| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Zhong, Wenhua Liu, Zhen Ya. Aberrant regulation of synchronous network activity by the attention-deficit/hyperactivity disorder-associated human dopamine D4 receptor variant D4.7 in the prefrontal cortex. The Journal of physiology. vol 594. issue 1. 2016-10-05. PMID:26541360. |
we found that activation of hd4.7 induced over-suppression of glutamatergic excitatory network bursts and under-suppression of gabaergic inhibitory network bursts in the prefrontal cortex (pfc) circuitry. |
2016-10-05 |
2023-08-13 |
mouse |
| Ping Zhong, Wenhua Liu, Zhen Ya. Aberrant regulation of synchronous network activity by the attention-deficit/hyperactivity disorder-associated human dopamine D4 receptor variant D4.7 in the prefrontal cortex. The Journal of physiology. vol 594. issue 1. 2016-10-05. PMID:26541360. |
we found that, compared to the normal four-repeat variant hd4.4, the adhd-linked variant hd4.7 induces more suppression of glutamatergic excitatory network bursts and less suppression of gabaergic inhibitory network bursts in the pfc circuitry. |
2016-10-05 |
2023-08-13 |
mouse |
| Yuki Aoyama, Kazuya Toriumi, Akihiro Mouri, Tomoya Hattori, Eriko Ueda, Akane Shimato, Nami Sakakibara, Yuka Soh, Takayoshi Mamiya, Taku Nagai, Hyoung-Chun Kim, Masayuki Hiramatsu, Toshitaka Nabeshima, Kiyofumi Yamad. Prenatal Nicotine Exposure Impairs the Proliferation of Neuronal Progenitors, Leading to Fewer Glutamatergic Neurons in the Medial Prefrontal Cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 41. issue 2. 2016-09-20. PMID:26105135. |
accordingly, the density of glutamatergic neurons in the medial prefrontal cortex (medial pfc) was reduced, implying glutamatergic dysregulation. |
2016-09-20 |
2023-08-13 |
mouse |
| Takashi Uehara, Tomiki Sumiyoshi, Masayoshi Kurach. New Pharmacotherapy Targeting Cognitive Dysfunction of Schizophrenia via Modulation of GABA Neuronal Function. Current neuropharmacology. vol 13. issue 6. 2016-09-09. PMID:26630957. |
it is assumed that an imbalance of excitatory and inhibitory (e-i) activity induced by low activity of glutamatergic projections and pv-positive gaba interneurons in the prefrontal cortex resulted in sustained neural firing and gamma oscillation, leading to impaired cognitive function. |
2016-09-09 |
2023-08-13 |
Not clear |
| Jonathan W Lovelace, Alex Corches, Philip A Vieira, Alex S Hiroto, Ken Mackie, Edward Korzu. An animal model of female adolescent cannabinoid exposure elicits a long-lasting deficit in presynaptic long-term plasticity. Neuropharmacology. vol 99. 2016-08-30. PMID:25979486. |
here we show in a mouse model of female adolescent cannabinoid exposure deficient endocannabinoid (ecb)-mediated signaling and presynaptic forms of long-term depression at adult central glutamatergic synapses in the prefrontal cortex. |
2016-08-30 |
2023-08-13 |
mouse |
| J A Brown, T S Ramikie, M J Schmidt, R Báldi, K Garbett, M G Everheart, L E Warren, L Gellért, S Horváth, S Patel, Károly Mirnic. Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes. Molecular psychiatry. vol 20. issue 12. 2016-08-29. PMID:25623945. |
follow-up electrophysiological studies revealed a significant reduction in γ-aminobutyric acid (gaba) release probability without alterations in postsynaptic membrane properties or changes in glutamatergic release probability in the prefrontal cortex pyramidal neurons. |
2016-08-29 |
2023-08-13 |
mouse |
| Alexey Kozlenkov, Minghui Wang, Panos Roussos, Sergei Rudchenko, Mihaela Barbu, Marina Bibikova, Brandy Klotzle, Andrew J Dwork, Bin Zhang, Yasmin L Hurd, Eugene V Koonin, Michael Wegner, Stella Drachev. Substantial DNA methylation differences between two major neuronal subtypes in human brain. Nucleic acids research. vol 44. issue 6. 2016-08-29. PMID:26612861. |
to elucidate the role of dna methylation in neuronal differentiation, we developed a new protocol for separation of nuclei from the two major populations of human prefrontal cortex neurons--gabaergic interneurons and glutamatergic (glu) projection neurons. |
2016-08-29 |
2023-08-13 |
human |
| Dominik Strzelecki, Michał Podgórski, Olga Kałużyńska, Ludomir Stefańczyk, Magdalena Kotlicka-Antczak, Agnieszka Gmitrowicz, Piotr Grzela. Adding Sarcosine to Antipsychotic Treatment in Patients with Stable Schizophrenia Changes the Concentrations of Neuronal and Glial Metabolites in the Left Dorsolateral Prefrontal Cortex. International journal of molecular sciences. vol 16. issue 10. 2016-07-22. PMID:26501260. |
in patients with schizophrenia, the function of the glutamatergic system in the prefrontal cortex is impaired, which may promote negative and cognitive symptoms. |
2016-07-22 |
2023-08-13 |
Not clear |
| A Dincer, D P Gavin, K Xu, B Zhang, J T Dudley, E E Schadt, S Akbaria. Deciphering H3K4me3 broad domains associated with gene-regulatory networks and conserved epigenomic landscapes in the human brain. Translational psychiatry. vol 5. 2016-07-19. PMID:26575220. |
approximately 120 of the broadest h3k4me3 peaks in human pfc neurons, including many genes related to glutamatergic and dopaminergic signaling, were fully conserved in chimpanzee, macaque and mouse cortical neurons. |
2016-07-19 |
2023-08-13 |
mouse |
| Mariana C Diana, Marcos L Santoro, Gabriela Xavier, Camila Mauricio Santos, Leticia N Spindola, Patrícia N Moretti, Vanessa K Ota, Rodrigo A Bressan, Vanessa C Abilio, Sintia I Belanger. Low expression of Gria1 and Grin1 glutamate receptors in the nucleus accumbens of Spontaneously Hypertensive Rats (SHR). Psychiatry research. vol 229. issue 3. 2016-07-06. PMID:26296755. |
the aim of this study is to investigate glutamatergic receptors (gria1 and grin1) and glycine transporter (glyt1) gene expression in the prefrontal cortex (pfc) and nucleus accumbens (nacc) of shr animals. |
2016-07-06 |
2023-08-13 |
rat |
| A L Gray, T M Hyde, A Deep-Soboslay, J E Kleinman, M S Sodh. Sex differences in glutamate receptor gene expression in major depression and suicide. Molecular psychiatry. vol 20. issue 9. 2016-06-07. PMID:26169973. |
our data reveal higher expression levels of the majority of glutamatergic genes tested in the dorsolateral prefrontal cortex (dlpfc) in mdd (f21,59=2.32, p=0.006). |
2016-06-07 |
2023-08-13 |
human |
| Crystle J Kelly, Mei Huang, Herbert Meltzer, Marco Martin. Reduced Glutamatergic Currents and Dendritic Branching of Layer 5 Pyramidal Cells Contribute to Medial Prefrontal Cortex Deactivation in a Rat Model of Neuropathic Pain. Frontiers in cellular neuroscience. vol 10. 2016-06-02. PMID:27252623. |
here we show that 1 week after a peripheral neuropathic injury (spared nerve injury model) pyramidal cells in layer 5 (l5) of the rat medial pfc show responses to excitatory glutamatergic inputs that are reduced by about 50%, as well as reduced frequency of spontaneous excitatory synaptic currents. |
2016-06-02 |
2023-08-13 |
rat |
| B Granseth, F K Andersson, S H Lindströ. The initial stage of reversal learning is impaired in mice hemizygous for the vesicular glutamate transporter (VGluT1). Genes, brain, and behavior. vol 14. issue 6. 2016-05-10. PMID:26113146. |
thus, our genetic disruption of modulatory glutamatergic signaling, including that arising from pfc, appears to have impaired the first stage of reversal learning (extinguishing responses to previously rewarded stimuli). |
2016-05-10 |
2023-08-13 |
mouse |
| Susana Mingote, Nao Chuhma, Sheila V Kusnoor, Bianca Field, Ariel Y Deutch, Stephen Raypor. Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 49. 2016-04-20. PMID:26658874. |
no glutamatergic connections were found in the dorsal striatum, hippocampus, basolateral amygdala, or prefrontal cortex. |
2016-04-20 |
2023-08-13 |
mouse |
| Fikri Birey, Michelle Kloc, Manideep Chavali, Israa Hussein, Michael Wilson, Daniel J Christoffel, Tony Chen, Michael A Frohman, John K Robinson, Scott J Russo, Arianna Maffei, Adan Aguirr. Genetic and Stress-Induced Loss of NG2 Glia Triggers Emergence of Depressive-like Behaviors through Reduced Secretion of FGF2. Neuron. vol 88. issue 5. 2016-03-21. PMID:26606998. |
here, we report that ablation of ng2 glia in the prefrontal cortex (pfc) of the adult brain causes deficits in excitatory glutamatergic neurotransmission and astrocytic extracellular glutamate uptake and induces depressive-like behaviors in mice. |
2016-03-21 |
2023-08-13 |
mouse |
| Heather C Brenhouse, Britta S Thompson, Kai C Sonntag, Susan L Anderse. Extinction and reinstatement to cocaine-associated cues in male and female juvenile rats and the role of D1 dopamine receptor. Neuropharmacology. vol 95. 2016-03-08. PMID:25749358. |
we used extinction of place preferences for cocaine in juvenile male and female rats following genetic, cell-specific overexpression of d1 on glutamatergic cells in the pfc. |
2016-03-08 |
2023-08-13 |
human |
| Wagner C Martins, Vanessa Valgas dos Santos, Alessandra Antunes dos Santos, Samuel Vandresen-Filho, Tharine A Dal-Cim, Karen A de Oliveira, Claudia B N Mendes-de-Aguiar, Marcelo Farina, Rui Daniel Prediger, Giordano Gubert Viola, Carla I Tasc. Atorvastatin Prevents Cognitive Deficits Induced by Intracerebroventricular Amyloid-β1-40 Administration in Mice: Involvement of Glutamatergic and Antioxidant Systems. Neurotoxicity research. vol 28. issue 1. 2016-02-17. PMID:25827781. |
these results extend the notion of the protective action of atorvastatin against neuronal toxicity induced by aβ1-40 demonstrating that a pretreatment with atorvastatin prevents the spatial learning and memory deficits induced by aβ in rodents and promotes changes in glutamatergic and antioxidant systems mainly in prefrontal cortex. |
2016-02-17 |
2023-08-13 |
mouse |
| Taira Mayanagi, Hiroki Yasuda, Kenji Sobu. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 42. 2016-01-25. PMID:26490870. |
these abnormal behaviors are caused by impaired glutamatergic synapse transmission accompanied by tiny-headed immature dendritic spines in the pfc, due to aberrant rap2 activation, which has roles in synapse formation and plasticity. |
2016-01-25 |
2023-08-13 |
mouse |
| Scott M Thompson, Angy J Kallarackal, Mark D Kvarta, Adam M Van Dyke, Tara A LeGates, Xiang Ca. An excitatory synapse hypothesis of depression. Trends in neurosciences. vol 38. issue 5. 2016-01-19. PMID:25887240. |
here, we propose an excitatory synapse hypothesis of depression in which chronic stress and genetic susceptibility cause changes in the strength of subsets of glutamatergic synapses at multiple locations, including the prefrontal cortex (pfc), hippocampus, and nucleus accumbens (nac), leading to a dysfunction of corticomesolimbic reward circuitry that underlies many of the symptoms of depression. |
2016-01-19 |
2023-08-13 |
Not clear |
| Xiusong Wang, Lei Liu, Wendy Adams, Shouxin Li, Qian Zhang, Bingjin Li, Min Wang, Ranji Cu. Cocaine exposure alters dopaminergic modulation of prefronto-accumbens transmission. Physiology & behavior. vol 145. 2016-01-04. PMID:25839095. |
in the nucleus accumbens (nac), dopamine transmission modulates glutamatergic input from the prefrontal cortex (pfc). |
2016-01-04 |
2023-08-13 |
rat |