| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander V Ovechkin, Neetu Tyagi, Utpal Sen, David Lominadze, Mesia M Steed, Karni S Moshal, Suresh C Tyag. 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice. American journal of physiology. Lung cellular and molecular physiology. vol 291. issue 5. 2006-11-29. PMID:16815886. |
hhcy is associated with activation of matrix metalloproteinases (mmps); however, it is unclear whether hhcy-dependent extracellular matrix (ecm) accumulation plays a role in arterial hypertrophy and hypertension. |
2006-11-29 |
2023-08-12 |
mouse |
| David L Garbers, Ted D Chrisman, Phi Wiegn, Takeshi Katafuchi, Joseph P Albanesi, Vincent Bielinski, Barbara Barylko, Margaret M Redfield, John C Burnet. Membrane guanylyl cyclase receptors: an update. Trends in endocrinology and metabolism: TEM. vol 17. issue 6. 2006-11-13. PMID:16815030. |
recent studies have demonstrated key roles for several membrane guanylyl cyclase receptors in the regulation of cell hyperplasia, hypertrophy, migration and extracellular matrix production, all of which having an impact on clinically relevant diseases, including tissue remodeling after injury. |
2006-11-13 |
2023-08-12 |
Not clear |
| S W Jones, S M V Brockbank, M L Mobbs, N J Le Good, S Soma-Haddrick, A J Heuze, C J Langham, D Timms, P Newham, M R C Needha. The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover. Osteoarthritis and cartilage. vol 14. issue 6. 2006-11-09. PMID:16647866. |
the orphan g-protein coupled receptor rdc1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover. |
2006-11-09 |
2023-08-12 |
human |
| Mangalalaxmy Subramanian, Ping-Ping Kuang, Lin Wei, David C Rishikof, Hanqiao Liu, Ronald H Goldstei. Modulation of amino acid uptake by TGF-beta in lung myofibroblasts. Journal of cellular biochemistry. vol 99. issue 1. 2006-11-06. PMID:16598748. |
transforming growth factor-beta (tgf-beta) stimulates amino acid uptake thereby inducing cell proliferation, cellular hypertrophy, and matrix synthesis. |
2006-11-06 |
2023-08-12 |
human |
| Maria Mirotsou, Victor J Dzau, Richard E Pratt, Ellen O Weinber. Physiological genomics of cardiac disease: quantitative relationships between gene expression and left ventricular hypertrophy. Physiological genomics. vol 27. issue 1. 2006-11-02. PMID:16835353. |
of genes with significant correlations to numerically continuous measurements of hypertrophy, we found enrichment for genes encoding extracellular matrix, growth-related and secreted proteins in the directly correlated subset, and for genes encoding mitochondria and metabolic/fatty acid oxidation proteins in the inversely correlated subset. |
2006-11-02 |
2023-08-12 |
mouse |
| Yung-Tsung Chiu, Ching-Chang Cheng, Nai-Nu Lin, Yi-Wen Hung, Ying-Tsung Chen, Shih-Lan Hsu, Ching-Shiang Chi, Yun-Ching F. High-dose norepinephrine induces disruption of myocardial extracellular matrix and left ventricular dilatation and dysfunction in a novel feline model. Journal of the Chinese Medical Association : JCMA. vol 69. issue 8. 2006-10-26. PMID:16970269. |
intravenous norepinephrine (ne) at a dose of 1-6 microg/kg/minute can induce increased extracellular matrix (ecm) and hypertrophic cardiomyopathy. |
2006-10-26 |
2023-08-12 |
Not clear |
| Sada Boodoo, Ernst W Spannhake, Jonathan D Powell, Maureen R Horto. Differential regulation of hyaluronan-induced IL-8 and IP-10 in airway epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 291. issue 3. 2006-10-05. PMID:16581825. |
at the cellular level, the hallmarks of airway inflammation are mucus gland hypertrophy with excess mucus production, accumulation of inflammatory mediators, inflammation in the airway walls and lumen, and breakdown and turnover of the extracellular matrix. |
2006-10-05 |
2023-08-12 |
Not clear |
| Hiroyuki Tsutsu. Mitochondrial oxidative stress and heart failure. Internal medicine (Tokyo, Japan). vol 45. issue 13. 2006-09-15. PMID:16880705. |
reactive oxygen species induce myocyte hypertrophy, apoptosis, and interstitial fibrosis by activating matrix metalloproteinases. |
2006-09-15 |
2023-08-12 |
Not clear |
| Siham Madani, Sabrina De Girolamo, Diana Marcela Muñoz, Ren-Ke Li, Gary Sweene. Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes. Cardiovascular research. vol 69. issue 3. 2006-08-18. PMID:16376323. |
both extracellular matrix remodeling and left ventricular hypertrophy are well-defined components of remodeling in heart failure, and here we further investigate the role of leptin, the obese gene product, on these parameters. |
2006-08-18 |
2023-08-12 |
human |
| Susanne Rutschow, Jun Li, Heinz-Peter Schultheiss, Matthias Pauschinge. Myocardial proteases and matrix remodeling in inflammatory heart disease. Cardiovascular research. vol 69. issue 3. 2006-08-18. PMID:16417902. |
the myocardial inflammatory reaction not only affects myocardial hypertrophy and apoptosis, but it has a major influence on the regulation of extracellular matrix turnover. |
2006-08-18 |
2023-08-12 |
Not clear |
| Ernestina Schipan. Hypoxia and HIF-1alpha in chondrogenesis. Annals of the New York Academy of Sciences. vol 1068. 2006-08-08. PMID:16831906. |
in endochondral bone development chondrocytes undergo proliferation, hypertrophic differentiation, mineralization of the surrounding matrix, death, blood vessel invasion, and finally replacement of cartilage with bone. |
2006-08-08 |
2023-08-12 |
Not clear |
| Ernestina Schipan. Hypoxia and HIF-1 alpha in chondrogenesis. Seminars in cell & developmental biology. vol 16. issue 4-5. 2006-07-14. PMID:16144691. |
in endochondral bone development chondrocytes undergo well-ordered and controlled phases of proliferation, hypertrophic differentiation, mineralization of the surrounding matrix, death, blood vessel invasion, and finally replacement of cartilage with bone. |
2006-07-14 |
2023-08-12 |
Not clear |
| Xiangsheng Feng, Jiaju Tan, Yingen Pan, Qiuhe Wu, Shubin Ruan, Rui Shen, Xiaodong Chen, Yongjun D. Control of hypertrophic scar from inception by using xenogenic (porcine) acellular dermal matrix (ADM) to cover deep second degree burn. Burns : journal of the International Society for Burn Injuries. vol 32. issue 3. 2006-06-29. PMID:16487662. |
control of hypertrophic scar from inception by using xenogenic (porcine) acellular dermal matrix (adm) to cover deep second degree burn. |
2006-06-29 |
2023-08-12 |
Not clear |
| C W Park, Y Zhang, X Zhang, J Wu, L Chen, D R Cha, D Su, M-T Hwang, X Fan, L Davis, G Striker, F Zheng, M Breyer, Y Gua. PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney international. vol 69. issue 9. 2006-06-21. PMID:16672921. |
this was accompanied by dramatically reduced glomerular hypertrophy and mesangial matrix expansion. |
2006-06-21 |
2023-08-12 |
mouse |
| Shintaro Kinugawa, Hiroyuki Tsutsu. [Oxidative stress and heart failure]. Nihon rinsho. Japanese journal of clinical medicine. vol 64. issue 5. 2006-06-15. PMID:16689364. |
the excessive reactive oxygen species (ros), produced by the electron leak in mitochondria of failing myocardium, play an important role in development and progression of heart failure (hf) and cardiac remodeling, which is associated with induction of myocyte hypertrophy and apoptosis and activation of matrix metalloproteinases. |
2006-06-15 |
2023-08-12 |
Not clear |
| T Pantsulai. Role of TGF-beta in pathogenesis of diabetic nephropathy. Georgian medical news. issue 131. 2006-06-12. PMID:16575121. |
diabetic nephropathy, a major long-term complication of diabetes mellitus is characterized by hypertrophy of the glomerular and tubuloepithelial structures and thickening of glomerular and tubular basement membranes and progressive accumulation of extracellular matrix proteins (fibronectin, collagens and laminin) in the mesangium and the interstitium. |
2006-06-12 |
2023-08-12 |
Not clear |
| T Pantsulai. Role of TGF-beta in pathogenesis of diabetic nephropathy. Georgian medical news. issue 131. 2006-06-12. PMID:16575121. |
of these, the cytokine transforming growth factor (tgf-beta) has emerged as having a key role in the development of renal hypertrophy and accumulation of extracellular matrix in diabetes. |
2006-06-12 |
2023-08-12 |
Not clear |
| Joji Ishikawa, Kazuomi Kario, Yoshio Matsui, Seiichi Shibasaki, Masato Morinari, Ruri Kaneda, Satoshi Hoshide, Kazuo Eguchi, Yukihiro Hojo, Kazuyuki Shimad. Collagen metabolism in extracellular matrix may be involved in arterial stiffness in older hypertensive patients with left ventricular hypertrophy. Hypertension research : official journal of the Japanese Society of Hypertension. vol 28. issue 12. 2006-06-05. PMID:16671339. |
collagen metabolism in extracellular matrix may be involved in arterial stiffness in older hypertensive patients with left ventricular hypertrophy. |
2006-06-05 |
2023-08-12 |
Not clear |
| Hsiu-Wen Chan, Nicola J Smith, Ross D Hannan, Walter G Thoma. Tackling the EGFR in pathological tissue remodelling. Pulmonary pharmacology & therapeutics. vol 19. issue 1. 2006-05-11. PMID:15979363. |
tissue remodelling is an adaptive physiological event initiated by physical and/or hormonal stimuli and characterised by extracellular matrix modifications, inflammation, cellular hypertrophy, proliferation and/or apoptosis. |
2006-05-11 |
2023-08-12 |
Not clear |
| John V Bonacci, Alastair G Stewar. Regulation of human airway mesenchymal cell proliferation by glucocorticoids and beta2-adrenoceptor agonists. Pulmonary pharmacology & therapeutics. vol 19. issue 1. 2006-05-11. PMID:16286235. |
one of the most consistently observed changes in asthmatic airways is an increased volume of airway smooth muscle (asm), that has been explained by proliferation, hypertrophy, extracellular matrix deposition within the smooth muscle bundles, and more recently, the migration of mesenchymal precursor cells to the airways. |
2006-05-11 |
2023-08-12 |
human |