| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Halil Ibrahim Canter, Ersoy Konas, Onder Bozdogan, Ibrahim Vargel, Bilgen Ozbatir, Filiz Oner, Yucel Er. Effect of slow-release 5-Fluorouracil on capsule formation around silicone breast implants: an experimental study with mice. Aesthetic plastic surgery. vol 31. issue 6. 2008-02-21. PMID:17578639. |
capsule formation around breast implants, development of tendon adhesions after tendon repair, intestinal brits after laparatomies, hypertrophic scars in skin incisions all are the results of excessive collagen synthesis to the extracellular matrix by fibroblasts. |
2008-02-21 |
2023-08-12 |
mouse |
| Sabine Rehm, Roberta A Thomas, Kim S Smith, Rosanna C Mirabile, Tracy L Gales, Scot L Eustis, Rogely W Boyc. Novel vascular lesions in mice given a non-peptide vitronectin receptor antagonist. Toxicologic pathology. vol 35. issue 7. 2008-02-21. PMID:18098042. |
vascular smooth muscle cell (vsmc) necrosis was observed in aorta and renal hilar arteries approximately 6 hours after dosing followed by loss of vsmc, adaptive medial thickening by vsmc hypertrophy and deposition of pas-positive matrix and collagen. |
2008-02-21 |
2023-08-12 |
mouse |
| Lyudmila Mikhaylova, Jennifer Malmquist, Maria Nurminskay. Regulation of in vitro vascular calcification by BMP4, VEGF and Wnt3a. Calcified tissue international. vol 81. issue 5. 2008-02-19. PMID:17982705. |
in this study we demonstrate that factors secreted by the hypertrophic chondrocytes induce matrix mineralization and osteoblastic transformation in cultured mouse vascular smooth muscle cells (vsmcs). |
2008-02-19 |
2023-08-12 |
mouse |
| Cornelia E Farnum, Michelle Tinsley, John W Hermanso. Postnatal bone elongation of the manus versus pes: analysis of the chondrocytic differentiation cascade in Mus musculus and Eptesicus fuscus. Cells, tissues, organs. vol 187. issue 1. 2008-02-06. PMID:18160802. |
bones elongate postnatally by endochondral ossification as cells of the cartilaginous growth plate undergo a differentiation cascade of proliferation, cellular hypertrophy and matrix synthesis. |
2008-02-06 |
2023-08-12 |
mouse |
| Soban Umar, Marleen Hessel, Paul Steendijk, Wilhelmina Bax, Cindy Schutte, Martin Schalij, Ernst van der Wall, Douwe Atsma, Arnoud van der Laars. Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. Pathology, research and practice. vol 203. issue 12. 2008-02-01. PMID:17913382. |
we investigated whether rv hypertrophy (rvh) and rv failure (rvf) were associated with activation of fak, nos1, and matrix metalloproteinases (mmps). |
2008-02-01 |
2023-08-12 |
rat |
| Christina Cheng, Evan Conte, Nancy Pleshko-Camacho, Chisa Hidak. Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. Matrix biology : journal of the International Society for Matrix Biology. vol 26. issue 7. 2008-01-31. PMID:17618099. |
differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. |
2008-01-31 |
2023-08-12 |
Not clear |
| Christina Cheng, Evan Conte, Nancy Pleshko-Camacho, Chisa Hidak. Differences in matrix accumulation and hypertrophy in superficial and deep zone chondrocytes are controlled by bone morphogenetic protein. Matrix biology : journal of the International Society for Matrix Biology. vol 26. issue 7. 2008-01-31. PMID:17618099. |
greater accumulation of proteoglycan (pg)-rich matrix in the untreated dzc was associated with a hypertrophic phenotype with large cell diameters and high gene expression levels of runt-related transcription factor-2 (runx2) as well as higher endogenous bmp activity. |
2008-01-31 |
2023-08-12 |
Not clear |
| Bishara S Atiye. Nonsurgical management of hypertrophic scars: evidence-based therapies, standard practices, and emerging methods. Aesthetic plastic surgery. vol 31. issue 5. 2008-01-29. PMID:17576505. |
hypertrophic scars, resulting from alterations in the normal processes of cutaneous wound healing, are characterized by proliferation of dermal tissue with excessive deposition of fibroblast-derived extracellular matrix proteins, especially collagen, over long periods, and by persistent inflammation and fibrosis. |
2008-01-29 |
2023-08-12 |
Not clear |
| Tomoko Shinzato, Yusuke Ohya, Minori Nakamoto, Akio Ishida, Shuichi Takishit. Beneficial effects of pioglitazone on left ventricular hypertrophy in genetically hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension. vol 30. issue 9. 2008-01-29. PMID:18037780. |
we evaluated lv geometry by echocardiography; myocyte hypertrophy, tissue fibrosis, and appearance of myofibroblasts by histological examination; mrna expression by real-time polymerase chain reaction (pcr); protein expression by western blot; activities of matrix metalloproteinase (mmp) by zymography; and production of reactive oxygen species (ros) by electron spin resonance spectroscopy or thiobarbituric acid reactive substances (tbars). |
2008-01-29 |
2023-08-12 |
rat |
| Amy Wang, Fuad N Ziyadeh, Eun Young Lee, Petr E Pyagay, Sun Hee Sung, Steven A Sheardown, Nicholas J Laping, Sheldon Che. Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. American journal of physiology. Renal physiology. vol 293. issue 5. 2007-12-18. PMID:17804483. |
in the smad3-ko mice, however, the defects that were improved were renal hypertrophy, mesangial matrix expansion, fibronectin overproduction, glomerular basement membrane thickening, plasma creatinine, and the blood urea nitrogen. |
2007-12-18 |
2023-08-12 |
mouse |
| Amy Wang, Fuad N Ziyadeh, Eun Young Lee, Petr E Pyagay, Sun Hee Sung, Steven A Sheardown, Nicholas J Laping, Sheldon Che. Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria. American journal of physiology. Renal physiology. vol 293. issue 5. 2007-12-18. PMID:17804483. |
it seems that the absence of smad3 modifies the natural course of murine diabetic nephropathy, providing renal functional protection and preventing structural lesions relating to kidney hypertrophy and matrix accumulation, even though albuminuria and changes in podocyte morphology persist. |
2007-12-18 |
2023-08-12 |
mouse |
| b' Sherrill L Adams, Arthur J Cohen, Luisa Lassov\\xc3\\xa. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. Journal of cellular physiology. vol 213. issue 3. 2007-12-14. PMID:17886256.' |
during endochondral bone formation, chondrocytes undergo a process of terminal differentiation or maturation, during which the rate of proliferation decreases, cells become hypertrophic, and the extracellular matrix is altered by production of a unique protein, collagen x, as well as proteins that promote mineralization. |
2007-12-14 |
2023-08-12 |
Not clear |
| b' Sherrill L Adams, Arthur J Cohen, Luisa Lassov\\xc3\\xa. Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation. Journal of cellular physiology. vol 213. issue 3. 2007-12-14. PMID:17886256.' |
the matrix surrounding the hypertrophic chondrocytes eventually becomes mineralized, and the mineralized matrix serves as a template for bone deposition. |
2007-12-14 |
2023-08-12 |
Not clear |
| Masaaki Imamura, Akihiro Kanematsu, Shingo Yamamoto, Yu Kimura, Isao Kanatani, Noriyuki Ito, Yasuhiko Tabata, Osamu Ogaw. Basic fibroblast growth factor modulates proliferation and collagen expression in urinary bladder smooth muscle cells. American journal of physiology. Renal physiology. vol 293. issue 4. 2007-11-30. PMID:17634401. |
these data suggest that bfgf from the urothelium could act as a paracrine signal that stimulates the proliferation and matrix production of bsmc, thereby contributing to the hypertrophic remodeling of the smooth muscle layer. |
2007-11-30 |
2023-08-12 |
rat |
| Kazuo Ohtake, Yuichi Ishiyama, Hiroyuki Uchida, Etsuko Muraki, Jun Kobayash. Dietary nitrite inhibits early glomerular injury in streptozotocin-induced diabetic nephropathy in rats. Nitric oxide : biology and chemistry. vol 17. issue 2. 2007-11-30. PMID:17681477. |
these improvements accompanied an improvement in the parameters of glomerular injury, including urinary protein and albumin excretion, histopathological glomerular hypertrophy, and mesangial matrix accumulation. |
2007-11-30 |
2023-08-12 |
rat |
| Rebecca Hjorten, Uwe Hansen, Robert A Underwood, Helena E Telfer, Russell J Fernandes, Deborah Krakow, Eiman Sebald, Sebastian Wachsmann-Hogiu, Peter Bruckner, Robin Jacquet, William J Landis, Peter H Byers, James M Pac. Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Bone. vol 41. issue 4. 2007-11-30. PMID:17693149. |
immunohistochemical analyses showed that type xxvii collagen was most evident in hypertrophic cartilage at the primary ossification center and at the growth plate and that it accumulated in the pericellular matrix. |
2007-11-30 |
2023-08-12 |
mouse |
| Philipp Fischer, Denise Hilfiker-Kleine. Survival pathways in hypertrophy and heart failure: the gp130-STAT axis. Basic research in cardiology. vol 102. issue 5. 2007-11-28. PMID:17918316. |
gp130 receptor mediated signaling promotes cardiomyocyte survival, induces hypertrophy, modulates cardiac extracellular matrix and cardiac function. |
2007-11-28 |
2023-08-12 |
human |
| Anita Woods, Guoyan Wang, Frank Beie. Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions. Journal of cellular physiology. vol 213. issue 1. 2007-10-26. PMID:17492773. |
at later stages, for example in growth plate chondrocytes, adhesion signaling from extracellular matrix (ecm) proteins through integrins and other ecm receptors such as the discoidin domain receptor (ddr) 2 (a collagen receptor) and annexin v is necessary for normal chondrocyte proliferation and hypertrophy. |
2007-10-26 |
2023-08-12 |
Not clear |
| Jian-yun Wang, Xiao-xing Yin, Yun-ming Wu, Dao-quan Tang, Yuan-yuan Gao, Mei-rong Wan, Xiao-yu Hou, Bei Zhan. Ginkgo biloba extract suppresses hypertrophy and extracellular matrix accumulation in rat mesangial cells. Acta pharmacologica Sinica. vol 27. issue 9. 2007-10-19. PMID:16923344. |
ginkgo biloba extract suppresses hypertrophy and extracellular matrix accumulation in rat mesangial cells. |
2007-10-19 |
2023-08-12 |
rat |
| Jian-yun Wang, Xiao-xing Yin, Yun-ming Wu, Dao-quan Tang, Yuan-yuan Gao, Mei-rong Wan, Xiao-yu Hou, Bei Zhan. Ginkgo biloba extract suppresses hypertrophy and extracellular matrix accumulation in rat mesangial cells. Acta pharmacologica Sinica. vol 27. issue 9. 2007-10-19. PMID:16923344. |
to observe the effects of ginkgo biloba extract (egb) on the hypertrophy of mesangial cells and the accumulation of extracellular matrix (ecm) in mesangial cells. |
2007-10-19 |
2023-08-12 |
rat |