| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mona Hedayat, Mohammad Jafar Mahmoudi, Noel R Rose, Nima Rezae. Proinflammatory cytokines in heart failure: double-edged swords. Heart failure reviews. vol 15. issue 6. 2011-02-08. PMID:20405319. |
cardiac myocyte hypertrophy, contractile dysfunction, cardiac myocyte apoptosis, and extracellular matrix remodeling contribute enormously to the development and progression of chronic heart failure. |
2011-02-08 |
2023-08-12 |
Not clear |
| Riccardo Lacchini, Anna L B Jacob-Ferreira, Marcelo R Luizon, Fernanda B Coeli, Tatiane C Izidoro-Toledo, Sandra Gasparini, Maria C Ferreira-Sae, Roberto Schreiber, Wilson Nadruz, Jose E Tanus-Santo. Matrix metalloproteinase 9 gene haplotypes affect left ventricular hypertrophy in hypertensive patients. Clinica chimica acta; international journal of clinical chemistry. vol 411. issue 23-24. 2011-01-19. PMID:20707992. |
matrix metalloproteinase 9 gene haplotypes affect left ventricular hypertrophy in hypertensive patients. |
2011-01-19 |
2023-08-12 |
Not clear |
| S Giovannini, J Diaz-Romero, T Aigner, P Heini, P Mainil-Varlet, D Nesi. Micromass co-culture of human articular chondrocytes and human bone marrow mesenchymal stem cells to investigate stable neocartilage tissue formation in vitro. European cells & materials. vol 20. 2011-01-19. PMID:20925023. |
msc produced cartilage-specific matrix only in +t+d but underwent hypertrophy in all pellet cultures. |
2011-01-19 |
2023-08-12 |
human |
| Elizabeth Sweeney, Douglas Roberts, Tina Corbo, Olena Jacenk. Congenic mice confirm that collagen X is required for proper hematopoietic development. PloS one. vol 5. issue 3. 2011-01-11. PMID:20209091. |
disrupted function of collagen x, a major hypertrophic cartilage matrix protein, resulted in skeletal and hematopoietic defects in endochondrally derived tissues. |
2011-01-11 |
2023-08-12 |
mouse |
| Doris Allerstorfer, Stefano Longato, Christoph Schwarzer, Reiner Fischer-Colbrie, Alison R Hayman, Michael J F Blume. VEGF and its role in the early development of the long bone epiphysis. Journal of anatomy. vol 216. issue 5. 2011-01-05. PMID:20525089. |
epiphyseal development further involves maturation of the resting chondrocytes into hypertrophic ones, associated with the mineralization of the cartilage matrix and eventual death of the latter cells. |
2011-01-05 |
2023-08-12 |
mouse |
| Cecelia C Yates, Priya Krishna, Diana Whaley, Richard Bodnar, Timothy Turner, Alan Well. Lack of CXC chemokine receptor 3 signaling leads to hypertrophic and hypercellular scarring. The American journal of pathology. vol 176. issue 4. 2010-12-14. PMID:20203286. |
these in vivo studies establish that the absence of cxcr3(-/-) signaling network results in hypertrophic and hypercellular scarring characterized by on-going wound regeneration, cellular proliferation, and scars in which immature matrix components are undergoing increased turnover resulting in a chronic inflammatory process. |
2010-12-14 |
2023-08-12 |
mouse |
| Marc Fajardo, Chuan-Ju Liu, Kirill Ilalov, Kenneth A Ego. Matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissue. Journal of orthopaedic trauma. vol 24. issue 9. 2010-12-07. PMID:20736794. |
matrix metalloproteinases that associate with and cleave bone morphogenetic protein-2 in vitro are elevated in hypertrophic fracture nonunion tissue. |
2010-12-07 |
2023-08-12 |
Not clear |
| Venkatapuram Seenu Reddy, Sumanth D Prabhu, Srinivas Mummidi, Anthony J Valente, Balachandar Venkatesan, Prakashsrinivasan Shanmugam, Patrice Delafontaine, Bysani Chandraseka. Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation. American journal of physiology. Heart and circulatory physiology. vol 299. issue 4. 2010-11-30. PMID:20693392. |
il-18 and the extracellular matrix metalloproteinase (mmp) inducer (emmprin) stimulate the expression of proinflammatory cytokines and mmps and are elevated in myocardial hypertrophy, remodeling, and failure. |
2010-11-30 |
2023-08-12 |
Not clear |
| Wenjian Dai, Weiqing He, Guangdong Shang, Jiandong Jiang, Yiguang Wang, Weijia Kon. Gene silencing of myofibrillogenesis regulator-1 by adenovirus-delivered small interfering RNA suppresses cardiac hypertrophy induced by angiotensin II in mice. American journal of physiology. Heart and circulatory physiology. vol 299. issue 5. 2010-11-29. PMID:20802139. |
in ang ii-infused mice, mr-1 silencing also blocked the upregulation of other genes related to cardiac hypertrophy or metabolism of the extracellular matrix. |
2010-11-29 |
2023-08-12 |
mouse |
| J Yanni, J O Tellez, P V Sutyagin, M R Boyett, H Dobrzynsk. Structural remodelling of the sinoatrial node in obese old rats. Journal of molecular and cellular cardiology. vol 48. issue 4. 2010-11-16. PMID:19729016. |
it is concluded that the age- (and/or obesity-) dependent decline in san function is associated with a structural remodelling of the san: an enlargement of the san, a hypertrophy of the san cells, and a remodelling of the extracellular matrix. |
2010-11-16 |
2023-08-12 |
rat |
| Mitsuo Kato, Lin Wang, Sumanth Putta, Mei Wang, Hang Yuan, Guangdong Sun, Linda Lanting, Ivan Todorov, John J Rossi, Rama Nataraja. Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells. The Journal of biological chemistry. vol 285. issue 44. 2010-11-16. PMID:20713358. |
increased accumulation of extracellular matrix proteins and hypertrophy induced by transforming growth factor-β1 (tgf-β) in renal mesangial cells (mc) are hallmark features of diabetic nephropathy. |
2010-11-16 |
2023-08-12 |
mouse |
| Kazuyo Yamaji-Kegan, Qingning Su, Daniel J Angelini, Allen C Myers, Chris Cheadle, Roger A John. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMalpha) increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism. Journal of immunology (Baltimore, Md. : 1950). vol 185. issue 9. 2010-11-12. PMID:20889544. |
we also found that himf-induced proliferative activity, hypertrophy, collagen, and extracellular matrix deposition in the pulmonary arteries are significantly less in il-4 ko mice than in wt mice. |
2010-11-12 |
2023-08-12 |
mouse |
| Wen-Hsiang Su, Ming-Huei Cheng, Wen-Ling Lee, Tsung-Shan Tsou, Wen-Hsun Chang, Chien-Sheng Chen, Peng-Hui Wan. Nonsteroidal anti-inflammatory drugs for wounds: pain relief or excessive scar formation? Mediators of inflammation. vol 2010. 2010-11-04. PMID:20671960. |
hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. |
2010-11-04 |
2023-08-12 |
Not clear |
| Zhaohui Pei, Rongsen Meng, Guangwei Li, Guangmei Yan, Changqing Xu, Zhiqiang Zhuang, Jun Ren, Zhenbiao W. Angiotensin-(1-7) ameliorates myocardial remodeling and interstitial fibrosis in spontaneous hypertension: role of MMPs/TIMPs. Toxicology letters. vol 199. issue 2. 2010-11-04. PMID:20837116. |
mean arterial pressure, left ventricular geometry, expression of the hypertrophic markers anp and β-mhc, collagen contents (type i and iii), collagenase (mmp-1), matrix metalloproteinase-2 (mmp-2) and tissue inhibitor of mmps-1 (timp-1) were evaluated in wky and shr rats with or without treatment. |
2010-11-04 |
2023-08-12 |
rat |
| D Saura, F Marín, V Climent, J González, V Roldán, D Hernández-Romero, M J Oliva, M Sabater, G de la Morena, G Y H Lip, M Valdé. Left atrial remodelling in hypertrophic cardiomyopathy: relation with exercise capacity and biochemical markers of tissue strain and remodelling. International journal of clinical practice. vol 63. issue 10. 2010-11-01. PMID:19769703. |
the aim of this study was to analyse the influence of lav on exercise performance in hypertrophic cardiomyopathy (hcm), and in a subset of subjects, assess the relation of lav and exercise performance to four biomarkers of disease pathophysiology: matrix metalloproteinase-2 (mmp-2) and tissue inhibitor of matrix metalloproteinase-1 (timp-1) (as indices of tissue remodelling), n-terminal portion of pro b-type natriuretic peptide (nt-pro-bnp) (associated with ventricular dysfunction) and c-reactive protein (crp, an index of inflammation). |
2010-11-01 |
2023-08-12 |
human |
| Vera Regitz-Zagrosek, Sabine Oertelt-Prigione, Ute Seeland, Roland Hetze. Sex and gender differences in myocardial hypertrophy and heart failure. Circulation journal : official journal of the Japanese Circulation Society. vol 74. issue 7. 2010-10-19. PMID:20558892. |
women with aortic stenosis have more concentric hypertrophy with better systolic function, less upregulation of extracellular matrix genes and better reversibility after unloading. |
2010-10-19 |
2023-08-12 |
Not clear |
| Chikara Ushiku, Douglas J Adams, Xi Jiang, Liping Wang, David W Row. Long bone fracture repair in mice harboring GFP reporters for cells within the osteoblastic lineage. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 28. issue 10. 2010-10-07. PMID:20839319. |
second, the hypertrophic chondrocytes are dispersed and the cartilage matrix mineralized by the advancing col3.6+ osteoblasts. |
2010-10-07 |
2023-08-12 |
mouse |
| Kelly L Hudkins, Warangkana Pichaiwong, Tomasz Wietecha, Jolanta Kowalewska, Miriam C Banas, Min W Spencer, Anja Mühlfeld, Mariko Koelling, Jeffrey W Pippin, Stuart J Shankland, Bardia Askari, Mary E Rabaglia, Mark P Keller, Alan D Attie, Charles E Alper. BTBR Ob/Ob mutant mice model progressive diabetic nephropathy. Journal of the American Society of Nephrology : JASN. vol 21. issue 9. 2010-09-23. PMID:20634301. |
glomerular hypertrophy and accumulation of mesangial matrix, characteristic of early dn, were present by 8 weeks, and glomerular lesions similar to those of advanced human dn were present by 20 weeks. |
2010-09-23 |
2023-08-12 |
mouse |
| B D Boyan, J Hurst-Kennedy, T A Denison, Z Schwart. 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)2D3 in hypertrophic cells. The Journal of steroid biochemistry and molecular biology. vol 121. issue 1-2. 2010-09-20. PMID:20307662. |
24r,25(oh)2d3 increases rc cell proliferation and inhibits activity of matrix processing enzymes, suggesting it stabilizes cells in the reserve zone, possibly by inhibiting the matrix degradation characteristic of apoptotic hypertrophic gc cells. |
2010-09-20 |
2023-08-12 |
rat |
| P M van der Kraan, E N Blaney Davidson, W B van den Ber. Bone morphogenetic proteins and articular cartilage: To serve and protect or a wolf in sheep clothing's? Osteoarthritis and cartilage. vol 18. issue 6. 2010-09-16. PMID:20211748. |
although bmps are considered protective for articular cartilage these factors can also be involved in chondrocyte hypertrophy and matrix degradation. |
2010-09-16 |
2023-08-12 |
Not clear |