| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V J Karthikeyan, Gregory Y H Li. Matrix metalloproteinases and hypertension: a link between left ventricular hypertrophy and diastolic dysfunction? The Tohoku journal of experimental medicine. vol 208. issue 2. 2006-05-10. PMID:16434829. |
matrix metalloproteinases and hypertension: a link between left ventricular hypertrophy and diastolic dysfunction? |
2006-05-10 |
2023-08-12 |
Not clear |
| Mustafa Saglam, Osman Karakaya, Ali Metin Esen, Irfan Barutcu, Serkan Dogan, Yusuf Karavelioglu, Hekim Karapinar, Taylan Akgun, Ozlem Esen, Nihal Ozdemir, Sembol Turkmen, Cihangir Kayma. Contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy and diastolic dysfunction in hypertensive subjects. The Tohoku journal of experimental medicine. vol 208. issue 2. 2006-05-10. PMID:16434834. |
contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy and diastolic dysfunction in hypertensive subjects. |
2006-05-10 |
2023-08-12 |
human |
| Mustafa Saglam, Osman Karakaya, Ali Metin Esen, Irfan Barutcu, Serkan Dogan, Yusuf Karavelioglu, Hekim Karapinar, Taylan Akgun, Ozlem Esen, Nihal Ozdemir, Sembol Turkmen, Cihangir Kayma. Contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy and diastolic dysfunction in hypertensive subjects. The Tohoku journal of experimental medicine. vol 208. issue 2. 2006-05-10. PMID:16434834. |
matrix metalloproteinases (mmps) are involved in the regulation of the extracellular matrix (ecm) of the myocardium and thus the pathogenesis of vascular and cardiac hypertrophy. |
2006-05-10 |
2023-08-12 |
human |
| Mustafa Saglam, Osman Karakaya, Ali Metin Esen, Irfan Barutcu, Serkan Dogan, Yusuf Karavelioglu, Hekim Karapinar, Taylan Akgun, Ozlem Esen, Nihal Ozdemir, Sembol Turkmen, Cihangir Kayma. Contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy and diastolic dysfunction in hypertensive subjects. The Tohoku journal of experimental medicine. vol 208. issue 2. 2006-05-10. PMID:16434834. |
in this study, we investigated contribution of plasma matrix metalloproteinases to development of left ventricular hypertrophy (lvh) and diastolic dysfunction in hypertensive subjects. |
2006-05-10 |
2023-08-12 |
human |
| Darko Bosnakovski, Morimichi Mizuno, Gonhyung Kim, Satoshi Takagi, Masahiro Okumur, Toru Fujina. Gene expression profile of bovine bone marrow mesenchymal stem cell during spontaneous chondrogenic differentiation in pellet culture system. The Japanese journal of veterinary research. vol 53. issue 3-4. 2006-05-08. PMID:16544933. |
of sox9 messenger ribonucleic acid (mrna), followed by high transcription of chondrocyte specific genes, collagen type ii and ix, biglycan and cartilage oligomeric matrix protein, and the final prehypertrophic and/or hypertrophic stage was distinguished by increased expression of collagen type x. |
2006-05-08 |
2023-08-12 |
cattle |
| Volker Roenicke, Stéphane Leclair, Anke Hoffmann, Michael Becker, Tania Szado, Thomas Kirsch, Oliver Stoss, Barbara T Navé, Thomas Henke. Emerging therapeutic targets in chronic heart failure: part II. Expert opinion on therapeutic targets. vol 7. issue 1. 2006-05-01. PMID:12556202. |
increased expression and activity of matrix metalloproteinases lead to altered composition and arrangement of the extracellular matrix, which is accompanied by eccentric hypertrophy of cardiomyocytes. |
2006-05-01 |
2023-08-12 |
Not clear |
| I Villemure, M A Chung, C S Seck, M H Kimm, J R Matyas, N A Dunca. Static compressive loading reduces the mRNA expression of type II and X collagen in rat growth-plate chondrocytes during postnatal growth. Connective tissue research. vol 46. issue 4-5. 2006-04-14. PMID:16546824. |
this suggests that mechanical compression influences chondrocytes of the hypertrophic zone to alter their expression of specific genes encoding proteins of the extracellular matrix, while pth-pthrp receptor mrna, a regulatory protein, remained unaffected by loading. |
2006-04-14 |
2023-08-12 |
rat |
| Timothy A Damron, Jason A Horton, Asghar Naqvi, Richard M Loomis, Bryan S Margulies, Judith A Strauss, Cornelia E Farnum, Joseph A Spadar. Combination radioprotectors maintain proliferation better than single agents by decreasing early parathyroid hormone-related protein changes after growth plate irradiation. Radiation research. vol 165. issue 3. 2006-04-12. PMID:16494524. |
by 2 weeks, positive findings unique to the combination-treatment animals included greater mean proliferation in the irradiated growth plate than on the contralateral side, smaller limb length discrepancies, reversal of the increased overall matrix area fraction, and reversal of the usual deficiency in indian hedgehog staining in the irradiated hypertrophic zone. |
2006-04-12 |
2023-08-12 |
rat |
| Melanie C Fisher, Carissa Meyer, Graham Garber, Caroline N Deal. Role of IGFBP2, IGF-I and IGF-II in regulating long bone growth. Bone. vol 37. issue 6. 2006-03-17. PMID:16183342. |
together, our results suggest that the mechanism of action whereby igfbp2 excess impairs long bone development is to inhibit igf-mediated proliferation and matrix synthesis by the cartilage model; reduce the proliferation and progression to hypertrophy by the maturing chondrocytes; and attenuate proliferation and formation of the periosteal bony collar. |
2006-03-17 |
2023-08-12 |
chicken |
| Keiichiro Kizaki, Muneyoshi Okada, Ryoichi Ito, Kazuki Yoshioka, Kazuyoshi Hashizume, Ken-ichiro Mutoh, Yukio Har. Induction of heparanase gene expression in ventricular myocardium of rats with isoproterenol-induced cardiac hypertrophy. Biological & pharmaceutical bulletin. vol 28. issue 12. 2006-03-09. PMID:16327176. |
gene expression of heparanase, matrix metalloproteinases (mmp)-2 and mmp-9 were examined in ventricles after chronic treatment with isoproterenol (iso) induced cardiac hypertrophy in rats. |
2006-03-09 |
2023-08-12 |
rat |
| Masako Baba, Jun Wada, Jun Eguchi, Izumi Hashimoto, Tatsuo Okada, Akihiro Yasuhara, Kenichi Shikata, Yashpal S Kanwar, Hirofumi Makin. Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycle-dependent mechanisms. Journal of the American Society of Nephrology : JASN. vol 16. issue 11. 2006-03-02. PMID:16177004. |
the injection of gal-9 into db/db mice significantly inhibited glomerular hypertrophy and mesangial matrix expansion and reduced urinary albumin excretion. |
2006-03-02 |
2023-08-12 |
mouse |
| Akiho Tsuchiya, Masato Yano, Jiraporn Tocharus, Hisae Kojima, Manabu Fukumoto, Masashi Kawaichi, Chio Ok. Expression of mouse HtrA1 serine protease in normal bone and cartilage and its upregulation in joint cartilage damaged by experimental arthritis. Bone. vol 37. issue 3. 2006-02-03. PMID:15993670. |
htra1 may, therefore, promote degeneration of cartilage by inducing terminal hypertrophic chondrocyte differentiation and by digesting cartilage matrix though its tgf-beta inhibitory activity and protease activity, respectively. |
2006-02-03 |
2023-08-12 |
mouse |
| Yves Gorin, Karen Block, James Hernandez, Basant Bhandari, Brent Wagner, Jeffrey L Barnes, Hanna E Abbou. Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney. The Journal of biological chemistry. vol 280. issue 47. 2006-02-03. PMID:16135519. |
renal hypertrophy and extracellular matrix accumulation are early features of diabetic nephropathy. |
2006-02-03 |
2023-08-12 |
rat |
| Pamela S Howard, Umberto Kucich, Douglas E Coplen, Yuling H. Transforming growth factor-beta1-induced hypertrophy and matrix expression in human bladder smooth muscle cells. Urology. vol 66. issue 6. 2006-01-26. PMID:16360482. |
transforming growth factor-beta1-induced hypertrophy and matrix expression in human bladder smooth muscle cells. |
2006-01-26 |
2023-08-12 |
human |
| C Carda, G Silvestrini, M E Gomez de Ferraris, A Peydró, E Bonucc. Osteoprotegerin (OPG) and RANKL expression and distribution in developing human craniomandibular joint. Tissue & cell. vol 37. issue 3. 2006-01-20. PMID:15899507. |
the main results were: opg and rankl mrna and protein were co-localized in the same cell types; opg and rankl were specially immunolocated in osteogenic cells; immunolabeling was often seen in the nucleus and cytoplasm of otherwise negative hypertrophic chondrocytes; ihc and ish labeling decreased from proliferative to hypertrophic chondrocytes; early osteocytes showed dual protein expression and some of the mature osteocytes were ish-negative; periosteal osteoclasts and chondroclasts were mostly stained by ihc and variably labeled by ish; the new bone matrix and trabecular borders showed intense immunolabeling. |
2006-01-20 |
2023-08-12 |
human |
| Akiko Kirimoto, Yuzo Takagi, Keiichi Ohya, Hitoyata Shimokaw. Effects of retinoic acid on the differentiation of chondrogenic progenitor cells, ATDC5. Journal of medical and dental sciences. vol 52. issue 3. 2006-01-12. PMID:16350840. |
in this study, we show that ra suppresses the cell growth, cartilage nodule formation, accumulation of proteoglycan, alkaline phosphatase (alpase) activity and mineralization and that ra dose dependently upregulates the levels of type x collagen and matrix metalloproteinase-13 (mmp-13) mrna which are marker proteins of hypertrophic chondrocytes, in atdc5 cells. |
2006-01-12 |
2023-08-12 |
Not clear |
| Ola Nilsson, Rose Marino, Francesco De Luca, Moshe Phillip, Jeffrey Baro. Endocrine regulation of the growth plate. Hormone research. vol 64. issue 4. 2005-12-30. PMID:16205094. |
within the growth plate, chondrocyte proliferation, hypertrophy, and cartilage matrix secretion result in chondrogenesis. |
2005-12-30 |
2023-08-12 |
human |
| Liju Yang, Paul G Scott, Carole Dodd, Abelardo Medina, Haiyan Jiao, Heather A Shankowsky, Aziz Ghahary, Edward E Tredge. Identification of fibrocytes in postburn hypertrophic scar. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 13. issue 4. 2005-12-23. PMID:16008729. |
we conclude that fibrocytes, which have been reported to be antigen-presenting cells, are recruited to wounds following extensive burn injury and could potentially upregulate the inflammatory response and synthesize collagen and other matrix macromolecules, thus contributing to the development of hypertrophic scarring. |
2005-12-23 |
2023-08-12 |
Not clear |
| Kazi Sazzad Hossain, Norio Amizuka, Nobuyki Ikeda, Kayoko Nozawa-Inoue, Akiko Suzuki, Minqi Li, Kiichi Takeuchi, Megumi Aita, Yoshiro Kawano, Masaaki Hoshino, Kimimitsu Oda, Ritsuo Takagi, Takeyasu Maed. Histochemical evidences on the chronological alterations of the hypertrophic zone of mandibular condylar cartilage. Microscopy research and technique. vol 67. issue 6. 2005-12-12. PMID:16173089. |
the hypertrophic chondrocytes lack the ability to proliferate, thus permitting matrix mineralization as well as vascular invasion from the bone in both the mandibular condyle and the epiphyseal cartilage. |
2005-12-12 |
2023-08-12 |
mouse |
| Edna D Lekgabe, Helen Kiriazis, Chongxin Zhao, Qi Xu, Xiao Lei Moore, Yidan Su, Ross A D Bathgate, Xiao-Jun Du, Chrishan S Samue. Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 46. issue 2. 2005-11-29. PMID:15967869. |
zymography was used to determine matrix metalloproteinase (mmp) expression and western blotting to determine proliferating cell nuclear antigen (pcna) expression and alpha-smooth muscle actin (alpha-sma)/myofibroblast expression, whereas cardiac hypertrophy was assessed by myocyte size and real-time polymerase chain reaction of associated genes. |
2005-11-29 |
2023-08-12 |
rat |