| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eric E Essick, Noriyuki Ouchi, Richard M Wilson, Koji Ohashi, Joanna Ghobrial, Rei Shibata, David R Pimentel, Flora Sa. Adiponectin mediates cardioprotection in oxidative stress-induced cardiac myocyte remodeling. American journal of physiology. Heart and circulatory physiology. vol 301. issue 3. 2011-11-01. PMID:21666115. |
reactive oxygen species (ros) induce matrix metalloproteinase (mmp) activity that mediates hypertrophy and cardiac remodeling. |
2011-11-01 |
2023-08-12 |
mouse |
| Karen E Porter, Neil A Turne. Statins and myocardial remodelling: cell and molecular pathways. Expert reviews in molecular medicine. vol 13. 2011-10-05. PMID:21718586. |
this review examines evidence for the cellular effects of statins in the heart, and discusses the underlying molecular mechanisms at the level of the cardiomyocyte (hypertrophy, cell death and contractile function) and the cardiac fibroblast (differentiation, proliferation, migration and extracellular matrix synthesis). |
2011-10-05 |
2023-08-12 |
Not clear |
| Amber P Sanchez, JingHong Zhao, Young You, Anne-Emilie Declèves, Maggie Diamond-Stanic, Kumar Sharm. Role of the USF1 transcription factor in diabetic kidney disease. American journal of physiology. Renal physiology. vol 301. issue 2. 2011-10-03. PMID:21543418. |
the degree of hyperglycemia and kidney hypertrophy were similar in all groups of diabetic mice; however, the usf1 -/- diabetic mice had significantly less albuminuria and mesangial matrix expansion than the wt diabetic mice. |
2011-10-03 |
2023-08-12 |
mouse |
| Toshiyuki Inoue, Kiichi Suzuki, Hideaki Maehara, Katsuji Shimiz. Human growth plate contains aggrecan fragments that can be generated by m-calpain. Connective tissue research. vol 52. issue 3. 2011-09-30. PMID:21117903. |
confocal immunostaining demonstrated colocalization of m-calpain and the aggrecan product within the lower hypertrophic chondrocytes and in limited region of the pericellular matrix. |
2011-09-30 |
2023-08-12 |
human |
| Jian-Guo Wu, Yan-Jie Wei, Xia Ran, Hong Zhang, Hua Nian, Lu-Ping Qi. Inhibitory effects of essential oil from rhizomes of Ligusticum chuanxiong on hypertrophic scarring in the rabbit ear model. Pharmaceutical biology. vol 49. issue 7. 2011-09-29. PMID:21639690. |
hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. |
2011-09-29 |
2023-08-12 |
rabbit |
| Federica Accornero, Jop H van Berlo, Matthew J Benard, John N Lorenz, Peter Carmeliet, Jeffery D Molkenti. Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism. Circulation research. vol 109. issue 3. 2011-09-22. PMID:21636802. |
paracrine growth factor-mediated crosstalk between cardiac myocytes and nonmyocytes in the heart is critical for programming adaptive cardiac hypertrophy in which myocyte size, capillary density, and the extracellular matrix function coordinately. |
2011-09-22 |
2023-08-12 |
Not clear |
| Nirmalya Dey, Falguni Das, Meenalakshmi M Mariappan, Chandi Charan Mandal, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes. The Journal of biological chemistry. vol 286. issue 29. 2011-09-16. PMID:21613227. |
hyperglycemia induces a wide array of signaling pathways in the kidney that lead to hypertrophy and matrix expansion, eventually culminating in progressive kidney failure. |
2011-09-16 |
2023-08-12 |
mouse |
| Nirmalya Dey, Falguni Das, Meenalakshmi M Mariappan, Chandi Charan Mandal, Nandini Ghosh-Choudhury, Balakuntalam S Kasinath, Goutam Ghosh Choudhur. MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes. The Journal of biological chemistry. vol 286. issue 29. 2011-09-16. PMID:21613227. |
high glucose-induced reduction of the tumor suppressor protein phosphatase and tensin homolog deleted in chromosome 10 (pten) contributes to renal cell hypertrophy and matrix expansion. |
2011-09-16 |
2023-08-12 |
mouse |
| b' R Paoletti, A Maffei, L Madaro, A Notte, E Stanganello, G Cifelli, P Carullo, M Molinaro, G Lembo, M Bouch\\xc3\\xa. Protein kinase C\\xce\\xb8 is required for cardiomyocyte survival and cardiac remodeling. Cell death & disease. vol 1. 2011-09-15. PMID:21364651.' |
histological analyses showed a reduction in the number of cardiomyocytes, combined with hypertrophy of the remaining cardiomyocytes, cardiac fibrosis, myofibroblast hyper-proliferation and matrix deposition. |
2011-09-15 |
2023-08-12 |
mouse |
| Ajay M Shah, Douglas L Man. In search of new therapeutic targets and strategies for heart failure: recent advances in basic science. Lancet (London, England). vol 378. issue 9792. 2011-09-13. PMID:21856484. |
such pathways include those that regulate cardiac myocyte hypertrophy, calcium homoeostasis, energetics, and cell survival, and processes that take place outside the cardiac myocyte--eg, in the myocardial vasculature and extracellular matrix. |
2011-09-13 |
2023-08-12 |
Not clear |
| Y-J Wei, X-Q Yan, L Ma, J-G Wu, H Zhang, L-P Qi. Oleanolic acid inhibits hypertrophic scarring in the rabbit ear model. Clinical and experimental dermatology. vol 36. issue 5. 2011-09-09. PMID:21392079. |
hypertrophic scarring, a common proliferative disorder of dermal fibroblasts, results from an overproduction of collagen and excessive deposition of extracellular matrix. |
2011-09-09 |
2023-08-12 |
rabbit |
| Ugo Ernesto Pazzaglia, Giampiero Beluffi, Anna Benetti, Maria Pia Bondioni, Guido Zarattin. A review of the actual knowledge of the processes governing growth and development of long bones. Fetal and pediatric pathology. vol 30. issue 3. 2011-08-29. PMID:21355682. |
when endochondral ossification starts a defined spatial disposition of chondrocytes and a corresponding organization of the intercellular matrix is set up, so that it is possible to identify a growth vector corresponding to the columns of piled chondrocytes with direction from hypertrophic toward the proliferative cell layers. |
2011-08-29 |
2023-08-12 |
human |
| Xiaofang Wu, Jennifer R Peters-Hall, Sumit Bose, Maria T Peña, Mary C Ros. Human bronchial epithelial cells differentiate to 3D glandular acini on basement membrane matrix. American journal of respiratory cell and molecular biology. vol 44. issue 6. 2011-08-23. PMID:20724555. |
to create a model system that investigates mechanisms resulting in hyperplasia and hypertrophy of respiratory tract submucosal glands, we developed an in vitro three-dimensional (3d) system wherein normal human bronchial epithelial (hbe) cells differentiated into glandular acini when grown on a basement membrane matrix. |
2011-08-23 |
2023-08-12 |
human |
| B Maisch, P Alter, S Pankuwei. Diabetic cardiomyopathy--fact or fiction? Herz. vol 36. issue 2. 2011-08-16. PMID:21424347. |
hyperglycemia with a shift from glucose metabolism to increased beta-oxidation and consecutive free fatty acid damage (lipotoxicity) to the myocardium, insulin resistance, renin-angiotensin-aldosterone system (raas) activation, altered calcium homeostasis and structural changes from the natural collagen network to a stiffer matrix due to advanced glycation endproduct (age) formation, hypertrophy and fibrosis contribute to the respective clinical phenotypes of dcm. |
2011-08-16 |
2023-08-12 |
Not clear |
| Srikanth Givvimani, Charu Munjal, Riyad Gargoum, Utpal Sen, Neetu Tyagi, Jonathan C Vacek, Suresh C Tyag. Hydrogen sulfide mitigates transition from compensatory hypertrophy to heart failure. Journal of applied physiology (Bethesda, Md. : 1985). vol 110. issue 4. 2011-08-15. PMID:21233344. |
we reported previously that although there is disruption of coordinated cardiac hypertrophy and angiogenesis in transition to heart failure, matrix metalloproteinase (mmp)-9 induced antiangiogenic factors play a vital role in this process. |
2011-08-15 |
2023-08-12 |
mouse |
| Mary B Goldring, Miguel Otero, Darren A Plumb, Cecilia Dragomir, Marta Favero, Karim El Hachem, Ko Hashimoto, Helmtrud I Roach, Eleonora Olivotto, Rosa Maria Borzì, Kenneth B Marc. Roles of inflammatory and anabolic cytokines in cartilage metabolism: signals and multiple effectors converge upon MMP-13 regulation in osteoarthritis. European cells & materials. vol 21. 2011-08-01. PMID:21351054. |
to identify and characterize effectors or regulators of cartilage remodeling in these processes, we are using culture models of primary human and mouse chondrocytes and cell lines and mouse genetic models to manipulate gene expression programs leading to matrix remodeling and subsequent chondrocyte hypertrophic differentiation, pivotal processes which both go astray in oa disease. |
2011-08-01 |
2023-08-12 |
mouse |
| Zhan-Feng Zhang, Yan-Gang Zhang, Da-Hai Hu, Ji-Hong Shi, Jia-Qi Liu, Zhou-Ting Zhao, Hong-Tao Wang, Xiao-Zhi Bai, Wei-Xia Cai, Hua-Yu Zhu, Chao-Wu Tan. Smad interacting protein 1 as a regulator of skin fibrosis in pathological scars. Burns : journal of the International Society for Burn Injuries. vol 37. issue 4. 2011-07-22. PMID:21236582. |
keloids and hypertrophic scars are significant symptomatic clinical problems characterized by the excessive and abnormal deposition of collagen-based extracellular matrix (ecm) components. |
2011-07-22 |
2023-08-12 |
Not clear |
| Mark W M Schellings, Geert C van Almen, E Helene Sage, Stephane Heyman. Thrombospondins in the heart: potential functions in cardiac remodeling. Journal of cell communication and signaling. vol 3. issue 3-4. 2011-07-14. PMID:19798592. |
cardiac remodeling after myocardial injury involves inflammation, angiogenesis, left ventricular hypertrophy and matrix remodeling. |
2011-07-14 |
2023-08-12 |
Not clear |
| Yun Hee Lee, Tae Yeon Kim, Young Mi Hon. Metalloproteinase-3 genotype as a predictor of cardiovascular risk in hypertensive adolescents. Korean circulation journal. vol 39. issue 8. 2011-07-14. PMID:19949639. |
hypertension develops as a result of cardiac hypertrophy and fibrosis or as a result of exchange of the extracellular matrix. |
2011-07-14 |
2023-08-12 |
Not clear |
| Hye-Na Cha, Jung Hyun Choi, Yong-Woon Kim, Jong-Yeon Kim, Myun-Whan Ahn, So-Young Par. Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 14. issue 6. 2011-07-14. PMID:21311678. |
cardiac hypertrophy was accompanied with increased interleukin-6 (il-6), transforming growth factor (tgf)-β, atrial natriuretic peptide (anp), collagen i and iii, and matrix metallopeptidase 2 (mmp-2). |
2011-07-14 |
2023-08-12 |
mouse |