| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hyo-Bum Kwa. Aging, exercise, and extracellular matrix in the heart. Journal of exercise rehabilitation. vol 9. issue 3. 2013-11-26. PMID:24278882. |
the cardiac remodeling involves loss of cardiac myocytes, reactive hypertrophy of the remaining cells, and increased extracellular matrix (ecm) and fibrosis in the aging heart, especially left ventricles. |
2013-11-26 |
2023-08-12 |
Not clear |
| Yi Lin, Makoto Kuro-o, Zhongjie Su. Genetic deficiency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice. Endocrinology. vol 154. issue 10. 2013-11-25. PMID:23928372. |
klotho deficiency in kl(+/-) mutant mice exacerbated stz-induced increases in urine albumin, blood urea nitrogen, expansion of mesangial matrix in renal glomeruli, and kidney hypertrophy, suggesting a protective role of klotho in kidney function and structure. |
2013-11-25 |
2023-08-12 |
mouse |
| E Kupidlowska, K Dobrzynska, E Parys, A M Zobe. Effect of coumarin and xanthotoxin on mitochondrial structure, oxygen uptake, and succinate dehydrogenase activity in onion root cells. Journal of chemical ecology. vol 20. issue 10. 2013-11-19. PMID:24241824. |
they caused changes in the structure of the mitochondrial matrix to become dense, and protrusions of mitochondrial membranes were visible parallelling their hypertrophy, indicating alteration in the structure and physiology of these organelles. |
2013-11-19 |
2023-08-12 |
Not clear |
| Takaaki Koga, Takahiro Niikura, Sang Yang Lee, Yoshihiro Dogaki, Etsuko Okumachi, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosak. In vitro hypertrophy and calcification of human fracture haematoma-derived cells in chondrogenic differentiation. International orthopaedics. vol 37. issue 5. 2013-11-14. PMID:23446329. |
in this study, we investigated whether haematoma-derived cells (hcs) could differentiate into hypertrophic chondrocytes and finally induce calcification of the extracellular matrix in vitro. |
2013-11-14 |
2023-08-12 |
human |
| Yusuke Kaida, Kei Fukami, Takanori Matsui, Yuichiro Higashimoto, Yuri Nishino, Nana Obara, Yosuke Nakayama, Ryotaro Ando, Maki Toyonaga, Seiji Ueda, Masayoshi Takeuchi, Hiroyoshi Inoue, Seiya Okuda, Sho-ichi Yamagish. DNA aptamer raised against AGEs blocks the progression of experimental diabetic nephropathy. Diabetes. vol 62. issue 9. 2013-11-12. PMID:23630304. |
urinary albumin and 8-hydroxy-2'-deoxy-guanosine levels were increased, and glomerular hypertrophy and enhanced extracellular matrix accumulation were observed in kkay/ta mice, all of which were prevented by ages-aptamer. |
2013-11-12 |
2023-08-12 |
mouse |
| William T Gerthoffer, Dedmer Schaafsma, Pawan Sharma, Saeid Ghavami, Andrew J Halayk. Motility, survival, and proliferation. Comprehensive Physiology. vol 2. issue 1. 2013-11-04. PMID:23728975. |
however, terminally differentiated smooth muscle cells are phenotypically plastic and have multifunctional capacity for proliferation, cellular hypertrophy, migration, and the synthesis of extracellular matrix and inflammatory mediators. |
2013-11-04 |
2023-08-12 |
Not clear |
| Xiao Hu, Huo Ran, Wang Dechang, Wang Yibing, Feng Yongqiang, Li Qian. Absence of the adenosine A(2A) receptor attenuates hypertrophic scarring in mice. Journal of burn care & research : official publication of the American Burn Association. vol 34. issue 3. 2013-10-31. PMID:23412328. |
hypertrophic scar following cutaneous wounding is the result of the body overproducing collagen, and it has been shown that the activation of the adenosine a(2a) receptor promotes tissue repair, wound healing, and extracellular matrix production. |
2013-10-31 |
2023-08-12 |
mouse |
| Otavio R Coelho-Filho, Ravi V Shah, Richard Mitchell, Tomas G Neilan, Heitor Moreno, Bridget Simonson, Raymond Kwong, Anthony Rosenzweig, Saumya Das, Michael Jerosch-Herol. Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling. Circulation. vol 128. issue 11. 2013-10-31. PMID:23912910. |
the goal was to validate a cardiac magnetic resonance-based approach for the combined assessment of extracellular matrix expansion and cardiomyocyte hypertrophy. |
2013-10-31 |
2023-08-12 |
Not clear |
| Mathias H Konstandin, Mirko Völkers, Brett Collins, Pearl Quijada, Mercedes Quintana, Andrea De La Torre, Lucy Ormachea, Shabana Din, Natalie Gude, Haruhiro Toko, Mark A Sussma. Fibronectin contributes to pathological cardiac hypertrophy but not physiological growth. Basic research in cardiology. vol 108. issue 5. 2013-10-17. PMID:23912225. |
while substantial information has been published on the nature of the fundamental molecular signaling involved in hypertrophy, the role of extracellular matrix protein fibronectin (fn) in hypertrophic signaling is unclear. |
2013-10-17 |
2023-08-12 |
Not clear |
| Yasumoto Matsui, Atsushi Harad. [Aging of joint]. Clinical calcium. vol 23. issue 1. 2013-09-25. PMID:23268297. |
in oa cartilage, increased degradation and decreased production of major matrix components, like type ii collagen and aggrecan occur, as well as chondrocyte hypertrophy or apoptosis. |
2013-09-25 |
2023-08-12 |
Not clear |
| Biljana Skrbic, Johannes L Bjørnstad, Henriette S Marstein, Cathrine R Carlson, Ivar Sjaastad, Ståle Nygård, Sigrid Bjørnstad, Geir Christensen, Theis Tønnesse. Differential regulation of extracellular matrix constituents in myocardial remodeling with and without heart failure following pressure overload. Matrix biology : journal of the International Society for Matrix Biology. vol 32. issue 2. 2013-09-23. PMID:23220517. |
thus, we examined potential differences in the regulation of myocardial extracellular matrix (ecm) constituents in mice with hypertrophy only (abnonhf) and with hf (abhf) as response to comparable pressure overload. |
2013-09-23 |
2023-08-12 |
mouse |
| Ville V Meretoja, Rebecca L Dahlin, Sarah Wright, F Kurtis Kasper, Antonios G Miko. The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds. Biomaterials. vol 34. issue 17. 2013-09-12. PMID:23489925. |
cells were cultured for six weeks within porous scaffolds, and their cellularity, cartilaginous matrix production (collagen ii/i expression ratio, hydroxyproline and gag content) and hypertrophy markers (collagen x expression, alp activity, calcium accumulation) were analyzed. |
2013-09-12 |
2023-08-12 |
Not clear |
| Ville V Meretoja, Rebecca L Dahlin, Sarah Wright, F Kurtis Kasper, Antonios G Miko. The effect of hypoxia on the chondrogenic differentiation of co-cultured articular chondrocytes and mesenchymal stem cells in scaffolds. Biomaterials. vol 34. issue 17. 2013-09-12. PMID:23489925. |
acs and co-cultures showed similarly high collagen ii/i expression ratio and gag rich matrix formation, whereas mscs produced the least hyaline cartilage-like matrix and obtained a hypertrophic phenotype with eventual calcification. |
2013-09-12 |
2023-08-12 |
Not clear |
| Indira Prasadam, Xinzhan Mao, Wei Shi, Ross Crawford, Yin Xia. Combination of MEK-ERK inhibitor and hyaluronic acid has a synergistic effect on anti-hypertrophic and pro-chondrogenic activities in osteoarthritis treatment. Journal of molecular medicine (Berlin, Germany). vol 91. issue 3. 2013-09-03. PMID:22965193. |
histology, immunostaining, rt-qpcr, western blotting and zymography were performed to assess the expression of cartilage matrix proteins and hypertrophic markers. |
2013-09-03 |
2023-08-12 |
human |
| Simona Hefetz-Sela, Philipp E Schere. Adipocytes: impact on tumor growth and potential sites for therapeutic intervention. Pharmacology & therapeutics. vol 138. issue 2. 2013-08-27. PMID:23353703. |
obesity is characterized by impaired adipose tissue function, leading to adipocyte hypertrophy, inflammation, hypoxia and induced angiogenesis, extracellular matrix remodeling and fibrosis as well as additional stress responses. |
2013-08-27 |
2023-08-12 |
Not clear |
| Nahoko Shintani, Klaus A Siebenrock, Ernst B Hunzike. TGF-ß1 enhances the BMP-2-induced chondrogenesis of bovine synovial explants and arrests downstream differentiation at an early stage of hypertrophy. PloS one. vol 8. issue 1. 2013-08-20. PMID:23301025. |
furthermore, the downstream differentiation of chondrocytes proceeds to the stage of terminal hypertrophy, which is inextricably coupled with undesired matrix mineralization. |
2013-08-20 |
2023-08-12 |
cattle |
| Pingping Chen-An, Kim Vietz Andreassen, Kim Henriksen, Morten Asser Karsdal, Anne-Christine Bay-Jense. Investigation of chondrocyte hypertrophy and cartilage calcification in a full-depth articular cartilage explants model. Rheumatology international. vol 33. issue 2. 2013-08-05. PMID:22453523. |
we speculated that this can become an important investigatory tool for investigation of matrix turnover, chondrocyte hypertrophy and cartilage calcification that are associated with djd pathogenesis. |
2013-08-05 |
2023-08-12 |
cattle |
| Ichiro Tsukamoto, Shinji Inoue, Takeshi Teramura, Toshiyuki Takehara, Kazuhiro Ohtani, Masao Akag. Activating types 1 and 2 angiotensin II receptors modulate the hypertrophic differentiation of chondrocytes. FEBS open bio. vol 3. 2013-08-01. PMID:23905010. |
activation of at1r suppressed and activation of at2r enhanced the expression of markers of hypertrophic differentiation, including type x collagen, matrix metalloproteinase 13 and runt-related transcription factor 2. |
2013-08-01 |
2023-08-12 |
Not clear |
| Kristina Rydell-Törmänen, Paul-André Risse, Varsha Kanabar, Rushita Bagchi, Michael P Czubryt, Jill R Johnso. Smooth muscle in tissue remodeling and hyper-reactivity: airways and arteries. Pulmonary pharmacology & therapeutics. vol 26. issue 1. 2013-07-22. PMID:22561160. |
these diseases may be marked by airway and/or vascular smooth muscle hypertrophy, proliferation and hyper-reactivity, and related conditions such as fibrosis and extracellular matrix remodeling. |
2013-07-22 |
2023-08-12 |
Not clear |
| J Julie Kim, Takeshi Kurita, Serdar E Bulu. Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer. Endocrine reviews. vol 34. issue 1. 2013-07-22. PMID:23303565. |
in uterine fibroids, progesterone promotes growth by increasing proliferation, cellular hypertrophy, and deposition of extracellular matrix. |
2013-07-22 |
2023-08-12 |
human |