| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sandro Goruppi, Richard D Patten, Thomas Force, John M Kyriaki. Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Molecular and cellular biology. vol 27. issue 3. 2007-03-05. PMID:17116693. |
helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. |
2007-03-05 |
2023-08-12 |
human |
| Sandro Goruppi, Richard D Patten, Thomas Force, John M Kyriaki. Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Molecular and cellular biology. vol 27. issue 3. 2007-03-05. PMID:17116693. |
cardiomyocyte hypertrophy and extracellular matrix remodeling, primarily mediated by inflammatory cytokine-stimulated cardiac fibroblasts, are critical cellular events in cardiac pathology. |
2007-03-05 |
2023-08-12 |
human |
| Sandro Goruppi, Richard D Patten, Thomas Force, John M Kyriaki. Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Molecular and cellular biology. vol 27. issue 3. 2007-03-05. PMID:17116693. |
the molecular components governing these processes remain nebulous, and few genes have been linked to both hypertrophy and matrix remodeling. |
2007-03-05 |
2023-08-12 |
human |
| Sandro Goruppi, Richard D Patten, Thomas Force, John M Kyriaki. Helix-loop-helix protein p8, a transcriptional regulator required for cardiomyocyte hypertrophy and cardiac fibroblast matrix metalloprotease induction. Molecular and cellular biology. vol 27. issue 3. 2007-03-05. PMID:17116693. |
here we show that p8, a small stress-inducible basic helix-loop-helix protein, is required for endothelin- and alpha-adrenergic agonist-induced cardiomyocyte hypertrophy and for tumor necrosis factor-stimulated induction, in cardiac fibroblasts, of matrix metalloproteases (mmps) 9 and 13-mmps linked to general inflammation and to adverse ventricular remodeling in heart failure. |
2007-03-05 |
2023-08-12 |
human |
| Balakuntalam S Kasinath, Meenalakshmi M Mariappan, Kavithalakshmi Sataranatarajan, Myung Ja Lee, Denis Felier. mRNA translation: unexplored territory in renal science. Journal of the American Society of Nephrology : JASN. vol 17. issue 12. 2007-02-27. PMID:16959824. |
ongoing work suggests an important role for mrna translation in compensatory renal growth, hypertrophy and extracellular matrix synthesis in diabetic nephropathy, growth factor synthesis by kidney cells, and glomerulonephritis. |
2007-02-27 |
2023-08-12 |
Not clear |
| Eleonora Olivotto, Roberta Vitellozzi, Patricia Fernandez, Elisabetta Falcieri, Michela Battistelli, Sabrina Burattini, Annalisa Facchini, Flavio Flamigni, Spartaco Santi, Andrea Facchini, Rosa Maria Borzi\. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. Journal of cellular physiology. vol 210. issue 2. 2007-02-09. PMID:17096385. |
chondrocyte hypertrophy and apoptosis induced by groalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin b. cxcr2 ligands contribute to chondrocyte hypertrophy and apoptosis, important determinants in cartilage pathophysiology. |
2007-02-09 |
2023-08-12 |
human |
| Eleonora Olivotto, Roberta Vitellozzi, Patricia Fernandez, Elisabetta Falcieri, Michela Battistelli, Sabrina Burattini, Annalisa Facchini, Flavio Flamigni, Spartaco Santi, Andrea Facchini, Rosa Maria Borzi\. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. Journal of cellular physiology. vol 210. issue 2. 2007-02-09. PMID:17096385. |
gene expression of key markers of hypertrophy (mmp-13, runx-2) and matrix synthesis (aggrecan), and of cathepsin b isoform cb(-2,3) was evaluated by real time pcr. |
2007-02-09 |
2023-08-12 |
human |
| Eleonora Olivotto, Roberta Vitellozzi, Patricia Fernandez, Elisabetta Falcieri, Michela Battistelli, Sabrina Burattini, Annalisa Facchini, Flavio Flamigni, Spartaco Santi, Andrea Facchini, Rosa Maria Borzi\. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. Journal of cellular physiology. vol 210. issue 2. 2007-02-09. PMID:17096385. |
this caused the downstream triggering of chondrocyte hypertrophy (mmp-13 and runx-2 upregulation, and calcium deposition) and apoptosis/anoikis following concurrence of matrix degrading activity, and inhibition of matrix synthesis which also involved the induction of cb(-2,3). |
2007-02-09 |
2023-08-12 |
human |
| Xiaoqiu Liu, Shu Qiang Sun, Aviv Hassid, Rennolds S Ostro. cAMP inhibits transforming growth factor-beta-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts. Molecular pharmacology. vol 70. issue 6. 2007-01-30. PMID:16959941. |
cardiac fibroblasts produce and degrade extracellular matrix and are critical in regulating cardiac remodeling and hypertrophy. |
2007-01-30 |
2023-08-12 |
Not clear |
| Katsuya Hiran. The roles of proteinase-activated receptors in the vascular physiology and pathophysiology. Arteriosclerosis, thrombosis, and vascular biology. vol 27. issue 1. 2007-01-22. PMID:17095716. |
in smooth muscle cells, pars mediate contraction, migration, proliferation, hypertrophy, and production of the extracellular matrix, thereby contributing to the development of vascular lesions and the pathophysiology of such vascular diseases as atherosclerosis. |
2007-01-22 |
2023-08-12 |
Not clear |
| Hiroyuki Tsutsui, Tomomi Ide, Shintaro Kinugaw. Mitochondrial oxidative stress, DNA damage, and heart failure. Antioxidants & redox signaling. vol 8. issue 9-10. 2007-01-04. PMID:16987026. |
reactive oxygen species induce myocyte hypertrophy, apoptosis, and interstitial fibrosis by activating matrix metalloproteinases. |
2007-01-04 |
2023-08-12 |
Not clear |
| Yiu-Fai Chen, Ji-An Feng, Peng Li, Dongqi Xing, Yun Zhang, Rosa Serra, Namasivayam Ambalavanan, Erum Majid-Hassan, Suzanne Opari. Dominant negative mutation of the TGF-beta receptor blocks hypoxia-induced pulmonary vascular remodeling. Journal of applied physiology (Bethesda, Md. : 1985). vol 100. issue 2. 2006-12-28. PMID:16223981. |
these data support the hypothesis that endogenous tgf-beta plays an important role in pulmonary vascular adaptation to chronic hypoxia and that disruption of tgf-beta signaling attenuates hypoxia-induced pulmonary hypertension, right ventricular hypertrophy, pulmonary arterial hypertrophy and muscularization, alveolar remodeling, and expression of extracellular matrix mrna in whole lung. |
2006-12-28 |
2023-08-12 |
mouse |
| Elodie Masson, Michel Lagarde, Nicolas Wiernsperger, Samer El Bawa. Hyperglycemia and glucosamine-induced mesangial cell cycle arrest and hypertrophy: Common or independent mechanisms? IUBMB life. vol 58. issue 7. 2006-12-22. PMID:16801212. |
while it is well accepted that the hp promotes extracellular matrix accumulation in the context of diabetic nephropathy, its involvement in the perturbations of cell cycle progression and hypertrophy of renal cells has been poorly investigated. |
2006-12-22 |
2023-08-12 |
Not clear |
| Tahir Durmus, Renée J LeClair, Kyoung-Sook Park, Aleksandra Terzic, Jeong K Yoon, Volkhard Lindne. Expression analysis of the novel gene collagen triple helix repeat containing-1 (Cthrc1). Gene expression patterns : GEP. vol 6. issue 8. 2006-12-20. PMID:16678498. |
abundant expression of cthrc1 was observed in the developing skeleton, i.e., in cartilage primordia, in growth plate cartilage with exclusion of the hypertrophic zone, in the bone matrix and periostium. |
2006-12-20 |
2023-08-12 |
mouse |
| Sverre E Kjeldsen, Arne Strand, Stevo Julius, Peter M Oki. Mechanism of angiotensin II type 1 receptor blocker action in the regression of left ventricular hypertrophy. Journal of clinical hypertension (Greenwich, Conn.). vol 8. issue 7. 2006-12-19. PMID:16849902. |
in the development of left ventricular hypertrophy there is growth of cardiomyocytes and accumulation of extracellular matrix and fibrosis. |
2006-12-19 |
2023-08-12 |
Not clear |
| John F Bateman, Richard Wilson, Susanna Freddi, Shireen R Lamandé, Ravi Savariraya. Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia. Human mutation. vol 25. issue 6. 2006-12-15. PMID:15880705. |
schmid metaphyseal chondrodysplasia (smcd) is a dominantly inherited cartilage disorder caused by mutations in the gene for the hypertrophic cartilage extracellular matrix structural protein, collagen x (col10a1). |
2006-12-15 |
2023-08-12 |
Not clear |
| Maria A Mello, Rocky S Tua. Effects of TGF-beta1 and triiodothyronine on cartilage maturation: in vitro analysis using long-term high-density micromass cultures of chick embryonic limb mesenchymal cells. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 24. issue 11. 2006-12-07. PMID:16955422. |
endochondral ossification is initiated by differentiation of mesenchymal cells into chondrocytes, which produce a cartilaginous matrix, proliferate, mature, and undergo hypertrophy, followed by matrix calcification, and substitution of cartilage by bone. |
2006-12-07 |
2023-08-12 |
chicken |
| Joachim Burkhard Grammer, Sabine Bleiziffer, Fabio Monticelli, Rüdiger Lange, Robert Bauernschmit. Calcineurin and matrix protein expression in cardiac hypertrophy: evidence for calcineurin B to control excessive hypertrophic signaling. Basic research in cardiology. vol 101. issue 4. 2006-12-05. PMID:16688406. |
calcineurin and matrix protein expression in cardiac hypertrophy: evidence for calcineurin b to control excessive hypertrophic signaling. |
2006-12-05 |
2023-08-12 |
human |
| Joachim Burkhard Grammer, Sabine Bleiziffer, Fabio Monticelli, Rüdiger Lange, Robert Bauernschmit. Calcineurin and matrix protein expression in cardiac hypertrophy: evidence for calcineurin B to control excessive hypertrophic signaling. Basic research in cardiology. vol 101. issue 4. 2006-12-05. PMID:16688406. |
in the compensatory state of human left ventricular hypertrophy (lvh), the remodeling processes in the extracellular matrix and the role of calcineurin (cn) are not completely understood. |
2006-12-05 |
2023-08-12 |
human |
| Ryszard Galus, Marek Antiszko, Paweł Włodarsk. [Clinical applications of hyaluronic acid]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 20. issue 119. 2006-12-05. PMID:16875173. |
ability of ha to create and fill space by organizing and modifying the extracellular matrix is widely used for soft tissue augmentation to limit age-related and photoinduced skin aging, but also may be used for correction of facial lipodystrophy and to prevent reccurence of hypertrophic scars or keloids. |
2006-12-05 |
2023-08-12 |
Not clear |