Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Norio Amizuka, Junko Shimomura, Takeyasu Maeda, Hidehiro Ozaw. [Mineralization and vascular invasion during endochondral bone formation]. Clinical calcium. vol 13. issue 4. 2005-05-11. PMID:15775105. |
the intercolumnar cartilage matrix of the hypertrophic zone is subjected to mineralization whereas the transverse partitions of the cartilage column are poorly mineralized. |
2005-05-11 |
2023-08-12 |
Not clear |
Andrew R Kompa, Walter G Thomas, Fiona See, Alex Tzanidis, Ross D Hannan, Henry Kru. Cardiovascular role of urotensin II: effect of chronic infusion in the rat. Peptides. vol 25. issue 10. 2005-05-06. PMID:15476946. |
direct effects of uii on the myocardium, include myocyte hypertrophy, extracellular matrix deposition and contractility. |
2005-05-06 |
2023-08-12 |
rat |
Gunnar Sjöberg, Anna Kostareva, Thomas Sejerse. [Hereditary cardiomyopathies: a review. Mutation of structural proteins a common cause of hereditary cardiomyopathy]. Lakartidningen. vol 102. issue 11. 2005-04-20. PMID:15835520. |
in general the genes causing hypertrophic cardiomyopathies code for proteins involved in the contractile apparatus, the sarcomere, and the genes causing dilated cardiomyopathy code for proteins that anchor the sarcomere to the cell membrane and extracellular matrix. |
2005-04-20 |
2023-08-12 |
Not clear |
Francisco Forriol, Frederic Shapir. Bone development: interaction of molecular components and biophysical forces. Clinical orthopaedics and related research. issue 432. 2005-04-06. PMID:15738800. |
most endochondral growth in length occurs at the physes by the coordinated actions of cell proliferation, matrix synthesis, and chondrocyte hypertrophy. |
2005-04-06 |
2023-08-12 |
Not clear |
Blanche Schroen, Stephane Heymans, Umesh Sharma, W Matthijs Blankesteijn, Saraswati Pokharel, Jack P M Cleutjens, J Gordon Porter, Chris T A Evelo, Rudy Duisters, Rick E W van Leeuwen, Ben J A Janssen, Jacques J M Debets, Jos F M Smits, Mat J A P Daemen, Harry J G M Crijns, Paul Bornstein, Yigal M Pint. Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. Circulation research. vol 95. issue 5. 2005-04-01. PMID:15284191. |
thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy. |
2005-04-01 |
2023-08-12 |
mouse |
Xinping Zhang, Navid Ziran, J Jeffery Goater, Edward M Schwarz, J Edward Puzas, Randy N Rosier, Michael Zuscik, Hicham Drissi, Regis J O'Keef. Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone. vol 34. issue 5. 2005-03-29. PMID:15121012. |
here, we show that stage e11.5 embryonic murine limb bud mesenchymal stem cells in micromass cell culture progress through the stages of chondrogenesis, chondrocyte hypertrophy, terminal differentiation, and matrix calcification. |
2005-03-29 |
2023-08-12 |
mouse |
Xinping Zhang, Navid Ziran, J Jeffery Goater, Edward M Schwarz, J Edward Puzas, Randy N Rosier, Michael Zuscik, Hicham Drissi, Regis J O'Keef. Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone. vol 34. issue 5. 2005-03-29. PMID:15121012. |
pge2 had minimal effects on chondrocyte hypertrophy but delayed terminal differentiation and matrix calcification. |
2005-03-29 |
2023-08-12 |
mouse |
Hiroyuki Tsutsu. Novel pathophysiological insight and treatment strategies for heart failure--lessons from mice and patients--. Circulation journal : official journal of the Japanese Circulation Society. vol 68. issue 12. 2005-03-29. PMID:15564690. |
oxidative stress causes myocyte hypertrophy, apoptosis, and interstitial fibrosis by activating matrix metalloproteinases, all of which result in myocardial remodeling and failure. |
2005-03-29 |
2023-08-12 |
mouse |
Myra H Wyckoff, Chirine El-Turk, Abbot Laptook, Charles Timmons, Francis H Gannon, Xiafang Zhang, Steven Mumm, Michael P Whyt. Neonatal lethal osteochondrodysplasia with low serum levels of alkaline phosphatase and osteocalcin. The Journal of clinical endocrinology and metabolism. vol 90. issue 2. 2005-03-24. PMID:15562030. |
histopathology at autopsy excluded impaired mineralization of skeletal matrix, but endochondral bone formation appeared disorganized with growth plate clustering of chondrocytes in hypertrophic zones and in zones of provisional calcification. |
2005-03-24 |
2023-08-12 |
Not clear |
C Alexakis, C Strup, P Mestries, D Mathé, J P Caruelle, D Barritault, P Ker. Regulation of the collagen phenotype expression of gamma-irradiated vascular smooth muscle cells by heparan mimetics (RGTA). Journal of biomedical materials research. Part A. vol 70. issue 4. 2005-03-22. PMID:15307164. |
restenosis is characterized by vascular smooth muscle cell (vsmc) proliferation and accumulation of collagen iii in a hypertrophic and disorganized extracellular matrix. |
2005-03-22 |
2023-08-12 |
Not clear |
Kathleen M Daumer, A Cevik Tufan, Rocky S Tua. Long-term in vitro analysis of limb cartilage development: involvement of Wnt signaling. Journal of cellular biochemistry. vol 93. issue 3. 2005-03-18. PMID:15372624. |
endochondral skeletal development involves the condensation of mesenchymal cells, their differentiation into chondrocytes, followed by chondrocyte maturation, hypertrophy, and matrix mineralization, and replacement by osteoblasts. |
2005-03-18 |
2023-08-12 |
chicken |
G Wol. New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology. European journal of clinical investigation. vol 34. issue 12. 2005-03-14. PMID:15606719. |
particularly, tgf-beta is important in the development of renal hypertrophy and accumulation of extracellular matrix components. |
2005-03-14 |
2023-08-12 |
Not clear |
G Wol. New insights into the pathophysiology of diabetic nephropathy: from haemodynamics to molecular pathology. European journal of clinical investigation. vol 34. issue 12. 2005-03-14. PMID:15606719. |
in fact, it has been shown that angiotensin ii is involved in almost every pathophysiological process implicated in the development of diabetic nephropathy (haemodynamic changes, hypertrophy, extracellular matrix accumulation, growth factor/cytokine induction, ros formation, podocyte damage, proteinuria, interstitial inflammation). |
2005-03-14 |
2023-08-12 |
Not clear |
Kotaro Tanimoto, Aya Suzuki, Shigeru Ohno, Koubun Honda, Nobuaki Tanaka, Takeyoshi Doi, Maiko Nakahara-Ohno, Kiyoshi Yoneno, Yuki Nakatani, Masashi Ueki, Tamami Yanagida, Reiko Kitamura, Kazuo Tann. Hyaluronidase expression in cultured growth plate chondrocytes during differentiation. Cell and tissue research. vol 318. issue 2. 2005-03-08. PMID:15503157. |
the expression levels of hyal1 and hyal2 mrnas were enhanced about 2.8-fold and 3.2-fold at the maximum during the early matrix forming stage, respectively, and by about 3.2-fold and 2.0-fold at the maximum in the hypertrophic stage, respectively. |
2005-03-08 |
2023-08-12 |
Not clear |
Kotaro Tanimoto, Aya Suzuki, Shigeru Ohno, Koubun Honda, Nobuaki Tanaka, Takeyoshi Doi, Maiko Nakahara-Ohno, Kiyoshi Yoneno, Yuki Nakatani, Masashi Ueki, Tamami Yanagida, Reiko Kitamura, Kazuo Tann. Hyaluronidase expression in cultured growth plate chondrocytes during differentiation. Cell and tissue research. vol 318. issue 2. 2005-03-08. PMID:15503157. |
haase activity was enhanced at the early matrix forming and hypertrophic stages. |
2005-03-08 |
2023-08-12 |
Not clear |
Zihua Zhou, Yu-Hua Liao, Yumiao Wei, Fen Wei, Bin Wang, Liudong Li, Min Wang, Kun Li. Cardiac remodeling after long-term stimulation by antibodies against the alpha1-adrenergic receptor in rats. Clinical immunology (Orlando, Fla.). vol 114. issue 2. 2005-03-08. PMID:15639650. |
in immunized rats, despite that systolic blood pressure (sbp) had no difference with normal control, the hypertrophy of heart and cardiomyocytes was observed, the collagen deposition in heart interstitium increased, and c-jun expression and matrix metalloproteinase (mmp)-2 mrna expression and activity in heart had increased. |
2005-03-08 |
2023-08-12 |
rat |
Stephane Heymans, Florea Lupu, Sven Terclavers, Bjorn Vanwetswinkel, Jean-Marc Herbert, Andrew Baker, Desire Collen, Peter Carmeliet, Lieve Moon. Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. The American journal of pathology. vol 166. issue 1. 2005-03-02. PMID:15631996. |
matrix metalloproteinases (mmps) have been invoked in various cardiac diseases, however, direct genetic evidence for a role of the plasminogen activator (pa) and mmp systems in pressure overload-induced lv hypertrophy and in heart failure is lacking. |
2005-03-02 |
2023-08-12 |
mouse |
Dominique Stickens, Danielle J Behonick, Nathalie Ortega, Babette Heyer, Bettina Hartenstein, Ying Yu, Amanda J Fosang, Marina Schorpp-Kistner, Peter Angel, Zena Wer. Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development (Cambridge, England). vol 131. issue 23. 2005-02-22. PMID:15539485. |
matrix metalloproteinase (mmp) 13 (collagenase 3) is poised to play a crucial role in bone formation and remodeling because of its expression both in terminal hypertrophic chondrocytes in the growth plate and in osteoblasts. |
2005-02-22 |
2023-08-12 |
mouse |
Wilfried Briest, Lars Homagk, Hideo A Baba, Alexander Deten, Beate Rassler, Andrea Tannapfel, Klaus F Wagner, Roland H Wenger, Heinz-Gerd Zimme. Cardiac remodeling in erythropoietin-transgenic mice. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 14. issue 4-6. 2005-02-15. PMID:15319531. |
the aim of this study was to examine whether this cardiac dysfunction was accompanied by hypertrophy of the heart with remodeling of the extracellular matrix (ecm). |
2005-02-15 |
2023-08-12 |
mouse |
Denise L Cecil, David M Rose, Robert Terkeltaub, Ru Liu-Brya. Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes. Arthritis and rheumatism. vol 52. issue 1. 2005-02-15. PMID:15641067. |
moreover, chondrocyte hypertrophy develops in situ in osteoarthritic (oa) articular cartilage and promotes dysregulated matrix repair and calcification. |
2005-02-15 |
2023-08-12 |
Not clear |