| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yeomoon Sim, Gunhyuk Park, Hyeyoon Eo, Eugene Huh, Pil Sung Gu, Seon-Pyo Hong, Youngmi Kim Pak, Myung Sook O. Protective effects of a herbal extract combination of Bupleurum falcatum, Paeonia suffruticosa, and Angelica dahurica against MPTP-induced neurotoxicity via regulation of nuclear receptor-related 1 protein. Neuroscience. vol 340. 2017-11-06. PMID:27771535. |
mabh prevented dopamine depletion and protected against dopaminergic neuronal degradation induced by mptp. |
2017-11-06 |
2023-08-13 |
mouse |
| Danielle E Mor, Elpida Tsika, Joseph R Mazzulli, Neal S Gould, Hanna Kim, Malcolm J Daniels, Shachee Doshi, Preetika Gupta, Jennifer L Grossman, Victor X Tan, Robert G Kalb, Kim A Caldwell, Guy A Caldwell, John H Wolfe, Harry Ischiropoulo. Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. Nature neuroscience. vol 20. issue 11. 2017-11-02. PMID:28920936. |
efforts to explain dopamine neuron vulnerability are hindered by the lack of dopaminergic cell death in α-synuclein transgenic mice. |
2017-11-02 |
2023-08-13 |
mouse |
| Yu Liu, Deyong Lin, Boliang Wu, Wenhua Zho. Ketamine abuse potential and use disorder. Brain research bulletin. vol 126. issue Pt 1. 2017-10-30. PMID:27261367. |
it is hypothesized that ketamine blocks nmda receptors on gamma-aminobutyric acid (gaba) neurons inside the thalamic reticular nucleus, which leads to disinhibition of dopaminergic neurons and increased release of dopamine. |
2017-10-30 |
2023-08-13 |
Not clear |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model. PloS one. vol 12. issue 10. 2017-10-27. PMID:29028815. |
the dopaminergic debris were found within spheroids (free-spheroids) which retained some proteins of dopaminergic neurons (e.g., tyrosine hydroxylase, the dopamine transporter protein, and app) but not others (e.g., α-synuclein). |
2017-10-27 |
2023-08-13 |
rat |
| Nathalie Boot, Matthijs Baas, Simon van Gaal, Roshan Cools, Carsten K W De Dre. Creative cognition and dopaminergic modulation of fronto-striatal networks: Integrative review and research agenda. Neuroscience and biobehavioral reviews. vol 78. 2017-10-26. PMID:28419830. |
it is proposed that (i) creative cognition benefits from both flexible and persistent processing, (ii) striatal dopamine and the integrity of the nigrostriatal dopaminergic pathway is associated with flexible processing, while (iii) prefrontal dopamine and the integrity of the mesocortical dopaminergic pathway is associated with persistent processing. |
2017-10-26 |
2023-08-13 |
human |
| Haisong Jiang, Sung-Ung Kang, Shuran Zhang, Senthilkumar Karuppagounder, Jinchong Xu, Yong-Kyu Lee, Bong-Gu Kang, Yunjong Lee, Jianmin Zhang, Olga Pletnikova, Juan C Troncoso, Shelia Pirooznia, Shaida A Andrabi, Valina L Dawson, Ted M Dawso. Adult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons. eNeuro. vol 3. issue 4. 2017-10-25. PMID:27622213. |
adult conditional pgc-1α knock-out mice show a significant loss of dopaminergic neurons that is accompanied by a reduction of dopamine in the striatum. |
2017-10-25 |
2023-08-13 |
mouse |
| Alicia Stievenard, Mathieu Méquinion, Zane B Andrews, Alain Destée, Marie-Christine Chartier-Harlin, Odile Viltart, Christel C Vanbesien-Maillio. Is there a role for ghrelin in central dopaminergic systems? Focus on nigrostriatal and mesocorticolimbic pathways. Neuroscience and biobehavioral reviews. vol 73. 2017-10-25. PMID:27914942. |
in this review, we discuss the role of ghrelin on dopaminergic neurons and its relevance in the search for new therapeutics for parkinson's disease- and anorexia nervosa-related dopamine deficits. |
2017-10-25 |
2023-08-13 |
Not clear |
| Chi Wang Ip, Laura-Christin Klaus, Akua A Karikari, Naomi P Visanji, Jonathan M Brotchie, Anthony E Lang, Jens Volkmann, James B Kopric. AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson's disease. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28143577. |
aav1/2-driven overexpression of human mutated a53t-α-synuclein in rat and monkey substantia nigra (sn) induces degeneration of nigral dopaminergic neurons and decreases striatal dopamine and tyrosine hydroxylase (th). |
2017-10-25 |
2023-08-13 |
mouse |
| Francesco Longo, Daniela Mercatelli, Salvatore Novello, Ludovico Arcuri, Alberto Brugnoli, Fabrizio Vincenzi, Isabella Russo, Giulia Berti, Omar S Mabrouk, Robert T Kennedy, Derya R Shimshek, Katia Varani, Luigi Bubacco, Elisa Greggio, Michele Morar. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28292328. |
density of striatal dopaminergic terminals, nigral cell counts, tyrosine hydroxylase protein levels as well as exocytotic dopamine release measured in striatal synaptosomes, or striatal extracellular dopamine levels monitored by in vivo microdialysis were similar between ≥12-month-old g2019s knock-in mice and wild-type controls. |
2017-10-25 |
2023-08-13 |
mouse |
| Francesco Longo, Daniela Mercatelli, Salvatore Novello, Ludovico Arcuri, Alberto Brugnoli, Fabrizio Vincenzi, Isabella Russo, Giulia Berti, Omar S Mabrouk, Robert T Kennedy, Derya R Shimshek, Katia Varani, Luigi Bubacco, Elisa Greggio, Michele Morar. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta neuropathologica communications. vol 5. issue 1. 2017-10-25. PMID:28292328. |
we conclude that the g2019s mutation causes progressive dysfunctions of dopamine transporters, along with serine129-phosphorylated α-synuclein overload, at striatal dopaminergic terminals, which are not associated with dopamine homeostasis dysregulation or neuron loss but might contribute to intrinsic dopaminergic terminal vulnerability. |
2017-10-25 |
2023-08-13 |
mouse |
| Oliver Grimm, Stefan Kaiser, Michael M Plichta, Philippe N Toble. Altered reward anticipation: Potential explanation for weight gain in schizophrenia? Neuroscience and biobehavioral reviews. vol 75. 2017-10-24. PMID:28143762. |
several lines of evidence, running from animal studies to preclinical and clinical studies, suggest that striatal dopaminergic neurotransmission is a major hub for the regulation of eating behavior and that dopamine links eating behavior to other motivated behavior. |
2017-10-24 |
2023-08-13 |
Not clear |
| Tiphaine Pouvreau, Emmanuelle Tagliabue, Yusuf Usun, Séverine Eybrard, Francisca Meyer, Alain Louilo. Neonatal Prefrontal Inactivation Results in Reversed Dopaminergic Responses in the Shell Subregion of the Nucleus Accumbens to NMDA Antagonists. ACS chemical neuroscience. vol 7. issue 7. 2017-10-19. PMID:27145294. |
the results showed that postnatal blockade of the prefrontal cortex led to increased locomotor activity as well as increased extracellular dopamine levels in the dorsomedian shell following administration of both noncompetitive nmda receptor antagonists, and, more markedly, after treatment with the more specific one, mk-801, whereas decreased dopaminergic levels were observed in respective controls. |
2017-10-19 |
2023-08-13 |
rat |
| Concepción García, Cristina Palomo-Garo, Yolanda Gómez-Gálvez, Javier Fernández-Rui. Cannabinoid-dopamine interactions in the physiology and physiopathology of the basal ganglia. British journal of pharmacology. vol 173. issue 13. 2017-10-12. PMID:26059564. |
additional evidence suggests that cb2 receptors may be located in nigrostriatal dopaminergic neurons, and that certain eicosanoid-related cannabinoids may directly activate trpv1 receptors, which have been found in nigrostriatal dopaminergic neurons, thus allowing in both cases a direct regulation of dopamine transmission by specific cannabinoids. |
2017-10-12 |
2023-08-13 |
Not clear |
| Anna Migdalska-Richards, Michal Wegrzynowicz, Raffaella Rusconi, Giulio Deangeli, Donato A Di Monte, Maria G Spillantini, Anthony H V Schapir. The L444P Gba1 mutation enhances alpha-synuclein induced loss of nigral dopaminergic neurons in mice. Brain : a journal of neurology. vol 140. issue 10. 2017-10-06. PMID:28969384. |
gba1 mutations alone did not alter the number of nigral dopaminergic neurons nor striatal dopamine levels. |
2017-10-06 |
2023-08-13 |
mouse |
| Kate Karelina, Kristopher R Gaier, Zachary M Wei. Traumatic brain injuries during development disrupt dopaminergic signaling. Experimental neurology. vol 297. 2017-10-05. PMID:28802560. |
in order to determine the effect of juvenile brain injury on dopaminergic signaling, female mice were injured at 21days of age and then beginning seven weeks later were assessed for behavioral sensitization to amphetamine, a drug that increases synaptic dopamine availability. |
2017-10-05 |
2023-08-13 |
mouse |
| Daniel J Foster, Jermaine M Wilson, Daniel H Remke, M Suhaib Mahmood, M Jashim Uddin, Jürgen Wess, Sachin Patel, Lawrence J Marnett, Colleen M Niswender, Carrie K Jones, Zixiu Xiang, Craig W Lindsley, Jerri M Rook, P Jeffrey Con. Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release. Neuron. vol 91. issue 6. 2017-10-03. PMID:27618677. |
here, we report that activation of m4 receptors on striatal spiny projection neurons results in a novel form of dopaminergic regulation resulting in a sustained depression of striatal dopamine release that is observed more than 30 min after removal of the muscarinic receptor agonist. |
2017-10-03 |
2023-08-13 |
Not clear |
| Hayate Javed, Mohammad Amjad Kamal, Shreesh Ojh. An Overview on the Role of α -Synuclein in Experimental Models of Parkinson's Disease from Pathogenesis to Therapeutics. CNS & neurological disorders drug targets. vol 15. issue 10. 2017-10-02. PMID:27658511. |
biochemically, pd is characterized by lack of dopamine production and its action due to loss of dopaminergic neurons and neuropathologically by the presence of intracytoplasmic inclusions known as lewy bodies, which mainly consist of presynaptic neuronal protein, α-synuclein (α-syn). |
2017-10-02 |
2023-08-13 |
mouse |
| Fernanda M Lopes, Leonardo Lisbôa da Motta, Marco A De Bastiani, Bianca Pfaffenseller, Bianca W Aguiar, Luiz F de Souza, Geancarlo Zanatta, Daiani M Vargas, Patrícia Schönhofen, Giovana F Londero, Liana M de Medeiros, Valder N Freire, Alcir L Dafre, Mauro A A Castro, Richard B Parsons, Fabio Klam. RA Differentiation Enhances Dopaminergic Features, Changes Redox Parameters, and Increases Dopamine Transporter Dependency in 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells. Neurotoxicity research. vol 31. issue 4. 2017-10-02. PMID:28155214. |
ra differentiation enhances dopaminergic features, changes redox parameters, and increases dopamine transporter dependency in 6-hydroxydopamine-induced neurotoxicity in sh-sy5y cells. |
2017-10-02 |
2023-08-13 |
human |
| E van de Giessen, J J Weinstein, C M Cassidy, M Haney, Z Dong, R Ghazzaoui, N Ojeil, L S Kegeles, X Xu, N P Vadhan, N D Volkow, M Slifstein, A Abi-Dargha. Deficits in striatal dopamine release in cannabis dependence. Molecular psychiatry. vol 22. issue 1. 2017-09-29. PMID:27001613. |
to test whether cannabis dependence is associated with a similar dopaminergic deficit, we examined striatal and extrastriatal dopamine release in severely cannabis-dependent participants (cd), free of any comorbid conditions, including nicotine use. |
2017-09-29 |
2023-08-13 |
human |
| Martin Paucar, Stanislav Beniaminov, Wojciech Paslawski, Per Svenningsso. PSP-CBS with Dopamine Deficiency in a Female with a FMR1 Premutation. Cerebellum (London, England). vol 15. issue 5. 2017-09-25. PMID:27230899. |
imaging displays a marked reduction of presynaptic dopaminergic uptake and cerebrospinal fluid analysis showed reduced dopamine metabolism; however, the patient is unresponsive to levodopa. |
2017-09-25 |
2023-08-13 |
Not clear |