| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan P Covey, Hannah M Dantrassy, Natalie E Zlebnik, Iness Gildish, Joseph F Chee. Compromised Dopaminergic Encoding of Reward Accompanying Suppressed Willingness to Overcome High Effort Costs Is a Prominent Prodromal Characteristic of the Q175 Mouse Model of Huntington's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 18. 2017-08-14. PMID:27147652. |
although dopamine in the nucleus accumbens (nac) critically regulates motivation and altered dopamine signaling is implicated in hd, the nature of dopaminergic deficits and contribution to symptoms in hd is poorly understood. |
2017-08-14 |
2023-08-13 |
mouse |
| Ping Su, Fang Li. A peptide disrupting the D2R-DAT interaction protects against dopamine neurotoxicity. Experimental neurology. vol 295. 2017-08-14. PMID:28579325. |
dopamine reuptake from extracellular space to cytosol leads to accumulation of dopamine, which triggers neurotoxicity in dopaminergic neurons. |
2017-08-14 |
2023-08-13 |
Not clear |
| Sandy Stayte, Peggy Rentsch, Anna R Tröscher, Maximilian Bamberger, Kong M Li, Bryce Visse. Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo. PloS one. vol 12. issue 1. 2017-08-10. PMID:28121982. |
parkinson's disease is a chronic neurodegenerative disease characterized by a significant loss of dopaminergic neurons within the substantia nigra pars compacta region and a subsequent loss of dopamine within the striatum. |
2017-08-10 |
2023-08-13 |
mouse |
| Jodi J Weinstein, Muhammad O Chohan, Mark Slifstein, Lawrence S Kegeles, Holly Moore, Anissa Abi-Dargha. Pathway-Specific Dopamine Abnormalities in Schizophrenia. Biological psychiatry. vol 81. issue 1. 2017-08-09. PMID:27206569. |
in light of the clinical evidence implicating dopamine in schizophrenia and the prominent hypotheses put forth regarding alterations in dopaminergic transmission in this disease, molecular imaging has been used to examine multiple aspects of the dopaminergic system. |
2017-08-09 |
2023-08-13 |
Not clear |
| Alexandra N Smith, David Kabeli. The effects of dopamine receptor 1 and 2 agonists and antagonists on sexual and aggressive behaviors in male green anoles. PloS one. vol 12. issue 2. 2017-08-09. PMID:28187160. |
dopamine is a conserved neurotransmitter among vertebrates and dopaminergic receptors are also highly conserved among taxa. |
2017-08-09 |
2023-08-13 |
Not clear |
| Seyedeh Shohreh Ebrahimi, Shahrbanoo Oryan, Esmael Izadpanah, Kambiz Hassanzade. Thymoquinone exerts neuroprotective effect in animal model of Parkinson's disease. Toxicology letters. vol 276. 2017-08-08. PMID:28526446. |
dopamine levels of dopaminergic areas in the substantia nigra (sn) and striatum (st) measured using high-performance liquid chromatography. |
2017-08-08 |
2023-08-13 |
rat |
| Lena Rademacher, Susanne Prinz, Oliver Winz, Karsten Henkel, Claudia A Dietrich, Jörn Schmaljohann, Siamak Mohammadkhani Shali, Ina Schabram, Christian Stoppe, Paul Cumming, Ralf-Dieter Hilgers, Yoshitaka Kumakura, Mark Coburn, Felix M Mottaghy, Gerhard Gründer, Ingo Vernaleke. Effects of Smoking Cessation on Presynaptic Dopamine Function of Addicted Male Smokers. Biological psychiatry. vol 80. issue 3. 2017-08-07. PMID:26803340. |
there is evidence of abnormal cerebral dopamine transmission in nicotine-dependent smokers, but it is unclear whether dopaminergic abnormalities are due to acute nicotine abuse or whether they persist with abstinence. |
2017-08-07 |
2023-08-13 |
Not clear |
| Lu Gao, Wenbo Zhou, Breanna Symmes, Curt R Free. Re-Cloning the N27 Dopamine Cell Line to Improve a Cell Culture Model of Parkinson's Disease. PloS one. vol 11. issue 8. 2017-08-07. PMID:27512998. |
in the current study, we have performed multiple rounds of clonal cultures and have identified a dopaminergic cell clone expressing high levels of th and the dopamine transporter (dat). |
2017-08-07 |
2023-08-13 |
rat |
| Guillaume Becker, Mohamed Ali Bahri, Anne Michel, Fabian Hustadt, Gaëtan Garraux, André Luxen, Christian Lemaire, Alain Plenevau. Comparative assessment of 6-[ Journal of neurochemistry. vol 141. issue 4. 2017-08-07. PMID:28294334. |
comparative assessment of 6-[ because of the progressive loss of nigro-striatal dopaminergic terminals in parkinson's disease (pd), in vivo quantitative imaging of dopamine (da) containing neurons in animal models of pd is of critical importance in the preclinical evaluation of highly awaited disease-modifying therapies. |
2017-08-07 |
2023-08-13 |
rat |
| Nicholas W Simon, Bita Moghadda. Methylphenidate has nonlinear dose effects on cued response inhibition in adults but not adolescents. Brain research. vol 1654. issue Pt B. 2017-07-31. PMID:27431940. |
despite early evidence for a hyperactive adolescent dopaminergic system, recent data suggest that adolescent dopamine may be functionally hypoactive compared to in adults. |
2017-07-31 |
2023-08-13 |
rat |
| Alejandra Boronat-García, Marcela Palomero-Rivero, Magdalena Guerra-Crespo, Diana Millán-Aldaco, René Drucker-Colí. Intrastriatal Grafting of Chromospheres: Survival and Functional Effects in the 6-OHDA Rat Model of Parkinson's Disease. PloS one. vol 11. issue 8. 2017-07-31. PMID:27525967. |
here, we found that bovine-derived chromosphere-cell cultures exhibit a greater fraction of cells with a dopaminergic phenotype and higher dopamine release than cc. |
2017-07-31 |
2023-08-13 |
human |
| Mika Hirasawa-Fujita, Michael J Bly, Vicki L Ellingrod, Gregory W Dalack, Edward F Domin. Genetic Variation of the Mu Opioid Receptor (OPRM1) and Dopamine D2 Receptor (DRD2) is Related to Smoking Differences in Patients with Schizophrenia but not Bipolar Disorder. Clinical schizophrenia & related psychoses. vol 11. issue 1. 2017-07-31. PMID:28548579. |
inasmuch as endogenous opioid and dopaminergic systems are involved in smoking reinforcement, it is important to study mu opioid receptor (oprm1) a118g (rs1799971), dopamine d2 receptor (drd2) taq1a (rs1800497) genotypes, and sex differences among patients with schizophrenia or bipolar disorder. |
2017-07-31 |
2023-08-13 |
human |
| Na Hyea Kang, Candace H Carriere, Sarra G Bahna, Lennard P Nile. Altered melatonin MT Brain research. vol 1652. 2017-07-28. PMID:27693415. |
based on the interaction between the melatonergic and dopaminergic systems, we hypothesized that 6-hydroxydopamine-induced degeneration of dopamine neurons would affect the expression of melatonin receptors in the nigrostriatal pathway. |
2017-07-28 |
2023-08-13 |
rat |
| Thorsten Kahnt, Philippe N Toble. Dopamine Modulates the Functional Organization of the Orbitofrontal Cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 6. 2017-07-27. PMID:28069917. |
the primate orbitofrontal cortex (ofc) receives dopaminergic input from midbrain nuclei, but the role of dopamine in the ofc is still unclear. |
2017-07-27 |
2023-08-13 |
Not clear |
| Tim D Aumann, Mai Raabus, Doris Tomas, Agustinus Prijanto, Leonid Churilov, Nicholas C Spitzer, Malcolm K Horn. Differences in Number of Midbrain Dopamine Neurons Associated with Summer and Winter Photoperiods in Humans. PloS one. vol 11. issue 7. 2017-07-26. PMID:27428306. |
recent evidence indicates the number of dopaminergic neurons in the adult rodent hypothalamus and midbrain is regulated by environmental cues, including photoperiod, and that this occurs via up- or down-regulation of expression of genes and proteins that are important for dopamine (da) synthesis in extant neurons ('da neurotransmitter switching'). |
2017-07-26 |
2023-08-13 |
Not clear |
| Teresia Osborn, Penelope J Hallet. Seq-ing Markers of Midbrain Dopamine Neurons. Cell stem cell. vol 20. issue 1. 2017-07-26. PMID:28061349. |
(2017) identify specific markers of midbrain dopaminergic progenitors to improve their derivation and predict dopamine neuron content after engraftment. |
2017-07-26 |
2023-08-13 |
human |
| Rajesh Narendran, Divya Tumuluru, Maureen A May, Kodavali V Chowdari, Michael L Himes, Kelli Fasenmyer, W Gordon Frankle, Vishwajit L Nimgaonka. Cortical Dopamine Transmission as Measured with the [11C]FLB 457 - Amphetamine PET Imaging Paradigm Is Not Influenced by COMT Genotype. PloS one. vol 11. issue 6. 2017-07-19. PMID:27322568. |
the use of baseline dopamine d1 and d2/3 receptor binding potential (bpnd) as a proxy for dopaminergic tone is problematic because they reflect both endogenous dopamine levels (a change in radiotracer's apparent affinity) and receptor density. |
2017-07-19 |
2023-08-13 |
Not clear |
| Elma Aflaki, Daniel K Borger, Nima Moaven, Barbara K Stubblefield, Steven A Rogers, Samarjit Patnaik, Frank J Schoenen, Wendy Westbroek, Wei Zheng, Patricia Sullivan, Hideji Fujiwara, Rohini Sidhu, Zayd M Khaliq, Grisel J Lopez, David S Goldstein, Daniel S Ory, Juan Marugan, Ellen Sidransk. A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 28. 2017-07-18. PMID:27413154. |
dopaminergic neurons from patients with type 2 and type 1 gaucher disease with parkinsonism had reduced dopamine storage and dopamine transporter reuptake. |
2017-07-18 |
2023-08-13 |
human |
| Laura A Volpicelli-Daley, Deniz Kirik, Lindsay E Stoyka, David G Standaert, Ashley S Harm. How can rAAV-α-synuclein and the fibril α-synuclein models advance our understanding of Parkinson's disease? Journal of neurochemistry. vol 139 Suppl 1. 2017-07-14. PMID:27018978. |
the key features of these models are described, and the extent to which they recapitulate features of pd, such as α-synuclein inclusion formation, loss of dopaminergic synapses in the striatum, motor defects, inflammation, and dopamine neuron death. |
2017-07-14 |
2023-08-13 |
Not clear |
| Chamila C Kadigamuwa, Mapa S T Mapa, Kandatege Wimalasen. Lipophilic Cationic Cyanines Are Potent Complex I Inhibitors and Specific in Vitro Dopaminergic Toxins with Mechanistic Similarities to Both Rotenone and MPP(.). Chemical research in toxicology. vol 29. issue 9. 2017-07-14. PMID:27510327. |
these and other findings suggest that the complex i inhibition, the expression of low levels of antioxidant enzymes, and presence of high levels of oxidatively labile radical propagator, dopamine, could be responsible for the specific increase in ros production in dopaminergic cells. |
2017-07-14 |
2023-08-13 |
Not clear |