| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chris Pickering, Lisa Gustafsson, Aleta Cebere, Ingrid Nylander, Sture Liljequis. Repeated maternal separation of male Wistar rats alters glutamate receptor expression in the hippocampus but not the prefrontal cortex. Brain research. vol 1099. issue 1. 2006-09-19. PMID:16784730. |
since this period corresponds to a time of extensive developmental changes in the glutamatergic system, glutamate receptor mrna expression was studied in the hippocampus and prefrontal cortex. |
2006-09-19 |
2023-08-12 |
rat |
| Carol A Tamming. The neurobiology of cognition in schizophrenia. The Journal of clinical psychiatry. vol 67 Suppl 9. 2006-09-19. PMID:16965183. |
those targets that show promise for pharmacologic focus include the dopamine receptors (especially d1) in the prefrontal cortex (pfc), the serotonin receptors in the pfc and anterior cingulate cortex, the glutamatergic excitatory synapse, the acetylcholine nicotinic receptors in the hippocampus, the acetylcholine muscarinic receptors, and the brain gamma-aminobutyric acid (gaba) system. |
2006-09-19 |
2023-08-12 |
Not clear |
| Ellas K Nanitsos, Khoa T D Nguyen, Frantisek St'astný, Vladimir J Balca. Glutamatergic hypothesis of schizophrenia: involvement of Na+/K+-dependent glutamate transport. Journal of biomedical science. vol 12. issue 6. 2006-05-25. PMID:16228297. |
hypothetical model based on deficient glutamatergic neurotransmission caused by hyperactive glutamate transport in astrocytes surrounding excitatory synapses in the prefrontal cortex is examined in relation to the aetiology of schizophrenia. |
2006-05-25 |
2023-08-12 |
Not clear |
| C Grasshoff, M Herrera-Marschitz, M Goiny, B D Kretschme. Modulation of ventral pallidal dopamine and glutamate release by the intravenous anesthetic propofol studied by in vivo microdialysis. Amino acids. vol 28. issue 2. 2006-05-24. PMID:15714256. |
hedonic and rewarding states like these are modulated by the dopaminergic system in the nucleus accumbens, prefrontal cortex and also in the ventral pallidum and by the glutamatergic system in the neocortex and limbic system. |
2006-05-24 |
2023-08-12 |
rat |
| Lars V Kristiansen, James H Meador-Woodruf. Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression. Schizophrenia research. vol 78. issue 1. 2006-02-06. PMID:16023328. |
several subcortical structures including the striatum are innervated by direct glutamatergic projections from the prefrontal cortex, and these connections may be affected in severe psychiatric illnesses. |
2006-02-06 |
2023-08-12 |
Not clear |
| Ludger Tebartz van Elst, Gabi Valerius, Martin Büchert, Thorsten Thiel, Nicholas Rüsch, Emanuel Bubl, Jürgen Hennig, Dieter Ebert, Hans M Olbric. Increased prefrontal and hippocampal glutamate concentration in schizophrenia: evidence from a magnetic resonance spectroscopy study. Biological psychiatry. vol 58. issue 9. 2005-12-20. PMID:16018980. |
to test the hypothesis that altered glutamatergic neurotransmission might play a role in the pathogenesis of schizophrenia, we measured glutamate and glutamine concentrations in the prefrontal cortex and the hippocampus of patients with chronic schizophrenia using high-field magnetic resonance spectroscopy. |
2005-12-20 |
2023-08-12 |
Not clear |
| Elizabeth Scarr, Monica Beneyto, James H Meador-Woodruff, Brian Dea. Cortical glutamatergic markers in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 30. issue 8. 2005-11-29. PMID:15886719. |
to better understand the changes in cortical glutamatergic markers in schizophrenia, we measured the binding of radioligands to the ionotropic glutamate receptors (n-methyl d-aspartate, [3h]cgp39653, [3h]mk-801), amino-3-hydroxy-5-methyl-4-isoxazole ([3h]ampa), kainate ([3h]kainate), and the high-affinity glutamate uptake site ([3h]aspartate) using in situ radioligand binding with autoradiography and levels of mrna for kainate receptors using in situ hybridization in the dorsolateral prefrontal cortex from 20 subjects with schizophrenia and 20 controls matched for age and sex. |
2005-11-29 |
2023-08-12 |
human |
| Daya S Gupta, Robert E McCullumsmith, Monica Beneyto, Vahram Haroutunian, Kenneth L Davis, James H Meador-Woodruf. Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia. Synapse (New York, N.Y.). vol 57. issue 3. 2005-10-27. PMID:15945063. |
thus, we hypothesized that abnormal expression of mglurs might contribute to glutamatergic dysfunction observed in the pfc and striatum in schizophrenia. |
2005-10-27 |
2023-08-12 |
Not clear |
| Tohru Ohnuma, Toshihito Suzuki, Heii Ara. Hypothesis: minimal changes in neural transmission in schizophrenia: decreased glutamatergic and GABAergic functions in the prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 6. 2005-10-27. PMID:15949884. |
hypothesis: minimal changes in neural transmission in schizophrenia: decreased glutamatergic and gabaergic functions in the prefrontal cortex. |
2005-10-27 |
2023-08-12 |
Not clear |
| Tohru Ohnuma, Toshihito Suzuki, Heii Ara. Hypothesis: minimal changes in neural transmission in schizophrenia: decreased glutamatergic and GABAergic functions in the prefrontal cortex. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 6. 2005-10-27. PMID:15949884. |
as the pathophysiology, decreased glutamatergic neurotransmission in the postmortem prefrontal cortex of schizophrenics has been suggested to underlie the condition. |
2005-10-27 |
2023-08-12 |
Not clear |
| Segundo J Guzman, Zoltan Gerevich, Jan G Hengstler, Peter Illes, Werner Kleeman. P2Y1 receptors inhibit both strength and plasticity of glutamatergic synaptic neurotransmission in the rat prefrontal cortex. Synapse (New York, N.Y.). vol 57. issue 4. 2005-10-27. PMID:15986393. |
p2y1 receptors inhibit both strength and plasticity of glutamatergic synaptic neurotransmission in the rat prefrontal cortex. |
2005-10-27 |
2023-08-12 |
rat |
| Constantinos D Paspalas, Patricia S Goldman-Raki. Presynaptic D1 dopamine receptors in primate prefrontal cortex: target-specific expression in the glutamatergic synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 25. issue 5. 2005-09-13. PMID:15689564. |
presynaptic d1 dopamine receptors in primate prefrontal cortex: target-specific expression in the glutamatergic synapse. |
2005-09-13 |
2023-08-12 |
Not clear |
| C L Nelson, M Sarter, J P Brun. Prefrontal cortical modulation of acetylcholine release in posterior parietal cortex. Neuroscience. vol 132. issue 2. 2005-07-05. PMID:15802188. |
the present study investigated the ability of cholinergic and glutamatergic transmission within pfc to regulate acetylcholine (ach) release in ppc. |
2005-07-05 |
2023-08-12 |
human |
| C L Nelson, M Sarter, J P Brun. Prefrontal cortical modulation of acetylcholine release in posterior parietal cortex. Neuroscience. vol 132. issue 2. 2005-07-05. PMID:15802188. |
these studies demonstrate the capacity of the pfc to regulate ach release in the ppc via glutamatergic and cholinergic prefrontal mechanisms. |
2005-07-05 |
2023-08-12 |
human |
| B Prieto-Gómez, A M Vázquez-Alvarez, J L Martínez-Peña, C Reyes-Vázquez, P B Yang, N Dafn. Methylphenidate and amphetamine modulate differently the NMDA and AMPA glutamatergic transmission of dopaminergic neurons in the ventral tegmental area. Life sciences. vol 77. issue 6. 2005-07-05. PMID:15921995. |
both psychostimulants increased the prefrontal cortex's (pfc) glutamatergic epsc in the vta-da neurons. |
2005-07-05 |
2023-08-12 |
rat |
| Patricia Ohrmann, Ansgar Siegmund, Thomas Suslow, Katharina Spitzberg, Anette Kersting, Volker Arolt, Walter Heindel, Bettina Pfleidere. Evidence for glutamatergic neuronal dysfunction in the prefrontal cortex in chronic but not in first-episode patients with schizophrenia: a proton magnetic resonance spectroscopy study. Schizophrenia research. vol 73. issue 2-3. 2005-06-09. PMID:15653258. |
evidence for glutamatergic neuronal dysfunction in the prefrontal cortex in chronic but not in first-episode patients with schizophrenia: a proton magnetic resonance spectroscopy study. |
2005-06-09 |
2023-08-12 |
Not clear |
| Patricia Ohrmann, Ansgar Siegmund, Thomas Suslow, Katharina Spitzberg, Anette Kersting, Volker Arolt, Walter Heindel, Bettina Pfleidere. Evidence for glutamatergic neuronal dysfunction in the prefrontal cortex in chronic but not in first-episode patients with schizophrenia: a proton magnetic resonance spectroscopy study. Schizophrenia research. vol 73. issue 2-3. 2005-06-09. PMID:15653258. |
we investigated the glutamatergic neuronal metabolism of the dorsolateral prefrontal cortex with localized 1h magnetic resonance spectroscopy in 18 first-episode patients, 21 chronic patients with schizophrenia, and 21 age-matched controls. |
2005-06-09 |
2023-08-12 |
Not clear |
| A Del Arco, F Mor. Glutamate-dopamine in vivo interaction in the prefrontal cortex modulates the release of dopamine and acetylcholine in the nucleus accumbens of the awake rat. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 1. 2005-06-07. PMID:15599608. |
these studies suggest that dopamine function in pfc is modulated locally by prefrontal glutamatergic inputs and that glutamate and dopamine can act simultaneously to regulate gaba release in pfc. |
2005-06-07 |
2023-08-12 |
rat |
| Carlos Matute, Marcello Melone, Ainara Vallejo-Illarramendi, Fiorenzo Cont. Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics. Glia. vol 49. issue 3. 2005-03-01. PMID:15494981. |
to verify whether altered glial glutamate uptake contributes to the reduced efficacy of glutamatergic transmission reported in the prefrontal cortex of schizophrenics, we studied the expression of glt-1, the transporter responsible for most glutamate transport, in autoptic samples of prefrontal cortex using real time quantitative rt-pcr, immunocytochemistry, and functional assays. |
2005-03-01 |
2023-08-12 |
xenopus_laevis |
| Bassem F El-Khodor, Gonzalo Flores, Lalit K Srivastava, Patricia Boks. Effects of birth insult and stress at adulthood on excitatory amino acid receptors in adult rat brain. Synapse (New York, N.Y.). vol 54. issue 3. 2005-01-31. PMID:15452866. |
glutamatergic transmission at the level of the nucleus accumbens, prefrontal cortex, and hippocampus are known to modulate subcortical da activity. |
2005-01-31 |
2023-08-12 |
rat |