| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ricarda Evens, Michael Hoefler, Karolina Biber, Ulrike Lueke. The Iowa Gambling Task in Parkinson's disease: A meta-analysis on effects of disease and medication. Neuropsychologia. vol 91. 2017-05-05. PMID:27475264. |
the dopamine overdose hypothesis assumes that dopaminergic effects follow an inverted u-shaped function, restoring some cognitive functions while overdosing others. |
2017-05-05 |
2023-08-13 |
Not clear |
| Kristoffer Carl Aberg, Kimberly Crystal Doell, Sophie Schwart. The left hemisphere learns what is right: Hemispatial reward learning depends on reinforcement learning processes in the contralateral hemisphere. Neuropsychologia. vol 89. 2017-05-04. PMID:27221149. |
because reward-based behavioural adaptation depends on the dopaminergic system and prediction error (pe) encoding in the ventral striatum, we hypothesized that hemispheric asymmetries in dopamine (da) function may determine individual spatial biases in reward learning. |
2017-05-04 |
2023-08-13 |
human |
| Ramin Ekhteiari Salmas, Philip Seeman, Busecan Aksoydan, Matthias Stein, Mine Yurtsever, Serdar Durdag. Biological Insights of the Dopaminergic Stabilizer ACR16 at the Binding Pocket of Dopamine D2 Receptor. ACS chemical neuroscience. vol 8. issue 4. 2017-05-02. PMID:28001043. |
biological insights of the dopaminergic stabilizer acr16 at the binding pocket of dopamine d2 receptor. |
2017-05-02 |
2023-08-13 |
human |
| Andrea Herrera, Patricia Muñoz, Harry W M Steinbusch, Juan Segura-Aguila. Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease? ACS chemical neuroscience. vol 8. issue 4. 2017-05-02. PMID:28233992. |
are dopamine oxidation metabolites involved in the loss of dopaminergic neurons in the nigrostriatal system in parkinson's disease? |
2017-05-02 |
2023-08-13 |
human |
| Andrea Herrera, Patricia Muñoz, Harry W M Steinbusch, Juan Segura-Aguila. Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease? ACS chemical neuroscience. vol 8. issue 4. 2017-05-02. PMID:28233992. |
aminochrome is formed within the cytoplasm of neuromelanin-containing dopaminergic neurons during the oxidation of dopamine to neuromelanin. |
2017-05-02 |
2023-08-13 |
human |
| Andrea Herrera, Patricia Muñoz, Harry W M Steinbusch, Juan Segura-Aguila. Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson's Disease? ACS chemical neuroscience. vol 8. issue 4. 2017-05-02. PMID:28233992. |
the oxidation of dopamine to neuromelanin is a normal and harmless process, because healthy individuals have intact neuromelanin-containing dopaminergic neurons. |
2017-05-02 |
2023-08-13 |
human |
| Marina Daiana Reguilón, Sandra Montagud-Romero, Carmen Ferrer-Pérez, Concepción Roger-Sánchez, María Asunción Aguilar, José Miñarro, Marta Rodríguez-Aria. Dopamine D European journal of pharmacology. vol 799. 2017-04-28. PMID:28132915. |
dopamine d social stress modifies the activity of brain areas involved in the rewarding effects of psychostimulants, inducing neuroadaptations in the dopaminergic mesolimbic system and modifying the sensitivity of dopamine receptors. |
2017-04-28 |
2023-08-13 |
Not clear |
| Peyton Weems, Jeremy Smith, Iain J Clarke, Lique M Coolen, Robert L Goodman, Michael N Lehma. Effects of Season and Estradiol on KNDy Neuron Peptides, Colocalization With D2 Dopamine Receptors, and Dopaminergic Inputs in the Ewe. Endocrinology. vol 158. issue 4. 2017-04-28. PMID:28324006. |
effects of season and estradiol on kndy neuron peptides, colocalization with d2 dopamine receptors, and dopaminergic inputs in the ewe. |
2017-04-28 |
2023-08-13 |
Not clear |
| Takashi Asano, Hirokazu Matsuzaki, Naohiro Iwata, Meiyan Xuan, Shinya Kamiuchi, Yasuhide Hibino, Takeshi Sakamoto, Mari Okazak. Protective Effects of Ferulic Acid against Chronic Cerebral Hypoperfusion-Induced Swallowing Dysfunction in Rats. International journal of molecular sciences. vol 18. issue 3. 2017-04-20. PMID:28273833. |
2vo rats had an increased level of superoxide anion radical, and decreased dopamine and tyrosine hydroxylase enzyme levels in the striatum, suggesting that 2vo augmented cerebral oxidative stress and impaired the striatal dopaminergic system. |
2017-04-20 |
2023-08-13 |
rat |
| Xiao-Huan Li, Chun-Fang Dai, Long Chen, Wei-Tao Zhou, Hui-Li Han, Zhi-Fang Don. 7,8-dihydroxyflavone Ameliorates Motor Deficits Via Suppressing α-synuclein Expression and Oxidative Stress in the MPTP-induced Mouse Model of Parkinson's Disease. CNS neuroscience & therapeutics. vol 22. issue 7. 2017-04-17. PMID:27079181. |
parkinson disease (pd) is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine content in the striatum, which is at least partly associated with α-synuclein protein overexpression in these neurons. |
2017-04-17 |
2023-08-13 |
mouse |
| Luke A Morgan, Oliver Grundman. Preclinical and Potential Applications of Common Western Herbal Supplements as Complementary Treatment in Parkinson's Disease. Journal of dietary supplements. vol 14. issue 4. 2017-04-17. PMID:28095073. |
current medication used in the treatment of pd aims to prevent the breakdown of dopamine or increase dopaminergic neurotransmission in the central nervous system. |
2017-04-17 |
2023-08-13 |
human |
| Daphne Atla. DopAmide: Novel, Water-Soluble, Slow-Release l-dihydroxyphenylalanine (l-DOPA) Precursor Moderates l-DOPA Conversion to Dopamine and Generates a Sustained Level of Dopamine at Dopaminergic Neurons. CNS neuroscience & therapeutics. vol 22. issue 6. 2017-04-14. PMID:26861609. |
dopamide: novel, water-soluble, slow-release l-dihydroxyphenylalanine (l-dopa) precursor moderates l-dopa conversion to dopamine and generates a sustained level of dopamine at dopaminergic neurons. |
2017-04-14 |
2023-08-13 |
Not clear |
| Baojian Guo, Chengyou Zheng, Wei Cai, Jiehong Cheng, Hongyu Wang, Haitao Li, Yewei Sun, Wei Cui, Yuqiang Wang, Yifan Han, Simon Ming-Yuen Lee, Zaijun Zhan. Multifunction of Chrysin in Parkinson's Model: Anti-Neuronal Apoptosis, Neuroprotection via Activation of MEF2D, and Inhibition of Monoamine Oxidase-B. Journal of agricultural and food chemistry. vol 64. issue 26. 2017-04-13. PMID:27245668. |
in this in vivo model of pd, chrysin rescued the dopaminergic neurons loss and alleviated the decrease in dopamine level induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. |
2017-04-13 |
2023-08-13 |
mouse |
| Florian Brugger, Kailash P Bhatia, Frank M C Besa. Valproate-Associated Parkinsonism: A Critical Review of the Literature. CNS drugs. vol 30. issue 6. 2017-04-11. PMID:27255404. |
a dopaminergic deficit was confirmed in three of six patients investigated with dopamine transporter imaging. |
2017-04-11 |
2023-08-13 |
Not clear |
| Diego Garcia-Borreguero, Irene Cano-Pumareg. New concepts in the management of restless legs syndrome. BMJ (Clinical research ed.). vol 356. 2017-03-31. PMID:28242627. |
however, the occurrence of dopaminergic augmentation and an overall increase in severity of symptoms during long term treatment with dopamine agonists is leading to a shift towards non-dopaminergic alternatives as initial treatments, and particularly to α |
2017-03-31 |
2023-08-13 |
Not clear |
| Liang Xiao-Feng, Zhu Wen-Ting, Xu Yuan-Yuan, Lai Chong-Fa, Zheng Lu, Rao Jin-Jun, Wang Wen-Y. Protective role of 6-Hydroxy-1-H-Indazole in an MPTP-induced mouse model of Parkinson's disease. European journal of pharmacology. vol 791. 2017-03-28. PMID:27614126. |
the results showed that mptp decreased the dopaminergic neurons in the substantia nigra and dopamine in the striatum, downregulated the expression of tyrosine hydroxylase (th), induced the impairment of behavior and hyperphosphorylation of tau, however, 6-hydroxy-1-h-indazole decreased the loss of dopaminergic neurons, increased dopamine concentration and th expression, alleviated the behavioral damage and level of phosphor-tau in the mptp-induced model of pd in c57bl/6 mice. |
2017-03-28 |
2023-08-13 |
mouse |
| Roshan Cool. The costs and benefits of brain dopamine for cognitive control. Wiley interdisciplinary reviews. Cognitive science. vol 7. issue 5. 2017-03-23. PMID:27507774. |
i aim to elucidate this across-task variability in dopaminergic drug efficacy by going beyond classic models that emphasize the importance of dopamine in the prefrontal cortex for cognitive control and working memory. |
2017-03-23 |
2023-08-13 |
Not clear |
| Willyan Franco Hilario, Alice Laschuk Herlinger, Lorena Bianchine Areal, Lívia Silveira de Moraes, Tamara Andrea Alarcon Ferreira, Tassiane Emanuelle Servane Andrade, Cristina Martins-Silva, Rita Gomes Wanderley Pire. Cholinergic and Dopaminergic Alterations in Nigrostriatal Neurons Are Involved in Environmental Enrichment Motor Protection in a Mouse Model of Parkinson's Disease. Journal of molecular neuroscience : MN. vol 60. issue 4. 2017-03-23. PMID:27660217. |
pd pharmacotherapy has been based on dopamine replacement in the striatum with the dopaminergic precursor 3,4-dihydroxyphenylalanine (l-dopa) and/or with dopaminergic agonists, alongside anticholinergic drugs in order to mitigate the motor abnormalities. |
2017-03-23 |
2023-08-13 |
mouse |
| Esmat Amiri, Rasoul Ghasemi, Maryam Moosav. Agmatine Protects Against 6-OHDA-Induced Apoptosis, and ERK and Akt/GSK Disruption in SH-SY5Y Cells. Cellular and molecular neurobiology. vol 36. issue 6. 2017-03-22. PMID:26346882. |
6-hydroxydopamine (6-ohda), a metabolite of dopamine is known to induce dopaminergic cell toxicity which makes that a suitable agent inducing an experimental model of parkinson's disease (pd). |
2017-03-22 |
2023-08-13 |
Not clear |
| A U Kurina, T S Pronina, L K Dilmukhametova, G V Maleev, M V Ugrumo. Cooperative Synthesis of Dopamine in Rat Mediobasal Hypothalamus as a Compensatory Mechanism in Hyperprolactinemia. Biochemistry. Biokhimiia. vol 82. issue 3. 2017-03-22. PMID:28320278. |
dopamine (da), synthesized in the mediobasal hypothalamus by dopaminergic neurons containing two enzymes of da synthesis - tyrosine hydroxylase and decarboxylase of aromatic l-amino acids, or by monoenzymatic non-dopaminergic neurons containing one da synthesis enzyme in cooperation, is known to have an inhibitory effect on prolactin secretion. |
2017-03-22 |
2023-08-13 |
rat |