| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Abad, J Camarasa, D Pubill, A Camins, E Escubed. Adaptive Plasticity in the Hippocampus of Young Mice Intermittently Exposed to MDMA Could Be the Origin of Memory Deficits. Molecular neurobiology. vol 53. issue 10. 2017-12-25. PMID:26687233. |
in parallel, mdma produced a decrease in dopamine (da) levels in the striatum at 2w, which were restored 3 months later, suggesting dopaminergic terminal regeneration (sprouting phenomenon). |
2017-12-25 |
2023-08-13 |
mouse |
| Chung-Yin Lin, Han-Yi Hsieh, Chiung-Mei Chen, Shang-Rung Wu, Chih-Hung Tsai, Chiung-Yin Huang, Mu-Yi Hua, Kuo-Chen Wei, Chih-Kuang Yeh, Hao-Li Li. Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model. Journal of controlled release : official journal of the Controlled Release Society. vol 235. 2017-12-25. PMID:27235980. |
dopamine (da) and its metabolites as well as dopamine active transporter (dat) were quantitatively analyzed to show dopaminergic neuronal dopamine secretion/activity/metabolism. |
2017-12-25 |
2023-08-13 |
mouse |
| Nihar J Mehta, Karam Asmaro, David J Hermiz, Meredith M Njus, Ashraf H Saleh, Karen A Beningo, David Nju. Hypochlorite converts cysteinyl-dopamine into a cytotoxic product: A possible factor in Parkinson's Disease. Free radical biology & medicine. vol 101. 2017-12-25. PMID:27682361. |
the dopamine oxidation product cysteinyl-dopamine has attracted attention as a contributor to the death of dopaminergic neurons in parkinson's disease. |
2017-12-25 |
2023-08-13 |
Not clear |
| Nihar J Mehta, Karam Asmaro, David J Hermiz, Meredith M Njus, Ashraf H Saleh, Karen A Beningo, David Nju. Hypochlorite converts cysteinyl-dopamine into a cytotoxic product: A possible factor in Parkinson's Disease. Free radical biology & medicine. vol 101. 2017-12-25. PMID:27682361. |
this suggests that dopamine oxidation to cysteinyl-dopamine followed by hypochlorite-dependent conversion to a cytotoxic redox-cycling product leads to the generation of reactive oxygen species and oxidative stress and may contribute to the death of dopaminergic neurons. |
2017-12-25 |
2023-08-13 |
Not clear |
| Neha Sharma, Bimla Nehr. Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson's Disease Model. Molecular neurobiology. vol 53. issue 5. 2017-12-22. PMID:26081143. |
subsequently, this resulted in dopaminergic loss as depicted by decreased tyrosine hydroxylase (th) expression with substantial loss in neurotransmitter dopamine and its metabolites, whereas treatment with apocyanin significantly reduced the number of glial fibrillary acidic protein (gfap) and iba-1-positive cells in lps-treated animals. |
2017-12-22 |
2023-08-13 |
rat |
| Filipe C Matheus, Daniel Rial, Joana I Real, Cristina Lemos, Reinaldo N Takahashi, Leandro J Bertoglio, Rodrigo A Cunha, Rui D Predige. Temporal Dissociation of Striatum and Prefrontal Cortex Uncouples Anhedonia and Defense Behaviors Relevant to Depression in 6-OHDA-Lesioned Rats. Molecular neurobiology. vol 53. issue 6. 2017-12-22. PMID:26164273. |
these temporally dissociated behavioral alterations were coupled to temporal- and structure-dependent alterations in dopaminergic markers such as dopamine d1 and d2 receptors and dopamine transporter, leading to altered dopamine sensitivity in dls and pfc circuits, evaluated electrophysiologically. |
2017-12-22 |
2023-08-13 |
rat |
| Alexis C Edwards, Silviu-Alin Bacanu, Tim B Bigdeli, Arden Moscati, Kenneth S Kendle. Evaluating the dopamine hypothesis of schizophrenia in a large-scale genome-wide association study. Schizophrenia research. vol 176. issue 2-3. 2017-12-21. PMID:27338758. |
the dopamine hypothesis, which posits that dysregulation of the dopaminergic system is etiologic for schizophrenia, is among the most enduring biological theories in psychiatry. |
2017-12-21 |
2023-08-13 |
Not clear |
| Kevin T Ball, Olivia Best, Jonathan Luo, Leah R Mille. Chronic restraint stress causes a delayed increase in responding for palatable food cues during forced abstinence via a dopamine D Behavioural brain research. vol 319. 2017-12-21. PMID:27845229. |
because chronic stress causes dopamine d1-like receptor-mediated alterations in prefrontal cortex (a relapse node), we also assessed dopaminergic involvement by administering either sch-23390 (10.0μg/kg; i.p. |
2017-12-21 |
2023-08-13 |
rat |
| Evgeniya V Efimova, Raul R Gainetdinov, Evgeny A Budygin, Tatyana D Sotnikov. Dopamine transporter mutant animals: a translational perspective. Journal of neurogenetics. vol 30. issue 1. 2017-12-20. PMID:27276191. |
the dopamine transporter (dat) plays an important homeostatic role in the control of both the extracellular and intraneuronal concentrations of dopamine, thereby providing effective control over activity of dopaminergic transmission. |
2017-12-20 |
2023-08-13 |
mouse |
| Mia Levite, Franca Marino, Marco Cosentin. Dopamine, T cells and multiple sclerosis (MS). Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 5. 2017-12-20. PMID:28283756. |
dopamine itself, and also few dopaminergic molecules/ drugs that are in clinical use for cardiac, neurological and other non-immune indications, have direct effects on human t cells (summarized in this review). |
2017-12-20 |
2023-08-13 |
human |
| Mia Levite, Franca Marino, Marco Cosentin. Dopamine, T cells and multiple sclerosis (MS). Journal of neural transmission (Vienna, Austria : 1996). vol 124. issue 5. 2017-12-20. PMID:28283756. |
extensive evidence in multiple sclerosis (ms) and experimental autoimmune encephalomyelitis (eae) show dopaminergic dysregulations in t cells in these diseases: d1-like drs are decreased in teffs of ms patients, and dopamine does not affect these cells. |
2017-12-20 |
2023-08-13 |
human |
| Andréia S Cunha, Filipe C Matheus, Morgana Moretti, Tuane B Sampaio, Anicleto Poli, Danúbia B Santos, Dirleise Colle, Mauricio P Cunha, Carlos H Blum-Silva, Louis P Sandjo, Flávio H Reginatto, Ana Lúcia S Rodrigues, Marcelo Farina, Rui D Predige. Agmatine attenuates reserpine-induced oral dyskinesia in mice: Role of oxidative stress, nitric oxide and glutamate NMDA receptors. Behavioural brain research. vol 312. 2017-12-19. PMID:27306571. |
however, no changes were observed in striatal immunocontent of proteins related to the dopaminergic system including tyrosine hydroxylase, dopamine transporter, vesicular monoamine transporter type 2, pdarpp-32[thr75], dopamine d1 and d2 receptors. |
2017-12-19 |
2023-08-13 |
mouse |
| Caroline Calice da Silva, Bárbara Nunes Azevedo, Denise Cantarelli Machado, Eduardo R Zimmer, Leo Anderson Meira Martins, Jaderson Costa da Cost. Dissociation between dopaminergic response and motor behavior following intrastriatal, but not intravenous, transplant of bone marrow mononuclear stem cells in a mouse model of Parkinson's disease. Behavioural brain research. vol 324. 2017-12-13. PMID:28167338. |
parkinson's disease is characterized by the progressive loss of dopaminergic neurons from the substantia nigra, a process that leads to a dopamine deficiency in the striatum. |
2017-12-13 |
2023-08-13 |
mouse |
| Guohua Yu, Ajun Deng, Wanbin Tang, Junzhi Ma, Chonggang Yuan, Jiyan M. Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity. Neurochemistry international. vol 96. 2017-12-12. PMID:26970393. |
we found that ht effectively protected dopaminergic sh-sy5y cells against dopamine (da) and 6-hydroxydopamine (6-ohda) induced cell death, but had no apparent effect on 1-methyl-4-phenylpyridinium (mpp(+))-induced cytotoxicity. |
2017-12-12 |
2023-08-13 |
Not clear |
| Nicola Warren, Cullen O'Gorman, Alexander Lehn, Dan Siskin. Dopamine dysregulation syndrome in Parkinson's disease: a systematic review of published cases. Journal of neurology, neurosurgery, and psychiatry. vol 88. issue 12. 2017-12-12. PMID:29018160. |
dopamine dysregulation syndrome (dds) is an uncommon complication of the treatment of parkinson's disease, characterised by addictive behaviour and excessive use of dopaminergic medication. |
2017-12-12 |
2023-08-13 |
Not clear |
| David R Bonsall, Michelle Kokkinou, Mattia Veronese, Christopher Coello, Lisa A Wells, Oliver D Howe. Single cocaine exposure does not alter striatal pre-synaptic dopamine function in mice: an [ Journal of neurochemistry. vol 143. issue 5. 2017-12-07. PMID:28921596. |
our findings suggest that while the regulation of dopamine synthesis and release in the striatum have been shown to change with chronic cocaine use, leading to a reduced basal tone, these adaptations to pre-synaptic dopaminergic neurons are not initiated following a single exposure to the drug. |
2017-12-07 |
2023-08-13 |
mouse |
| Andrew Vo, Ken N Seergobin, Penny A MacDonal. Effects of levodopa on stimulus-response learning versus response selection in healthy young adults. Behavioural brain research. vol 317. 2017-12-04. PMID:27743941. |
according to this account, dopaminergic therapy should worsen cognitive functions in healthy young adults who have normal dopamine levels. |
2017-12-04 |
2023-08-13 |
human |
| Omar Ouachikh, Carine Chassain, Guilhem Pagès, Franck Durif, Aziz Hafid. mGlu5 receptor antagonist blocks bromocriptine-induced conditioned place preference in bilateral mesolimbic-lesioned rat. Behavioural brain research. vol 317. 2017-11-29. PMID:27638036. |
dopamine dysregulation syndrome (dds) has been attributed to both dopamine replacement therapies (drt) and the mesencephalic dopaminergic lesion. |
2017-11-29 |
2023-08-13 |
rat |
| Steven Tran, Amanda Facciol, Magda Nowicki, Diptendu Chatterjee, Robert Gerla. Acute alcohol exposure increases tyrosine hydroxylase protein expression and dopamine synthesis in zebrafish. Behavioural brain research. vol 317. 2017-11-29. PMID:27666381. |
in the current study, we characterize the effects of alcohol on the zebrafish dopaminergic system by focusing on tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis. |
2017-11-29 |
2023-08-13 |
zebrafish |
| Andrew Vo, Ken N Seergobin, Sarah A Morrow, Penny A MacDonal. Levodopa impairs probabilistic reversal learning in healthy young adults. Psychopharmacology. vol 233. issue 14. 2017-11-27. PMID:27241710. |
these paradoxical effects are explained by the dopamine overdose hypothesis, which proposes that effects of dopaminergic therapy on a cognitive function is determined by the baseline dopamine levels in brain regions mediating that function. |
2017-11-27 |
2023-08-13 |
Not clear |