| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Wei, E Y Yuen, W Liu, X Li, P Zhong, I N Karatsoreos, B S McEwen, Z Ya. Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition. Molecular psychiatry. vol 19. issue 5. 2015-01-19. PMID:23835908. |
blocking aromatase, the enzyme for the biosynthesis of estrogen, revealed the stress-induced glutamatergic deficits and memory impairment in females, and the level of aromatase was significantly higher in the pfc of females than in males. |
2015-01-19 |
2023-08-12 |
rat |
| Eden Flores-Barrera, Daniel R Thomases, Li-Jun Heng, Daryn K Cass, Adriana Caballero, Kuei Y Tsen. Late adolescent expression of GluN2B transmission in the prefrontal cortex is input-specific and requires postsynaptic protein kinase A and D1 dopamine receptor signaling. Biological psychiatry. vol 75. issue 6. 2015-01-19. PMID:24041503. |
the acquisition of these functions is linked to the protracted development of the prefrontal cortex (pfc) and dopamine facilitation of glutamatergic transmission. |
2015-01-19 |
2023-08-12 |
Not clear |
| Iskra Pollak Dorocic, Daniel Fürth, Yang Xuan, Yvonne Johansson, Laura Pozzi, Gilad Silberberg, Marie Carlén, Konstantinos Meleti. A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei. Neuron. vol 83. issue 3. 2014-12-29. PMID:25102561. |
we identified and functionally confirmed monosynaptic glutamatergic inputs from prefrontal cortex and lateral habenula onto serotonergic neurons as well as a direct gabaergic input from striatal projection neurons. |
2014-12-29 |
2023-08-13 |
Not clear |
| Eric McKimm, Beau Corkill, Dan Goldowitz, Lorraine M Albritton, Ramin Homayouni, Charles D Blaha, Guy Mittlema. Glutamate dysfunction associated with developmental cerebellar damage: relevance to autism spectrum disorders. Cerebellum (London, England). vol 13. issue 3. 2014-12-22. PMID:24307139. |
using a mouse model, we investigated the possibility that developmental cerebellar purkinje cell loss could disrupt glutamatergic cerebellar projections to the pfc that ultimately modulate da release. |
2014-12-22 |
2023-08-12 |
mouse |
| Hao-wei Shen, Cassandra D Gipson, Martijn Huits, Peter W Kaliva. Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24232172. |
two nacore afferents contributing to cocaine reinstatement are glutamatergic inputs from the prelimbic prefrontal cortex (pl) and dopamine from the ventral tegmental area (vta). |
2014-12-01 |
2023-08-12 |
rat |
| Mohammad M Khan, Krishnan M Dhandapani, Quan-Guang Zhang, Darrell W Bran. Estrogen regulation of spine density and excitatory synapses in rat prefrontal and somatosensory cerebral cortex. Steroids. vol 78. issue 6. 2014-11-06. PMID:23276632. |
as a whole, the studies demonstrate that e2 enhances spine density in both the pfc and ssc, and that e2 enhances excitatory glutamatergic synapse formation in cortical neurons via a rapid extranuclear er-mediated signaling mechanism that involves up-regulation of glur1 and mediation by akt and erk signaling pathways. |
2014-11-06 |
2023-08-12 |
rat |
| Joanne Wallace, Rosanna K Jackson, Tanya L Shotton, Ishaana Munjal, Richard McQuade, Sarah E Gartsid. Characterization of electrically evoked field potentials in the medial prefrontal cortex and orbitofrontal cortex of the rat: modulation by monoamines. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 2. 2014-10-21. PMID:23932190. |
glutamatergic, gabaergic, and monoaminergic dysfunction in the prefrontal cortex has been hypothesised to underlie symptoms in neuropsychiatric disorders. |
2014-10-21 |
2023-08-12 |
rat |
| Aram Parsegian, Ronald E Se. Dysregulation of dopamine and glutamate release in the prefrontal cortex and nucleus accumbens following methamphetamine self-administration and during reinstatement in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 4. 2014-10-10. PMID:23995583. |
these deficits may be related to changes in the prefrontal cortex (pfc) and its glutamatergic projections to the nucleus accumbens (nac). |
2014-10-10 |
2023-08-12 |
rat |
| Bartłomiej Pochwat, Bernadeta Szewczyk, Magdalena Sowa-Kucma, Agata Siwek, Urszula Doboszewska, Wojciech Piekoszewski, Piotr Gruca, Mariusz Papp, Gabriel Nowa. Antidepressant-like activity of magnesium in the chronic mild stress model in rats: alterations in the NMDA receptor subunits. The international journal of neuropsychopharmacology. vol 17. issue 3. 2014-09-17. PMID:24067405. |
moreover, the effect of cms and magnesium (with an effective dose) on the level of the proteins related to the glutamatergic system (glun1, glun2a, glun2b and psd-95) in the hippocampus, prefrontal cortex (pfc) and amygdala were examined. |
2014-09-17 |
2023-08-12 |
rat |
| Daniel R Thomases, Daryn K Cass, Jacqueline D Meyer, Adriana Caballero, Kuei Y Tsen. Early adolescent MK-801 exposure impairs the maturation of ventral hippocampal control of basolateral amygdala drive in the adult prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 27. 2014-08-29. PMID:24990926. |
the functional maturation of the pfc is dependent upon proper integration of glutamatergic inputs from the ventral hippocampus (vhipp) and the basolateral amygdala (bla). |
2014-08-29 |
2023-08-13 |
rat |
| Die Zhang, Andrei Dragomir, Yasemin M Akay, Metin Aka. Nicotine exposure increases the complexity of dopamine neurons in the parainterfascicular nucleus (PIF) sub-region of VTA. Journal of neuroengineering and rehabilitation. vol 11. 2014-08-22. PMID:24920473. |
recent publications highlight differences within the sub-regions of the ventral tegmental area (vta) including the parabrachial pigmented nucleus (pbp), parainterfascicular nucleus (pif) and paranigral nucleus (pn) in the projections to the prefrontal cortex (pfc) and the glutamatergic pathway. |
2014-08-22 |
2023-08-13 |
Not clear |
| Tsung-Ung W Wo. Neurobiology of schizophrenia onset. Current topics in behavioral neurosciences. vol 16. 2014-07-31. PMID:23975845. |
specifically, converging lines of evidence suggest that oxidative stress, extracellular matrix (ecm) deficit and impaired glutamatergic innervation may contribute to the functional impairment of pv neurons, which may then lead to aberrant developmental synaptic pruning of pyramidal cell circuits during adolescence in the pfc. |
2014-07-31 |
2023-08-12 |
Not clear |
| Gabriel C Quinter. Role of nucleus accumbens glutamatergic plasticity in drug addiction. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24109187. |
moreover, these therapeutic drugs target the glutamatergic circuitry between the pfc and the nac. |
2014-06-24 |
2023-08-12 |
human |
| Ryan T Lalumier. Optogenetic dissection of amygdala functioning. Frontiers in behavioral neuroscience. vol 8. 2014-04-21. PMID:24723867. |
findings from such studies have provided evidence that particular patterns of activity in basolateral amygdala (bla) glutamatergic neurons are related to memory consolidation processes, while other work has indicated the critical nature of amygdala inputs to the prefrontal cortex and nucleus accumbens (na) in regulating behavior dependent on those downstream structures. |
2014-04-21 |
2023-08-13 |
Not clear |
| Ute Krügel, László Köles, Péter Illé. Integration of neuronal and glial signalling by pyramidal cells of the rat prefrontal cortex; control of cognitive functions and addictive behaviour by purinergic mechanisms. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 15. issue 4. 2014-04-11. PMID:24380961. |
especially, layer v pyramidal cells integrating afferent innervations from dopaminergic cell groups in the ventral tegmental area, glutamatergic inputs from the thalamus and neighbouring pfc pyramical cells, as well as gabaergic inputs from local interneurons are crucial for processing short-term working memory. |
2014-04-11 |
2023-08-12 |
rat |
| Kelly A Butts, Anthony G Phillip. Glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area. The international journal of neuropsychopharmacology. vol 16. issue 8. 2014-03-14. PMID:23590841. |
glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area. |
2014-03-14 |
2023-08-12 |
Not clear |
| Eunice Y Yuen, Ping Zhong, Xiangning Li, Jing Wei, Zhen Ya. Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals. The Journal of biological chemistry. vol 288. issue 36. 2014-02-04. PMID:23884421. |
the restoration of pfc glutamatergic transmission in stress conditions may enable d4 receptors to serve as a synaptic stabilizer in normal and pathological conditions. |
2014-02-04 |
2023-08-12 |
rat |
| Hatam Ahmadi, Mohammad Nasehi, Parvin Rostami, Mohammad Reza Zarrindas. Involvement of the nucleus accumbens shell dopaminergic system in prelimbic NMDA-induced anxiolytic-like behaviors. Neuropharmacology. vol 71. 2014-01-10. PMID:23566820. |
nucleus accumbens (nac) and prefrontal cortex (pfc) dopaminergic and glutamatergic systems are involved in fear/anxiety-related behaviors; meanwhile nac dopaminergic system activity is mediated by pfc via nac glutamatergic projections. |
2014-01-10 |
2023-08-12 |
Not clear |
| Akihito Uezato, Toru Nishikaw. [Molecular pathology of schizophrenia]. Nihon rinsho. Japanese journal of clinical medicine. vol 71. issue 4. 2013-09-25. PMID:23678584. |
in the prefrontal cortex of patients with schizophrenia; dysfunctional nmda-type glutamate receptors on gabaergic interneurons cause disinhibition of pyramidal glutamatergic neurons, resulting in increase in the firing of dopaminergic neurons. |
2013-09-25 |
2023-08-12 |
Not clear |
| Dharmendra B Goswami, Courtney S Jernigan, Agata Chandran, Abiye H Iyo, Warren L May, Mark C Austin, Craig A Stockmeier, Beata Karolewic. Gene expression analysis of novel genes in the prefrontal cortex of major depressive disorder subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 43. 2013-09-19. PMID:23261523. |
dysregulation of the glutamatergic system has been implicated not only in the treatment of major depressive disorder (mdd), but also in the excitotoxic effects of stress and anxiety on the prefrontal cortex, which may precede the onset of a depressive episode. |
2013-09-19 |
2023-08-12 |
human |