| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dimitri Ryczko, Jackson J Cone, Michael H Alpert, Laurent Goetz, François Auclair, Catherine Dubé, Martin Parent, Mitchell F Roitman, Simon Alford, Réjean Dubu. A descending dopamine pathway conserved from basal vertebrates to mammals. Proceedings of the National Academy of Sciences of the United States of America. vol 113. issue 17. 2016-12-13. PMID:27071118. |
the conservation of a descending dopaminergic pathway across vertebrates warrants re-evaluating dopamine's role in locomotion. |
2016-12-13 |
2023-08-13 |
human |
| Patrícia Reckziegel, Pan Chen, Sam Caito, Priscila Gubert, Félix Alexandre Antunes Soares, Roselei Fachinetto, Michael Aschne. Extracellular dopamine and alterations on dopamine transporter are related to reserpine toxicity in Caenorhabditis elegans. Archives of toxicology. vol 90. issue 3. 2016-11-14. PMID:25579234. |
we hypothesized that the involuntary movements induced by reserpine in rodents are induced by dopaminergic toxicity caused by extracellular dopamine accumulation. |
2016-11-14 |
2023-08-13 |
caenorhabditis_elegans |
| Stephen P Currie, Denis Combes, Nicholas W Scott, John Simmers, Keith T Silla. A behaviorally related developmental switch in nitrergic modulation of locomotor rhythmogenesis in larval Xenopus tadpoles. Journal of neurophysiology. vol 115. issue 3. 2016-11-14. PMID:26763775. |
moreover, while the effects of no and dopamine are similar, the two modulators act in parallel rather than no operating serially by modulating dopaminergic signaling. |
2016-11-14 |
2023-08-13 |
xenopus_laevis |
| Milena Pinto, Nadee Nissanka, Susana Peralta, Roberta Brambilla, Francisca Diaz, Carlos T Morae. Pioglitazone ameliorates the phenotype of a novel Parkinson's disease mouse model by reducing neuroinflammation. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:27038906. |
the cause of the motor symptoms is the loss of dopaminergic neurons in the substantia nigra with consequent depletion of dopamine in the striatum. |
2016-11-08 |
2023-08-13 |
mouse |
| HongNa Yang, Jing Wang, Feng Wang, XiaoDun Liu, Heng Chen, WeiMing Duan, TingYu Q. Dopaminergic Neuronal Differentiation from the Forebrain-Derived Human Neural Stem Cells Induced in Cultures by Using a Combination of BMP-7 and Pramipexole with Growth Factors. Frontiers in neural circuits. vol 10. 2016-10-31. PMID:27147976. |
transplantation of dopaminergic (da) neurons is considered to be the most promising therapeutic strategy for replacing degenerated dopamine cells in the midbrain of parkinson's disease (pd), thereby restoring normal neural circuit function and slow clinical progression of the disease. |
2016-10-31 |
2023-08-13 |
human |
| Rachel J Sizemore, Rong Zhang, Naili Lin, Liping Goddard, Timothy Wastney, Louise C Parr-Brownlie, John N J Reynolds, Dorothy E Oorscho. Marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons, and striatal spiny projection neurons in the rat. The Journal of comparative neurology. vol 524. issue 5. 2016-10-24. PMID:26355230. |
a similar comparison between populations of dopamine neurons revealed a two times greater number of somatic synapses on vta dopaminergic neurons than snpc dopaminergic neurons. |
2016-10-24 |
2023-08-13 |
rat |
| B J Laoye, O A Okurumeh, O V Obagaye, M O Olagunju, O O Bankole, O O Olubiyi, O M Ogundel. Dopamine binds calmodulin during autoregulation of dopaminergic D2 receptor signaling through CaMKIIα-calmodulin complex. Journal of receptor and signal transduction research. vol 36. issue 3. 2016-10-24. PMID:26446938. |
dopamine binds calmodulin during autoregulation of dopaminergic d2 receptor signaling through camkiiα-calmodulin complex. |
2016-10-24 |
2023-08-13 |
Not clear |
| B J Laoye, O A Okurumeh, O V Obagaye, M O Olagunju, O O Bankole, O O Olubiyi, O M Ogundel. Dopamine binds calmodulin during autoregulation of dopaminergic D2 receptor signaling through CaMKIIα-calmodulin complex. Journal of receptor and signal transduction research. vol 36. issue 3. 2016-10-24. PMID:26446938. |
the role of dopaminergic d2 receptor (d2r) autoregulation in dopamine (da) neurotransmission cannot be overemphasized in cause and progression of disorders associated with complex behaviors. |
2016-10-24 |
2023-08-13 |
Not clear |
| Nilesh Sudhakar Ambhore, Karthik Yamjala, Shubhashri Mohire, Kalidhindi Rama Satyanarayana Raju, Shashank Mulukutla, Vishakantha Murthy, Mahesh Tondhawada, Kannan Elang. Pharmacokinetic and tissue distribution studies of 1,9-pyrazoloanthrone, a c-Jun-N-terminal kinase inhibitor in Wistar rats by a simple and sensitive HPLC method. Journal of pharmaceutical and biomedical analysis. vol 120. 2016-10-24. PMID:26704630. |
jnk pathway activates c-jun(s) which are responsible for cell apoptosis; as a result, inhibitors of jnk pathway have the potential to prevent dopaminergic neurons from death and decrease the loss of dopamine in substantia nigra pars compacta (snpc). |
2016-10-24 |
2023-08-13 |
rat |
| M Levit. Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases. Acta physiologica (Oxford, England). vol 216. issue 1. 2016-10-21. PMID:25728499. |
dopamine and t cells: dopamine receptors and potent effects on t cells, dopamine production in t cells, and abnormalities in the dopaminergic system in t cells in autoimmune, neurological and psychiatric diseases. |
2016-10-21 |
2023-08-13 |
Not clear |
| M Levit. Dopamine and T cells: dopamine receptors and potent effects on T cells, dopamine production in T cells, and abnormalities in the dopaminergic system in T cells in autoimmune, neurological and psychiatric diseases. Acta physiologica (Oxford, England). vol 216. issue 1. 2016-10-21. PMID:25728499. |
parkinson disease, alzheimer's disease, schizophrenia and tourette), patient's t cells seem to have abnormal drs expression and/or responses to dopamine or production of dopamine, (xiii) drugs that affect the dopaminergic system have potent effects on t cells (e.g. |
2016-10-21 |
2023-08-13 |
Not clear |
| Yue Yu, Mohtashim H Shamsi, Dimitar L Krastev, Michael D M Dryden, Yen Leung, Aaron R Wheele. A microfluidic method for dopamine uptake measurements in dopaminergic neurons. Lab on a chip. vol 16. issue 3. 2016-10-20. PMID:26725686. |
a microfluidic method for dopamine uptake measurements in dopaminergic neurons. |
2016-10-20 |
2023-08-13 |
Not clear |
| Yue Yu, Mohtashim H Shamsi, Dimitar L Krastev, Michael D M Dryden, Yen Leung, Aaron R Wheele. A microfluidic method for dopamine uptake measurements in dopaminergic neurons. Lab on a chip. vol 16. issue 3. 2016-10-20. PMID:26725686. |
a key to understanding da dysfunction is the accurate measurement of dopamine uptake by dopaminergic neurons. |
2016-10-20 |
2023-08-13 |
Not clear |
| Ting-Yi Wang, Kiara F Bruggeman, Jessica A Kauhausen, Alexandra L Rodriguez, David R Nisbet, Clare L Paris. Functionalized composite scaffolds improve the engraftment of transplanted dopaminergic progenitors in a mouse model of Parkinson's disease. Biomaterials. vol 74. 2016-10-19. PMID:26454047. |
in vitro we confirmed the ability of the scaffolds to support ventral midbrain (vm) dopamine progenitors, and provide sustained delivery of gdnf - capable of eliciting effects on cell survival and dopaminergic axon growth. |
2016-10-19 |
2023-08-13 |
mouse |
| Venissa Machado, Tanja Zöller, Abdelraheim Attaai, Björn Spitta. Microglia-Mediated Neuroinflammation and Neurotrophic Factor-Induced Protection in the MPTP Mouse Model of Parkinson's Disease-Lessons from Transgenic Mice. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26821015. |
parkinson's disease (pd) is a neurodegenerative disease characterised by histopathological and biochemical manifestations such as loss of midbrain dopaminergic (da) neurons and decrease in dopamine levels accompanied by a concomitant neuroinflammatory response in the affected brain regions. |
2016-10-19 |
2023-08-13 |
mouse |
| Stefan Hallgren, Henrik Viber. Postnatal exposure to PFOS, but not PBDE 99, disturb dopaminergic gene transcription in the mouse CNS. Environmental toxicology and pharmacology. vol 41. 2016-10-18. PMID:26686188. |
here, 10 days old mice were exposed to single oral doses of either pfos, pbde99 or vehicle control and were examined for changes in dopaminergic gene transcription in cns tissue collected at 24h or 2 months post exposure.qpcr analyses of brain tissue from mice euthanized 24h post exposure revealed that pfos affected transcription of dopamine receptor-d5 (drd5) in cerebral cortex and tyrosine hydroxylase (th) in the hippocampus. |
2016-10-18 |
2023-08-13 |
mouse |
| Manuela Meireles, Luís M Rodríguez-Alcalá, Cláudia Marques, Sónia Norberto, Joana Freitas, Iva Fernandes, Nuno Mateus, Ana Gomes, Ana Faria, Conceição Calha. Effect of chronic consumption of blackberry extract on high-fat induced obesity in rats and its correlation with metabolic and brain outcomes. Food & function. vol 7. issue 1. 2016-10-17. PMID:26462860. |
be decreased levels of bdnf and also interacted with the dopaminergic system, increasing dopamine turnover in the striatum, and reverting dopamine content induced by a high-fat diet in the prefrontal cortex. |
2016-10-17 |
2023-08-13 |
rat |
| Puneet Bagga, Anup N Chugani, Anant B Pate. Neuroprotective effects of caffeine in MPTP model of Parkinson's disease: A (13)C NMR study. Neurochemistry international. vol 92. 2016-10-17. PMID:26626997. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by degeneration of nigrostriatal dopaminergic neurons with an accompanying neuroinflammation leading to loss of dopamine in the basal ganglia. |
2016-10-17 |
2023-08-13 |
mouse |
| Mathieu Schmitt, Benjamin Dehay, Erwan Bezard, F Javier Garcia-Ladon. Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line. Synapse (New York, N.Y.). vol 70. issue 3. 2016-10-17. PMID:26695835. |
the trophic potential of statins and their impact on the expression of dopaminergic synaptic markers and dopamine (da) transport function in sh-sy5y cells has been investigated. |
2016-10-17 |
2023-08-13 |
Not clear |
| Matthew W Rice, Rosalinda C Roberts, Miguel Melendez-Ferro, Emma Perez-Costa. Mapping dopaminergic deficiencies in the substantia nigra/ventral tegmental area in schizophrenia. Brain structure & function. vol 221. issue 1. 2016-10-14. PMID:25269834. |
these data support the existence of pathway-specific dopaminergic deficits that would affect the dopamine input to the cortex without significant neuronal loss. |
2016-10-14 |
2023-08-13 |
Not clear |