| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Susan H Brunssen, Daniel L Morgan, Frederick M Parham, G Jean Harr. Carbon monoxide neurotoxicity: transient inhibition of avoidance response and delayed microglia reaction in the absence of neuronal death. Toxicology. vol 194. issue 1-2. 2004-01-07. PMID:14636696. |
histological examination showed no evidence of delayed neuronal death or astrocyte reactivity in the hippocampus or cerebellum; however, a distinct focal staining of reactive microglia in both regions was evident in animals exposed to 4000 ppm co. |
2004-01-07 |
2023-08-12 |
rat |
| Christine T Ekdahl, Jan-Hendrik Claasen, Sara Bonde, Zaal Kokaia, Olle Lindval. Inflammation is detrimental for neurogenesis in adult brain. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14581618. |
here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats. |
2004-01-05 |
2023-08-12 |
rat |
| Christine T Ekdahl, Jan-Hendrik Claasen, Sara Bonde, Zaal Kokaia, Olle Lindval. Inflammation is detrimental for neurogenesis in adult brain. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14581618. |
our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation. |
2004-01-05 |
2023-08-12 |
rat |
| M Sean Grady, Jay S Charleston, Don Maris, Brent M Witgen, Jonathan Lifshit. Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: analysis by stereological estimation. Journal of neurotrauma. vol 20. issue 10. 2004-01-05. PMID:14588110. |
at 14 days post-injury, strict morphological criteria enabled the estimation of neurons, astrocytes, oligodendrocytes, and microglia in defined hippocampal subregions. |
2004-01-05 |
2023-08-12 |
rat |
| Heasuk Lee, Young Ok Kim, Hocheol Kim, Sun Yeou Kim, Hae Sook Noh, Sang Soo Kang, Gyeong Jae Cho, Wan Sung Choi, Kyoungho Su. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 13. 2003-11-12. PMID:12897065. |
in both animal models, wogonin conferred neuroprotection by attenuating the death of hippocampal neurons, and the neuroprotective effect was associated with inhibition of the inflammatory activation of microglia. |
2003-11-12 |
2023-08-12 |
Not clear |
| Alicia A Babcock, William A Kuziel, Serge Rivest, Trevor Owen. Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 21. 2003-09-16. PMID:12944523. |
a population of mac1/cd11b+ cd45high macrophages (distinct from cd45low microglia) was specifically detected within the lesion-reactive hippocampus by 12 hr after injury. |
2003-09-16 |
2023-08-12 |
mouse |
| Alicia A Babcock, William A Kuziel, Serge Rivest, Trevor Owen. Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 21. 2003-09-16. PMID:12944523. |
in situ hybridization combined with immunohistochemistry for ionized binding calcium adapter molecule (iba)1 or glial fibrillary acidic protein (gfap) identified iba1+ microglia and gfap+ astrocytes as major sources of mcp-1/ccl2 within the lesion-reactive hippocampus. |
2003-09-16 |
2023-08-12 |
mouse |
| Nam-Gon Kim, Heasuk Lee, Eunyung Son, Oh-Young Kwon, Jae-Yong Park, Jae-Hoon Park, Gyeong Jae Cho, Wan Sung Choi, Kyoungho Su. Hypoxic induction of caspase-11/caspase-1/interleukin-1beta in brain microglia. Brain research. Molecular brain research. vol 114. issue 2. 2003-09-05. PMID:12829320. |
caspase-11-expressing cells in hippocampus were morphologically identified as microglia. |
2003-09-05 |
2023-08-12 |
mouse |
| H Zhao, L N Du, J W Jiang, G C Wu, X D Ca. [Modulatory effect of orphanin FQ on the IL-1beta transcripts in hippocampus]. Sheng li xue bao : [Acta physiologica Sinica]. vol 53. issue 3. 2003-08-29. PMID:12589406. |
based on the results, we conclude that orphanin fq functions as a neuroimmune modulator, and provokes immune response via mediation of il-lbeta derived from neuron, astrocyte and microglia in hippocampus. |
2003-08-29 |
2023-08-12 |
Not clear |
| Karin Borges, Marla Gearing, Dayna L McDermott, Amy B Smith, Antoine G Almonte, Bruce H Wainer, Raymond Dingledin. Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model. Experimental neurology. vol 182. issue 1. 2003-08-06. PMID:12821374. |
beta2 microglobulin-positive activated microglia, normally absent in brains without se, became abundant over 3-31 days in regions of neuronal loss, including the hippocampus and the amygdala. |
2003-08-06 |
2023-08-12 |
mouse |
| C Cunningham, R Deacon, H Wells, D Boche, S Waters, C Picanco Diniz, H Scott, J N P Rawlins, V H Perr. Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease. The European journal of neuroscience. vol 17. issue 10. 2003-07-28. PMID:12786981. |
at this time, microglia activation and prpsc deposition was visible selectively throughout the limbic system, including the hippocampus, entorhinal cortex, medial and lateral septum, mamillary bodies, dorsal thalamus and, to a lesser degree, in regions of the brainstem. |
2003-07-28 |
2023-08-12 |
mouse |
| Ilker Y Eyüpoglu, Ingo Bechmann, Robert Nitsc. Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 9. 2003-06-25. PMID:12692086. |
modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus. |
2003-06-25 |
2023-08-12 |
Not clear |
| Ilker Y Eyüpoglu, Ingo Bechmann, Robert Nitsc. Modification of microglia function protects from lesion-induced neuronal alterations and promotes sprouting in the hippocampus. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 17. issue 9. 2003-06-25. PMID:12692086. |
here we show that, after entorhinal cortex lesion, activation of microglia, but not other glial cells, leads to massive secondary dendritic changes of deafferentiated hippocampal neurons. |
2003-06-25 |
2023-08-12 |
Not clear |
| Anton B Tonchev, Tetsumori Yamashima, Liang Zhao, Hideyuki Okan. Differential proliferative response in the postischemic hippocampus, temporal cortex, and olfactory bulb of young adult macaque monkeys. Glia. vol 42. issue 3. 2003-06-10. PMID:12673828. |
the ischemic insult significantly increased the number of proliferating cells in the hippocampus and temporal neocortex, where the majority brdu-labeled cells expressed markers for microglia (iba1, cd68, and ham56) or astrocytes (s-100beta and glial fibrillary acidic protein [gfap]). |
2003-06-10 |
2023-08-12 |
monkey |
| Ikuko Mohri, Naomi Eguchi, Kinuko Suzuki, Yoshihiro Urade, Masako Taniik. Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain. Glia. vol 42. issue 3. 2003-06-10. PMID:12673832. |
spaciotemporal evaluation of microglial development and migration with hpgds immunostaining revealed the following three major possible migration pathways of microglia in the postnatal brain: from the lateral ventricle via subventricular zones to brain parenchyma; from the leptomeninges around the cerebellopontine angle to the cerebellar white matter; and from the overlying leptomeninges to the hippocampus, basal forebrain, and brainstem. |
2003-06-10 |
2023-08-12 |
mouse |
| C K Petito, B Adkins, M McCarthy, B Roberts, I Khami. CD4+ and CD8+ cells accumulate in the brains of acquired immunodeficiency syndrome patients with human immunodeficiency virus encephalitis. Journal of neurovirology. vol 9. issue 1. 2003-05-09. PMID:12587067. |
monocytes, microglia, and multinucleated giant cells were immunoreactive for cd4 in aids cases with hippocampal hive but microglia in remaining aids cases and controls were cd4-. |
2003-05-09 |
2023-08-12 |
human |
| C Ananth, P Gopalakrishnakone, C Kau. Induction of inducible nitric oxide synthase expression in activated microglia following domoic acid (DA)-induced neurotoxicity in the rat hippocampus. Neuroscience letters. vol 338. issue 1. 2003-04-10. PMID:12565138. |
induction of inducible nitric oxide synthase expression in activated microglia following domoic acid (da)-induced neurotoxicity in the rat hippocampus. |
2003-04-10 |
2023-08-12 |
rat |
| C Ananth, P Gopalakrishnakone, C Kau. Induction of inducible nitric oxide synthase expression in activated microglia following domoic acid (DA)-induced neurotoxicity in the rat hippocampus. Neuroscience letters. vol 338. issue 1. 2003-04-10. PMID:12565138. |
neuronal degeneration followed by glial activation (microglia and astrocytes) and nitric oxide synthase (nos) expression in the hippocampus was investigated at 3 months after domoic acid (da) administration and compared with da treated rats at 5 days time interval which was reported earlier. |
2003-04-10 |
2023-08-12 |
rat |
| Lary C Walker, Michael J Callahan, Feng Bian, Robert A Durham, Alex E Roher, William J Lipinsk. Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice. Peptides. vol 23. issue 7. 2003-04-03. PMID:12128081. |
five months following injection of ad-extract, an isolated cluster of abeta-immunoreactive microglia was sometimes evident in the ipsilateral entorhinal cortex; the strong innervation of the hippocampus by entorhinal cortical neurons suggests the possible spread of seeded pathology from the injection site via neuronal transport mechanisms. |
2003-04-03 |
2023-08-12 |
mouse |
| Karin Schüppel, Kurt Brauer, Wolfgang Härtig, Jens Grosche, Bernadette Earley, Brian E Leonard, Gert Brückne. Perineuronal nets of extracellular matrix around hippocampal interneurons resist destruction by activated microglia in trimethyltin-treated rats. Brain research. vol 958. issue 2. 2003-03-27. PMID:12470883. |
perineuronal nets of extracellular matrix around hippocampal interneurons resist destruction by activated microglia in trimethyltin-treated rats. |
2003-03-27 |
2023-08-12 |
rat |