not clear |
| Gigliola Grassi Zucconi, Maria Assunta Laurenzi, Massimo Semprevivo, Federica Torni, Jan Ake Lindgren, Eva Marinucc. Microglia activation and cell death in response to diethyl-dithiocarbamate acute administration. The Journal of comparative neurology. vol 446. issue 2. 2002-05-09. PMID:11932932. |
administration of ddtc at two different doses, microglia were already activated in selected areas of the rat brain (hippocampal dentate gyrus, entorhinal-pyriform cortex and hypothalamus) after 1 hour, reaching a peak at 3-6 hours and subsided within 6-48 hours, depending on the brain region. |
2002-05-09 |
2023-08-12 |
rat |
| M J Picklo, S J Olson, J D Hayes, W R Markesbery, T J Montin. Elevation of AKR7A2 (succinic semialdehyde reductase) in neurodegenerative disease. Brain research. vol 916. issue 1-2. 2002-01-14. PMID:11597610. |
our results show that in the cerebral cortex and hippocampus, akr7a2 is primarily localized to glial cells, astrocytes and microglia. |
2002-01-14 |
2023-08-12 |
Not clear |
| L C Park, H Zhang, G E Gibso. Co-culture with astrocytes or microglia protects metabolically impaired neurons. Mechanisms of ageing and development. vol 123. issue 1. 2002-01-04. PMID:11640948. |
td primary hippocampal neurons were either cultured alone, or co-cultured with primary astrocytes or microglia. |
2002-01-04 |
2023-08-12 |
Not clear |
| M R Dandrea, P A Reiser, N A Gumula, B M Hertzog, P Andrade-Gordo. Application of triple immunohistochemistry to characterize amyloid plaque-associated inflammation in brains with Alzheimer's disease. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 76. issue 2. 2001-12-04. PMID:11440311. |
we used our routine single immunohistochemical (ihc) labeling protocol to label amyloid plaques, an ad neuropathological hallmark, activated microglia, and reactive astrocytes in serial sections of ad hippocampus and entorhinal cortex of brain. |
2001-12-04 |
2023-08-12 |
Not clear |
| M R Dandrea, P A Reiser, N A Gumula, B M Hertzog, P Andrade-Gordo. Application of triple immunohistochemistry to characterize amyloid plaque-associated inflammation in brains with Alzheimer's disease. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 76. issue 2. 2001-12-04. PMID:11440311. |
because serial sectioning limited our ability to confirm these findings, we developed a triple ihc protocol to investigate the association of activated microglia and reactive astrocytes simultaneously with amyloid plaques in sections of ad brain entorhinal cortex and hippocampus. |
2001-12-04 |
2023-08-12 |
Not clear |
| L F Lue, D G Walker, L Brachova, T G Beach, J Rogers, A M Schmidt, D M Stern, S D Ya. Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism. Experimental neurology. vol 171. issue 1. 2001-10-11. PMID:11520119. |
using brain tissue from ad and nondemented (nd) individuals, rage expression was shown to be present on microglia and neurons of the hippocampus, entorhinal cortex, and superior frontal gyrus. |
2001-10-11 |
2023-08-12 |
Not clear |
| X R Lu, W Y On. Heme oxgenase-1 is expressed in viable astrocytes and microglia but in degenerating pyramidal neurons in the kainate-lesioned rat hippocampus. Experimental brain research. vol 137. issue 3-4. 2001-10-04. PMID:11355387. |
heme oxgenase-1 is expressed in viable astrocytes and microglia but in degenerating pyramidal neurons in the kainate-lesioned rat hippocampus. |
2001-10-04 |
2023-08-12 |
rat |
| O M Mitrasinovic, G V Perez, F Zhao, Y L Lee, C Poon, G M Murph. Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response. The Journal of biological chemistry. vol 276. issue 32. 2001-09-06. PMID:11387343. |
by using a co-culture of c-fms-transfected murine microglia and rat organotypic hippocampal slices and a species-specific real time reverse transcriptase-polymerase chain reaction assay and enzyme-linked immunosorbent assay, we showed that m-csfr overexpression on exogenous microglia induced expression of interleukin-1alpha by the organotypic culture. |
2001-09-06 |
2023-08-12 |
mouse |
| Y Taniwak. [The microglial activation and the expression of heat shock protein 27 through the propagation pathway of kainic acid-induced hippocampal seizure in the rat]. Fukuoka igaku zasshi = Hukuoka acta medica. vol 92. issue 2. 2001-07-12. PMID:11280925. |
we studied activation of microglia and expression of the 27 kda heat shock protein (hsp27) in the brain during kainic acid-induced acute hippocampal seizures in rats. |
2001-07-12 |
2023-08-12 |
rat |
| J Bu, N Akhtar, A Nishiyam. Transient expression of the NG2 proteoglycan by a subpopulation of activated macrophages in an excitotoxic hippocampal lesion. Glia. vol 34. issue 4. 2001-07-12. PMID:11360302. |
changes in ng2+ cells were examined in kainic acid-induced excitotoxic lesions of the hippocampus, and the relationship between ng2+ cells and reactive astrocytes and microglia was investigated between 1 and 90 days after lesioning. |
2001-07-12 |
2023-08-12 |
Not clear |
| E Aronica, B Yankaya, D Troost, E A van Vliet, F H Lopes da Silva, J A Gorte. Induction of neonatal sodium channel II and III alpha-isoform mRNAs in neurons and microglia after status epilepticus in the rat hippocampus. The European journal of neuroscience. vol 13. issue 6. 2001-06-21. PMID:11285025. |
induction of neonatal sodium channel ii and iii alpha-isoform mrnas in neurons and microglia after status epilepticus in the rat hippocampus. |
2001-06-21 |
2023-08-12 |
rat |
| K Palin, F Pousset, D Verrier, R Dantzer, K Kelley, P Parnet, J Lestag. Characterization of interleukin-1 receptor antagonist isoform expression in the brain of lipopolysaccharide-treated rats. Neuroscience. vol 103. issue 1. 2001-05-24. PMID:11311797. |
double immunofluorescence staining revealed interleukin-1 receptor antagonist positive neurons and microglia in hippocampus 24h after lipopolysaccharide stimulation. |
2001-05-24 |
2023-08-12 |
rat |