| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James G McLarnon, Jae K Ryu, Douglas G Walker, Hyun B Cho. Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. Journal of neuropathology and experimental neurology. vol 65. issue 11. 2006-12-27. PMID:17086106. |
the expression of the purinergic receptor subtype p2x(7)r, a nonselective cationic channel activated by high levels of adenosine triphosphate (atp), has been studied in adult microglia obtained from alzheimer disease (ad) and nondemented (nd) brains, in fetal human microglia exposed to abeta(1-42) peptide and in vivo in abeta(1-42)-injected rat hippocampus. |
2006-12-27 |
2023-08-12 |
human |
| James G McLarnon, Jae K Ryu, Douglas G Walker, Hyun B Cho. Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus. Journal of neuropathology and experimental neurology. vol 65. issue 11. 2006-12-27. PMID:17086106. |
in vivo, double immunostaining analysis showed considerable p2x(7)r colocalized with microglia after injection of abeta(1-42) (1 nmol) into rat hippocampus. |
2006-12-27 |
2023-08-12 |
human |
| Michael Ewers, David G Morgan, Marcia N Gordon, Diana S Woodruff-Pa. Associative and motor learning in 12-month-old transgenic APP+PS1 mice. Neurobiology of aging. vol 27. issue 8. 2006-12-20. PMID:15993985. |
moreover, cortical amyloid burden and hippocampal microglia activation correlated significantly with decreased ppi. |
2006-12-20 |
2023-08-12 |
mouse |
| Y Hayashi, Y Tomimatsu, H Suzuki, J Yamada, Z Wu, H Yao, Y Kagamiishi, N Tateishi, M Sawada, H Nakanish. The intra-arterial injection of microglia protects hippocampal CA1 neurons against global ischemia-induced functional deficits in rats. Neuroscience. vol 142. issue 1. 2006-12-20. PMID:16844302. |
when pkh26-labeled immortalized microglial cells, gmir1, were injected into the subclavian artery, these exogenous microglia were found to accumulate in the hippocampus at 24 h after ischemia. |
2006-12-20 |
2023-08-12 |
rat |
| Y Hayashi, Y Tomimatsu, H Suzuki, J Yamada, Z Wu, H Yao, Y Kagamiishi, N Tateishi, M Sawada, H Nakanish. The intra-arterial injection of microglia protects hippocampal CA1 neurons against global ischemia-induced functional deficits in rats. Neuroscience. vol 142. issue 1. 2006-12-20. PMID:16844302. |
the protective effect of the intra-arterial injected microglia against the ischemia-induced neuronal degeneration in the hippocampus was substantiated by immunohistochemical and immunoblot analyses. |
2006-12-20 |
2023-08-12 |
rat |
| John F Bowyer, Syed Al. High doses of methamphetamine that cause disruption of the blood-brain barrier in limbic regions produce extensive neuronal degeneration in mouse hippocampus. Synapse (New York, N.Y.). vol 60. issue 7. 2006-12-07. PMID:16952162. |
a very rapid activation of brain microglia and/or infiltration of macrophages in regions of notable iggir increase with intense neurodegeneration were seen within 24 h. the phagocytosis rate of neurons in the hippocampus was so rapid that fj-c labeling was virtually nonexistent 3 days after meth. |
2006-12-07 |
2023-08-12 |
mouse |
| Sonia Franciosi, Jae K Ryu, Hyun B Choi, Lesley Radov, Seung U Kim, James G McLarno. Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 45. 2006-11-28. PMID:17093087. |
additionally, toxicity of supernatant from abeta(1-42)-treated microglia on cultured rat hippocampal neurons was reduced if 4-ap was included with peptide. |
2006-11-28 |
2023-08-12 |
human |
| Douglas W Ethell, Daniel Shippy, Chuanhai Cao, Jennifer R Cracchiolo, Melissa Runfeldt, Brett Blake, Gary W Arendas. Abeta-specific T-cells reverse cognitive decline and synaptic loss in Alzheimer's mice. Neurobiology of disease. vol 23. issue 2. 2006-11-27. PMID:16733088. |
recipients had lower levels of soluble abeta in the hippocampus, less plaque-associated microglia, and more intense synaptophysin immunoreactivity, compared with untreated controls. |
2006-11-27 |
2023-08-12 |
mouse |
| Olga Chechneva, Klaus Dinkel, Fabio Cavaliere, Monica Martinez-Sanchez, Klaus G Reyman. Anti-inflammatory treatment in oxygen-glucose-deprived hippocampal slice cultures is neuroprotective and associated with reduced cell proliferation and intact neurogenesis. Neurobiology of disease. vol 23. issue 2. 2006-11-27. PMID:16733089. |
using organotypic hippocampal cultures (ohc), we investigated the interplay between neuronal damage (propidium iodide uptake), microglia activation (ox-42 immunohistochemistry), cell proliferation (bromodeoxyuridine incorporation), and neurogenesis (double labeling of bromodeoxyuridine with doublecortin or beta-iii tubulin) after oxygen-glucose deprivation (ogd). |
2006-11-27 |
2023-08-12 |
Not clear |
| Maria Domercq, Liliana Brambilla, Ethel Pilati, Julie Marchaland, Andrea Volterra, Paola Bezz. P2Y1 receptor-evoked glutamate exocytosis from astrocytes: control by tumor necrosis factor-alpha and prostaglandins. The Journal of biological chemistry. vol 281. issue 41. 2006-11-27. PMID:16882655. |
in mixed hippocampal cultures, the p2y1r-evoked process occurs in astrocytes but not in neurons or microglia. |
2006-11-27 |
2023-08-12 |
mouse |
| Jun Yamada, Makoto Sawada, Hiroshi Nakanish. Cell cycle-dependent regulation of kainate-induced inward currents in microglia. Biochemical and biophysical research communications. vol 349. issue 3. 2006-11-07. PMID:16962563. |
furthermore, the immunoreactivity for glur6/7 was found to increase in activated microglia in the post-ischemic hippocampus. |
2006-11-07 |
2023-08-12 |
rat |
| M Oksman, H Iivonen, E Hogyes, Z Amtul, B Penke, I Leenders, L Broersen, D Lütjohann, T Hartmann, H Tanil. Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice. Neurobiology of disease. vol 23. issue 3. 2006-11-01. PMID:16765602. |
dha diet also decreased the number of activated microglia in hippocampus and increased exploratory activity of transgenic mice, but did not improve their spatial learning in the water maze. |
2006-11-01 |
2023-08-12 |
mouse |
| M Sawada, K Imamura, T Nagats. Role of cytokines in inflammatory process in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017556. |
the activated microglia in pd were observed not only in the nigro-striatal region, but also in various brain regions such as the hippocampus and cerebral cortex. |
2006-10-24 |
2023-08-12 |
mouse |
| M Sawada, K Imamura, T Nagats. Role of cytokines in inflammatory process in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017556. |
we examined the distribution of activated microglia and the expression of cytokines and neurotrophins in the hippocampus of pd and lewy body disease (lbd). |
2006-10-24 |
2023-08-12 |
mouse |
| M Sawada, K Imamura, T Nagats. Role of cytokines in inflammatory process in Parkinson's disease. Journal of neural transmission. Supplementum. issue 70. 2006-10-24. PMID:17017556. |
the results suggest activated microglia in the hippocampus to be probably neuroprotective in pd, but those to be neurotoxic in lbd. |
2006-10-24 |
2023-08-12 |
mouse |
| Masato Ogura, Noritaka Nakamichi, Katsura Takano, Hirotaka Oikawa, Yuki Kambe, Yu Ohno, Hideo Taniura, Yukio Yoned. Functional expression of A glutamine transporter responsive to down-regulation by lipopolysaccharide through reduced promoter activity in cultured rat neocortical astrocytes. Journal of neuroscience research. vol 83. issue 8. 2006-09-08. PMID:16583402. |
semiquantitative reverse transcription-polymerase chain reaction revealed similarly high expression of mrna for glnt by rat brain neocortical astrocytes as well as neurons, with progressively lower expression by cerebellar astrocytes, hippocampal astrocytes, and whole-brain microglia in culture. |
2006-09-08 |
2023-08-12 |
rat |
| S A Joseph, E Lynd-Balta, M K O'Banion, P M Rappold, J Daschner, A Allen, J Padowsk. Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures. Neuroscience. vol 140. issue 3. 2006-09-08. PMID:16677768. |
additional results from all seizure groups showed cyclooxygenase-1 induction in microglia, which was confirmed by western blot analysis of hippocampus. |
2006-09-08 |
2023-08-12 |
Not clear |
| Matthew G Frank, Julie L Wieseler-Frank, Linda R Watkins, Steven F Maie. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. Journal of neuroscience methods. vol 151. issue 2. 2006-05-18. PMID:16125247. |
rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. |
2006-05-18 |
2023-08-12 |
rat |
| Matthew G Frank, Julie L Wieseler-Frank, Linda R Watkins, Steven F Maie. Rapid isolation of highly enriched and quiescent microglia from adult rat hippocampus: immunophenotypic and functional characteristics. Journal of neuroscience methods. vol 151. issue 2. 2006-05-18. PMID:16125247. |
the present microglia isolation method yielded highly enriched hippocampal microglia, which were devoid of other cns macrophage subtypes and exhibited attributes reflecting a quiescent phenotype characteristic of microglia observed in situ under non-pathological conditions. |
2006-05-18 |
2023-08-12 |
rat |
| Yoshinori Hayashi, Hitoshi Ishibashi, Kenji Hashimoto, Hiroshi Nakanish. Potentiation of the NMDA receptor-mediated responses through the activation of the glycine site by microglia secreting soluble factors. Glia. vol 53. issue 6. 2006-05-16. PMID:16498631. |
it was also noted that an increased glycine productivity of microglia was observed in the hippocampus in the acute phase of neuronal injury. |
2006-05-16 |
2023-08-12 |
Not clear |