Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Lanyu Zhang, Shanshan Pang, Bo Deng, Lihua Qian, Juan Chen, Junjie Zou, Jiaoyang Zheng, Linghui Yang, Chunyang Zhang, Xiangfang Chen, Zhimin Liu, Yingying L. High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol. The international journal of biochemistry & cell biology. vol 44. issue 4. 2012-06-15. PMID:22245600. |
renal hypertrophy and extracellular matrix accumulation are early features of diabetic nephropathy. |
2012-06-15 |
2023-08-12 |
rat |
Donghong Fang, Hongyu Guan, Juan Liu, Guohong Wei, Weijian Ke, Bin Yao, Haipeng Xiao, Yanbing L. Early intensive insulin therapy attenuates the p38 pathway in the renal cortex and indices of nephropathy in diabetic rats. Endocrine journal. vol 59. issue 1. 2012-06-04. PMID:22068113. |
glomerular hypertrophy and mesangial matrix expansion were prominent in the 16wdm and li groups while the ei groups remained normal and similar to the 16wnc group. |
2012-06-04 |
2023-08-12 |
rat |
Donghong Fang, Hongyu Guan, Juan Liu, Guohong Wei, Weijian Ke, Bin Yao, Haipeng Xiao, Yanbing L. Early intensive insulin therapy attenuates the p38 pathway in the renal cortex and indices of nephropathy in diabetic rats. Endocrine journal. vol 59. issue 1. 2012-06-04. PMID:22068113. |
however, late insulin therapy did not abrogate the increased renal cortical p38 mapk pathway activation in diabetic rats and led to glomerular hypertrophy and extracellular matrix expansion. |
2012-06-04 |
2023-08-12 |
rat |
Franck Simon, Daniele Bergeron, Sébastien Larochelle, Carlos A Lopez-Vallé, Hervé Genest, Alexis Armour, Véronique J Mouli. Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis. Burns : journal of the International Society for Burn Injuries. vol 38. issue 3. 2012-05-23. PMID:22040932. |
hypertrophic scars are a pathological process characterized by an excessive deposition of extracellular matrix components. |
2012-05-23 |
2023-08-12 |
human |
Franck Simon, Daniele Bergeron, Sébastien Larochelle, Carlos A Lopez-Vallé, Hervé Genest, Alexis Armour, Véronique J Mouli. Enhanced secretion of TIMP-1 by human hypertrophic scar keratinocytes could contribute to fibrosis. Burns : journal of the International Society for Burn Injuries. vol 38. issue 3. 2012-05-23. PMID:22040932. |
the dermal matrix of these rhs was recreated using mesenchymal cells from three different origins (skin, wound and hypertrophic scar). |
2012-05-23 |
2023-08-12 |
human |
Dutmanee Seriwatanachai, Nateetip Krishnamra, Narattaphol Charoenphandh. Chondroregulatory action of prolactin on proliferation and differentiation of mouse chondrogenic ATDC5 cells in 3-dimensional micromass cultures. Biochemical and biophysical research communications. vol 420. issue 1. 2012-05-16. PMID:22405773. |
a recent investigation in lactating rats has provided evidence that the lactogenic hormone prolactin (prl) increases endochondral bone growth and bone elongation, presumably by accelerating apoptosis of hypertrophic chondrocytes in the growth plate and/or subsequent chondrogenic matrix mineralization. |
2012-05-16 |
2023-08-12 |
mouse |
Saurabh Dahiya, Shephali Bhatnagar, Sajedah M Hindi, Chunhui Jiang, Pradyut K Paul, Shihuan Kuang, Ashok Kuma. Elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice. Human molecular genetics. vol 20. issue 22. 2012-05-15. PMID:21846793. |
elevated levels of active matrix metalloproteinase-9 cause hypertrophy in skeletal muscle of normal and dystrophin-deficient mdx mice. |
2012-05-15 |
2023-08-12 |
mouse |
G P Sidgwick, A Baya. Extracellular matrix molecules implicated in hypertrophic and keloid scarring. Journal of the European Academy of Dermatology and Venereology : JEADV. vol 26. issue 2. 2012-05-14. PMID:21838832. |
extracellular matrix molecules implicated in hypertrophic and keloid scarring. |
2012-05-14 |
2023-08-12 |
Not clear |
Norio Amizuka, Tomoka Hasegawa, Kimimitsu Oda, Paulo Henrique Luiz de Freitas, Kazuto Hoshi, Minqi Li, Hidehiro Ozaw. Histology of epiphyseal cartilage calcification and endochondral ossification. Frontiers in bioscience (Elite edition). vol 4. 2012-05-14. PMID:22202021. |
cartilage calcification is carried out by chondrocytes as they hypertrophy and begin to secrete matrix vesicles. |
2012-05-14 |
2023-08-12 |
Not clear |
Norio Amizuka, Tomoka Hasegawa, Kimimitsu Oda, Paulo Henrique Luiz de Freitas, Kazuto Hoshi, Minqi Li, Hidehiro Ozaw. Histology of epiphyseal cartilage calcification and endochondral ossification. Frontiers in bioscience (Elite edition). vol 4. 2012-05-14. PMID:22202021. |
hypertrophic chondrocytes secrete vesicles in the cartilaginous matrix of intercolumnar septae only, forming well-calcified longitudinal septae and poorly-calcified transverse partitions. |
2012-05-14 |
2023-08-12 |
Not clear |
P S Skagen, T Horn, H A Kruse, B Staergaard, M M Rapport, T Nicolaise. Osteochondritis dissecans (OCD), an endoplasmic reticulum storage disease?: a morphological and molecular study of OCD fragments. Scandinavian journal of medicine & science in sports. vol 21. issue 6. 2012-05-01. PMID:20561273. |
further, von kossa staining and tem showed empty lacunae close to mineralized "islands" in the cartilage and hypertrophic chondrocytes containing accumulated matrix proteins. |
2012-05-01 |
2023-08-12 |
Not clear |
Geert W Schmid-Schönbei. An emerging role of degrading proteinases in hypertension and the metabolic syndrome: autodigestion and receptor cleavage. Current hypertension reports. vol 14. issue 1. 2012-05-01. PMID:22081429. |
an emerging body of evidence suggests that human and experimental hypertensives may exhibit uncontrolled activity of proteinases, including the family of matrix metalloproteinases, recognized for their ability to restructure the extracellular matrix proteins and to play a role in hypertrophy. |
2012-05-01 |
2023-08-12 |
human |
Kirk R Hutchinson, Anuradha Guggilam, Mary J Cismowski, Maarten L Galantowicz, Thomas A West, James A Stewart, Xiaojin Zhang, Kevin C Lord, Pamela A Lucches. Temporal pattern of left ventricular structural and functional remodeling following reversal of volume overload heart failure. Journal of applied physiology (Bethesda, Md. : 1985). vol 111. issue 6. 2012-04-30. PMID:21885799. |
structural and functional changes were correlated to lv collagen content, extracellular matrix (ecm) proteins, and hypertrophic markers. |
2012-04-30 |
2023-08-12 |
rat |
Maurizio Mandala, George Oso. Physiological remodelling of the maternal uterine circulation during pregnancy. Basic & clinical pharmacology & toxicology. vol 110. issue 1. 2012-04-30. PMID:21902814. |
the process of maternal gestational uterine vascular remodelling involves a number of cellular processes and mechanisms, including trophoblast invasion, hyperplasia and hypertrophy, and changes in extracellular matrix composition. |
2012-04-30 |
2023-08-12 |
rat |
Anna Leychenko, Eugene Konorev, Mayumi Jijiwa, Michelle L Matte. Stretch-induced hypertrophy activates NFkB-mediated VEGF secretion in adult cardiomyocytes. PloS one. vol 6. issue 12. 2012-04-23. PMID:22174951. |
it is characterized by extracellular matrix remodeling and hypertrophic growth of adult cardiomyocytes. |
2012-04-23 |
2023-08-12 |
rat |
Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
calcineurin a-β is required for hypertrophy but not matrix expansion in the diabetic kidney. |
2012-04-16 |
2023-08-12 |
mouse |
Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
previously, we found that inhibition of calcineurin with cyclosporine reduced renal hypertrophy and blocked glomerular matrix expansion in the diabetic kidney. |
2012-04-16 |
2023-08-12 |
mouse |
Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
therefore, we examined the role of calcineurin β in diabetic renal hypertrophy and glomerular matrix expansion. |
2012-04-16 |
2023-08-12 |
mouse |
Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
type i diabetes was induced in wild-type and β(-/-) mice and then renal function, extracellular matrix expansion and hypertrophy were evaluated. |
2012-04-16 |
2023-08-12 |
mouse |
Ramesh N Reddy, Taylor L Knotts, Brian R Roberts, Jeffery D Molkentin, S Russ Price, Jennifer L Gooc. Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney. Journal of cellular and molecular medicine. vol 15. issue 2. 2012-04-16. PMID:19778355. |
in conclusion, loss of the β isoform of calcineurin is sufficient to reproduce beneficial aspects of cyclosporine on diabetic renal hypertrophy but not matrix expansion. |
2012-04-16 |
2023-08-12 |
mouse |