| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Franck Simon, Daniele Bergeron, S\\xc3\\xa9bastien Larochelle, Carlos A Lopez-Vall\\xc3\\xa9, Herv\\xc3\\xa9 Genest, Alexis Armour, V\\xc3\\xa9ronique J Mouli. Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis. Burns : journal of the International Society for Burn Injuries. vol 38. issue 3. 2012-05-23. PMID:22040932. |
hypertrophic scars are a pathological process characterized by an excessive deposition of extracellular matrix components. |
2012-05-23 |
2023-08-12 |
human |
| Franck Simon, Daniele Bergeron, S\\xc3\\xa9bastien Larochelle, Carlos A Lopez-Vall\\xc3\\xa9, Herv\\xc3\\xa9 Genest, Alexis Armour, V\\xc3\\xa9ronique J Mouli. Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis. Burns : journal of the International Society for Burn Injuries. vol 38. issue 3. 2012-05-23. PMID:22040932. |
the dermal matrix of these rhs was recreated using mesenchymal cells from three different origins (skin, wound and hypertrophic scar). |
2012-05-23 |
2023-08-12 |
human |
| Dutmanee Seriwatanachai, Nateetip Krishnamra, Narattaphol Charoenphandh. Chondroregulatory action of prolactin on proliferation and differentiation of mouse chondrogenic ATDC5 cells in 3-dimensional micromass cultures. Biochemical and biophysical research communications. vol 420. issue 1. 2012-05-16. PMID:22405773. |
a recent investigation in lactating rats has provided evidence that the lactogenic hormone prolactin (prl) increases endochondral bone growth and bone elongation, presumably by accelerating apoptosis of hypertrophic chondrocytes in the growth plate and/or subsequent chondrogenic matrix mineralization. |
2012-05-16 |
2023-08-12 |
mouse |
| Saurabh Dahiya, Shephali Bhatnagar, Sajedah M Hindi, Chunhui Jiang, Pradyut K Paul, Shihuan Kuang, Ashok Kuma. Elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice. Human molecular genetics. vol 20. issue 22. 2012-05-15. PMID:21846793. |
elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice. |
2012-05-15 |
2023-08-12 |
mouse |
| G P Sidgwick, A Baya. Extracellular matrix molecules implicated in hypertrophic and keloid scarring. Journal of the European Academy of Dermatology and Venereology : JEADV. vol 26. issue 2. 2012-05-14. PMID:21838832. |
extracellular matrix molecules implicated in hypertrophic and keloid scarring. |
2012-05-14 |
2023-08-12 |
Not clear |
| Norio Amizuka, Tomoka Hasegawa, Kimimitsu Oda, Paulo Henrique Luiz de Freitas, Kazuto Hoshi, Minqi Li, Hidehiro Ozaw. Histology of epiphyseal cartilage calcification and endochondral ossification. Frontiers in bioscience (Elite edition). vol 4. 2012-05-14. PMID:22202021. |
cartilage calcification is carried out by chondrocytes as they hypertrophy and begin to secrete matrix vesicles. |
2012-05-14 |
2023-08-12 |
Not clear |
| Norio Amizuka, Tomoka Hasegawa, Kimimitsu Oda, Paulo Henrique Luiz de Freitas, Kazuto Hoshi, Minqi Li, Hidehiro Ozaw. Histology of epiphyseal cartilage calcification and endochondral ossification. Frontiers in bioscience (Elite edition). vol 4. 2012-05-14. PMID:22202021. |
hypertrophic chondrocytes secrete vesicles in the cartilaginous matrix of intercolumnar septae only, forming well-calcified longitudinal septae and poorly-calcified transverse partitions. |
2012-05-14 |
2023-08-12 |
Not clear |
| P S Skagen, T Horn, H A Kruse, B Staergaard, M M Rapport, T Nicolaise. Osteochondritis dissecans (OCD), an endoplasmic reticulum storage disease?: a morphological and molecular study of OCD fragments. Scandinavian journal of medicine & science in sports. vol 21. issue 6. 2012-05-01. PMID:20561273. |
further, von kossa staining and tem showed empty lacunae close to mineralized "islands" in the cartilage and hypertrophic chondrocytes containing accumulated matrix proteins. |
2012-05-01 |
2023-08-12 |
Not clear |
| Geert W Schmid-Sch\\xc3\\xb6nbei. An emerging role of degrading proteinases in hypertension and the metabolic syndrome: autodigestion and receptor cleavage. Current hypertension reports. vol 14. issue 1. 2012-05-01. PMID:22081429. |
an emerging body of evidence suggests that human and experimental hypertensives may exhibit uncontrolled activity of proteinases, including the family of matrix metalloproteinases, recognized for their ability to restructure the extracellular matrix proteins and to play a role in hypertrophy. |
2012-05-01 |
2023-08-12 |
human |
| Kirk R Hutchinson, Anuradha Guggilam, Mary J Cismowski, Maarten L Galantowicz, Thomas A West, James A Stewart, Xiaojin Zhang, Kevin C Lord, Pamela A Lucches. Temporal pattern of left ventricular structural and functional remodeling following reversal of volume overload heart failure. Journal of applied physiology (Bethesda, Md. : 1985). vol 111. issue 6. 2012-04-30. PMID:21885799. |
structural and functional changes were correlated to lv collagen content, extracellular matrix (ecm) proteins, and hypertrophic markers. |
2012-04-30 |
2023-08-12 |
rat |
| Maurizio Mandala, George Oso. Physiological remodelling of the maternal uterine circulation during pregnancy. Basic & clinical pharmacology & toxicology. vol 110. issue 1. 2012-04-30. PMID:21902814. |
the process of maternal gestational uterine vascular remodelling involves a number of cellular processes and mechanisms, including trophoblast invasion, hyperplasia and hypertrophy, and changes in extracellular matrix composition. |
2012-04-30 |
2023-08-12 |
rat |
| Anna Leychenko, Eugene Konorev, Mayumi Jijiwa, Michelle L Matte. Stretch-induced hypertrophy activates NFkB-mediated VEGF secretion in adult cardiomyocytes. PloS one. vol 6. issue 12. 2012-04-23. PMID:22174951. |
it is characterized by extracellular matrix remodeling and hypertrophic growth of adult cardiomyocytes. |
2012-04-23 |
2023-08-12 |
rat |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
calcineurin a-\xce\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. |
2012-04-16 |
2023-08-12 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
previously, we found that inhibition of calcineurin with cyclosporine reduced renal hypertrophy and blocked glomerular matrix expansion in the diabetic kidney. |
2012-04-16 |
2023-08-12 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
therefore, we examined the role of calcineurin \xce\xb2 in diabetic renal hypertrophy and glomerular matrix expansion. |
2012-04-16 |
2023-08-12 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
type i diabetes was induced in wild-type and \xce\xb2(-/-) mice and then renal function, extracellular matrix expansion and hypertrophy were evaluated. |
2012-04-16 |
2023-08-12 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
in conclusion, loss of the \xce\xb2 isoform of calcineurin is sufficient to reproduce beneficial aspects of cyclosporine on diabetic renal hypertrophy but not matrix expansion. |
2012-04-16 |
2023-08-12 |
mouse |
| Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-\\xce\\xb2 is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
therefore, while multiple signals appear to regulate matrix, calcineurin \xce\xb2 appears to be a central mechanism involved in organ hypertrophy. |
2012-04-16 |
2023-08-12 |
mouse |
| Maria C Guido, Carolina F Clemente, Ana I Moretti, Hermes V Barbeiro, Victor Debbas, Elia G Caldini, Kleber G Franchini, Francisco G Sorian. Small interfering RNA targeting focal adhesion kinase prevents cardiac dysfunction in endotoxemia. Shock (Augusta, Ga.). vol 37. issue 1. 2012-04-16. PMID:21921830. |
the hearts of lipopolysaccharide-injected rats showed collagen deposition, increased matrix metalloproteinase 2 activity, and myocyte hypertrophy, as well as reduced 24-h +dp/dt and -dp/dt, together with hypotension, increased left ventricular end-diastolic pressure, and elevated levels of fak (phosphorylated and unphosphorylated). |
2012-04-16 |
2023-08-12 |
rat |
| Hak Joo Lee, Meenalakshmi M Mariappan, Denis Feliers, Rita C Cavaglieri, Kavithalakshmi Sataranatarajan, Hanna E Abboud, Goutam Ghosh Choudhury, Balakuntalam S Kasinat. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. The Journal of biological chemistry. vol 287. issue 7. 2012-04-16. PMID:22158625. |
high glucose stimulation of global protein synthesis, cellular hypertrophy, and matrix laminin and type iv collagen content was inhibited by sodium hydrosulfide (nahs), an h(2)s donor. |
2012-04-16 |
2023-08-12 |
mouse |