| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Chiarelli, S Gaspari, M L Marcovecchi. Role of growth factors in diabetic kidney disease. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 41. issue 8. 2009-09-28. PMID:19452424. |
these growth factors, which are generally expressed in the normal kidney and whose levels increase in relation to diabetes, have been implicated in the control of renal matrix composition, cell hypertrophy, proliferation and survival, modulation of cells of the immune system, and enzymes involved in glucose metabolism. |
2009-09-28 |
2023-08-12 |
human |
| Jonas Hansson, Lars Lind, Johannes Hulthe, Johan Sundströ. Relations of serum MMP-9 and TIMP-1 levels to left ventricular measures and cardiovascular risk factors: a population-based study. European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. vol 16. issue 3. 2009-09-24. PMID:19387352. |
extracellular matrix remodeling is a hallmark of pathological left ventricular (lv) hypertrophy and heart failure. |
2009-09-24 |
2023-08-12 |
Not clear |
| Guo-You Zhang, Xuan Li, Xing-Long Chen, Zhi-Jie Li, Qing Yu, Liang-Fu Jiang, Jian Ding, Wei-Yang Ga. Contribution of epidermal stem cells to hypertrophic scars pathogenesis. Medical hypotheses. vol 73. issue 3. 2009-09-22. PMID:19427134. |
accepting the hypothesis to be correct, a therapy that inhibits cell and extracellular matrix proliferation can be used to prevent the hypertrophic scars formation. |
2009-09-22 |
2023-08-12 |
Not clear |
| Guo-You Zhang, Xuan Li, Xing-Long Chen, Zhi-Jie Li, Qing Yu, Liang-Fu Jiang, Jian Ding, Wei-Yang Ga. Contribution of epidermal stem cells to hypertrophic scars pathogenesis. Medical hypotheses. vol 73. issue 3. 2009-09-22. PMID:19427134. |
current therapies are only partially effective and safe because they couldn't inhibit the cell and extracellular matrix proliferation and eliminate other relative factors of hypertrophic scars formation at all, such as: absence of epidermal-mesenchymal interaction, and at the same time inducing death (apoptosis and necrosis) of other normal cells. |
2009-09-22 |
2023-08-12 |
Not clear |
| Xiang Wang, Tatsujiro Oka, Fung L Chow, Stephan B Cooper, Jeff Odenbach, Gary D Lopaschuk, Zamaneh Kassiri, Carlos Fernandez-Patro. Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis. Hypertension (Dallas, Tex. : 1979). vol 54. issue 3. 2009-09-18. PMID:19581512. |
cardiac remodeling is associated with hypertrophy and fibrosis processes, which may depend on the activity of matrix metalloproteinases (mmps) and "a disintegrin and metalloproteinases" (adams). |
2009-09-18 |
2023-08-12 |
mouse |
| Lalit P Singh, Yan Jiang, Davis W Chen. Proteomic identification of 14-3-3zeta as an adapter for IGF-1 and Akt/GSK-3beta signaling and survival of renal mesangial cells. International journal of biological sciences. vol 3. issue 1. 2009-09-10. PMID:17200689. |
recently we demonstrated that igf-1 expression is increased in the diabetic kidney and that it may involve in renal hypertrophy and extracellular matrix protein (ecm) accumulation in mesangial cells as seen in diabetic glomerulopathy. |
2009-09-10 |
2023-08-12 |
Not clear |
| Helge Bertram, Stephane Boeuf, Jasper Wachters, Sandra Boehmer, Christian Heisel, Michael W Hofmann, Dorothea Piecha, Wiltrud Richte. Matrix metalloprotease inhibitors suppress initiation and progression of chondrogenic differentiation of mesenchymal stromal cells in vitro. Stem cells and development. vol 18. issue 6. 2009-09-02. PMID:19327011. |
common chondrogenic in vitro protocols, however, induce hypertrophic markers like col10a1, matrix metalloproteinase 13 (mmp13), and alkaline phosphatase (alp) reminiscent of endochondral bone formation. |
2009-09-02 |
2023-08-12 |
cattle |
| Helge Bertram, Stephane Boeuf, Jasper Wachters, Sandra Boehmer, Christian Heisel, Michael W Hofmann, Dorothea Piecha, Wiltrud Richte. Matrix metalloprotease inhibitors suppress initiation and progression of chondrogenic differentiation of mesenchymal stromal cells in vitro. Stem cells and development. vol 18. issue 6. 2009-09-02. PMID:19327011. |
proteases are important players in matrix remodeling, display inhibitory effects on growth plate development and mmp13 inhibition prevented hypertrophy of bovine chondrocytes. |
2009-09-02 |
2023-08-12 |
cattle |
| Christine Perret-Guillaume, Laure Joly, Piotr Jankowski, Athanase Beneto. Benefits of the RAS blockade: clinical evidence before the ONTARGET study. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. vol 27. issue 2. 2009-09-01. PMID:19491620. |
activation of the at1 angiotensin ii (ang ii) receptors has various effects including vasoconstriction, hypertrophy, and possibly hyperplasia of vascular smooth muscle cells and cardiomyocytes and increase in extracellular collagen matrix synthesis. |
2009-09-01 |
2023-08-12 |
Not clear |
| Ashok Jadhav, Joseph Fomusi Ndisan. Heme arginate suppresses cardiac lesions and hypertrophy in deoxycorticosterone acetate-salt hypertension. Experimental biology and medicine (Maywood, N.J.). vol 234. issue 7. 2009-08-27. PMID:19429856. |
in hypertension, elevated levels of oxidative/inflammatory mediators including nuclear factor kappab (nf-kappab), activating protein (ap-1), c-jun-nh2-terminal kinase (jnk), and cell-regulatory proteins such as transforming growth factor beta (tgf-beta), trigger the mobilization of extracellular matrix (ecm) leading to fibrosis, hypertrophy and impairment of cardiac function. |
2009-08-27 |
2023-08-12 |
Not clear |
| Willem M van der Veer, Monica C T Bloemen, Magda M W Ulrich, Grietje Molema, Paul P van Zuijlen, Esther Middelkoop, Frank B Niesse. Potential cellular and molecular causes of hypertrophic scar formation. Burns : journal of the International Society for Burn Injuries. vol 35. issue 1. 2009-08-03. PMID:18952381. |
it seems that a wide array of subsequent processes are involved in hypertrophic scar formation, like an affected haemostasis, exaggerated inflammation, prolonged reepithelialization, overabundant extracellular matrix production, augmented neovascularization, atypical extracellular matrix remodeling and reduced apoptosis. |
2009-08-03 |
2023-08-12 |
Not clear |
| Chuan Cao, Shirong Li, Xia Dai, Yanqing Chen, Zhi Feng, Yun Zhao, Jun W. Genistein inhibits proliferation and functions of hypertrophic scar fibroblasts. Burns : journal of the International Society for Burn Injuries. vol 35. issue 1. 2009-08-03. PMID:18976864. |
hypertrophic scarring is abnormal proliferation of dermal fibroblasts and excessive deposition of extracellular matrix. |
2009-08-03 |
2023-08-12 |
Not clear |
| Erol Saygili, Obaida R Rana, Christian Meyer, Christopher Gemein, Michael G Andrzejewski, Andreas Ludwig, Christian Weber, Ulrich Schotten, Alexander Krüttgen, Joachim Weis, Robert H G Schwinger, Karl Mischke, Tienush Rassaf, Malte Kelm, Patrick Schauert. The angiotensin-calcineurin-NFAT pathway mediates stretch-induced up-regulation of matrix metalloproteinases-2/-9 in atrial myocytes. Basic research in cardiology. vol 104. issue 4. 2009-07-29. PMID:19148693. |
atrial stretch has been shown to induce cellular hypertrophy and extracellular matrix remodeling (ecm) via angiotensin-ii dependent pathways and the matrix metalloproteinases system (mmps). |
2009-07-29 |
2023-08-12 |
Not clear |
| Claudete Maria Zanatta, Luís Henrique Canani, Sandra Pinho Silveiro, Lucas Burttet, Gustavo Nabinger, Jorge Luiz Gros. [Endothelin system function in diabetic nephropathy]. Arquivos brasileiros de endocrinologia e metabologia. vol 52. issue 4. 2009-07-21. PMID:18604370. |
activation of this receptor in renal cells leads to a complex signaling cascade resulting in stimulation of mesangial cell hypertrophy, proliferation, contraction, and extracellular matrix accumulation. |
2009-07-21 |
2023-08-12 |
Not clear |
| Oksana Shynlova, Prudence Tsui, Shabana Jaffer, Stephen J Ly. Integration of endocrine and mechanical signals in the regulation of myometrial functions during pregnancy and labour. European journal of obstetrics, gynecology, and reproductive biology. vol 144 Suppl 1. 2009-07-13. PMID:19299064. |
we propose that the myometrium undergoes dramatic changes in phenotype from early pregnancy until the onset of labour, characterized by an early proliferative phase, an intermediate phase of cellular hypertrophy and matrix elaboration, a third phase in which the cells assume a contractile phenotype and the final phase in which cells become highly active and committed to labour. |
2009-07-13 |
2023-08-12 |
rat |
| Xiao-Fan Xie, Li-Xin He, Xiao-Feng Hao, Bi Chen, Chi-Yu Jia, Zhi-Gang Sun, Yu-Jue Cao, Dong Hai L. [Expression of matrix metalloproteinase-2, -9 and their inhibitor-1 in hypertrophic scars]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 23. issue 6. 2009-07-07. PMID:18457258. |
[expression of matrix metalloproteinase-2, -9 and their inhibitor-1 in hypertrophic scars]. |
2009-07-07 |
2023-08-12 |
Not clear |
| Xiao-Fan Xie, Li-Xin He, Xiao-Feng Hao, Bi Chen, Chi-Yu Jia, Zhi-Gang Sun, Yu-Jue Cao, Dong Hai L. [Expression of matrix metalloproteinase-2, -9 and their inhibitor-1 in hypertrophic scars]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 23. issue 6. 2009-07-07. PMID:18457258. |
to investigate the gene expression of matrix metalloproteinases (mmp-2, mmp-9) and tissue inhibitor of metalloproteinase-1 (timp-1) in proliferative and mature hypertrophic scars. |
2009-07-07 |
2023-08-12 |
Not clear |
| Franciszek Burdan, Justyna Szumiło, Agnieszka Korobowicz, Rabia Farooquee, Sagar Patel, Ankit Patel, Anjalee Dave, Michał Szumiło, Michał Solecki, Robert Klepacz, Jarosław Dudk. Morphology and physiology of the epiphyseal growth plate. Folia histochemica et cytobiologica. vol 47. issue 1. 2009-07-01. PMID:19419931. |
this multilayer structure is formed by the proliferation and hypertrophy of cells that synthesize the extracellular matrix composed of collagen (mainly type ii, ix, x, xi) and proteoglycans (aggrecan, decorin, annexin ii, v and vi). |
2009-07-01 |
2023-08-12 |
Not clear |
| Ezequiel J Molina, Jon Palma, Dipin Gupta, Denise Torres, John P Gaughan, Steven Houser, Mahender Mach. Reverse remodeling is associated with changes in extracellular matrix proteases and tissue inhibitors after mesenchymal stem cell (MSC) treatment of pressure overload hypertrophy. Journal of tissue engineering and regenerative medicine. vol 3. issue 2. 2009-06-15. PMID:19065545. |
reverse remodeling is associated with changes in extracellular matrix proteases and tissue inhibitors after mesenchymal stem cell (msc) treatment of pressure overload hypertrophy. |
2009-06-15 |
2023-08-12 |
rat |
| Ezequiel J Molina, Jon Palma, Dipin Gupta, Denise Torres, John P Gaughan, Steven Houser, Mahender Mach. Reverse remodeling is associated with changes in extracellular matrix proteases and tissue inhibitors after mesenchymal stem cell (MSC) treatment of pressure overload hypertrophy. Journal of tissue engineering and regenerative medicine. vol 3. issue 2. 2009-06-15. PMID:19065545. |
changes in ventricular extracellular matrix (ecm) composition of pressure overload hypertrophy determine clinical outcomes. |
2009-06-15 |
2023-08-12 |
rat |