| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuyo Yamaji-Kegan, Qingning Su, Daniel J Angelini, Allen C Myers, Chris Cheadle, Roger A John. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 9. 2010-11-12. PMID:20889544. |
we also found that himf-induced proliferative activity, hypertrophy, collagen, and extracellular matrix deposition in the pulmonary arteries are significantly less in il-4 ko mice than in wt mice. |
2010-11-12 |
2023-08-12 |
mouse |
| Wen-Hsiang Su, Ming-Huei Cheng, Wen-Ling Lee, Tsung-Shan Tsou, Wen-Hsun Chang, Chien-Sheng Chen, Peng-Hui Wan. Nonsteroidal anti-inflammatory drugs for wounds: pain relief or excessive scar formation? Mediators of inflammation. vol 2010. 2010-11-04. PMID:20671960. |
hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. |
2010-11-04 |
2023-08-12 |
Not clear |
| Zhaohui Pei, Rongsen Meng, Guangwei Li, Guangmei Yan, Changqing Xu, Zhiqiang Zhuang, Jun Ren, Zhenbiao W. Angiotensin-(1-7) ameliorates myocardial remodeling and interstitial fibrosis in spontaneous hypertension: role of MMPs/TIMPs. Toxicology letters. vol 199. issue 2. 2010-11-04. PMID:20837116. |
mean arterial pressure, left ventricular geometry, expression of the hypertrophic markers anp and \xce\xb2-mhc, collagen contents (type i and iii), collagenase (mmp-1), matrix metalloproteinase-2 (mmp-2) and tissue inhibitor of mmps-1 (timp-1) were evaluated in wky and shr rats with or without treatment. |
2010-11-04 |
2023-08-12 |
rat |
| D Saura, F Mar\\xc3\\xadn, V Climent, J Gonz\\xc3\\xa1lez, V Rold\\xc3\\xa1n, D Hern\\xc3\\xa1ndez-Romero, M J Oliva, M Sabater, G de la Morena, G Y H Lip, M Vald\\xc3\\xa9. Left atrial remodelling in hypertrophic cardiomyopathy: relation with exercise capacity and biochemical markers of tissue strain and remodelling. International journal of clinical practice. vol 63. issue 10. 2010-11-01. PMID:19769703. |
the aim of this study was to analyse the influence of lav on exercise performance in hypertrophic cardiomyopathy (hcm), and in a subset of subjects, assess the relation of lav and exercise performance to four biomarkers of disease pathophysiology: matrix metalloproteinase-2 (mmp-2) and tissue inhibitor of matrix metalloproteinase-1 (timp-1) (as indices of tissue remodelling), n-terminal portion of pro b-type natriuretic peptide (nt-pro-bnp) (associated with ventricular dysfunction) and c-reactive protein (crp, an index of inflammation). |
2010-11-01 |
2023-08-12 |
human |
| Vera Regitz-Zagrosek, Sabine Oertelt-Prigione, Ute Seeland, Roland Hetze. Sex and gender differences in myocardial hypertrophy and heart failure. Circulation journal : official journal of the Japanese Circulation Society. vol 74. issue 7. 2010-10-19. PMID:20558892. |
women with aortic stenosis have more concentric hypertrophy with better systolic function, less upregulation of extracellular matrix genes and better reversibility after unloading. |
2010-10-19 |
2023-08-12 |
Not clear |
| Chikara Ushiku, Douglas J Adams, Xi Jiang, Liping Wang, David W Row. Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 28. issue 10. 2010-10-07. PMID:20839319. |
second, the hypertrophic chondrocytes are dispersed and the cartilage matrix mineralized by the advancing col3.6+ osteoblasts. |
2010-10-07 |
2023-08-12 |
mouse |
| Kelly L Hudkins, Warangkana Pichaiwong, Tomasz Wietecha, Jolanta Kowalewska, Miriam C Banas, Min W Spencer, Anja M\\xc3\\xbchlfeld, Mariko Koelling, Jeffrey W Pippin, Stuart J Shankland, Bardia Askari, Mary E Rabaglia, Mark P Keller, Alan D Attie, Charles E Alper. BTBR Ob/Ob mutant mice model progressive diabetic nephropathy. Journal of the American Society of Nephrology : JASN. vol 21. issue 9. 2010-09-23. PMID:20634301. |
glomerular hypertrophy and accumulation of mesangial matrix, characteristic of early dn, were present by 8 weeks, and glomerular lesions similar to those of advanced human dn were present by 20 weeks. |
2010-09-23 |
2023-08-12 |
mouse |
| B D Boyan, J Hurst-Kennedy, T A Denison, Z Schwart. 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)2D3 in hypertrophic cells. The Journal of steroid biochemistry and molecular biology. vol 121. issue 1-2. 2010-09-20. PMID:20307662. |
24r,25(oh)2d3 increases rc cell proliferation and inhibits activity of matrix processing enzymes, suggesting it stabilizes cells in the reserve zone, possibly by inhibiting the matrix degradation characteristic of apoptotic hypertrophic gc cells. |
2010-09-20 |
2023-08-12 |
rat |
| P M van der Kraan, E N Blaney Davidson, W B van den Ber. Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's? Osteoarthritis and cartilage. vol 18. issue 6. 2010-09-16. PMID:20211748. |
although bmps are considered protective for articular cartilage these factors can also be involved in chondrocyte hypertrophy and matrix degradation. |
2010-09-16 |
2023-08-12 |
Not clear |
| Yu-Yu Lin, Nobuaki Tanaka, Satoru Ohkuma, Yasunori Iwabuchi, Yuki Tanne, Takashi Kamiya, Ryo Kunimatsu, Yu-Ching Huang, Motoko Yoshioka, Tomomi Mitsuyoshi, Kotaro Tanimoto, Eiji Tanaka, Kazuo Tann. Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system. European journal of oral sciences. vol 118. issue 2. 2010-09-16. PMID:20487004. |
chondrocytes co-cultured with unstressed osteoblasts showed a phenotypic shift to hypertrophic chondrocytes, characterized by decreased expression of type ii collagen, aggrecan, sry-related hmg box (sox-9), and cartilage oligomeric matrix protein (comp) genes and increased expression of type x collagen and bone sialoprotein (bsp) genes, suggesting that the co-culture may change the chondrocyte differentiation to some extent. |
2010-09-16 |
2023-08-12 |
Not clear |
| Hiroaki Kitaoka, Toru Kubo, Makoto Okawa, Kayo Hayato, Naohito Yamasaki, Yoshihisa Matsumura, Yoshinori L Do. Impact of metalloproteinases on left ventricular remodeling and heart failure events in patients with hypertrophic cardiomyopathy. Circulation journal : official journal of the Japanese Circulation Society. vol 74. issue 6. 2010-09-07. PMID:20453389. |
the impact of matrix metalloproteinase (mmp) on left ventricular (lv) remodeling and heart failure events is unresolved in patients with hypertrophic cardiomyopathy (hcm). |
2010-09-07 |
2023-08-12 |
Not clear |
| Pamela Lockyer, Jonathan C Schisler, Cam Patterson, Monte S Willi. Minireview: Won't get fooled again: the nonmetabolic roles of peroxisome proliferator-activated receptors (PPARs) in the heart. Molecular endocrinology (Baltimore, Md.). vol 24. issue 6. 2010-09-02. PMID:20016041. |
in this review, we describe what is known about these extrametabolic roles of ppars, including regulation of cardiac inflammation, extracellular matrix remodeling, oxidative stress, and regulation of cardiac hypertrophy. |
2010-09-02 |
2023-08-12 |
Not clear |
| A G Gasanov, T V Bershova, E N Basargina, M I Bakano. [Molecular mechanisms of genetic damages of the myocardium in cardiomyopathy]. Biomeditsinskaia khimiia. vol 56. issue 3. 2010-08-31. PMID:20695211. |
the role of the genetic factors coding contractile proteins, proteins of thin and thick filaments, and also extracellular matrix proteins in processes of formation and development of hypertrophic (hcm) and dilated (dcm) cardiomyopathy are analyzed. |
2010-08-31 |
2023-08-12 |
Not clear |
| Deepa Taneja, Joel Thompson, Patricia Wilson, Katie Brandewie, Liliana Schaefer, Bonnie Mitchell, Lisa R Tannoc. Reversibility of renal injury with cholesterol lowering in hyperlipidemic diabetic mice. Journal of lipid research. vol 51. issue 6. 2010-08-17. PMID:20110440. |
consumption of the high-cholesterol diet exacerbated the development of diabetic nephropathy with elevations in urine albumin excretion, glomerular and renal hypertrophy, and mesangial matrix expansion. |
2010-08-17 |
2023-08-12 |
mouse |
| Kyoung-Hwan Choi, Byung Hyune Choi, So Ra Park, Byoung Ju Kim, Byoung-Hyun Mi. The chondrogenic differentiation of mesenchymal stem cells on an extracellular matrix scaffold derived from porcine chondrocytes. Biomaterials. vol 31. issue 20. 2010-08-10. PMID:20394983. |
the loss of chondrogenic phenotypes was accompanied by the calcification of matrix, and hypertrophic changes by immunohistochemistry for osteocalcin and collagen type i and x. |
2010-08-10 |
2023-08-12 |
mouse |
| Li Kong, Qingyun Tian, Fengjin Guo, Maria T Mucignat, Roberto Perris, Sandy Sercu, Joseph Merregaert, Paul E Di Cesare, Chuan-Ju Li. Interaction between cartilage oligomeric matrix protein and extracellular matrix protein 1 mediates endochondral bone growth. Matrix biology : journal of the International Society for Matrix Biology. vol 29. issue 4. 2010-07-27. PMID:20138147. |
ecm1 inhibits chondrocyte hypertrophy, matrix mineralization, and endochondral bone formation, and comp overcomes the inhibition by ecm1. |
2010-07-27 |
2023-08-12 |
Not clear |
| Christine Y Chuang, Megan S Lord, James Melrose, Martin D Rees, Sarah M Knox, Craig Freeman, Renato V Iozzo, John M Whiteloc. Heparan sulfate-dependent signaling of fibroblast growth factor 18 by chondrocyte-derived perlecan. Biochemistry. vol 49. issue 26. 2010-07-21. PMID:20507176. |
in this study, perlecan was localized in the pericellular matrix of hypertrophic chondrocytes in developing human cartilage rudiments. |
2010-07-21 |
2023-08-12 |
human |
| Takayoshi Suganami, Yoshihiro Ogaw. Adipose tissue macrophages: their role in adipose tissue remodeling. Journal of leukocyte biology. vol 88. issue 1. 2010-07-12. PMID:20360405. |
indeed, obese adipose tissue is characterized by adipocyte hypertrophy, followed by increased angiogenesis, immune cell infiltration, extracellular matrix overproduction, and thus, increased production of proinflammatory adipocytokines during the progression of chronic inflammation. |
2010-07-12 |
2023-08-12 |
Not clear |
| Ashley S Hammond, Jie Ning, Carol V Ward, Matthew J Ravos. Mammalian limb loading and chondral modeling during ontogeny. Anatomical record (Hoboken, N.J. : 2007). vol 293. issue 4. 2010-07-07. PMID:20235322. |
moreover, chondrocyte hypertrophy and proliferation were found to be responsive to locomotor loading and thus more important factors in chondral modeling than the extracellular matrix variables that were examined herein. |
2010-07-07 |
2023-08-12 |
Not clear |
| Yun Wang, Erika Bella, Christopher S D Lee, Claudio Migliaresi, Linda Pelcastre, Zvi Schwartz, Barbara D Boyan, Antonella Mott. The synergistic effects of 3-D porous silk fibroin matrix scaffold properties and hydrodynamic environment in cartilage tissue regeneration. Biomaterials. vol 31. issue 17. 2010-06-28. PMID:20303584. |
a hydrodynamic environment was beneficial to chondrocyte proliferation, differentiation, and integrin gene expression in a pore size dependent manner with superior cartilage matrix production but limited hypertrophic differentiation obtained using chondrocyte-seeded sl500 scaffolds. |
2010-06-28 |
2023-08-12 |
Not clear |