| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Madeline Murphy, John Crean, Derek P Brazil, Denise Sadlier, Finian Martin, Catherine Godso. Regulation and consequences of differential gene expression in diabetic kidney disease. Biochemical Society transactions. vol 36. issue Pt 5. 2008-11-12. PMID:18793165. |
central to the pathology of dn are cytokines and growth factors such as tgf-beta (transforming growth factor beta) superfamily members, including bmps (bone morphogenetic protein) and tgf-beta1, which play key roles in fibrogenic responses of the kidney, including podocyte loss, mesangial cell hypertrophy, matrix accumulation and tubulointerstitial fibrosis. |
2008-11-12 |
2023-08-12 |
human |
| Yasunori Sakakura, Toru Shibui, Kazuharu Irie, Toshihiko Yajim. Metabolic mode peculiar to Meckel's cartilage: immunohistochemical comparisons of hypoxia-inducible factor-1alpha and glucose transporters in developing endochondral bones in mice. European journal of oral sciences. vol 116. issue 4. 2008-11-10. PMID:18705802. |
the middle portion of meckel's cartilage resembles endochondral bone formation accompanied by chondrocyte hypertrophy and death, cartilaginous matrix calcification, and chondroclastic resorption. |
2008-11-10 |
2023-08-12 |
mouse |
| M Horvat-Gordon, F Yu, D Burns, R M Leac. Ovocleidin (OC 116) is present in avian skeletal tissues. Poultry science. vol 87. issue 8. 2008-11-04. PMID:18648057. |
using western blotting, we found oc-116 in the matrix of chick cortical bone and laying hen medullary bone as well as in hypertrophic chondrocyte lysates. |
2008-11-04 |
2023-08-12 |
chicken |
| Yusuke Shinoda, Naoshi Ogata, Akiro Higashikawa, Ichiro Manabe, Takayuki Shindo, Takashi Yamada, Fumitaka Kugimiya, Toshiyuki Ikeda, Naohiro Kawamura, Yosuke Kawasaki, Kensuke Tsushima, Norifumi Takeda, Ryozo Nagai, Kazuto Hoshi, Kozo Nakamura, Ung-il Chung, Hiroshi Kawaguch. Kruppel-like factor 5 causes cartilage degradation through transactivation of matrix metalloproteinase 9. The Journal of biological chemistry. vol 283. issue 36. 2008-10-20. PMID:18617520. |
although chondrocyte proliferation and differentiation were normal, cartilage matrix degradation was impaired in klf5+/- mice, causing delay in replacement of cartilage with bone at the primary ossification center in the embryonic limbs and elongation of hypertrophic chondrocyte layer in the neonatal growth plates. |
2008-10-20 |
2023-08-12 |
mouse |
| Allison A Stewart, Christopher R Byron, Holly C Pondenis, Matthew C Stewar. Effect of dexamethasone supplementation on chondrogenesis of equine mesenchymal stem cells. American journal of veterinary research. vol 69. issue 8. 2008-10-14. PMID:18672964. |
to determine whether expansion of equine mesenchymal stem cells (mscs) by use of fibroblast growth factor-2 (fgf-2) prior to supplementation with dexamethasone during the chondrogenic pellet culture phase would increase chondrocytic matrix markers without stimulating a hypertrophic chondrocytic phenotype. |
2008-10-14 |
2023-08-12 |
Not clear |
| Karen Block, Assaad Eid, Kathy K Griendling, Duck-Yoon Lee, Yohann Wittrant, Yves Gori. Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression. The Journal of biological chemistry. vol 283. issue 35. 2008-10-03. PMID:18559349. |
activation of glomerular mesangial cells (mcs) by angiotensin ii (ang ii) leads to hypertrophy and extracellular matrix accumulation. |
2008-10-03 |
2023-08-12 |
Not clear |
| H K Graham, M Horn, A W Traffor. Extracellular matrix profiles in the progression to heart failure. European Young Physiologists Symposium Keynote Lecture-Bratislava 2007. Acta physiologica (Oxford, England). vol 194. issue 1. 2008-10-03. PMID:18577182. |
one of the key targets in cardiology is the elucidation of the molecular mechanisms which mediate pathological remodelling of this matrix causing the transition from compensatory hypertrophy to congestive decompensated heart failure. |
2008-10-03 |
2023-08-12 |
Not clear |
| Eleonora Marsich, Pamela Mozetic, Fulvia Ortolani, Magali Contin, Maurizio Marchini, Amedeo Vetere, Sabrina Pacor, Sabrina Semeraro, Franco Vittur, Sergio Paolett. Galectin-1 in cartilage: expression, influence on chondrocyte growth and interaction with ECM components. Matrix biology : journal of the International Society for Matrix Biology. vol 27. issue 6. 2008-09-30. PMID:18558481. |
induction of matrix degradation and hypertrophy marker expression). |
2008-09-30 |
2023-08-12 |
Not clear |
| Hang Yuan, Linda Lanting, Zhong-Gao Xu, Shu-Lian Li, Piotr Swiderski, Sumanth Putta, Mahesh Jonnalagadda, Mitsuo Kato, Rama Nataraja. Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes. American journal of physiology. Renal physiology. vol 295. issue 2. 2008-09-25. PMID:18562637. |
we previously showed that the 12/15-lipoxygenase (12/15-lo) pathway of arachidonate acid metabolism is involved in multiple events related to diabetic nephropathy (dn), including glomerular hypertrophy and extracellular matrix deposition (kang sw, adler sg, nast cc, lapage j, gu jl, nadler jl, natarajan r. kidney int 59: 1354-1362, 2001; kang sw, natarajan r, shahed a, nast cc, lapage j, mundel p, kashtan c, adler sg. |
2008-09-25 |
2023-08-12 |
mouse |
| Ju Lin Xie, Hui Ning Bian, Shao Hai Qi, Hua De Chen, Hou Dong Li, Ying Bin Xu, Tian Zeng Li, Xu Sheng Liu, Hui Z Liang, Bang Rong Xin, Yong Hua. Basic fibroblast growth factor (bFGF) alleviates the scar of the rabbit ear model in wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 16. issue 4. 2008-09-23. PMID:18638277. |
to investigate the effect of bfgf on the hypertrophic scar in the rabbit ear model and to clarify the mechanisms of bfgf on treatment for scar in wound healing, the rabbit ear model of wound healing was created and treated topically with bfgf once daily for 3 months; then we examined the changes of macroscopic and histopathological characteristics of scars and the expression of collagen and collagenase-1 (matrix metalloproteinase-1). |
2008-09-23 |
2023-08-12 |
rabbit |
| Denise L Cecil, Robert Terkeltau. Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes. Journal of immunology (Baltimore, Md. : 1950). vol 180. issue 12. 2008-09-05. PMID:18523305. |
we conclude that transamidation by tg2 transforms s100a11 into a covalently bonded homodimer that acquires the capacity to signal through the p38 mapk pathway, accelerate chondrocyte hypertrophy and matrix catabolism, and thereby couple inflammation with chondrocyte activation to potentially promote oa progression. |
2008-09-05 |
2023-08-12 |
mouse |
| E V Chetkina, A R Pu. [Type II collagen fragment capacity to induce collagen cleavage and hypertrophy of articular chondrocyte]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 5. 2008-08-19. PMID:18589731. |
our results show that the induction of collagenase activity by cryptic peptide sequence of type ii collagen is accompanied by chondrocyte hypertrophy and associated cellular and matrix changes. |
2008-08-19 |
2023-08-12 |
Not clear |
| Luciano F Borges, Elia G Caldini, Cláudia N Battlhener, Sérgio B Garcia, Sérgio Zucoloto, Gregório S Montes, Sebastião R Tabog. Differential distribution of some extracellular matrix fibers in an experimentally denervated rat megaileum. Micron (Oxford, England : 1993). vol 39. issue 4. 2008-08-12. PMID:17433699. |
the thickening is due to hyperplasia and hypertrophy of the smooth muscle cells and increased extracellular matrix components. |
2008-08-12 |
2023-08-12 |
rat |
| Shunichi Shibata, Otto Baba, Tsuyoshi Oda, Tamaki Yokohama-Tamaki, Chunlin Qin, William T Butler, Yasunori Sakakura, Yoshiro Takan. An immunohistochemical and ultrastructural study of the pericellular matrix of uneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice. Archives of oral biology. vol 53. issue 3. 2008-08-11. PMID:18068147. |
an immunohistochemical and ultrastructural study of the pericellular matrix of uneroded hypertrophic chondrocytes in the mandibular condyle of aged c-src-deficient mice. |
2008-08-11 |
2023-08-12 |
mouse |
| Brent E Bobick, William M Kuly. Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling. Birth defects research. Part C, Embryo today : reviews. vol 84. issue 2. 2008-08-06. PMID:18546337. |
endochondral ossification is a highly regulated, multistep cell specification program involving the initial differentiation of prechondrogenic mesenchymal cells into hyaline chondrocytes, terminal differentiation of hyaline chondrocytes into hypertrophic chondrocytes, and finally, apoptosis of hypertrophic chondrocytes followed by bone matrix deposition. |
2008-08-06 |
2023-08-12 |
Not clear |
| Xi-Qiao Wang, Ying-Kai Liu, Zhi-Gang Mao, Chun Qing, Shu-Liang Lu, Da-Zhong X. Isolation, culture and characterization of endothelial cells from human hypertrophic scar. Endothelium : journal of endothelial cell research. vol 15. issue 3. 2008-08-06. PMID:18568951. |
recently, the authors developed a reliable technique to obtain endothelial cells from hypertrophic scars that involved separation of cells from the scar tissue matrix and isolation from other cell types. |
2008-08-06 |
2023-08-12 |
human |
| Yongmei Liu, Barry I Freedman, Kathryn P Burdon, Carl D Langefeld, Timothy Howard, David Herrington, David C Goff, Donald W Bowden, Lynne E Wagenknecht, Catherine C Hedrick, Stephen S Ric. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. American journal of kidney diseases : the official journal of the National Kidney Foundation. vol 52. issue 2. 2008-08-05. PMID:18640486. |
these products can induce cell hypertrophy, cell proliferation, and extracellular matrix deposition, potentially leading to diabetic nephropathy. |
2008-08-05 |
2023-08-12 |
Not clear |
| Vanessa Roldán, Francisco Marín, Juan R Gimeno, Francisco Ruiz-Espejo, Josefa González, Eloisa Feliu, Antonio García-Honrubia, Daniel Saura, Gonzalo de la Morena, Mariano Valdés, Vicente Vicent. Matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy. American heart journal. vol 156. issue 1. 2008-07-31. PMID:18585501. |
matrix metalloproteinases and tissue remodeling in hypertrophic cardiomyopathy. |
2008-07-31 |
2023-08-12 |
Not clear |
| Biao Feng, Shali Chen, Jane Chiu, Biju George, Subrata Chakrabart. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. American journal of physiology. Endocrinology and metabolism. vol 294. issue 6. 2008-07-22. PMID:18413674. |
diabetic cardiomyopathy, structurally characterized by cardiomyocyte hypertrophy and increased extracellular matrix (ecm) protein deposition, eventually leads to heart failure. |
2008-07-22 |
2023-08-12 |
rat |
| Michihiko Usui, Lianping Xing, Hicham Drissi, Michael Zuscik, Regis O'Keefe, Di Chen, Brendan F Boyc. Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 23. issue 3. 2008-06-24. PMID:17967138. |
we report that hypertrophic chondrocytes induce osteoclast formation through rankl production stimulated by bmp2 and runx2/smad1 and thus they may regulate resorption of calcified matrix by osteoclasts at growth plates. |
2008-06-24 |
2023-08-12 |
chicken |