| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah R Mikelman, Bipasha Guptaroy, Margaret E Gneg. Tamoxifen and its active metabolites inhibit dopamine transporter function independently of the estrogen receptors. Journal of neurochemistry. vol 141. issue 1. 2017-07-13. PMID:28075498. |
as one of the primary mechanisms by which dopamine signaling is regulated, the dopamine transporter (dat) is an attractive pharmacological target for the treatment of diseases based in dopaminergic dysfunction. |
2017-07-13 |
2023-08-13 |
Not clear |
| Brajesh Kumar Singh, Vinod Kumar, Amit Kumar Chauhan, Ashish Dwivedi, Shweta Singh, Ashutosh Kumar, Deepali Singh, Devendra Kumar Patel, Ratan Singh Ray, Swatantra Kumar Jain, Chetna Sing. Neuronal Nitric Oxide Synthase Negatively Regulates Zinc-Induced Nigrostriatal Dopaminergic Neurodegeneration. Molecular neurobiology. vol 54. issue 4. 2017-07-11. PMID:26995406. |
snp/snap discernibly alleviated zn-induced neurobehavioral impairments, dopaminergic neurodegeneration, tyrosine hydroxylase (th) expression, and striatal dopamine depletion. |
2017-07-11 |
2023-08-13 |
human |
| b' C\\xc3\\xa9sar Quiroz, Seema Gulyani, Wan Ruiqian, Jordi Bonaventura, Roy Cutler, Virginia Pearson, Richard P Allen, Christopher J Earley, Mark P Mattson, Sergi Ferr\\xc3\\xa. Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome. Neuropharmacology. vol 111. 2017-07-11. PMID:27600688.' |
nevertheless, they develop the main neurochemical dopaminergic changes found in rls, such as decrease in striatal dopamine d |
2017-07-11 |
2023-08-13 |
Not clear |
| Sabrina Scholz-Kornehl, Martin Schwärze. Circuit Analysis of a Drosophila Dopamine Type 2 Receptor That Supports Anesthesia-Resistant Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 30. 2017-07-10. PMID:27466338. |
additionally, dopaminergic neurons themselves require d2r, suggesting a critical role in dopamine release via its recognized autoreceptor function. |
2017-07-10 |
2023-08-13 |
drosophila_melanogaster |
| James B Koprich, Tom H Johnston, Gabriela Reyes, Vanessa Omana, Jonathan M Brotchi. Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson's Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Expression of Alpha Synuclein and Dopaminergic Degeneration in Macaque. PloS one. vol 11. issue 11. 2017-07-06. PMID:27902767. |
when injected into 4 sites within each substantia nigra (7 μl per site, 1.7 x 1012 gp/ml), this vector provided expression lasting at least 4 months, and a 50% loss of nigral dopaminergic neurons and a 60% reduction in striatal dopamine. |
2017-07-06 |
2023-08-13 |
human |
| Daniela Elgueta, María S Aymerich, Francisco Contreras, Andro Montoya, Marta Celorrio, Estefanía Rojo-Bustamante, Eduardo Riquelme, Hugo González, Mónica Vásquez, Rafael Franco, Rodrigo Pachec. Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease. Neuropharmacology. vol 113. issue Pt A. 2017-06-30. PMID:27693549. |
treatment of mptpp-intoxicated mice with pg01037 (30 mg/kg, administrated twice a week for five weeks) attenuated the loss of dopaminergic neurons in the substantia nigra pars compacta, as evaluated by stereological analysis, and the loss of striatal dopaminergic terminals, as determined by densitometric analyses of tyrosine hydroxylase and dopamine transporter immunoreactivities. |
2017-06-30 |
2023-08-13 |
mouse |
| Kishore K Joshi, Tarmie L Matlack, Christopher Rong. Dopamine signaling promotes the xenobiotic stress response and protein homeostasis. The EMBO journal. vol 35. issue 17. 2017-06-29. PMID:27261197. |
here, we show that dopaminergic mechanosensory neurons in c. elegans release the neurohormone dopamine to promote proteostasis in epithelia. |
2017-06-29 |
2023-08-13 |
Not clear |
| A H Ashok, T R Marques, S Jauhar, M M Nour, G M Goodwin, A H Young, O D Howe. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Molecular psychiatry. vol 22. issue 5. 2017-06-29. PMID:28289283. |
in bipolar depression imaging studies show increased dopamine transporter levels, but changes in other aspects of dopaminergic function are inconsistent. |
2017-06-29 |
2023-08-13 |
Not clear |
| A H Ashok, T R Marques, S Jauhar, M M Nour, G M Goodwin, A H Young, O D Howe. The dopamine hypothesis of bipolar affective disorder: the state of the art and implications for treatment. Molecular psychiatry. vol 22. issue 5. 2017-06-29. PMID:28289283. |
tentatively, this evidence suggests a model where an elevation in striatal d2/3 receptor availability would lead to increased dopaminergic neurotransmission and mania, whilst increased striatal dopamine transporter (dat) levels would lead to reduced dopaminergic function and depression. |
2017-06-29 |
2023-08-13 |
Not clear |
| Lauren E Sweet, Joseph H Bisesi, E N Y Lei, Michael H W Lam, Stephen J Klain. The effects of bupropion on hybrid striped bass brain chemistry and predatory behavior. Environmental toxicology and chemistry. vol 35. issue 8. 2017-06-28. PMID:26748934. |
although bupropion altered the concentration of dopamine and many of the dopaminergic neurotransmitter metabolite concentrations in the brains on day 3 of the exposure, it did not alter the time to capture prey. |
2017-06-28 |
2023-08-13 |
human |
| Guillermo Aquino-Miranda, Juan Escamilla-Sánchez, Raúl González-Pantoja, Antonio Bueno-Nava, José-Antonio Arias-Montañ. Histamine H3 receptor activation inhibits dopamine synthesis but not release or uptake in rat nucleus accumbens. Neuropharmacology. vol 106. 2017-06-27. PMID:26169221. |
we studied the effect of activating histamine h3 receptors (h3rs) on rat nucleus accumbens (rnacc) dopaminergic transmission by analyzing [(3)h]-dopamine uptake by synaptosomes, and dopamine synthesis and depolarization-evoked [(3)h]-dopamine release in slices. |
2017-06-27 |
2023-08-13 |
rat |
| Roberto De Luca, Tatsiana Suvorava, Danqing Yang, Wilhelm Baumgärtel, Georg Kojda, Helmut L Haas, Olga A Sergeev. Identification of histaminergic neurons through histamine 3 receptor-mediated autoinhibition. Neuropharmacology. vol 106. 2017-06-27. PMID:26297536. |
using a reporter mouse model with expression of the tomato fluorescent protein under the dopamine transporter promoter (tmt-dat) we discovered a new group of neurons in the histaminergic tuberomamillary nucleus (tmn), which, in contrast to tuberoinfundibular dopaminergic neurons of the dorsomedial arcuate nucleus, do not express tyrosine hydroxylase but can synthesize and store dopamine. |
2017-06-27 |
2023-08-13 |
mouse |
| Pier Francesca Porceddu, Ismail Ogunbayode Ishola, Liliana Contu, Micaela Morell. Metformin Prevented Dopaminergic Neurotoxicity Induced by 3,4-Methylenedioxymethamphetamine Administration. Neurotoxicity research. vol 30. issue 1. 2017-06-26. PMID:27251371. |
the neuroprotective effect of metformin on mdma-induced dopaminergic damage was evaluated by dopamine transporter (dat) and tyrosine hydroxylase (th) immunohistochemistry in snc and cpu. |
2017-06-26 |
2023-08-13 |
mouse |
| Kirsty Roberts, Andrew J Hemmings, Meriel Moore-Colyer, Matthew O Parker, Sebastian D McBrid. Neural modulators of temperament: A multivariate approach to personality trait identification in the horse. Physiology & behavior. vol 167. 2017-06-23. PMID:27597134. |
a relationship between dopamine and temperament has previously been described in human cases of dopaminergic dysfunction. |
2017-06-23 |
2023-08-13 |
human |
| Kirsty Roberts, Andrew J Hemmings, Meriel Moore-Colyer, Matthew O Parker, Sebastian D McBrid. Neural modulators of temperament: A multivariate approach to personality trait identification in the horse. Physiology & behavior. vol 167. 2017-06-23. PMID:27597134. |
potential mechanisms involving neural dopaminergic and gabaergic systems are presented, in addition to how such alterations could be utilised to probe for equine dopamine dysfunction pending future research. |
2017-06-23 |
2023-08-13 |
human |
| Douglas A Grow, DeNard V Simmons, Jorge A Gomez, Matthew J Wanat, John R McCarrey, Carlos A Paladini, Christopher S Navar. Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells. Stem cells translational medicine. vol 5. issue 9. 2017-06-22. PMID:27343168. |
we confirmed that bipsc-derived dopaminergic neurons resemble those found in the human midbrain based on cell type-specific expression of dopamine markers th and girk2. |
2017-06-22 |
2023-08-13 |
human |
| Matan Soll, Orit Bar Am, Atif Mahammed, Irena Saltsman, Silvia Mandel, Moussa B H Youdim, Zeev Gros. Neurorescue by a ROS Decomposition Catalyst. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27442690. |
important findings that accompanied the ability to rescue dopaminergic neurons were increased expression of phenotypic dopaminergic proteins, such as tyrosine hydroxylase (th) and dopamine transporter (dat), which were significantly depleted upon 6-ohda-mediated damage. |
2017-06-21 |
2023-08-13 |
Not clear |
| Kristen A Stout, Amy R Dunn, Kelly M Lohr, Shawn P Alter, Rachel A Cliburn, Thomas S Guillot, Gary W Mille. Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized Mice. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27501345. |
we report subregional differences in dopamine release, measured by ex vivo fast-scan cyclic voltammetry: rostral ventral pallidum exhibits increased dopamine release and uptake compared with caudal ventral pallidum, which is correlated with tissue expression of dopaminergic proteins. |
2017-06-21 |
2023-08-13 |
mouse |
| Kristen A Stout, Amy R Dunn, Kelly M Lohr, Shawn P Alter, Rachel A Cliburn, Thomas S Guillot, Gary W Mille. Selective Enhancement of Dopamine Release in the Ventral Pallidum of Methamphetamine-Sensitized Mice. ACS chemical neuroscience. vol 7. issue 10. 2017-06-21. PMID:27501345. |
moreover, this presynaptic dopaminergic plasticity occurred only in the ventral pallidum and not in the ventral or dorsal striatum, suggesting that dopamine release in the ventral pallidum may be integrally important to drug-induced sensitization. |
2017-06-21 |
2023-08-13 |
mouse |
| Nathan T Rodeberg, Justin A Johnson, Elizabeth S Bucher, R Mark Wightma. Dopamine Dynamics during Continuous Intracranial Self-Stimulation: Effect of Waveform on Fast-Scan Cyclic Voltammetry Data. ACS chemical neuroscience. vol 7. issue 11. 2017-06-21. PMID:27548680. |
many drugs of abuse that affect icss behavior target the dopaminergic system, and optogenetic activation of dopamine neurons is sufficient to support self-stimulation. |
2017-06-21 |
2023-08-13 |
Not clear |