| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Troels Rahbek-Clemmensen, Matthew D Lycas, Simon Erlendsson, Jacob Eriksen, Mia Apuschkin, Frederik Vilhardt, Trine N Jørgensen, Freja H Hansen, Ulrik Gethe. Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains. Nature communications. vol 8. issue 1. 2018-01-26. PMID:28963530. |
here, we use super-resolution imaging to show that the dopamine transporter is dynamically sequestrated into cholesterol-dependent nanodomains in the plasma membrane of presynaptic varicosities and neuronal projections of dopaminergic neurons. |
2018-01-26 |
2023-08-13 |
Not clear |
| Troels Rahbek-Clemmensen, Matthew D Lycas, Simon Erlendsson, Jacob Eriksen, Mia Apuschkin, Frederik Vilhardt, Trine N Jørgensen, Freja H Hansen, Ulrik Gethe. Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains. Nature communications. vol 8. issue 1. 2018-01-26. PMID:28963530. |
the molecular organization of the dopamine transporter in nanodomains is reversibly reduced by short-term activation of nmda-type ionotropic glutamate receptors, implicating dopamine transporter nanodomain distribution as a potential mechanism to modulate dopaminergic neurotransmission in response to excitatory input.the dopamine transporter (dat) has a crucial role in the regulation of neurotransmission. |
2018-01-26 |
2023-08-13 |
Not clear |
| Jacob Taylor, William S Anderson, Jason Brandt, Zoltan Mari, Gregory M Ponton. Neuropsychiatric Complications of Parkinson Disease Treatments: Importance of Multidisciplinary Care. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 24. issue 12. 2018-01-17. PMID:27746069. |
specifically, they describe the clinical associations between motor fluctuations and anxiety and depressive symptoms, the compulsive overuse of dopaminergic medications prescribed for motor symptoms (the dopamine dysregulation syndrome), and neuropsychiatric complications of these medications, including impulse control disorders, psychosis, and manic syndromes. |
2018-01-17 |
2023-08-13 |
Not clear |
| Sinead E Shortall, Clare H Spicer, Francis J P Ebling, A Richard Green, Kevin C F Fone, Madeleine V Kin. Contribution of serotonin and dopamine to changes in core body temperature and locomotor activity in rats following repeated administration of mephedrone. Addiction biology. vol 21. issue 6. 2018-01-16. PMID:26180025. |
this study examined the effects of repeated mephedrone administration on locomotor activity, body temperature and striatal dopamine and 5-hydroxytryptamine (5-ht) levels and the role of dopaminergic and serotonergic neurons in these responses. |
2018-01-16 |
2023-08-13 |
rat |
| Thomas M Jeitner, Mike Kalogiannis, Boris F Krasnikov, Irving Gomolin, Morgan R Peltier, Graham R Mora. Linking Inflammation and Parkinson Disease: Hypochlorous Acid Generates Parkinsonian Poisons. Toxicological sciences : an official journal of the Society of Toxicology. vol 151. issue 2. 2018-01-16. PMID:27026709. |
overall, our findings suggest that chlorination of dopamine by hocl generates toxins that selectively kill dopaminergic neurons in the substantia nigra in a manner comparable to mpp+. |
2018-01-16 |
2023-08-13 |
mouse |
| Alba Tristán-Noguero, Héctor Díez, Cristina Jou, Mercè Pineda, Aida Ormazábal, Aurora Sánchez, Rafael Artuch, Àngels Garcia-Cazorl. Study of a fetal brain affected by a severe form of tyrosine hydroxylase deficiency, a rare cause of early parkinsonism. Metabolic brain disease. vol 31. issue 3. 2018-01-12. PMID:26686676. |
we observed a decreased expression in th and in other dopaminergic proteins, such as vmat 1 and 2 and dopamine receptors, especially d2dr. |
2018-01-12 |
2023-08-13 |
human |
| Steven De Laet, Hilde Colpin, Karla Van Leeuwen, Wim Van den Noortgate, Stephan Claes, Annelies Janssens, Luc Goossens, Karine Verschuere. Transactional Links Between Teacher-Student Relationships and Adolescent Rule-Breaking Behavior and Behavioral School Engagement: Moderating Role of a Dopaminergic Genetic Profile Score. Journal of youth and adolescence. vol 45. issue 6. 2018-01-12. PMID:27013478. |
in addition, we examined the moderating effect of genes by means of a biologically informed multilocus genetic profile score (bimps), a composite score reflecting the cumulative effect of multiple dopaminergic genes, with a higher score indicating higher dopamine signaling in the adolescent brain. |
2018-01-12 |
2023-08-13 |
Not clear |
| Mei Liu, Adam D Bachstetter, Wayne A Cass, Jonathan Lifshitz, Guoying Bin. Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury. Journal of neurotrauma. vol 34. issue 2. 2018-01-12. PMID:27142118. |
loss of neurons was accompanied by increased extracellular dopamine (da) turnover in the striatum, indicating enhanced dopaminergic activity in functional compensation after nigrostriatal damage. |
2018-01-12 |
2023-08-13 |
rat |
| Nivedita Bhattacharjee, Anupom Bora. Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson's disease. Neurochemistry international. vol 101. 2018-01-12. PMID:27732886. |
unilateral intranigral infusion of hcy (1.0 μmol in 2 μl) caused inhibition of mitochondrial complex-i activity, decrease in the level of striatal dopamine, loss of midbrain dopaminergic neurons, and motor abnormalities. |
2018-01-12 |
2023-08-13 |
rat |
| Carla Ferrada, Ramón Sotomayor-Zárate, Jorge Abarca, Katia Gyslin. The activation of metabotropic glutamate 5 receptors in the rat ventral tegmental area increases dopamine extracellular levels. Neuroreport. vol 28. issue 1. 2018-01-10. PMID:27870780. |
vta dopaminergic neurons release dopamine (da) from axon terminals in the innervated regions and somatodendritically in the vta itself. |
2018-01-10 |
2023-08-13 |
rat |
| Tian Wang, Lijie Wang, Cuiting Li, Bing Han, Zhenhua Wang, Ji Li, Yan Lv, Shuyun Wang, Fenghua F. Hydroxysafflor Yellow A Improves Motor Dysfunction in the Rotenone-Induced Mice Model of Parkinson's Disease. Neurochemical research. vol 42. issue 5. 2018-01-09. PMID:28097465. |
hsya treatment increased not only the number of th-containing dopaminergic neurons in substantia nigra, but also the dopamine content in the striatum in pd mice. |
2018-01-09 |
2023-08-13 |
mouse |
| Emily Barkley-Levenson, Adriana Galvá. Eye blink rate predicts reward decisions in adolescents. Developmental science. vol 20. issue 3. 2018-01-03. PMID:27061442. |
the ventral striatum displays hyper-responsiveness to reward in adolescents relative to other age groups, and animal research on the developmental trajectory of the dopaminergic system suggests that dopamine may underlie adolescent sensitivity to reward. |
2018-01-03 |
2023-08-13 |
human |
| Alpana Singh, Poonam Verma, Gillela Balaji, Supriti Samantaray, Kochupurackal P Mohanakuma. Nimodipine, an L-type calcium channel blocker attenuates mitochondrial dysfunctions to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. Neurochemistry international. vol 99. 2018-01-03. PMID:27395789. |
it attenuated mptp-induced loss of dopaminergic tyrosine hydroxylase positive neurons in substantia nigra, improved mitochondrial oxygen consumption and inhibited reactive oxygen species production in the striatal mitochondria measured using dichlorodihydrofluorescein fluorescence, but failed to block striatal dopamine depletion. |
2018-01-03 |
2023-08-13 |
mouse |
| Cody A Siciliano, Jason L Locke, Tiffany A Mathews, Marcelo F Lopez, Howard C Becker, Sara R Jone. Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains. Alcohol (Fayetteville, N.Y.). vol 58. 2018-01-03. PMID:27425261. |
together, these findings show differential autoreceptor effects on dopamine synthesis between c57bl/6j and dba/2j mice, and suggest that decreased dopaminergic activity is associated with excessive drinking. |
2018-01-03 |
2023-08-13 |
mouse |
| Payam Piray, Hanneke E M den Ouden, Marieke E van der Schaaf, Ivan Toni, Roshan Cool. Dopaminergic Modulation of the Functional Ventrodorsal Architecture of the Human Striatum. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 1. 2018-01-02. PMID:26494799. |
using systematic pharmacological manipulation of dopamine d2-receptors and resting-state functional imaging, we defined the functional architecture of the human striatum and quantified the effects of dopaminergic drugs on intrinsic effective connectivity between striatal subregions. |
2018-01-02 |
2023-08-13 |
human |
| Jacob J Crouse, Joseph R Phillips, Marjan Jahanshahi, Ahmed A Moustaf. Postural instability and falls in Parkinson's disease. Reviews in the neurosciences. vol 27. issue 5. 2018-01-02. PMID:26966928. |
the delayed effect of dopaminergic medication combined with the success of extrastriatal deep brain stimulation suggests that pi involves neurotransmitter systems other than dopamine and brain regions extending beyond the basal ganglia, further challenging the traditional view of pd as a predominantly single-system neurodegenerative disease. |
2018-01-02 |
2023-08-13 |
Not clear |
| Zahra Shahpiri, Roodabeh Bahramsoltani, Mohammad Hosein Farzaei, Fatemeh Farzaei, Roja Rahim. Phytochemicals as future drugs for Parkinson's disease: a comprehensive review. Reviews in the neurosciences. vol 27. issue 6. 2018-01-02. PMID:27124673. |
phytochemicals perform their antiparkinsonian effect through several mechanisms of action, including suppressing apoptosis (via the reduction of bax/bcl-2, caspase-3, -8, and -9, and α-synuclein accumulation), decreasing dopaminergic neuronal loss and dopamine depletion, reducing the expression of proinflammatory cytokines (such as prostaglandin e2, interleukin-6, interleukin-1β, and nuclear factor-κb), and modulating nuclear and cellular inflammatory signaling, elevation of neurotrophic factors, and improvement of antioxidant status. |
2018-01-02 |
2023-08-13 |
Not clear |
| Thomas Mülle. Current and investigational non-dopaminergic agents for management of motor symptoms (including motor complications) in Parkinson's disease. Expert opinion on pharmacotherapy. vol 18. issue 14. 2018-01-02. PMID:28847181. |
these so-called motor complications are characterized by involuntary movements as a result of an overstimulation of the nigrostriatal dopaminergic system or by temporary recurrence of motor symptoms, when beneficial effects of dopamine substituting drugs vane. |
2018-01-02 |
2023-08-13 |
Not clear |
| Thomas Mülle. Current and investigational non-dopaminergic agents for management of motor symptoms (including motor complications) in Parkinson's disease. Expert opinion on pharmacotherapy. vol 18. issue 14. 2018-01-02. PMID:28847181. |
expert opinion: non dopaminergic modulation of dopamine replacement is currently mostly investigated in well defined and selected patients with motor complications to get approval. |
2018-01-02 |
2023-08-13 |
Not clear |
| Xiou Cao, Alejandro Aballa. Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner. Current biology : CB. vol 26. issue 17. 2017-12-27. PMID:27524480. |
our findings indicate that dopamine signaling from the nervous system controls immunity in a cell-non-autonomous manner and identifies the dopaminergic system as a potential therapeutic target for not only infectious diseases but also a range of conditions that arise as a consequence of malfunctioning immune responses. |
2017-12-27 |
2023-08-13 |
caenorhabditis_elegans |