| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jürgen Pauluhn, Ulrich Moh. Experimental approaches to evaluate respiratory allergy in animal models. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 56. issue 4-5. 2005-07-26. PMID:15816351. |
the pathology of asthma is associated with reversible narrowing of airways, associated with prominent features that involve structural changes in the airway walls and extracellular matrix remodeling including abnormalities of bronchial smooth muscle, eosinophilic inflammation of the bronchial wall, hyperplasia and hypertrophy of mucous glands. |
2005-07-26 |
2023-08-12 |
human |
| Claes C Strøm, Mark Aplin, Thorkil Ploug, Tue E H Christoffersen, Jozef Langfort, Michael Viese, Henrik Galbo, Stig Haunsø, Søren P Sheik. Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy. The FEBS journal. vol 272. issue 11. 2005-07-21. PMID:15943803. |
expression changes in genes encoding extracellular matrix proteins, cytoskeletal elements, signalling factors and ribosomal proteins mimicked changes previously described in maladaptive hypertrophy. |
2005-07-21 |
2023-08-12 |
rat |
| Elangovan Vellaichamy, Madan L Khurana, Jude Fink, Kailash N Pande. Involvement of the NF-kappa B/matrix metalloproteinase pathway in cardiac fibrosis of mice lacking guanylyl cyclase/natriuretic peptide receptor A. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15710627. |
the findings of this study demonstrate that disruption of npra/cgmp signaling promotes hypertrophic growth and extracellular matrix remodeling, leading to the development of cardiac hypertrophy, myocardial fibrosis, and congestive heart failure. |
2005-07-12 |
2023-08-12 |
mouse |
| Yoshihiro Tamamura, Tomohiro Otani, Naoko Kanatani, Eiki Koyama, Jirota Kitagaki, Toshihisa Komori, Yoshihiko Yamada, Frank Costantini, Satoshi Wakisaka, Maurizio Pacifici, Masahiro Iwamoto, Motomi Enomoto-Iwamot. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15760903. |
activation in mature cells instead stimulated hypertrophy, matrix mineralization, and expression of terminal markers such as metalloprotease (mmp)-13 and vascular endothelial growth factor. |
2005-07-12 |
2023-08-12 |
mouse |
| Jürgen Kopp, Ellen Preis, Harun Said, Bernd Hafemann, Lucia Wickert, Axel M Gressner, Norbert Pallua, Steven Doole. Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts. The Journal of biological chemistry. vol 280. issue 22. 2005-07-12. PMID:15788410. |
human fibroproliferative disorders like hypertrophic scarring of the skin are characterized by increased contractility and excess extracellular matrix synthesis. |
2005-07-12 |
2023-08-12 |
human |
| Jürgen Kopp, Ellen Preis, Harun Said, Bernd Hafemann, Lucia Wickert, Axel M Gressner, Norbert Pallua, Steven Doole. Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts. The Journal of biological chemistry. vol 280. issue 22. 2005-07-12. PMID:15788410. |
in summary, our data indicate that autocrine tgf-beta/smad signaling is involved in contractility and matrix gene expression of fibroblasts from normal and hypertrophic scars. |
2005-07-12 |
2023-08-12 |
human |
| A D Hodgkinson, T Page, B A Millward, A G Demain. A novel polymorphism in the 5' flanking region of the glucose transporter (GLUT1) gene is strongly associated with diabetic nephropathy in patients with Type 1 diabetes mellitus. Journal of diabetes and its complications. vol 19. issue 2. 2005-06-30. PMID:15745834. |
glucose transporter 1 (glut1) activity has been implicated in renal hypertrophy and extracellular matrix formation in mesangial cells. |
2005-06-30 |
2023-08-12 |
Not clear |
| Young-Sook Kim, Zhong-Gao Xu, Marpadga A Reddy, Shu-Lian Li, Linda Lanting, Kumar Sharma, Sharon G Adler, Rama Nataraja. Novel interactions between TGF-{beta}1 actions and the 12/15-lipoxygenase pathway in mesangial cells. Journal of the American Society of Nephrology : JASN. vol 16. issue 2. 2005-06-28. PMID:15615821. |
diabetic nephropathy (dn) is characterized by mesangial cell (mc) hypertrophy and progressive accumulation of glomerular extracellular matrix (ecm). |
2005-06-28 |
2023-08-12 |
mouse |
| Kristen A Johnson, Robert A Terkeltau. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15691824. |
chondrocyte maturation to hypertrophy, associated with up-regulated transglutaminase 2 (tg2) expression, mediates not only physiologic growth plate mineralization but also pathologic matrix calcification and dys-regulated matrix repair in osteoarthritic articular cartilage. |
2005-06-07 |
2023-08-12 |
mouse |
| Kristen A Johnson, Robert A Terkeltau. External GTP-bound transglutaminase 2 is a molecular switch for chondrocyte hypertrophic differentiation and calcification. The Journal of biological chemistry. vol 280. issue 15. 2005-06-07. PMID:15691824. |
following transfection of tg2 site-directed mutants into chondrocytic cells, we observed that wild type tg2, and tg catalytic site and fibronectin-binding mutants promoted type x collagen expression and matrix calcification consistent with chondrocyte hypertrophic differentiation. |
2005-06-07 |
2023-08-12 |
mouse |
| P Pacaud, V Sauzeau, G Loiran. Rho proteins and vascular diseases. Archives des maladies du coeur et des vaisseaux. vol 98. issue 3. 2005-05-26. PMID:15816329. |
typically, arterial diseases are associated with functional and structural wall alterations including modified contractile properties, smooth muscle cell hypertrophy and proliferation, endothelial dysfunction, excessive extracellular matrix accumulation and inflammation. |
2005-05-26 |
2023-08-12 |
Not clear |
| Yan Wang, Frank Middleton, Jason A Horton, Lee Reichel, Cornelia E Farnum, Timothy A Damro. Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways. Bone. vol 35. issue 6. 2005-05-19. PMID:15589209. |
longitudinal bone growth results from coordination of proliferation and hypertrophy of chondrocytes, calcification of the matrix, vascular invasion, and completion of endochondral bone formation in the growth plate. |
2005-05-19 |
2023-08-12 |
rat |
| Anke Schnapper, Wilfried Meye. Osteopontin distribution in the canine skeleton during growth and structural maturation. Cells, tissues, organs. vol 178. issue 3. 2005-05-19. PMID:15655333. |
opn was expressed in hypertrophic chondrocytes of epiphyseal cartilage and in chondrocytes of the deep zone of mature articular cartilage, where extracellular matrix was also stained. |
2005-05-19 |
2023-08-12 |
Not clear |
| Judith Bellemare, Charles J Roberge, Danielle Bergeron, Carlos A Lopez-Vallé, Michel Roy, Véronique J Mouli. Epidermis promotes dermal fibrosis: role in the pathogenesis of hypertrophic scars. The Journal of pathology. vol 206. issue 1. 2005-05-17. PMID:15772942. |
hypertrophic scarring is a pathological process characterized by fibroblastic hyperproliferation and by excessive deposition of extracellular matrix components. |
2005-05-17 |
2023-08-12 |
Not clear |
| Björn Samnegård, Stefan H Jacobson, Georg Jaremko, Bo-Lennart Johansson, Karin Ekberg, Britta Isaksson, Linda Eriksson, John Wahren, Mats Sjöquis. C-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 20. issue 3. 2005-05-16. PMID:15665028. |
c-peptide prevents glomerular hypertrophy and mesangial matrix expansion in diabetic rats. |
2005-05-16 |
2023-08-12 |
rat |
| Norio Amizuka, Junko Shimomura, Takeyasu Maeda, Hidehiro Ozaw. [Mineralization and vascular invasion during endochondral bone formation]. Clinical calcium. vol 13. issue 4. 2005-05-11. PMID:15775105. |
the intercolumnar cartilage matrix of the hypertrophic zone is subjected to mineralization whereas the transverse partitions of the cartilage column are poorly mineralized. |
2005-05-11 |
2023-08-12 |
Not clear |
| Andrew R Kompa, Walter G Thomas, Fiona See, Alex Tzanidis, Ross D Hannan, Henry Kru. Cardiovascular role of urotensin II: effect of chronic infusion in the rat. Peptides. vol 25. issue 10. 2005-05-06. PMID:15476946. |
direct effects of uii on the myocardium, include myocyte hypertrophy, extracellular matrix deposition and contractility. |
2005-05-06 |
2023-08-12 |
rat |
| Gunnar Sjöberg, Anna Kostareva, Thomas Sejerse. [Hereditary cardiomyopathies: a review. Mutation of structural proteins a common cause of hereditary cardiomyopathy]. Lakartidningen. vol 102. issue 11. 2005-04-20. PMID:15835520. |
in general the genes causing hypertrophic cardiomyopathies code for proteins involved in the contractile apparatus, the sarcomere, and the genes causing dilated cardiomyopathy code for proteins that anchor the sarcomere to the cell membrane and extracellular matrix. |
2005-04-20 |
2023-08-12 |
Not clear |
| Francisco Forriol, Frederic Shapir. Bone development: interaction of molecular components and biophysical forces. Clinical orthopaedics and related research. issue 432. 2005-04-06. PMID:15738800. |
most endochondral growth in length occurs at the physes by the coordinated actions of cell proliferation, matrix synthesis, and chondrocyte hypertrophy. |
2005-04-06 |
2023-08-12 |
Not clear |
| Blanche Schroen, Stephane Heymans, Umesh Sharma, W Matthijs Blankesteijn, Saraswati Pokharel, Jack P M Cleutjens, J Gordon Porter, Chris T A Evelo, Rudy Duisters, Rick E W van Leeuwen, Ben J A Janssen, Jacques J M Debets, Jos F M Smits, Mat J A P Daemen, Harry J G M Crijns, Paul Bornstein, Yigal M Pint. Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Circulation research. vol 95. issue 5. 2005-04-01. PMID:15284191. |
thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. |
2005-04-01 |
2023-08-12 |
mouse |