| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rongyi Zhou, Xinmin Han, Jiaojiao Wang, Jichao Su. Baicalin may have a therapeutic effect in attention deficit hyperactivity disorder. Medical hypotheses. vol 85. issue 6. 2016-08-30. PMID:26604025. |
we hypothesize that baicalin may protect dopaminergic neurons and increase brain dopamine levels, thus serving as an effective novel treatment for adhd. |
2016-08-30 |
2023-08-13 |
Not clear |
| Guillaume Daniel, Alessandra Musso, Elpida Tsika, Aris Fiser, Liliane Glauser, Olga Pletnikova, Bernard L Schneider, Darren J Moor. α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9). Neurobiology of disease. vol 73. 2016-08-29. PMID:25461191. |
we further demonstrate that the aav-mediated overexpression of human atp13a2 is not sufficient to attenuate dopaminergic neurodegeneration, neuropathology, and striatal dopamine and motoric deficits induced by human α-synuclein expression in a rat model of pd. |
2016-08-29 |
2023-08-13 |
human |
| Yukihiro Ohno, Saki Shimizu, Kentaro Tokudome, Naofumi Kunisawa, Masashi Sas. New insight into the therapeutic role of the serotonergic system in Parkinson's disease. Progress in neurobiology. vol 134. 2016-08-25. PMID:26455457. |
while dopaminergic agents such as l-3,4-dihydroxyphenylalanine (l-dopa) and dopamine d2 agonists are widely used for the treatment of pd, there is still high clinical unmet need for novel medications that overcome the limitations of current therapies. |
2016-08-25 |
2023-08-13 |
Not clear |
| Andrew D Bolton, Yasunobu Murata, Rory Kirchner, Sung-Yon Kim, Andrew Young, Tru Dang, Yuchio Yanagawa, Martha Constantine-Pato. A Diencephalic Dopamine Source Provides Input to the Superior Colliculus, where D1 and D2 Receptors Segregate to Distinct Functional Zones. Cell reports. vol 13. issue 5. 2016-08-24. PMID:26565913. |
we surmise that a13 mimics dopaminergic effects that we observed in sc slices, which suggests that dopamine in the sc may reduce the tendency of an animal to orient or attend to salient stimuli. |
2016-08-24 |
2023-08-13 |
Not clear |
| Muzaffer Ilhan, Ozlem Timirci Kahraman, Saime Turan, Seda Turgut, Ozcan Karaman, Umit Zeybek, Samir Shukurov, Ilhan Yaylim, Ertugrul Tasa. Does DRD2 polymorphism influence the clinical characteristics of prolactinoma? Annales d'endocrinologie. vol 76. issue 5. 2016-08-23. PMID:26514951. |
genetic alterations explaining the clinical variability of prolactinomas still could not be clarified and dopamine d2 receptor (drd2) polymorphism is a putative candidate for the variable response to dopaminergic treatment. |
2016-08-23 |
2023-08-13 |
Not clear |
| Katrina L Paumier, Kelvin C Luk, Fredric P Manfredsson, Nicholas M Kanaan, Jack W Lipton, Timothy J Collier, Kathy Steece-Collier, Christopher J Kemp, Stephanie Celano, Emily Schulz, Ivette M Sandoval, Sheila Fleming, Elliott Dirr, Nicole K Polinski, John Q Trojanowski, Virginia M Lee, Caryl E Sortwel. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of disease. vol 82. 2016-08-19. PMID:26093169. |
pff injected rats exhibited bilateral reductions in striatal dopaminergic innervation at 60 and 180 days and bilateral decreases in homovanillic acid; however, dopamine reduction was observed only in the striatum ipsilateral to pff injection. |
2016-08-19 |
2023-08-13 |
mouse |
| Fu-Xing Zuo, Xin-Jie Bao, Xi-Cai Sun, Jun Wu, Qing-Ran Bai, Guo Chen, Xue-Yuan Li, Qiang-Yi Zhou, Yuan-Fan Yang, Qin Shen, Ren-Zhi Wan. Transplantation of Human Neural Stem Cells in a Parkinsonian Model Exerts Neuroprotection via Regulation of the Host Microenvironment. International journal of molecular sciences. vol 16. issue 11. 2016-08-19. PMID:26556344. |
parkinson's disease (pd) is characterized by a progressive loss of dopaminergic neurons and consequent dopamine (da) deficit, and current treatment still remains a challenge. |
2016-08-19 |
2023-08-13 |
mouse |
| T Nidheesh, Chinnu Salim, P S Rajini, P V Sures. Antioxidant and neuroprotective potential of chitooligomers in Caenorhabditis elegans exposed to Monocrotophos. Carbohydrate polymers. vol 135. 2016-08-18. PMID:26453861. |
the neuroprotective effect of cos was examined in n2 worms in terms of brood size, lifespan, egg laying, dopamine content, acetylcholinesterase and carboxylesterase activity and by direct visualization and quantification of degeneration of dopaminergic neurons in bz555. |
2016-08-18 |
2023-08-13 |
caenorhabditis_elegans |
| T Nidheesh, Chinnu Salim, P S Rajini, P V Sures. Antioxidant and neuroprotective potential of chitooligomers in Caenorhabditis elegans exposed to Monocrotophos. Carbohydrate polymers. vol 135. 2016-08-18. PMID:26453861. |
exposure to cos extended lifespan, normalized egg laying, increased brood size, decreased the dopaminergic neurodegeneration, increased the dopamine content and increased ache and carboxylesterase activity in c. elegans treated with mcp. |
2016-08-18 |
2023-08-13 |
caenorhabditis_elegans |
| Tuncay Çakır, Gülsüm Doğan, Volkan Subaşı, Meral Bilgilisoy Filiz, Nur Ülker, Şebnem Koldaş Doğan, Naciye Füsun Torama. An evaluation of sleep quality and the prevalence of restless leg syndrome in vitamin D deficiency. Acta neurologica Belgica. vol 115. issue 4. 2016-08-17. PMID:25904436. |
vitamin d is known to increase levels of dopamine and its metabolites in the brain and also protects dopaminergic neurons against dopaminergic toxins. |
2016-08-17 |
2023-08-13 |
Not clear |
| Sarah Sushchyk, Zheng-Xiong Xi, Jia Bei Wan. Combination of Levo-Tetrahydropalmatine and Low Dose Naltrexone: A Promising Treatment for Prevention of Cocaine Relapse. The Journal of pharmacology and experimental therapeutics. vol 357. issue 2. 2016-08-16. PMID:26903543. |
cocaine, as a potent dopamine transporter blocker, specifically induces alterations in the dopaminergic as well as other monoaminergic neurotransmissions, which lead to cocaine abuse and dependence. |
2016-08-16 |
2023-08-13 |
rat |
| Jenni Kononoff Vanhanen, Saara Nuutinen, Mervi Tuominen, Pertti Panul. Histamine H3 Receptor Regulates Sensorimotor Gating and Dopaminergic Signaling in the Striatum. The Journal of pharmacology and experimental therapeutics. vol 357. issue 2. 2016-08-16. PMID:26945087. |
dopaminergic drugs increased ppi of h3r knockout mice to the same level as in control mice, suggesting that changes in dopamine receptors might underlie deficient ppi response when h3r is lacking. |
2016-08-16 |
2023-08-13 |
mouse |
| Sarah Y Branch, Cang Chen, Ramaswamy Sharma, James D Lechleiter, Senlin Li, Michael J Beckstea. Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053209. |
additionally, dopaminergic neurons from mitopark mice showed a progressive decrease of endogenous dopamine levels, decreased dopamine release, and smaller d2 dopamine receptor-mediated outward currents. |
2016-08-15 |
2023-08-13 |
mouse |
| Daniel Farré, Ana Muñoz, Estefanía Moreno, Irene Reyes-Resina, Júlia Canet-Pons, Iria G Dopeso-Reyes, Alberto J Rico, Carme Lluís, Josefa Mallol, Gemma Navarro, Enric I Canela, Antonio Cortés, José L Labandeira-García, Vicent Casadó, José L Lanciego, Rafael Franc. Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia. Molecular neurobiology. vol 52. issue 3. 2016-08-10. PMID:25344317. |
radioligand binding assays to rat striatal dopamine d1 receptors showed that brain lateralization of the dopaminergic system were not due to changes in expression but in agonist affinity. |
2016-08-10 |
2023-08-13 |
rat |
| Marco Cosentino, Marco Ferrari, Natasa Kustrimovic, Emanuela Rasini, Franca Marin. Influence of dopamine receptor gene polymorphisms on circulating T lymphocytes: A pilot study in healthy subjects. Human immunology. vol 76. issue 10. 2016-08-09. PMID:26429319. |
dopamine is a key transmitter in the neuroimmune network, acting through five dopaminergic receptors (dr): the d1-like d1 and d5 and the d2-like d2, d3 and d4. |
2016-08-09 |
2023-08-13 |
human |
| Yang Sheng, Emily Filichia, Elizabeth Shick, Kenzie L Preston, Karran A Phillips, Leslie Cooperman, Zhicheng Lin, Paul Tesar, Barry J Hoffer, Yu Lu. Lower Dopamine D2 Receptor Expression Levels in Human Dopaminergic Neurons Derived From Opioid-Dependent iPSCs. The American journal of psychiatry. vol 173. issue 4. 2016-08-08. PMID:27035534. |
lower dopamine d2 receptor expression levels in human dopaminergic neurons derived from opioid-dependent ipscs. |
2016-08-08 |
2023-08-13 |
human |
| Johannes C M Schlachetzki, Thomas Grimm, Zinayida Schlachetzki, Nada M B Ben Abdallah, Benjamin Ettle, Patrizia Vöhringer, Boris Ferger, Beate Winner, Silke Nuber, Jürgen Winkle. Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of α-synuclein. Journal of neuroscience research. vol 94. issue 1. 2016-08-05. PMID:26451750. |
we observed a persistent reduction of striatal dopamine and a loss of tyrosine hydroxylase-expressing neurons in the substantia nigra pars compacta in contrast to a complete recovery of tyrosine hydroxylase-immunoreactive dopaminergic fibers within the striatum. |
2016-08-05 |
2023-08-13 |
Not clear |
| Bryan A Killinger, Anna Moszczynsk. Epothilone D prevents binge methamphetamine-mediated loss of striatal dopaminergic markers. Journal of neurochemistry. vol 136. issue 3. 2016-08-05. PMID:26465779. |
exposure to binge methamphetamine (meth) can result in a permanent or transient loss of dopaminergic (daergic) markers such as dopamine (da), dopamine transporter, and tyrosine hydroxylase (th) in the striatum. |
2016-08-05 |
2023-08-13 |
rat |
| Bertalan Polner, Ahmed A Moustafa, Helga Nagy, Annamária Takáts, Orsolya Győrfi, Szabolcs Kér. Dopamine improves exploration after expectancy violations and induces psychotic-like experiences in patients with Parkinson's disease. Neuroscience letters. vol 616. 2016-08-04. PMID:26820375. |
in this study, we investigate the dopaminergic modulation of schizotypal traits and exploration after expectancy violations in parkinson's disease (pd) patients on dopamine replacement therapy. |
2016-08-04 |
2023-08-13 |
Not clear |
| Hiroshi Kawaguchi, Hitoshi Shimada, Fumitoshi Kodaka, Masayuki Suzuki, Hitoshi Shinotoh, Shigeki Hirano, Jeff Kershaw, Yuichi Inoue, Masaki Nakamura, Taeko Sasai, Mina Kobayashi, Tetsuya Suhara, Hiroshi It. Principal Component Analysis of Multimodal Neuromelanin MRI and Dopamine Transporter PET Data Provides a Specific Metric for the Nigral Dopaminergic Neuronal Density. PloS one. vol 11. issue 3. 2016-08-03. PMID:26954690. |
principal component analysis of multimodal neuromelanin mri and dopamine transporter pet data provides a specific metric for the nigral dopaminergic neuronal density. |
2016-08-03 |
2023-08-13 |
human |