| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Andrea Herrera-Soto, Gabriela Díaz-Veliz, Sergio Mora, Patricia Muñoz, Pablo Henny, Harry W M Steinbusch, Juan Segura-Aguila. On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo. Neurotoxicity research. vol 32. issue 1. 2018-03-27. PMID:28285345. |
because of a recent report that substantia nigra pars compacta (snpc) tyrosine hydroxylase (t-oh) levels were unaltered by aminochrome when there was cell shrinkage of dopaminergic neurons along with a reduction in striatal dopamine release, the following study was conducted to more accurately determine the role of dt-diaphorase in aminochrome neurotoxicity. |
2018-03-27 |
2023-08-13 |
rat |
| Kamal Awad, Abdelrahman Ibrahim Abushouk, Ahmed Helal AbdelKarim, Maged Mohammed, Ahmed Negida, Ali S Shalas. Bee venom for the treatment of Parkinson's disease: How far is it possible? Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-26. PMID:28477460. |
parkinson's disease (pd) is the second most common neurodegenerative disease, characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta leading to depletion of striatal dopamine and motor symptoms as bradykinesia, resting tremors, rigidity, and postural instability. |
2018-03-26 |
2023-08-13 |
bee |
| Kamal Awad, Abdelrahman Ibrahim Abushouk, Ahmed Helal AbdelKarim, Maged Mohammed, Ahmed Negida, Ali S Shalas. Bee venom for the treatment of Parkinson's disease: How far is it possible? Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 91. 2018-03-26. PMID:28477460. |
several mechanisms were suggested for these findings including the ability of bvt to attenuate neuroinflammation, inhibit apoptosis of dopaminergic neurons, protect against glutamate-induced neurotoxicity, and restore normal dopamine levels in the nigrostriatal pathway. |
2018-03-26 |
2023-08-13 |
bee |
| Taryn E Grieder, Olivier George, Mandy Yee, Michael A Bergamini, Michal Chwalek, Geith Maal-Bared, Hector Vargas-Perez, Derek van der Koo. Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism. The European journal of neuroscience. vol 46. issue 1. 2018-03-26. PMID:28498560. |
genetic deletion of α5 nachr subunits leads to a behavioural phenotype that exactly matches that observed after antagonizing dopamine receptors, thus we suggest that modulation of nicotinic receptors containing α5 subunits may modify dopaminergic signalling, suggesting novel therapeutic treatments for smoking cessation. |
2018-03-26 |
2023-08-13 |
mouse |
| N B Chesnokova, T A Pavlenko, M V Ugrumo. [Ophthalmic disorders as a manifestation of Parkinson's disease]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 117. issue 9. 2018-03-26. PMID:29053133. |
dopaminergic neurons and dopamine receptors are present in all structures of the eye. |
2018-03-26 |
2023-08-13 |
human |
| V V Pavshintsev, L S Podshivalova, O Y Frolova, M V Belopolskaya, O A Averina, E A Kushnir, N V Marmiy, M L Lova. Effects of Mitochondrial Antioxidant SkQ1 on Biochemical and Behavioral Parameters in a Parkinsonism Model in Mice. Biochemistry. Biokhimiia. vol 82. issue 12. 2018-03-23. PMID:29486701. |
skq1 administration increased dopamine quantity and decreased signs of sensory-motor deficiency as well as destruction of dopaminergic neurons in the substantia nigra and ventral tegmental area in mice with the parkinson-like condition. |
2018-03-23 |
2023-08-13 |
mouse |
| Mari H Savolainen, Katrina Albert, Mikko Airavaara, Timo T Myöhäne. Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse. Experimental brain research. vol 235. issue 7. 2018-03-22. PMID:28439627. |
we found that lactacystin induced a parkinson's disease-like motor phenotype 5-7 days after injection in young and adult mice, and this was associated with widespread neuroinflammation based on glial cell markers, asyn accumulation in substantia nigra, striatal dopamine decrease, and loss of dopaminergic cell bodies in the substantia nigra and terminals in the striatum. |
2018-03-22 |
2023-08-13 |
mouse |
| Yukari Suda, Naoko Kuzumaki, Michiko Narita, Yusuke Hamada, Masahiro Shibasaki, Kenichi Tanaka, Hideki Tamura, Takashi Kawamura, Takashige Kondo, Akihiro Yamanaka, Minoru Narit. Effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-22. PMID:29378186. |
effect of ghrelin on the motor deficit caused by the ablation of nigrostriatal dopaminergic cells or the inhibition of striatal dopamine receptors. |
2018-03-22 |
2023-08-13 |
Not clear |
| Xiao H Wang, Christopher L Souders, Yuan H Zhao, Christopher J Martyniu. Paraquat affects mitochondrial bioenergetics, dopamine system expression, and locomotor activity in zebrafish (Danio rerio). Chemosphere. vol 191. 2018-03-15. PMID:29031050. |
we also measured endpoints related to larval behavior and dopaminergic signaling as paraquat is associated with degeneration of dopamine neurons. |
2018-03-15 |
2023-08-13 |
zebrafish |
| Daijiro Yanagisawa, Keisuke Oda, Masatoshi Inden, Shigehiro Morikawa, Toshiro Inubushi, Takashi Taniguchi, Masanori Hijioka, Yoshihisa Kitamura, Ikuo Tooyam. Fluorodopa is a Promising Fluorine-19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease. Journal of neuroscience research. vol 95. issue 7. 2018-03-12. PMID:27792255. |
it has been estimated that approximately 80% of the striatal dopamine and 50% of nigral dopaminergic neurons are lost before the onset of typical motor symptoms, indicating that early diagnosis of pd using noninvasive imaging is feasible. |
2018-03-12 |
2023-08-13 |
rat |
| J Andrew Albers, Pratap Chand, A Michael Anc. Multifactorial sleep disturbance in Parkinson's disease. Sleep medicine. vol 35. 2018-03-07. PMID:28619181. |
pathophysiologically, pd is characterized by selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta (snpc) and striatal dopamine depletion. |
2018-03-07 |
2023-08-13 |
Not clear |
| Alberto J Rico, Iria G Dopeso-Reyes, Eva Martínez-Pinilla, Diego Sucunza, Diego Pignataro, Elvira Roda, David Marín-Ramos, José L Labandeira-García, Susan R George, Rafael Franco, José L Lancieg. Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation. Brain structure & function. vol 222. issue 4. 2018-03-05. PMID:27612857. |
neurochemical evidence supporting dopamine d1-d2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation. |
2018-03-05 |
2023-08-13 |
monkey |
| Mathieu Schmitt, Benjamin Dehay, Erwan Bezard, F Javier Garcia-Ladon. U18666A, an activator of sterol regulatory element binding protein pathway, modulates presynaptic dopaminergic phenotype of SH-SY5Y neuroblastoma cells. Synapse (New York, N.Y.). vol 71. issue 9. 2018-03-01. PMID:28407359. |
our results, in line with previously reported effects of statins, demonstrate that direct stimulation of srebp translocation is associated to differentiation toward a dopaminergic-like phenotype and suggest that srebp-mediated transcriptional activity may lead to the restoration of the presynaptic dopamine markers and may contribute to neuroprotection of dopaminergic neurons. |
2018-03-01 |
2023-08-13 |
Not clear |
| Lizheng Wang, Zixuan Wang, Xiaoyu Xu, Rui Zhu, Jinpeng Bi, Wenmo Liu, Xinyao Feng, Hui Wu, Haihong Zhang, Jiaxin Wu, Wei Kong, Bin Yu, Xianghui Y. Recombinant AAV8-mediated intrastriatal gene delivery of CDNF protects rats against methamphetamine neurotoxicity. International journal of medical sciences. vol 14. issue 4. 2018-03-01. PMID:28553166. |
however, the effect of cerebral dopamine neurotrophic factor (cdnf), which has been reported to be more specific and efficient than gdnf in protecting dopaminergic neurons against 6-ohda toxicity, in attenuating meth neurotoxicity has not been determined. |
2018-03-01 |
2023-08-13 |
rat |
| Elena A Kozina, Aleksandr R Kim, Anna Y Kurina, Michael V Ugrumo. Cooperative synthesis of dopamine by non-dopaminergic neurons as a compensatory mechanism in the striatum of mice with MPTP-induced Parkinsonism. Neurobiology of disease. vol 98. 2018-02-27. PMID:27940203. |
since the late 80s it has been repeatedly shown that besides dopaminergic neurons, the brain contains so-called monoenzymatic neurons possessing one of the enzymes of dopamine (da) synthesis, tyrosine hydroxylase (th) or aromatic l-amino acid decarboxylase (aadc). |
2018-02-27 |
2023-08-13 |
mouse |
| Lanying Song, Marissa McMackin, Andy Nguyen, Gino Cortopass. Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism. Neurobiology of disease. vol 100. 2018-02-22. PMID:28042097. |
these double-mutant 'twinkpark' mice had 1, the highest mtdna deletion concentration in sn; 2, the lowest mitochondrial function and membrane potential; 3, the most severe neurobehavioral deficits at 19months; 4, the least dopaminergic neurons in the sn and lowest dopamine levels, i.e. |
2018-02-22 |
2023-08-13 |
mouse |
| Victor S Van Laar, Sarah B Berman, Teresa G Hasting. Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone. Neurobiology of disease. vol 91. 2018-02-20. PMID:27001148. |
mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone. |
2018-02-20 |
2023-08-13 |
rat |
| Victor S Van Laar, Sarah B Berman, Teresa G Hasting. Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone. Neurobiology of disease. vol 91. 2018-02-20. PMID:27001148. |
these results suggest that altering levels of mic60 in dopaminergic neuronal cells significantly affects both mitochondrial homeostasis and cellular vulnerability to the pd-relevant stressors dopamine and rotenone, carrying implications for pd pathogenesis. |
2018-02-20 |
2023-08-13 |
rat |
| A Samà, C Pérez-López, D Rodríguez-Martín, A Català, J M Moreno-Aróstegui, J Cabestany, E de Mingo, A Rodríguez-Moliner. Estimating bradykinesia severity in Parkinson's disease by analysing gait through a waist-worn sensor. Computers in biology and medicine. vol 84. 2018-02-20. PMID:28351715. |
current pd therapies are based on dopamine replacement, and given that bradykinesia is the symptom that best correlates with the dopaminergic deficiency, the knowledge of its fluctuations may be useful in the diagnosis, treatment and better understanding of the disease progression. |
2018-02-20 |
2023-08-13 |
Not clear |
| Tarek K Rajji, Benoit H Mulsant, Shinichiro Nakajima, Fernando Caravaggio, Takefumi Suzuki, Hiroyuki Uchida, Philip Gerretsen, Wanna Mar, Bruce G Pollock, David C Mamo, Ariel Graff-Guerrer. Cognition and Dopamine D The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 25. issue 1. 2018-02-15. PMID:27745822. |
cognition and dopamine d to assess the impact of reducing the dose of antipsychotics on cognition and dopaminergic d |
2018-02-15 |
2023-08-13 |
Not clear |