| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E Y Yuen, W Liu, I N Karatsoreos, Y Ren, J Feng, B S McEwen, Z Ya. Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory. Molecular psychiatry. vol 16. issue 2. 2011-05-04. PMID:20458323. |
working memory, a key function relying on glutamatergic transmission in pfc, is enhanced in acutely stressed animals through an sgk-dependent mechanism. |
2011-05-04 |
2023-08-12 |
Not clear |
| A Konradsson-Geuken, H Q Wu, C R Gash, K S Alexander, A Campbell, Y Sozeri, R Pellicciari, R Schwarcz, J P Brun. Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry. Neuroscience. vol 169. issue 4. 2011-04-18. PMID:20600676. |
since kyna levels are elevated in the pfc of individuals with schizophrenia, and since prefrontal glutamatergic and nicotinic transmission mediate cognitive flexibility, normalization of kyna levels in the pfc may constitute an effective treatment strategy for alleviating cognitive deficits in schizophrenia. |
2011-04-18 |
2023-08-12 |
rat |
| A Marzo, J Bai, J Caboche, P Vanhoutte, S Otan. Cellular mechanisms of long-term depression induced by noradrenaline in rat prefrontal neurons. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20434527. |
in the present study, we investigated long-term effects of bath-applied na (12.5 min) on glutamatergic synaptic transmission in rat pfc pyramidal neurons maintained in vitro. |
2011-03-04 |
2023-08-12 |
rat |
| A Marzo, J Bai, J Caboche, P Vanhoutte, S Otan. Cellular mechanisms of long-term depression induced by noradrenaline in rat prefrontal neurons. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20434527. |
together, these results demonstrate that na can lastingly depress glutamatergic synapses in rat pfc neurons through mechanisms involving alpha-adrenoceptors, nmda receptors, and the activation of postsynaptic erk1/2. |
2011-03-04 |
2023-08-12 |
rat |
| José Javier Miguel-Hidalgo, Robert Waltzer, Angela A Whittom, Mark C Austin, Grazyna Rajkowska, Craig A Stockmeie. Glial and glutamatergic markers in depression, alcoholism, and their comorbidity. Journal of affective disorders. vol 127. issue 1-3. 2011-03-01. PMID:20580095. |
alteration of glutamatergic neurotransmission in the prefrontal cortex (pfc) may contribute to the pathophysiology of alcoholism and major depressive disorder (mdd). |
2011-03-01 |
2023-08-12 |
human |
| Timothy W Whitfield, Xiangdang Shi, Wei-Lun Sun, Jacqueline F McGint. The suppressive effect of an intra-prefrontal cortical infusion of BDNF on cocaine-seeking is Trk receptor and extracellular signal-regulated protein kinase mitogen-activated protein kinase dependent. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 3. 2011-02-23. PMID:21248106. |
we have previously demonstrated that infusion of bdnf into the dorsomedial prefrontal cortex (dmpfc) immediately after the last of 10 cocaine sa sessions attenuates contextual, cue- and cocaine prime-induced reinstatement of cocaine-seeking (berglind et al., 2007) and normalizes cocaine-induced disruption of glutamatergic transmission in the nucleus accumbens (berglind et al., 2009). |
2011-02-23 |
2023-08-12 |
rat |
| J de Almeida, G Mengo. D2 and D4 dopamine receptor mRNA distribution in pyramidal neurons and GABAergic subpopulations in monkey prefrontal cortex: implications for schizophrenia treatment. Neuroscience. vol 170. issue 4. 2011-01-18. PMID:20727949. |
in the present work we report double in situ hybridization histochemistry experiments to determine the prevalence of d2 receptor mrna and d4 receptor mrna in glutamatergic neurons, gabaergic interneurons and both parvalbumin and calbindin gabaergic subpopulations in monkey prefrontal cortex layer v. we found that around 54% of glutamatergic neurons express d2 mrna and 75% express d4 mrna, while gad-positive interneurons express around 34% and 47% respectively. |
2011-01-18 |
2023-08-12 |
monkey |
| A J Fallgatter, A-C Ehlis, M J Herrmann, C Hohoff, A Reif, C M Freitag, J Decker. DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophrenias. Genes, brain, and behavior. vol 9. issue 5. 2010-11-15. PMID:20180862. |
dysbindin (dtnbp1) is a recently characterized protein that seems to be involved in the modulation of glutamatergic neurotransmission in the human brain, thereby influencing prefrontal cortex function and associated cognitive processes. |
2010-11-15 |
2023-08-12 |
human |
| Mario Mezler, Hervé Geneste, Laura Gault, Gerard J Mare. LY-2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia. Current opinion in investigational drugs (London, England : 2000). vol 11. issue 7. 2010-10-05. PMID:20571979. |
furthermore, mglur2 acts as a glutamatergic autoreceptor in the brain regions that are believed to be important in the pathophysiology of schizophrenia, such as the prefrontal cortex, striatum, hippocampal formation and the thalamus. |
2010-10-05 |
2023-08-12 |
mouse |
| Deranda B Lester, Tiffany D Rogers, Charles D Blah. Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS neuroscience & therapeutics. vol 16. issue 3. 2010-09-22. PMID:20370804. |
in close coordination with glutamatergic and gabaergic activity, these excitatory cholinergic projections activate nicotinic and muscarinic acetylcholine receptors within the substantia nigra and ventral tegmental area to modulate dopamine transmission in the dorsal/ventral striatum and prefrontal cortex. |
2010-09-22 |
2023-08-12 |
Not clear |
| Danielle Marra de Freitas-Silva, Letícia de Souza Resende, Silvia Rejane Castanheira Pereira, Glaura Conceição Franco, Angela Maria Ribeir. Maternal thiamine restriction during lactation induces cognitive impairments and changes in glutamate and GABA concentrations in brain of rat offspring. Behavioural brain research. vol 211. issue 1. 2010-08-17. PMID:20211656. |
gabaergic and glutamatergic parameters were measured in thalamus, prefrontal cortex and hippocampus by high performance liquid chromatography (hplc). |
2010-08-17 |
2023-08-12 |
rat |
| Maria Rosaria Melis, Salvatora Succu, Cristina Cocco, Emanuela Caboni, Fabrizio Sanna, Antonio Boi, Gian Luca Ferri, Antonio Argiola. Oxytocin induces penile erection when injected into the ventral subiculum: role of nitric oxide and glutamic acid. Neuropharmacology. vol 58. issue 7. 2010-07-19. PMID:20156463. |
no in turn increases glutamic acid neurotransmission, leading to penile erection, possibly through neural (glutamatergic) efferent projections from the ventral subiculum to extra-hippocampal brain areas (e.g., prefrontal cortex) modulating the activity of mesolimbic dopaminergic neurons. |
2010-07-19 |
2023-08-12 |
rat |
| Xavier López-Gil, Francesc Artigas, Albert Adel. Unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex. Current pharmaceutical design. vol 16. issue 5. 2010-06-25. PMID:19909228. |
unraveling monoamine receptors involved in the action of typical and atypical antipsychotics on glutamatergic and serotonergic transmission in prefrontal cortex. |
2010-06-25 |
2023-08-12 |
rat |
| D A Mitrano, J-F Pare, Y Smit. Ultrastructural relationships between cortical, thalamic, and amygdala glutamatergic inputs and group I metabotropic glutamate receptors in the rat accumbens. The Journal of comparative neurology. vol 518. issue 8. 2010-06-01. PMID:20151362. |
glutamatergic inputs to the accumbens originate from multiple sources, including the prefrontal cortex, basolateral amygdala, and midline thalamus. |
2010-06-01 |
2023-08-12 |
rat |
| Glen Acosta, Wendy Hasenkamp, James B Daunais, David P Friedman, Kathleen A Grant, Scott E Hemb. Ethanol self-administration modulation of NMDA receptor subunit and related synaptic protein mRNA expression in prefrontal cortical fields in cynomolgus monkeys. Brain research. vol 1318. 2010-05-20. PMID:20043891. |
glutamatergic transmission is integral to cortico-cortical and cortico-subcortical communication, and alcohol-induced changes in the abundance of the receptor subunits and/or their splice variants may result in critical functional impairments of prefrontal cortex in the alcohol-addicted state. |
2010-05-20 |
2023-08-12 |
monkey |
| Shoji Tanak. Model-based parametric study of frontostriatal abnormalities in schizophrenia patients. BMC psychiatry. vol 10. 2010-05-06. PMID:20187970. |
one would attribute this relationship primarily to the circuitry comprised of the glutamatergic projection from the pfc to the striatum and the gabaergic projection from the striatum to the midbrain da nucleus. |
2010-05-06 |
2023-08-12 |
Not clear |
| Vinay Parikh, Jinzhao Ji, Michael W Decker, Martin Sarte. Prefrontal beta2 subunit-containing and alpha7 nicotinic acetylcholine receptors differentially control glutamatergic and cholinergic signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 9. 2010-05-05. PMID:20203212. |
transients were recorded in mice lacking beta2 or alpha7 nachrs and in rats after removal of thalamic glutamatergic or midbrain dopaminergic inputs to prefrontal cortex. |
2010-05-05 |
2023-08-12 |
mouse |
| Byron Ky Bitanihirwe, Maribel P Lim, Tsung-Ung W Wo. N-methyl-D-aspartate receptor expression in parvalbumin-containing inhibitory neurons in the prefrontal cortex in bipolar disorder. Bipolar disorders. vol 12. issue 1. 2010-04-29. PMID:20148871. |
in this study, we addressed the hypothesis that, in the prefrontal cortex (pfc), disturbances of glutamatergic regulation of the class of inhibitory neurons that contain the calcium buffer parvalbumin (pv) via n-methyl-d-aspartate (nmda) receptor may contribute to the pathophysiology of bipolar disorder. |
2010-04-29 |
2023-08-12 |
Not clear |
| Hui-Qiu Wu, Edna F R Pereira, John P Bruno, Roberto Pellicciari, Edson X Albuquerque, Robert Schwarc. The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19690987. |
the cognitive deficits seen in schizophrenia patients are likely related to abnormal glutamatergic and cholinergic neurotransmission in the prefrontal cortex. |
2010-04-21 |
2023-08-12 |
rat |
| James David Jentsch, Heather Trantham-Davidson, Corey Jairl, Matthew Tinsley, Tyrone D Cannon, Antonieta Lavi. Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 12. 2010-01-12. PMID:19641486. |
deep-layer pyramidal neurons recorded in the prefrontal cortex of mutant mice showed reductions in paired-pulse facilitation, and evoked and miniature excitatory post-synaptic currents, indicating a difference in the function of pre-synaptic glutamatergic terminals as well as elevated spike thresholds. |
2010-01-12 |
2023-08-12 |
mouse |