| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jens Neumann, Matthias Gunzer, Herwig O Gutzeit, Oliver Ullrich, Klaus G Reymann, Klaus Dinke. Microglia provide neuroprotection after ischemia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 6. 2006-05-08. PMID:16473887. |
using a model of exogenous application of fluorescence-labeled bv2 microglia in pathophysiologically relevant concentrations onto organotypic hippocampal slice cultures, we investigated the specific effects of microglia on neuronal damage after ischemic injury. |
2006-05-08 |
2023-08-12 |
Not clear |
| K Saud, R Herrera-Molina, R Von Bernhard. Pro- and anti-inflammatory cytokines regulate the ERK pathway: implication of the timing for the activation of microglial cells. Neurotoxicity research. vol 8. issue 3-4. 2006-04-27. PMID:16371322. |
in hippocampal cultures exposed to lps+ifn-gamma, tgf-beta1 was induced whereas in microglial cell cultures lps+ifn-gamma induced the secretion of il-1beta. |
2006-04-27 |
2023-08-12 |
Not clear |
| Kosuke Kajitani, Hiroo Yamaguchi, Yukihiko Dan, Masato Furuichi, Dongchon Kang, Yusaku Nakabepp. MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 6. 2006-04-26. PMID:16467516. |
mth1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity. |
2006-04-26 |
2023-08-12 |
mouse |
| Kosuke Kajitani, Hiroo Yamaguchi, Yukihiko Dan, Masato Furuichi, Dongchon Kang, Yusaku Nakabepp. MTH1, an oxidized purine nucleoside triphosphatase, suppresses the accumulation of oxidative damage of nucleic acids in the hippocampal microglia during kainate-induced excitotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 6. 2006-04-26. PMID:16467516. |
mth1-null and wild-type mice exhibited a similar degree of ca3 neuron loss after kainate administration; however, the 8-oxog levels that accumulated in mitochondrial dna and cellular rna in the ca3 microglia significantly increased in the mth1-null mice in comparison with wild-type mice, thus demonstrating that mth1 efficiently suppresses the accumulation of 8-oxog in both cellular dna and rna in the hippocampus, especially in microglia, caused by excitotoxicity. |
2006-04-26 |
2023-08-12 |
mouse |
| Yaniv Ziv, Noga Ron, Oleg Butovsky, Gennady Landa, Einav Sudai, Nadav Greenberg, Hagit Cohen, Jonathan Kipnis, Michal Schwart. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nature neuroscience. vol 9. issue 2. 2006-03-29. PMID:16415867. |
this work identifies t lymphocytes and microglia as being important to the maintenance of hippocampal neurogenesis and spatial learning abilities in adulthood. |
2006-03-29 |
2023-08-12 |
mouse |
| Yaniv Ziv, Noga Ron, Oleg Butovsky, Gennady Landa, Einav Sudai, Nadav Greenberg, Hagit Cohen, Jonathan Kipnis, Michal Schwart. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nature neuroscience. vol 9. issue 2. 2006-03-29. PMID:16415867. |
hippocampal neurogenesis induced by an enriched environment was associated with the recruitment of t cells and the activation of microglia. |
2006-03-29 |
2023-08-12 |
mouse |
| Peter H Jellinck, Martin Kaufmann, Andres Gottfried-Blackmore, Gist Croft, Valarie Byford, Bruce S McEwen, Glenville Jones, Karen Bulloc. Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microglia. The Journal of steroid biochemistry and molecular biology. vol 98. issue 1. 2006-03-23. PMID:16203131. |
bv2 mouse microglia were virtually unable to hydroxylate dhea at c-7 and converted ad to a major unknown metabolite not observed with mouse bhc hippocampal cells. |
2006-03-23 |
2023-08-12 |
mouse |
| Hantamalala Ralay Ranaivo, Jeffrey M Craft, Wenhui Hu, Ling Guo, Laura K Wing, Linda J Van Eldik, D Martin Watterso. Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 2. 2006-03-17. PMID:16407564. |
oral mw01-5-188wh therapy begun 3 weeks after initiation of intracerebroventricular infusion of human abeta decreased the numbers of activated astrocytes and microglia and the cytokine levels in the hippocampus without modifying amyloid plaque burden or altering peripheral tissue cytokine upregulation in response to an in vivo inflammatory challenge. |
2006-03-17 |
2023-08-12 |
mouse |
| Zhongmin Xiang, Vahram Haroutunian, Lap Ho, Dushant Purohit, Giulio Maria Pasinett. Microglia activation in the brain as inflammatory biomarker of Alzheimer's disease neuropathology and clinical dementia. Disease markers. vol 22. issue 1-2. 2006-03-17. PMID:16410654. |
in the hippocampus, a significant increase in microglia immunostaining was found in the pyramidal cell layer of ca1 as early as cdr 1, and in the upper molecular layer of the dentate gyrus in cdr 0.5. |
2006-03-17 |
2023-08-12 |
human |
| Chol Seung Lim, Da-Qing Jin, Hyejung Mok, Sang Jin Oh, Jung Uk Lee, Jae Kwan Hwang, Ilho Ha, Jung-Soo Ha. Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. Journal of neuroscience research. vol 82. issue 6. 2006-03-14. PMID:16273545. |
antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia. |
2006-03-14 |
2023-08-12 |
rat |
| Olivera M Mitrasinovic, Alicia Grattan, Christopher C Robinson, Nicolae B Lapustea, Clara Poon, Heather Ryan, Connie Phong, Greer M Murph. Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 17. 2006-03-09. PMID:15858070. |
to determine whether m-csfr-induced microglial activation affects neuronal survival, we assembled a coculture system consisting of bv-2 microglia transfected to overexpress the m-csfr and hippocampal organotypic slices treated with nmda. |
2006-03-09 |
2023-08-12 |
mouse |
| Olivera M Mitrasinovic, Alicia Grattan, Christopher C Robinson, Nicolae B Lapustea, Clara Poon, Heather Ryan, Connie Phong, Greer M Murph. Microglia overexpressing the macrophage colony-stimulating factor receptor are neuroprotective in a microglial-hippocampal organotypic coculture system. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 17. 2006-03-09. PMID:15858070. |
twenty-four hours after assembly of the coculture, microglia overexpressing m-csfr proliferated at a higher rate than nontransfected control cells and exhibited enhanced migration toward nmda-injured hippocampal cultures. |
2006-03-09 |
2023-08-12 |
mouse |
| Staci D Bilbo, Joseph C Biedenkapp, Andre Der-Avakian, Linda R Watkins, Jerry W Rudy, Steven F Maie. Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 35. 2006-03-07. PMID:16135757. |
in experiment 1, peripheral infection with escherichia coli on postnatal day 4 increased cytokines and corticosterone in the periphery, and cytokine and microglial cell marker gene expression in the hippocampus of neonate pups. |
2006-03-07 |
2023-08-12 |
rat |
| Staci D Bilbo, Joseph C Biedenkapp, Andre Der-Avakian, Linda R Watkins, Jerry W Rudy, Steven F Maie. Neonatal infection-induced memory impairment after lipopolysaccharide in adulthood is prevented via caspase-1 inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 35. 2006-03-07. PMID:16135757. |
microglial cell marker mrna was elevated in hippocampus in saline controls infected as neonates. |
2006-03-07 |
2023-08-12 |
rat |
| K Dobrenis, H-Y Chang, M H Pina-Benabou, A Woodroffe, S C Lee, R Rozental, D C Spray, E Sceme. Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons. Journal of neuroscience research. vol 82. issue 3. 2006-02-24. PMID:16211561. |
importantly, similar frequency of low-strength electrical coupling was also obtained between microglia and neurons in cocultures prepared from neocortical or hippocampal rodent tissue. |
2006-02-24 |
2023-08-12 |
mouse |
| W Shawn Carbonell, Shin-Ichi Murase, Alan F Horwitz, James W Mandel. Migration of perilesional microglia after focal brain injury and modulation by CC chemokine receptor 5: an in situ time-lapse confocal imaging study. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 30. 2006-02-15. PMID:16049180. |
finally, activated microglia in the denervated hippocampal stratum oriens did not migrate extensively, whereas human immunodeficiency virus-1 tat-activated microglia migrated nearly twice as fast as those at the stab lesion, indicating a nonuniform microglial response to different stimuli. |
2006-02-15 |
2023-08-12 |
mouse |
| Sang-Ho Choi, Da Yong Lee, Seung Up Kim, Byung Kwan Ji. Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 16. 2006-02-14. PMID:15843610. |
in parallel, thrombin-activated microglia, assessed by ox-42 and ox-6 immunohistochemistry, and ros production, assessed by hydroethidine histochemistry, were observed in the hippocampal ca1 area in which degeneration of hippocampal neurons occurred. |
2006-02-14 |
2023-08-12 |
Not clear |
| Sang-Ho Choi, Da Yong Lee, Seung Up Kim, Byung Kwan Ji. Thrombin-induced oxidative stress contributes to the death of hippocampal neurons in vivo: role of microglial NADPH oxidase. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 16. 2006-02-14. PMID:15843610. |
additional studies demonstrated that thrombin induced the upregulation of membrane (gp91(phox)) and cytosolic (p47(phox) and p67(phox)) components, translocation of cytosolic proteins (p47(phox), p67(phox), and rac1) to the membrane, and p67(phox) expression of the nadph oxidase in microglia in the hippocampus in vivo, indicating the activation of nadph oxidase. |
2006-02-14 |
2023-08-12 |
Not clear |
| Christopher B Fordyce, Ravi Jagasia, Xiaoping Zhu, Lyanne C Schlichte. Microglia Kv1.3 channels contribute to their ability to kill neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 31. 2006-02-07. PMID:16079396. |
using a transwell cell-culture system that allows separate drug treatment of microglia or neurons, we found that activated microglia killed postnatal hippocampal neurons through a process that requires kv1.3 channel activity in microglia but not in neurons. |
2006-02-07 |
2023-08-12 |
rat |
| Han Kyu Lee, Young Jun Seo, Seong Soo Choi, Min Soo Kwon, Eon Jeong Shim, Jin Young Lee, Hong Won Su. Role of gamma-aminobutyricacidB(GABA(B)) receptors in the regulation of kainic acid-induced cell death in mouse hippocampus. Experimental & molecular medicine. vol 37. issue 6. 2006-02-01. PMID:16391514. |
activated astrocytes, which was presented by gfap ir, and activated microglia, which was presented by the ox-42 ir, may be a good indicator for measuring the cell death in hippocampal regions by ka excitotoxicity. |
2006-02-01 |
2023-08-12 |
mouse |