| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nora D Volkow, Gene-Jack Wang, Frank Telang, Joanna S Fowler, Jean Logan, Anna-Rose Childress, Millard Jayne, Yeming Ma, Christopher Won. Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues. NeuroImage. vol 39. issue 3. 2008-03-25. PMID:18024160. |
this suggests that dopamine increases associated with conditioned cues are not primary responses but reflect downstream stimulation of dopamine cells (presumably glutamatergic afferents from prefrontal cortex and/or amygdala). |
2008-03-25 |
2023-08-12 |
human |
| Jean-Claude Béïque, Mays Imad, Ljiljana Mladenovic, Jay A Gingrich, Rodrigo Andrad. Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 23. 2008-01-22. PMID:17535909. |
previous studies have shown that activation of 5-ht(2a)rs in this region results in a robust increase in spontaneous glutamatergic synaptic activity, and these results have led to the widely held idea that hallucinogens elicit their effect by modulating synaptic transmission within the pfc. |
2008-01-22 |
2023-08-12 |
Not clear |
| Alessandro Barbon, Fabio Fumagalli, Luca La Via, Luca Caracciolo, Giorgio Racagni, Marco Andrea Riva, Sergio Barlat. Chronic phencyclidine administration reduces the expression and editing of specific glutamate receptors in rat prefrontal cortex. Experimental neurology. vol 208. issue 1. 2008-01-17. PMID:17706642. |
combining all the data, it can be inferred that the pcp treatment induced a specific and site-selective reduction of glutamatergic neurotransmission in the prefrontal cortex but not in the hippocampus. |
2008-01-17 |
2023-08-12 |
rat |
| John A Gray, Bryan L Rot. Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophrenia bulletin. vol 33. issue 5. 2007-12-06. PMID:17617664. |
these molecular targets include dopamine receptors in the prefrontal cortex, nicotinic and muscarinic acetylcholine receptors, the glutamatergic excitatory synapse, various serotonin receptors, and the gamma-aminobutyric acid (gaba) system. |
2007-12-06 |
2023-08-12 |
Not clear |
| J de Almeida, G Mengo. Quantitative analysis of glutamatergic and GABAergic neurons expressing 5-HT(2A) receptors in human and monkey prefrontal cortex. Journal of neurochemistry. vol 103. issue 2. 2007-11-20. PMID:17635672. |
quantitative analysis of glutamatergic and gabaergic neurons expressing 5-ht(2a) receptors in human and monkey prefrontal cortex. |
2007-11-20 |
2023-08-12 |
human |
| J de Almeida, G Mengo. Quantitative analysis of glutamatergic and GABAergic neurons expressing 5-HT(2A) receptors in human and monkey prefrontal cortex. Journal of neurochemistry. vol 103. issue 2. 2007-11-20. PMID:17635672. |
there is no quantitative information on the percentage of glutamatergic and gabaergic cells that express 5-ht(2a) receptors in human and monkey pfc. |
2007-11-20 |
2023-08-12 |
human |
| J de Almeida, G Mengo. Quantitative analysis of glutamatergic and GABAergic neurons expressing 5-HT(2A) receptors in human and monkey prefrontal cortex. Journal of neurochemistry. vol 103. issue 2. 2007-11-20. PMID:17635672. |
these results indicate that, while the majority of glutamatergic neurons can be sensitive to 5-ht action via 5-ht(2a) receptors, this modulation occurs only in a limited population of gabaergic interneurons and provides new neuroanatomical information about the role played by serotonin through 5-ht(2a) receptors in the pfc and on the sites of action for drugs such as antipsychotics and antidepressants used in treatment of psychiatric disorders. |
2007-11-20 |
2023-08-12 |
human |
| Howard L Fields, Gregory O Hjelmstad, Elyssa B Margolis, Saleem M Nicol. Ventral tegmental area neurons in learned appetitive behavior and positive reinforcement. Annual review of neuroscience. vol 30. 2007-09-21. PMID:17376009. |
however, the vta also sends gabaergic and glutamatergic projections to the nucleus accumbens and prefrontal cortex. |
2007-09-21 |
2023-08-12 |
Not clear |
| Mercè Amargós-Bosch, Albert Adell, Francesc Artiga. Antipsychotic drugs reverse the AMPA receptor-stimulated release of 5-HT in the medial prefrontal cortex. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17394545. |
under the working hypothesis that atypical antipsychotic drugs may partly exert their action in pfc, we assessed their action on the in vivo 5-ht release evoked by increasing glutamatergic transmission in rat medial pfc (mpfc). |
2007-09-07 |
2023-08-12 |
rat |
| Mercè Amargós-Bosch, Albert Adell, Francesc Artiga. Antipsychotic drugs reverse the AMPA receptor-stimulated release of 5-HT in the medial prefrontal cortex. Journal of neurochemistry. vol 102. issue 2. 2007-09-07. PMID:17394545. |
these results suggest that, besides their action in limbic striatum, antipsychotic drugs may attenuate glutamatergic transmission in pfc, possibly by interacting with 5-ht(2a) and/or alpha(1)-adrenoceptors. |
2007-09-07 |
2023-08-12 |
rat |
| H Ollat, B Laurent, S Bakchine, B-F Michel, J Touchon, B Duboi. [Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease]. L'Encephale. vol 33. issue 2. 2007-09-06. PMID:17675917. |
sulbutiamine potentializes cholinergic and glutamatergic transmissions, mainly in hippocampus and prefrontal cortex. |
2007-09-06 |
2023-08-12 |
Not clear |
| Janusz K Rybakowski, Alina Borkowska, Maria Skibinska, Joanna Hause. Polymorphisms of the Fyn kinase gene and a performance on the Wisconsin Card Sorting Test in schizophrenia. Psychiatric genetics. vol 17. issue 3. 2007-08-06. PMID:17417065. |
the glutamatergic system has been implicated in the pathogenesis and prefrontal cortex dysfunctions in schizophrenia. |
2007-08-06 |
2023-08-12 |
Not clear |
| Janusz K Rybakowski, Alina Borkowska, Maria Skibinska, Joanna Hause. Polymorphisms of the Fyn kinase gene and a performance on the Wisconsin Card Sorting Test in schizophrenia. Psychiatric genetics. vol 17. issue 3. 2007-08-06. PMID:17417065. |
the src-family tyrosine kinase fyn plays a key role in the interaction between brain-derived neurotrophic factor and glutamatergic receptor n-methyl-d-aspartate, in prefrontal cortex. |
2007-08-06 |
2023-08-12 |
Not clear |
| Janusz K Rybakowski, Alina Borkowska, Maria Skibinska, Joanna Hause. Polymorphisms of the Fyn kinase gene and a performance on the Wisconsin Card Sorting Test in schizophrenia. Psychiatric genetics. vol 17. issue 3. 2007-08-06. PMID:17417065. |
the main finding of the study is showing a relationship between polymorphisms of the fyn gene, related to the function of glutamatergic system, and a performance on neuropsychological test of prefrontal cortex activity in schizophrenic patients. |
2007-08-06 |
2023-08-12 |
Not clear |
| Valentina Ferretti, Francesca Sargolini, Alberto Oliverio, Andrea Mele, Pascal Roulle. Effects of intra-accumbens NMDA and AMPA receptor antagonists on short-term spatial learning in the Morris water maze task. Behavioural brain research. vol 179. issue 1. 2007-07-24. PMID:17289166. |
in particular, it has been suggested that glutamatergic afferences from the hippocampus and the prefrontal cortex provide the main source of contextual information to the nac. |
2007-07-24 |
2023-08-12 |
mouse |
| Rina Murai, Yukihiro Noda, Kanae Matsui, Hiroyuki Kamei, Akihiro Mouri, Kazuhisa Matsuba, Astumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshim. Hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and NMDA-CaMKII signaling. Behavioural brain research. vol 180. issue 2. 2007-07-24. PMID:17451820. |
hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and nmda-camkii signaling. |
2007-07-24 |
2023-08-12 |
mouse |
| Rina Murai, Yukihiro Noda, Kanae Matsui, Hiroyuki Kamei, Akihiro Mouri, Kazuhisa Matsuba, Astumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshim. Hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and NMDA-CaMKII signaling. Behavioural brain research. vol 180. issue 2. 2007-07-24. PMID:17451820. |
these results suggest that repeated pcp treatment disrupts pre- and post-synaptic glutamatergic neurotransmission and induces morphological changes in the pfc and that such changes cause the emotional deficits exhibited in pcp-treated mice. |
2007-07-24 |
2023-08-12 |
mouse |
| Akihiro Mouri, Yukihiro Noda, Akihiro Noda, Tomonobu Nakamura, Takanobu Tokura, Yoshimitsu Yura, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshim. Involvement of a dysfunctional dopamine-D1/N-methyl-d-aspartate-NR1 and Ca2+/calmodulin-dependent protein kinase II pathway in the impairment of latent learning in a model of schizophrenia induced by phencyclidine. Molecular pharmacology. vol 71. issue 6. 2007-07-18. PMID:17344353. |
the infusion of a dopamine-d1 receptor agonist into the prefrontal cortex attenuated the impairment of latent learning and decrease of learning-associated nr1 phosphorylation in the pcp-treated mice, suggesting a functional linkage between glutamatergic and dopaminergic signaling. |
2007-07-18 |
2023-08-12 |
mouse |
| Robert D Mair, Julie A Kaue. Amphetamine depresses excitatory synaptic transmission at prefrontal cortical layer V synapses. Neuropharmacology. vol 52. issue 1. 2007-03-02. PMID:16895728. |
dopamine modulates the function of glutamatergic synapses in prefrontal cortex, modifying synaptic strength and influencing synaptic plasticity. |
2007-03-02 |
2023-08-12 |
Not clear |
| Angus W MacDonald, Matthew V Chafe. Translational and developmental perspective on N-methyl-D-aspartate synaptic deficits in schizophrenia. Development and psychopathology. vol 18. issue 3. 2007-01-10. PMID:17152404. |
we describe the hypothesis that this failure reflects an impairment in n-methyl-d-aspartate (nmda) glutamatergic neurotransmission, that is likely to involve both the dysregulated function of nmda synapses, as well as the physical loss of nmda synapses, particularly in prefrontal cortex. |
2007-01-10 |
2023-08-12 |
Not clear |