| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paige N Vinson, P Jeffrey Con. Metabotropic glutamate receptors as therapeutic targets for schizophrenia. Neuropharmacology. vol 62. issue 3. 2012-09-27. PMID:21620876. |
activation of the group ii mglu receptors (mglu(2) and mglu(3)) and the group i mglu(5) are hypothesized to normalize the disruption of thalamocortical glutamatergic circuitry that results in abnormal glutamaterigic signaling in the prefrontal cortex (pfc). |
2012-09-27 |
2023-08-12 |
Not clear |
| Kazuya Toriumi, Akihiro Mouri, Shiho Narusawa, Yuki Aoyama, Natsumi Ikawa, Lingling Lu, Taku Nagai, Takayoshi Mamiya, Hyoung-Chun Kim, Toshitaka Nabeshim. Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22257896. |
prenatal nmda receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex. |
2012-08-14 |
2023-08-12 |
mouse |
| Kazuya Toriumi, Akihiro Mouri, Shiho Narusawa, Yuki Aoyama, Natsumi Ikawa, Lingling Lu, Taku Nagai, Takayoshi Mamiya, Hyoung-Chun Kim, Toshitaka Nabeshim. Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 6. 2012-08-14. PMID:22257896. |
consequently, the density of glutamatergic neurons in the prefrontal cortex was decreased, probably resulting in glutamatergic hypofunction. |
2012-08-14 |
2023-08-12 |
mouse |
| Janine B Lee, Jing Wei, Wenhua Liu, Jia Cheng, Jian Feng, Zhen Ya. Histone deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex. The Journal of physiology. vol 590. issue 7. 2012-08-07. PMID:22331421. |
recently it has been shown that acute stress affects pfc functions by potentiating glutamatergic transmission via a mechanism dependent on glucocorticoid receptor (gr) and its downstream target, serum and glucocorticoid-inducible kinase (sgk). |
2012-08-07 |
2023-08-12 |
Not clear |
| Huai-Xing Wang, Wen-Jun Ga. Prolonged exposure to NMDAR antagonist induces cell-type specific changes of glutamatergic receptors in rat prefrontal cortex. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22182778. |
prolonged exposure to nmdar antagonist induces cell-type specific changes of glutamatergic receptors in rat prefrontal cortex. |
2012-07-27 |
2023-08-12 |
rat |
| Huai-Xing Wang, Wen-Jun Ga. Prolonged exposure to NMDAR antagonist induces cell-type specific changes of glutamatergic receptors in rat prefrontal cortex. Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22182778. |
we investigated the functional changes of glutamatergic receptors in the pyramidal cells and fast-spiking (fs) interneurons in the adolescent rat prefrontal cortex in mk-801 model of schizophrenia. |
2012-07-27 |
2023-08-12 |
rat |
| M Behnam Ghasemzadeh, Preethi Vasudevan, Chad Giles, Anthony Purgianto, Chad Seubert, John R Mantsc. Glutamatergic plasticity in medial prefrontal cortex and ventral tegmental area following extended-access cocaine self-administration. Brain research. vol 1413. 2012-06-12. PMID:21855055. |
these data suggest that extinction of drug seeking is associated with selective glutamatergic plasticity in prefrontal cortex and ventral tegmental area that include modulation of receptor trafficking to postsynaptic density. |
2012-06-12 |
2023-08-12 |
rat |
| Annalisa Tassone, Graziella Madeo, Tommaso Schirinzi, Daniela Vita, Francesca Puglisi, Giulia Ponterio, Franco Borsini, Antonio Pisani, Paola Bons. Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission. Neuropharmacology. vol 61. issue 4. 2012-05-25. PMID:21619890. |
we investigated the effect of 5-ht6 receptor subtype activation on glutamatergic transmission by means of whole-cell patch-clamp electrophysiological recordings from medium spiny neurons of the striatum and layer v pyramidal neurons of the prefrontal cortex. |
2012-05-25 |
2023-08-12 |
Not clear |
| Natalia Gorelova, Patrick J Mulholland, L Judson Chandler, Jeremy K Seaman. The glutamatergic component of the mesocortical pathway emanating from different subregions of the ventral midbrain. Cerebral cortex (New York, N.Y. : 1991). vol 22. issue 2. 2012-05-07. PMID:21666135. |
however, the relative density of the glutamatergic projection to the pfc from these rostromedial regions is unknown. |
2012-05-07 |
2023-08-12 |
Not clear |
| Eunice Y Yuen, Jing Wei, Wenhua Liu, Ping Zhong, Xiangning Li, Zhen Ya. Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex. Neuron. vol 73. issue 5. 2012-05-01. PMID:22405206. |
inhibition of proteasomes or knockdown of nedd4-1 and fbx2 in pfc prevented the loss of glutamatergic responses and recognition memory in stressed animals. |
2012-05-01 |
2023-08-12 |
rat |
| Eunice Y Yuen, Jing Wei, Wenhua Liu, Ping Zhong, Xiangning Li, Zhen Ya. Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex. Neuron. vol 73. issue 5. 2012-05-01. PMID:22405206. |
our results suggest that repeated stress dampens pfc glutamatergic transmission by facilitating glutamate receptor turnover, which causes the detrimental effect on pfc-dependent cognitive processes. |
2012-05-01 |
2023-08-12 |
rat |
| Ting Chen, Die Zhang, Andrei Dragomir, Kunikazu Kobayashi, Yasemin Akay, Metin Aka. Investigating the influence of PFC transection and nicotine on dynamics of AMPA and NMDA receptors of VTA dopaminergic neurons. Journal of neuroengineering and rehabilitation. vol 8. 2012-04-05. PMID:22018308. |
the addictive behavior and firing pattern of the vta da neurons are thought to be controlled by the glutamatergic synaptic input from prefrontal cortex (pfc). |
2012-04-05 |
2023-08-12 |
Not clear |
| Gil D Hoftman, David A Lewi. Postnatal developmental trajectories of neural circuits in the primate prefrontal cortex: identifying sensitive periods for vulnerability to schizophrenia. Schizophrenia bulletin. vol 37. issue 3. 2011-09-09. PMID:21505116. |
here, we review the development of glutamatergic and γ-aminobutyric acid (gaba)-ergic circuits in macaque monkey prefrontal cortex and discuss how these trajectories may help to identify sensitive periods during which environmental exposures, such as those associated with increased risk for schizophrenia, might lead to the types of abnormalities in prefrontal cortical function present in schizophrenia. |
2011-09-09 |
2023-08-12 |
monkey |
| Corrado Corti, John Henry Xuereb, Luca Crepaldi, Mauro Corsi, Francesca Michielin, Francesco Ferragut. Altered levels of glutamatergic receptors and Na+/K+ ATPase-α1 in the prefrontal cortex of subjects with schizophrenia. Schizophrenia research. vol 128. issue 1-3. 2011-08-24. PMID:21353485. |
altered levels of glutamatergic receptors and na+/k+ atpase-α1 in the prefrontal cortex of subjects with schizophrenia. |
2011-08-24 |
2023-08-12 |
human |
| Corrado Corti, John Henry Xuereb, Luca Crepaldi, Mauro Corsi, Francesca Michielin, Francesco Ferragut. Altered levels of glutamatergic receptors and Na+/K+ ATPase-α1 in the prefrontal cortex of subjects with schizophrenia. Schizophrenia research. vol 128. issue 1-3. 2011-08-24. PMID:21353485. |
although several pharmacological evidences point to abnormal glutamatergic transmission in schizophrenia, changes in the expression of glutamatergic receptors in the prefrontal cortex of patients with schizophrenia remains equivocal. |
2011-08-24 |
2023-08-12 |
human |
| Corrado Corti, John Henry Xuereb, Luca Crepaldi, Mauro Corsi, Francesca Michielin, Francesco Ferragut. Altered levels of glutamatergic receptors and Na+/K+ ATPase-α1 in the prefrontal cortex of subjects with schizophrenia. Schizophrenia research. vol 128. issue 1-3. 2011-08-24. PMID:21353485. |
our findings support and expand the hypothesis of glutamatergic dysfunction in prefrontal cortex in the pathophysiology of schizophrenia. |
2011-08-24 |
2023-08-12 |
human |
| Lingling Lu, Takayoshi Mamiya, Ping Lu, Kazuya Toriumi, Akihiro Mouri, Masayuki Hiramatsu, Li-Bo Zou, Toshitaka Nabeshim. Prenatal exposure to PCP produces behavioral deficits accompanied by the overexpression of GLAST in the prefrontal cortex of postpubertal mice. Behavioural brain research. vol 220. issue 1. 2011-07-15. PMID:21277907. |
altered glutamatergic neurotransmission in the prefrontal cortex (pfc) has been implicated in a myriad of neuropsychiatric disorders. |
2011-07-15 |
2023-08-12 |
mouse |
| Michiko Nakazato, Kenji Hashimoto, Ulrike Schmidt, Kate Tchanturia, Iain C Campbell, David A Collier, Masaomi Iyo, Janet Treasur. Serum glutamine, set-shifting ability and anorexia nervosa. Annals of general psychiatry. vol 9. 2011-07-14. PMID:20576166. |
animal studies have established that glutamatergic pathways in the prefrontal cortex play an important role in set-shifting ability. |
2011-07-14 |
2023-08-12 |
Not clear |
| Danielle S Counotte, Natalia A Goriounova, Ka Wan Li, Maarten Loos, Roel C van der Schors, Dustin Schetters, Anton N M Schoffelmeer, August B Smit, Huibert D Mansvelder, Tommy Pattij, Sabine Spijke. Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence. Nature neuroscience. vol 14. issue 4. 2011-05-26. PMID:21336271. |
we found that adolescent nicotine exposure induced lasting attentional disturbances and reduced mglur2 protein and function on presynaptic terminals of pfc glutamatergic synapses. |
2011-05-26 |
2023-08-12 |
rat |
| Kristen J Brennand, Anthony Simone, Jessica Jou, Chelsea Gelboin-Burkhart, Ngoc Tran, Sarah Sangar, Yan Li, Yangling Mu, Gong Chen, Diana Yu, Shane McCarthy, Jonathan Sebat, Fred H Gag. Modelling schizophrenia using human induced pluripotent stem cells. Nature. vol 473. issue 7346. 2011-05-18. PMID:21490598. |
although post-mortem studies have revealed reduced brain volume, cell size, spine density and abnormal neural distribution in the prefrontal cortex and hippocampus of sczd brain tissue and neuropharmacological studies have implicated dopaminergic, glutamatergic and gabaergic activity in sczd, the cell types affected in sczd and the molecular mechanisms underlying the disease state remain unclear. |
2011-05-18 |
2023-08-12 |
human |