| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark W M Schellings, Geert C van Almen, E Helene Sage, Stephane Heyman. Thrombospondins in the heart: potential functions in cardiac remodeling. Journal of cell communication and signaling. vol 3. issue 3-4. 2011-07-14. PMID:19798592. |
cardiac remodeling after myocardial injury involves inflammation, angiogenesis, left ventricular hypertrophy and matrix remodeling. |
2011-07-14 |
2023-08-12 |
Not clear |
| Yun Hee Lee, Tae Yeon Kim, Young Mi Hon. Metalloproteinase-3 genotype as a predictor of cardiovascular risk in hypertensive adolescents. Korean circulation journal. vol 39. issue 8. 2011-07-14. PMID:19949639. |
hypertension develops as a result of cardiac hypertrophy and fibrosis or as a result of exchange of the extracellular matrix. |
2011-07-14 |
2023-08-12 |
Not clear |
| Hye-Na Cha, Jung Hyun Choi, Yong-Woon Kim, Jong-Yeon Kim, Myun-Whan Ahn, So-Young Par. Metformin Inhibits Isoproterenol-induced Cardiac Hypertrophy in Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 14. issue 6. 2011-07-14. PMID:21311678. |
cardiac hypertrophy was accompanied with increased interleukin-6 (il-6), transforming growth factor (tgf)-β, atrial natriuretic peptide (anp), collagen i and iii, and matrix metallopeptidase 2 (mmp-2). |
2011-07-14 |
2023-08-12 |
mouse |
| Michael R Zile, Stacia M Desantis, Catalin F Baicu, Robert E Stroud, Sheila B Thompson, Catherine D McClure, Shannon M Mehurg, Francis G Spinal. Plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure. Circulation. Heart failure. vol 4. issue 3. 2011-07-14. PMID:21350055. |
plasma biomarkers that reflect determinants of matrix composition identify the presence of left ventricular hypertrophy and diastolic heart failure. |
2011-07-14 |
2023-08-12 |
Not clear |
| Takashi Nishida, Azusa Maeda, Satoshi Kubota, Masaharu Takigaw. Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells. Biorheology. vol 45. issue 3-4. 2011-07-13. PMID:18836231. |
the aim of this study is to determine the influence of mechanical load magnitude and frequency on cartilage metabolism in terms of the expression of hypertrophic chondrocyte-specific gene product 24/connective tissue growth factor/ccn family 2 (hcs24/ctgf/ccn2), as an essential mediator of extracellular matrix (ecm) production. |
2011-07-13 |
2023-08-12 |
human |
| Keith A Hruska, Suresh Mathe. The roles of the skeleton and phosphorus in the CKD mineral bone disorder. Advances in chronic kidney disease. vol 18. issue 2. 2011-07-11. PMID:21406294. |
phosphorus stimulates fgf-23 secretion by osteocytes and expression of the osteoblastic transcriptome, thereby increasing extracellular matrix mineralization in atherosclerotic plaques, hypertrophic cartilage, and skeletal osteoblast surfaces. |
2011-07-11 |
2023-08-12 |
Not clear |
| Daisuke Saito, Yohei Maeshima, Tatsuyo Nasu, Hiroko Yamasaki, Katsuyuki Tanabe, Hitoshi Sugiyama, Hikaru Sonoda, Yasufumi Sato, Hirofumi Makin. Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis. American journal of physiology. Renal physiology. vol 300. issue 4. 2011-07-01. PMID:21228103. |
adhvash-1 treatment resulted in significant suppression of glomerular hypertrophy, glomerular hyperfiltration, albuminuria, increase in the cd31(+) glomerular endothelial area, f4/80(+) monocyte/macrophage infiltration, the accumulation of type iv collagen, and mesangial matrix. |
2011-07-01 |
2023-08-12 |
mouse |
| H Yamasaki, Y Maeshima, T Nasu, D Saito, K Tanabe, K Hirokoshi-Kawahara, H Sugiyama, Y Sakai, H Makin. Intermittent administration of a sustained-release prostacyclin analog ONO-1301 ameliorates renal alterations in a rat type 1 diabetes model. Prostaglandins, leukotrienes, and essential fatty acids. vol 84. issue 3-4. 2011-06-28. PMID:21177088. |
sr-ono significantly suppressed albuminuria, glomerular hypertrophy, mesangial matrix accumulation, glomerular accumulation of monocyte/macrophage, increase in glomerular levels of pro-fibrotic factor transforming growth factor (tgf)-beta1 and the number of glomerular alpha-smooth muscle actin (sma)(+) cells in diabetic animals. |
2011-06-28 |
2023-08-12 |
rat |
| Sara Hinds, Weining Bian, Robert G Dennis, Nenad Bursa. The role of extracellular matrix composition in structure and function of bioengineered skeletal muscle. Biomaterials. vol 32. issue 14. 2011-06-22. PMID:21324402. |
optimized matrix composition yielded significant cellular hypertrophy (protein/dna ratio = 11.4 ± 4.1 vs. 6.5 ± 1.9 μg/μg in control) and a prolonged ca(2+) transient half-width (ca(50) = 232.8 ± 33.3 vs. 101.7 ± 19.8 ms). |
2011-06-22 |
2023-08-12 |
rat |
| Anne Marie Rauten, Petra Surlin, B Oprea, Izabela Siloşi, Mihaela Moisa, D Caramizaru, Mihaela Văt. Matrix metalloproteinase 9 levels in gingival crevicular fluid in patients after periodontal microsurgery for orthodontic induced gingival hypertrophy. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 52. issue 1 Suppl. 2011-06-09. PMID:21424088. |
matrix metalloproteinase 9 levels in gingival crevicular fluid in patients after periodontal microsurgery for orthodontic induced gingival hypertrophy. |
2011-06-09 |
2023-08-12 |
Not clear |
| Mahipal Singh, Cerrone R Foster, Suman Dalal, Krishna Sing. Role of osteopontin in heart failure associated with aging. Heart failure reviews. vol 15. issue 5. 2011-06-02. PMID:20127409. |
the post-mi infarct healing process involves temporarily overlapping phases that include the following--(1) inflammation with migration and adhesion of neutrophils and macrophages, phagocytosis and inflammatory gene expression; (2) tissue repair with fibroblast adhesion and proliferation, myofibroblast differentiation, extracellular matrix deposition and scar formation; and (3) structural and functional remodeling of infarcted and non-infarcted myocardium through cardiac myocyte apoptosis, hypertrophy and myocardial angiogenesis. |
2011-06-02 |
2023-08-12 |
mouse |
| Sunila Mahavadi, Robert S Flynn, John R Grider, Li-Ya Qiao, Karnam S Murthy, Krystina B Hazelgrove, John F Kuemmerl. Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/-) mice. Inflammatory bowel diseases. vol 17. issue 3. 2011-05-31. PMID:20722057. |
strictures occur in ≈ 30% of patients with crohn's disease (cd) and are characterized by intestinal smooth muscle hyperplasia, hypertrophy, and fibrosis due to excess extracellular matrix production including collagen. |
2011-05-31 |
2023-08-12 |
mouse |
| Chetan P Hans, Yumei Feng, Amarjit S Naura, Dana Troxclair, Mourad Zerfaoui, Danish Siddiqui, Ju Jihang, Hogyoung Kim, Alan D Kaye, Khalid Matrougui, Eric Lazartigues, A Hamid Boulare. Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 20. issue 2. 2011-05-26. PMID:20434371. |
given that characteristics of dilated cardiomyopathy closely associate with atherosclerosis and are mediated by an imbalance between matrix metalloproteinases (mmps) and timps, we hypothesized that parp-1 gene deletion may protect against hf-induced cardiac hypertrophy and dilatations by altering timp-2/mmps balance in favor of a maintenance of tissue homeostasis. |
2011-05-26 |
2023-08-12 |
Not clear |
| Motofumi Sasaki, Kenichi Shikata, Shinichi Okada, Satoshi Miyamoto, Shingo Nishishita, Hitomi Usui Kataoka, Chikage Sato, Jun Wada, Daisuke Ogawa, Hirofumi Makin. The macrophage is a key factor in renal injuries caused by glomerular hyperfiltration. Acta medica Okayama. vol 65. issue 2. 2011-05-19. PMID:21519365. |
the 5/6 nephrectomized mice showed glomerular hypertrophy and an increase in the extracellular matrix in the glomeruli. |
2011-05-19 |
2023-08-12 |
mouse |
| Robert S Flynn, Sunila Mahavadi, Karnam S Murthy, John R Grider, John M Kellum, Homayoon Akbari, John F Kuemmerl. Endogenous IGFBP-3 regulates excess collagen expression in intestinal smooth muscle cells of Crohn's disease strictures. Inflammatory bowel diseases. vol 17. issue 1. 2011-05-12. PMID:20848532. |
strictures are characterized by intestinal smooth muscle cell hyperplasia, smooth muscle cell hypertrophy, and fibrosis due to excess net extracellular matrix production, including collagen. |
2011-05-12 |
2023-08-12 |
human |
| Sandeep Kumar, Rachid Seqqat, Sravanthi Chigurupati, Rajesh Kumar, Kenneth M Baker, David Young, Subha Sen, Sudhiranjan Gupt. Inhibition of nuclear factor κB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. Free radical biology & medicine. vol 50. issue 1. 2011-05-09. PMID:21047552. |
inhibition of nuclear factor κb regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. |
2011-05-09 |
2023-08-12 |
mouse |
| Sandeep Kumar, Rachid Seqqat, Sravanthi Chigurupati, Rajesh Kumar, Kenneth M Baker, David Young, Subha Sen, Sudhiranjan Gupt. Inhibition of nuclear factor κB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules. Free radical biology & medicine. vol 50. issue 1. 2011-05-09. PMID:21047552. |
increased production of ros and nuclear factor κb (nf-κb) activation provide a strong link between oxidative stress and extracellular matrix (ecm) remodeling in cardiac hypertrophy. |
2011-05-09 |
2023-08-12 |
mouse |
| Francis I Achike, Nim-Hin Peter To, Huidi Wang, Chiu-Yin Kwa. Obesity, metabolic syndrome, adipocytes and vascular function: A holistic viewpoint. Clinical and experimental pharmacology & physiology. vol 38. issue 1. 2011-05-04. PMID:21083697. |
excess fat deposition requires space, created by adipocyte (hypertrophy and hyperplasia) and extracellular matrix (ecm) remodelling. |
2011-05-04 |
2023-08-12 |
Not clear |
| Takashi Nishida, Kenji Emura, Satoshi Kubota, Karen M Lyons, Masaharu Takigaw. CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP). Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 26. issue 2. 2011-04-28. PMID:20721934. |
the phenotype of ccn2 null mice, having an expanded hypertrophic zone, indicates that the resorption of the cartilage extracellular matrix is impaired therein. |
2011-04-28 |
2023-08-12 |
mouse |
| Emmanuelle David, Pierre Guihard, Bénédicte Brounais, Anne Riet, Céline Charrier, Séverine Battaglia, François Gouin, Stéphanie Ponsolle, Ronan Le Bot, Carl D Richards, Dominique Heymann, Françoise Rédini, Frédéric Blanchar. Direct anti-cancer effect of oncostatin M on chondrosarcoma. International journal of cancer. vol 128. issue 8. 2011-04-18. PMID:21344373. |
in two tested cell lines, osm induced a hypertrophic chondrocyte differentiation, with an induced cbfa1/sox9 ratio and induced coll10, matrix metalloproteinase 13 (mmp13) and rankl expression. |
2011-04-18 |
2023-08-12 |
rat |