| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bo Zhao, Junling Zhu, Dongqing Dai, Junling Xing, Jiahou He, Zhanyan Fu, Lei Zhang, Zhuyi Li, Wenting Wan. Differential dopaminergic regulation of inwardly rectifying potassium channel mediated subthreshold dynamics in striatal medium spiny neurons. Neuropharmacology. vol 107. 2017-06-19. PMID:27018450. |
our findings demonstrated the differential dopaminergic regulation role of kir, which mediates distinct subthreshold dynamics, and thus, contributes to the role of dopamine in fine tuning the balance of the striatal direct and indirect pathway activities. |
2017-06-19 |
2023-08-13 |
mouse |
| Daniele Caligiore, Francesco Mannella, Michael A Arbib, Gianluca Baldassarr. Dysfunctions of the basal ganglia-cerebellar-thalamo-cortical system produce motor tics in Tourette syndrome. PLoS computational biology. vol 13. issue 3. 2017-06-19. PMID:28358814. |
in particular, the model: (i) reproduces the main results of recent experiments about the involvement of the basal ganglia-cerebellar-thalamo-cortical system in tic generation; (ii) suggests an explanation of the system-level mechanisms underlying motor tic production: in this respect, the model predicts that the interplay between dopaminergic signal and cortical activity contributes to triggering the tic event and that the recently discovered basal ganglia-cerebellar anatomical pathway may support the involvement of the cerebellum in tic production; (iii) furnishes predictions on the amount of tics generated when striatal dopamine increases and when the cortex is externally stimulated. |
2017-06-19 |
2023-08-13 |
Not clear |
| Xiao-Feng Zhang, Mark Thompson, Yi-Hua X. Multifactorial theory applied to the neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease. Laboratory investigation; a journal of technical methods and pathology. vol 96. issue 5. 2017-06-12. PMID:26829122. |
oxidative stress and the metabolic processes of pq-inducing excitotoxicity, α-synuclein aggregate formation, autophagy, alteration of dopamine catabolism, and inactivation of tyrosine hydroxylase are positioned as causes for the loss of dopaminergic cells. |
2017-06-12 |
2023-08-13 |
human |
| Ingrid Morales, Alberto Sanchez, Clara Rodriguez-Sabate, Manuel Rodrigue. The astrocytic response to the dopaminergic denervation of the striatum. Journal of neurochemistry. vol 139. issue 1. 2017-06-09. PMID:27230040. |
increasing evidence suggests that the dopaminergic degeneration which characterizes parkinson's disease starts in the striatal dopamine terminals and progresses retrogradely to the body of dopamine cells in the substantia nigra. |
2017-06-09 |
2023-08-13 |
rat |
| Tien-Chun Yang, Pei-Chun Wu, I-Fang Chung, Jhih-Hang Jiang, Ming-Ji Fann, Lung-Sen Ka. Cell death caused by the synergistic effects of zinc and dopamine is mediated by a stress sensor gene Gadd45b - implication in the pathogenesis of Parkinson's disease. Journal of neurochemistry. vol 139. issue 1. 2017-06-09. PMID:27385273. |
the pathogenesis of parkinson's disease (pd) is not completely understood, zinc (zn(2+) ) and dopamine (da) have been shown to involve in the degeneration of dopaminergic cells. |
2017-06-09 |
2023-08-13 |
mouse |
| Tien-Chun Yang, Pei-Chun Wu, I-Fang Chung, Jhih-Hang Jiang, Ming-Ji Fann, Lung-Sen Ka. Cell death caused by the synergistic effects of zinc and dopamine is mediated by a stress sensor gene Gadd45b - implication in the pathogenesis of Parkinson's disease. Journal of neurochemistry. vol 139. issue 1. 2017-06-09. PMID:27385273. |
zinc and dopamine are implicated in the degeneration of dopaminergic neurons. |
2017-06-09 |
2023-08-13 |
mouse |
| Li-Ping Liang, Jie Huang, Ruth Fulton, Jennifer N Pearson-Smith, Brian J Day, Manisha Pate. Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson's disease. Toxicology and applied pharmacology. vol 326. 2017-06-06. PMID:28400118. |
all of these compounds protected against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neurotoxicity, including dopamine depletion in the striatum, dopaminergic neuronal loss in the substantial nigra, and increased oxidative/nitrative stress indices (glutathione disulfide and 3-nitrotyrosine) in the ventral midbrain of the mice without inhibiting mptp metabolism. |
2017-06-06 |
2023-08-13 |
mouse |
| Michal Rolinski, Ludovica Griffanti, Paola Piccini, Andreas A Roussakis, Konrad Szewczyk-Krolikowski, Ricarda A Menke, Timothy Quinnell, Zenobia Zaiwalla, Johannes C Klein, Clare E Mackay, Michele T M H. Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson's disease. Brain : a journal of neurology. vol 139. issue Pt 8. 2017-06-05. PMID:27297241. |
furthermore, we explore the relationship between resting state functional magnetic resonance imaging basal ganglia network dysfunction and loss of dopaminergic neurons assessed with dopamine transporter single photon emission computerized tomography, and perform morphometric analyses to assess grey matter loss. |
2017-06-05 |
2023-08-13 |
human |
| Yan Ke, Wentao Li, Zhiqun Tan, Zhikuan Yan. Induction of dopamine D1 and D5 receptors in R28 cells by light exposures. Biochemical and biophysical research communications. vol 486. issue 3. 2017-06-02. PMID:28336436. |
these results suggest that dopamine receptors in the retinal cells might actively respond to the environmental lighting to act as an important player in the activation of the dopaminergic system in the ocular structures relevant to the lighting-induced pathogenic development of myopia. |
2017-06-02 |
2023-08-13 |
rat |
| Yingying Sun, A Ninh Pham, T David Wait. Elucidation of the interplay between Fe(II), Fe(III), and dopamine with relevance to iron solubilization and reactive oxygen species generation by catecholamines. Journal of neurochemistry. vol 137. issue 6. 2017-06-01. PMID:26991725. |
the non-enzymatically catalyzed oxidation of dopamine (da) and the resultant formation of powerful oxidants such as the hydroxyl radical ((•) oh) through 'fenton chemistry' in the presence of iron within dopaminergic neurons are thought to contribute to the damage of cells or even lead to neuronal degenerative diseases such as parkinson's disease. |
2017-06-01 |
2023-08-13 |
Not clear |
| Michiel F Dirkx, Hanneke E M den Ouden, Esther Aarts, Monique H M Timmer, Bastiaan R Bloem, Ivan Toni, Rick C Helmic. Dopamine controls Parkinson's tremor by inhibiting the cerebellar thalamus. Brain : a journal of neurology. vol 140. issue 3. 2017-05-29. PMID:28073788. |
although parkinson's disease is characterized by dopamine depletion in the basal ganglia, the dopaminergic basis of resting tremor remains unclear: dopaminergic medication reduces tremor in some patients, but many patients have a dopamine-resistant tremor. |
2017-05-29 |
2023-08-13 |
Not clear |
| Charles R E Wilson, Julien Vezoli, Frederic M Stoll, Maïlys C M Faraut, Vincent Leviel, Kenneth Knoblauch, Emmanuel Procy. Prefrontal Markers and Cognitive Performance Are Dissociated during Progressive Dopamine Lesion. PLoS biology. vol 14. issue 11. 2017-05-24. PMID:27824858. |
using longitudinal recordings of frontal neurophysiological markers over many months during progressive dopaminergic lesion in non-human primates, we provide data that fail to support a simple interaction between dopamine, frontal function, and cognition. |
2017-05-24 |
2023-08-13 |
Not clear |
| Yu-Chia Chen, Svetlana Semenova, Stanislav Rozov, Maria Sundvik, Joshua L Bonkowsky, Pertti Panul. A Novel Developmental Role for Dopaminergic Signaling to Specify Hypothalamic Neurotransmitter Identity. The Journal of biological chemistry. vol 291. issue 42. 2017-05-22. PMID:27539857. |
further, we demonstrated that th2 knockdown increased histamine neuron number and histamine levels, whereas increased dopaminergic signaling using the dopamine precursor l-dopa (l-3,4-dihydroxyphenylalanine) or dopamine receptor agonists reduced the number of histaminergic neurons. |
2017-05-22 |
2023-08-13 |
zebrafish |
| Marija Fjodorova, Eduardo M Torres, Stephen B Dunnet. Transplantation site influences the phenotypic differentiation of dopamine neurons in ventral mesencephalic grafts in Parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131726. |
here we used rat foetal midbrain progenitors at two developmental stages corresponding to a peak in either a9 or a10 neurogenesis and examined their commitment to respective dopaminergic phenotypes by grafting cells into different forebrain regions that contain targets of either nigral a9 dopamine innervation (dorsal striatum), ventral tegmental area a10 dopamine innervation (nucleus accumbens and prefrontal cortex), or only sparse dopamine but rich noradrenaline innervation (hippocampus). |
2017-05-16 |
2023-08-13 |
rat |
| Fei Hao, Chun Yang, Sha-Sha Chen, Yan-Yan Wang, Wei Zhou, Qiang Hao, Tao Lu, Barry Hoffer, Li-Ru Zhao, Wei-Ming Duan, Qun-Yuan X. Long-term protective effects of AAV9-mesencephalic astrocyte-derived neurotrophic factor gene transfer in parkinsonian rats. Experimental neurology. vol 291. 2017-05-16. PMID:28131727. |
the hmanf gene transfer promoted the survival of nigral dopaminergic neurons, regeneration of striatal dopaminergic fibers and an upregulation of striatal dopamine levels, resulting in a long-term improvement of rotational behavior up to 16weeks after viral injections. |
2017-05-16 |
2023-08-13 |
human |
| Leonardo A Parra, Tracy B Baust, Amanda D Smith, Juliann D Jaumotte, Michael J Zigmond, Soledad Torres, Rehana K Leak, Jose A Pino, Gonzalo E Torre. The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization. The Journal of biological chemistry. vol 291. issue 34. 2017-05-12. PMID:27365397. |
overexpression of hsc70 in dopaminergic mn9d cells consistently resulted in increased th activity whereas knockdown of hsc70 by short hairpin rna resulted in decreased th activity and dopamine levels. |
2017-05-12 |
2023-08-13 |
mouse |
| H A Slagter, N C van Wouwe, K Kanoff, R P P P Grasman, D O Claassen, W P M van den Wildenberg, S A Wyli. Dopamine and temporal attention: An attentional blink study in Parkinson's disease patients on and off medication. Neuropsychologia. vol 91. 2017-05-10. PMID:27613667. |
we specifically examined 1) differences in the magnitude of the ab between unmedicated parkinson patients, who have depleted levels of striatal dopamine, and healthy controls, and 2) effects of two dopaminergic medications (l-dopa and dopamine agonists) on the ab in the parkinson patients at the group level and as a function of individual baseline performance. |
2017-05-10 |
2023-08-13 |
Not clear |
| Wei Hung Chang, Kao Chin Chen, I Hui Lee, Mei Hung Chi, Po See Chen, Wei Jen Yao, Nan Tsing Chiu, Yen Kuang Yan. Unaltered Dopamine Transporter Availability in Drug-Naive Patients With Schizophrenia After 6 Months of Antipsychotics Treatment: A Naturalistic Study. Journal of clinical psychopharmacology. vol 37. issue 1. 2017-05-10. PMID:28027110. |
dopaminergic dysfunction, namely, dopamine transporter (dat) availability variations in patients with drug-naive schizophrenia after long-term treatment, is still not well understood. |
2017-05-10 |
2023-08-13 |
Not clear |
| Elisa Straulino, Tomaso Scaravilli, Maria Bulgheroni, Enrico D'Amico, Umberto Castiell. It's all in the type of the task: Dopamine modulates kinematic patterns during competitive vs. cooperative interaction in Parkinson's disease. Neuropsychologia. vol 93. issue Pt A. 2017-05-09. PMID:27756693. |
since parkinson's disease (pd) provides a model for assessing dopaminergic dysfunctions in humans, our study was designed to investigate social interactions in pd patients receiving dopamine replacement therapy (levodopa=l-dopa) and in neurologically healthy controls. |
2017-05-09 |
2023-08-13 |
human |
| A Tammimaki, A Aonurm-Helm, M Kaenmaki, P T Mannist. Elimination of extracellular dopamine in the medial prefrontal cortex of conscious mice analysed using selective enzyme and uptake inhibitors. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 67. issue 2. 2017-05-05. PMID:27226189. |
this seems to indicate that such an extensive treatment induces a fast and effective shut-down of dopamine release both in the mpfc and striatum to protect the brain from excess dopaminergic stimulation. |
2017-05-05 |
2023-08-13 |
mouse |