| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José-Luis Ríos, María Onteniente, Dolores Picazo, María-Carmen Montesino. Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs. Planta medica. vol 82. issue 11-12. 2017-03-16. PMID:27224274. |
parkinson's disease is a progressive neurodegenerative dysfunction characterized by the loss of pigmented dopaminergic neurons of the nigrostriatal system with a consequent dopamine decrease. |
2017-03-16 |
2023-08-13 |
Not clear |
| José-Luis Ríos, María Onteniente, Dolores Picazo, María-Carmen Montesino. Medicinal Plants and Natural Products as Potential Sources for Antiparkinson Drugs. Planta medica. vol 82. issue 11-12. 2017-03-16. PMID:27224274. |
the reduction of dopamine levels produces neuronal damage, depigmentation of the substantia nigra, and the presence of intracellular inclusions in dopaminergic neurons. |
2017-03-16 |
2023-08-13 |
Not clear |
| Jia Yu, Xueting Li, Junwei Yang, Yanping Wu, Baixiang L. Effects of Simazine Exposure on Neuronal Development-Related Factors in MN9D Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-03-16. PMID:27513680. |
material and methods we used western blotting and real-time quantitative pcr to analyze the effects of simazine on dopamine neuronal development-related factors in mn9d dopaminergic cells. |
2017-03-16 |
2023-08-13 |
Not clear |
| Eliane Brito Cortez Lima, Caren Nádia Soares de Sousa, Lucas Nascimento Meneses, Yuri Freitas E Silva Pereira, Natália Castelo Branco Matos, Rayanne Brito de Freitas, Nycole Brito Cortez Lima, Manoel Cláudio Azevedo Patrocínio, Luzia Kalyne Almeida Moreira Leal, Glauce Socorro Barros Viana, Silvânia Maria Mendes Vasconcelo. Involvement of monoaminergic systems in anxiolytic and antidepressive activities of the standardized extract of Cocos nucifera L. Journal of natural medicines. vol 71. issue 1. 2017-03-14. PMID:27770304. |
the anxiolytic effect of hecn appears to be related to the gabaergic system, while its antidepressant effect depends upon its interaction with the serotoninergic, noradrenergic (α1 receptors), and dopaminergic (d2 dopamine receptors) systems. |
2017-03-14 |
2023-08-13 |
mouse |
| Hyemin Min, Esther Youn, Ichiro Kawasaki, Yhong-Hee Shi. Caffeine-induced food-avoidance behavior is mediated by neuroendocrine signals in Caenorhabditis elegans. BMB reports. vol 50. issue 1. 2017-03-10. PMID:27697105. |
in this process, the dopaminergic signaling appears to be the major pathway because the reduced aversion behavior in cat-2 mutants and mutants of jnk/mapk pathway genes was significantly recovered by pretreatment with dopamine. |
2017-03-10 |
2023-08-13 |
caenorhabditis_elegans |
| Masahiko Kawano, Hidehiro Oshibuchi, Takaaki Kawano, Hiroyuki Muraoka, Takahiro Tsutsumi, Makiko Yamada, Ken Inada, Jun Ishigook. Dopamine dynamics during emotional cognitive processing: Implications of the specific actions of clozapine compared with haloperidol. European journal of pharmacology. vol 781. 2017-03-08. PMID:27085900. |
although both antipsychotics attenuated phasic dopamine release in both the non-sensitised and sensitised rats, the attenuation extent was greater for clozapine than for haloperidol under both dopaminergic conditions. |
2017-03-08 |
2023-08-13 |
rat |
| Masahiko Kawano, Hidehiro Oshibuchi, Takaaki Kawano, Hiroyuki Muraoka, Takahiro Tsutsumi, Makiko Yamada, Ken Inada, Jun Ishigook. Dopamine dynamics during emotional cognitive processing: Implications of the specific actions of clozapine compared with haloperidol. European journal of pharmacology. vol 781. 2017-03-08. PMID:27085900. |
however, the specific dopaminergic state-dependent action of clozapine on both basal dopamine levels and stress-induced dopamine release may be the underlying mechanism for its superior clinical effect on emotional cognitive processing in patients with schizophrenia. |
2017-03-08 |
2023-08-13 |
rat |
| Adriana Wawer, Ilona Joniec-Maciejak, Anna Sznejder-Pachołek, Joanna Schwenkgrub, Agnieszka Ciesielska, Dagmara Mirowska-Guze. Exogenous α-Synuclein Monomers Alter Dopamine Metabolism in Murine Brain. Neurochemical research. vol 41. issue 8. 2017-03-03. PMID:27161373. |
among many functions, asn plays an important role in regulation of dopaminergic system by controlling dopamine concentration at nerve terminals. |
2017-03-03 |
2023-08-13 |
mouse |
| Sandra Gómez-López, Ana Valeria Martínez-Silva, Teresa Montiel, Daniel Osorio-Gómez, Federico Bermúdez-Rattoni, Lourdes Massieu, Diana Escalante-Alcald. Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration. Scientific reports. vol 6. 2017-03-02. PMID:27063549. |
yet, adult plpp3-deficient mice exhibited no alterations in the number of dopaminergic neurons or in the basal levels of striatal extracellular dopamine (da). |
2017-03-02 |
2023-08-13 |
mouse |
| Alfonso Fasano, Silke Appel-Cresswell, Mandar Jog, Mateusz Zurowkski, Sarah Duff-Canning, Melanie Cohn, Marina Picillo, Christopher R Honey, Michel Panisset, Renato Puppi Munho. Medical Management of Parkinson's Disease after Initiation of Deep Brain Stimulation. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 43. issue 5. 2017-02-22. PMID:27670207. |
dopaminergic medications are usually reduced, but whether the levodopa or dopamine agonist is to be reduced is left to the personal preference of the treating physician. |
2017-02-22 |
2023-08-13 |
Not clear |
| Seok-Jae Kang, Jin Young Ahn, Joong-Seok Kim, Jin Whan Cho, Ji Young Kim, Yun Young Choi, Hee-Tae Ki. 24-Hour Ambulatory Blood Pressure Monitoring in SWEDDs Patients With Parkinsonism. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 43. issue 3. 2017-02-17. PMID:26853109. |
patients diagnosed with parkinson's disease (pd) on clinics who subsequently turn out to have normal dopamine transporter images have been referred to as scans without evidence of dopaminergic deficits (swedds) patients. |
2017-02-17 |
2023-08-13 |
Not clear |
| Kathryn A Wyman-Chick, Phillip K Martin, Michal Minár, Ryan W Schroede. Cognition in Patients With a Clinical Diagnosis of Parkinson Disease and Scans Without Evidence of Dopaminergic Deficit (SWEDD): 2-Year Follow-Up. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. vol 29. issue 4. 2017-02-09. PMID:27984256. |
more than 10% of patients clinically diagnosed with parkinson disease demonstrate normal dopamine uptake on dopamine transporter single-photon emission computed tomography (datscan), but little is known about how cognitive function differs between patients with dopamine deficiency on datscan and patients with scans without evidence of dopaminergic deficit (swedd). |
2017-02-09 |
2023-08-13 |
Not clear |
| Jun Zhang, Xianyun Wang, Jing Li, Rui Huang, Xuerui Yu, Ci Dong, Pujuan Liu, Fan Zhang, Jie Hu, Yixin Qi, Jing Zhang, Quanhai Li, Baoyong Ya. The Preclinical Research Progress of Stem Cells Therapy in Parkinson's Disease. BioMed research international. vol 2016. 2017-02-01. PMID:27379248. |
the effectiveness of drug treatments gradually diminishes because the conversion to dopamine within the brain is increasingly disrupted by the progressive degeneration of the dopaminergic terminals. |
2017-02-01 |
2023-08-13 |
Not clear |
| Paul D Dodson, Jakob K Dreyer, Katie A Jennings, Emilie C J Syed, Richard Wade-Martins, Stephanie J Cragg, J Paul Bolam, Peter J Magil. Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 15. 2017-01-31. PMID:27001837. |
computational modeling revealed that the movement-related firing of these dopaminergic neurons can manifest as rapid and robust fluctuations in striatal dopamine concentration and receptor activity. |
2017-01-31 |
2023-08-13 |
mouse |
| Paul D Dodson, Jakob K Dreyer, Katie A Jennings, Emilie C J Syed, Richard Wade-Martins, Stephanie J Cragg, J Paul Bolam, Peter J Magil. Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 15. 2017-01-31. PMID:27001837. |
importantly, in aged mice harboring a genetic burden relevant for human parkinson's disease, the precise movement-related firing of snc dopaminergic neurons and the resultant striatal dopamine signaling were lost. |
2017-01-31 |
2023-08-13 |
mouse |
| E R Mingazov, M V Ugrumo. Gene expression of proteins of the vesicle cycle in the striatum and motor cortex under functional failure of nigrostriatal system. Doklady. Biochemistry and biophysics. vol 470. issue 1. 2017-01-25. PMID:27817030. |
degeneration of dopaminergic neurons in the substantia nigra and the decrease in the dopamine level in the striatum lead to dysfunctions of motor behavior. |
2017-01-25 |
2023-08-13 |
Not clear |
| Ilhong Yun, Julak Lee, Seung-Gon Ki. Dopaminergic Polymorphisms, Academic Achievement, and Violent Delinquency. International journal of offender therapy and comparative criminology. vol 59. issue 13. 2017-01-24. PMID:25326467. |
at the same time, a novel empirical study from molecular genetics drawing on the national longitudinal study of adolescent health (add health) data has revealed that polymorphisms in three dopaminergic genes (dopamine transporter [dat1], dopamine d2 receptor [drd2], and dopamine d4 receptor [drd4]) are also linked to adolescents' grade point averages (gpas). |
2017-01-24 |
2023-08-13 |
Not clear |
| Masatoshi Inden, Kazuyuki Takata, Daijiro Yanagisawa, Eishi Ashihara, Ikuo Tooyama, Shun Shimohama, Yoshihisa Kitamur. α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior. Neurochemistry international. vol 94. 2017-01-19. PMID:26911419. |
both nicotine- and galantamine-induced rotations were significantly blocked by flupenthixol (an antagonist of both d1 and d2 dopamine receptors) and mecamylamine (an antagonist of nachrs), suggesting that galantamine modulation of nachrs on striatal dopaminergic terminals regulates dopamine receptor-mediated movement. |
2017-01-19 |
2023-08-13 |
rat |
| Masatoshi Inden, Kazuyuki Takata, Daijiro Yanagisawa, Eishi Ashihara, Ikuo Tooyama, Shun Shimohama, Yoshihisa Kitamur. α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior. Neurochemistry international. vol 94. 2017-01-19. PMID:26911419. |
these results suggest that galantamine can enhance striatal dopamine release through allosteric modulation of α4 nachrs on nigrostriatal dopaminergic terminals. |
2017-01-19 |
2023-08-13 |
rat |
| Astrid Rohwedder, Nana L Wenz, Bernhard Stehle, Annina Huser, Nobuhiro Yamagata, Marta Zlatic, James W Truman, Hiromu Tanimoto, Timo Saumweber, Bertram Gerber, Andreas S Thu. Four Individually Identified Paired Dopamine Neurons Signal Reward in Larval Drosophila. Current biology : CB. vol 26. issue 5. 2017-01-10. PMID:26877086. |
we study larval drosophila, in which only approximately 120 of a total of 10,000 neurons are dopaminergic, as judged by the expression of tyrosine hydroxylase (th), the rate-limiting enzyme of dopamine biosynthesis [5, 13]. |
2017-01-10 |
2023-08-13 |
drosophila_melanogaster |