| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M M Sidor, S M Spencer, K Dzirasa, P K Parekh, K M Tye, M R Warden, R N Arey, J F Enwright, J P R Jacobsen, S Kumar, E M Remillard, M G Caron, K Deisseroth, C A McClun. Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. Molecular psychiatry. vol 20. issue 11. 2016-08-02. PMID:25560763. |
mood-cycling coincides with abnormal daytime spikes in ventral tegmental area (vta) dopaminergic activity, tyrosine hydroxylase (th) levels and dopamine synthesis. |
2016-08-02 |
2023-08-13 |
mouse |
| Bryce D Grier, Leonardo Belluscio, Claire E J Cheetha. Olfactory Sensory Activity Modulates Microglial-Neuronal Interactions during Dopaminergic Cell Loss in the Olfactory Bulb. Frontiers in cellular neuroscience. vol 10. 2016-07-29. PMID:27471450. |
dopaminergic (da) neurons in the glomerular layer (gl) of the ob are particularly plastic, with loss of sensory input rapidly reducing tyrosine hydroxylase (th) expression and dopamine production, followed by a substantial reduction in da neuron number. |
2016-07-29 |
2023-08-13 |
mouse |
| Dan Lindholm, Johanna Mäkelä, Valentina Di Liberto, Giuseppa Mudò, Natale Belluardo, Ove Eriksson, Mart Saarm. Current disease modifying approaches to treat Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 73. issue 7. 2016-07-28. PMID:26616211. |
in particular, studies employing glial cell line-derived neurotrophic factor (gdnf) and its family member neurturin (nrtn), as well as the recently described cerebral dopamine neurotrophic factor (cdnf) and the mesencephalic astrocyte-derived neurotrophic factor (manf) have shown positive results in protecting and repairing dopaminergic neurons in various models of pd. |
2016-07-28 |
2023-08-13 |
Not clear |
| Lacey Pflibsen, Katherine A Stang, Michelle D Sconce, Vanessa B Wilson, Rebecca L Hood, Charles K Meshul, Suzanne H Mitchel. Executive function deficits and glutamatergic protein alterations in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Journal of neuroscience research. vol 93. issue 12. 2016-07-27. PMID:26332770. |
because dopaminergic treatment does not necessarily alleviate deficits in executive function, it has been hypothesized that dysfunction of neurotransmitters/systems other than dopamine (da) may be associated with this decrease in cognitive function. |
2016-07-27 |
2023-08-13 |
mouse |
| Darya L Zabelina, Lorenza Colzato, Mark Beeman, Bernhard Homme. Dopamine and the Creative Mind: Individual Differences in Creativity Are Predicted by Interactions between Dopamine Genes DAT and COMT. PloS one. vol 11. issue 1. 2016-07-26. PMID:26783754. |
taken altogether, our findings support the idea that human creativity relies on dopamine, and on the interaction between frontal and striatal dopaminergic pathways in particular. |
2016-07-26 |
2023-08-13 |
human |
| Judith Mylius, Max F K Happel, Alexander G Gorkin, Ying Huang, Henning Scheich, Michael Brosc. Fast transmission from the dopaminergic ventral midbrain to the sensory cortex of awake primates. Brain structure & function. vol 220. issue 6. 2016-07-25. PMID:25084746. |
thus, we speculate that the dopaminergic ventral midbrain exerts a temporally precise, phasic influence on sensory cortex using fast-acting non-dopaminergic transmitters and that their effects are modulated by dopamine on a longer timescale. |
2016-07-25 |
2023-08-13 |
monkey |
| Chia-Hung Chien, Ming-Jen Lee, Houng-Chi Liou, Horng-Huei Liou, Wen-Mei F. Microglia-Derived Cytokines/Chemokines Are Involved in the Enhancement of LPS-Induced Loss of Nigrostriatal Dopaminergic Neurons in DJ-1 Knockout Mice. PloS one. vol 11. issue 3. 2016-07-25. PMID:26982707. |
in addition, direct intranigral lps challenge caused a greater loss of nigrostriatal dopaminergic neurons and striatal dopamine content in dj-1 ko mice than in wt mice. |
2016-07-25 |
2023-08-13 |
mouse |
| Mona Buhusi, Kaitlin Olsen, Benjamin Z Yang, Catalin V Buhus. Stress-Induced Executive Dysfunction in GDNF-Deficient Mice, A Mouse Model of Parkinsonism. Frontiers in behavioral neuroscience. vol 10. 2016-07-22. PMID:27445722. |
glial-derived neurotrophic factor (gdnf) is essential for regulating dopamine (da) release in the basal ganglia and for the survival of dopaminergic neurons; gdnf-deficient mice are considered an animal model for aging-related parkinsonism. |
2016-07-22 |
2023-08-13 |
mouse |
| María Sierra, Sébastien Carnicella, Antonio P Strafella, Amélie Bichon, Eugénie Lhommée, Anna Castrioto, Stephan Chabardes, Stéphane Thobois, Paul Krac. Apathy and Impulse Control Disorders: Yin & Yang of Dopamine Dependent Behaviors. Journal of Parkinson's disease. vol 5. issue 3. 2016-07-21. PMID:25870025. |
icds are part of the hyperdopaminergic behavioural spectrum, which also includes punding, and dopamine dysregulation syndrome (dds), which are all related to non-physiological dopaminergic stimulation induced by antiparkinsonian drugs. |
2016-07-21 |
2023-08-13 |
Not clear |
| María Sierra, Sébastien Carnicella, Antonio P Strafella, Amélie Bichon, Eugénie Lhommée, Anna Castrioto, Stephan Chabardes, Stéphane Thobois, Paul Krac. Apathy and Impulse Control Disorders: Yin & Yang of Dopamine Dependent Behaviors. Journal of Parkinson's disease. vol 5. issue 3. 2016-07-21. PMID:25870025. |
clinical observations in drug addiction and pd as well as data from studies in dopamine depleted rodents provide hints allowing to argue that both pulsatile d1 and d2 receptor stimulation and the severity of dopaminergic denervation are risk factors to develop punding behavior and dds. |
2016-07-21 |
2023-08-13 |
Not clear |
| Fábio Teixeira Kuhn, Verônica Tironi Dias, Karine Roversi, Luciana Taschetto Vey, Daniele Leão de Freitas, Camila Simonetti Pase, Katiane Roversi, Juliana Cristina Veit, Tatiana Emanuelli, Marilise Escobar Bürge. Cross-Generational trans Fat Consumption Favors Self-Administration of Amphetamine and Changes Molecular Expressions of BDNF, DAT, and D1/D2 Receptors in the Cortex and Hippocampus of Rats. Neurotoxicity research. vol 28. issue 4. 2016-07-21. PMID:26188494. |
anxiety-like symptoms and locomotor index were assessed in elevated plus maze and open-field (of), respectively, while brain molecular expressions of dopaminergic receptors, dopamine transporter (dat), and bdnf were determined in the cortex and hippocampus. |
2016-07-21 |
2023-08-13 |
rat |
| Rafieh Alizadeh, Gholamreza Hassanzadeh, Mansoureh Soleimani, Mohammad Taghi Joghataei, Vahid Siavashi, Zhinoos Khorgami, Mahmoudreza Hadjighasse. Gender and age related changes in number of dopaminergic neurons in adult human olfactory bulb. Journal of chemical neuroanatomy. vol 69. 2016-07-20. PMID:26212581. |
dopamine is one of the major brain neurotransmitters, and the loss of dopaminergic neurons in basal ganglia cause motor deficits in parkinson's disease. |
2016-07-20 |
2023-08-13 |
human |
| Mia Apuschkin, Sara Stilling, Troels Rahbek-Clemmensen, Gunnar Sørensen, Guillaume Fortin, Freja Herborg Hansen, Jacob Eriksen, Louis-Eric Trudeau, Kristoffer Egerod, Ulrik Gether, Mattias Rickha. A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. The European journal of neuroscience. vol 42. issue 7. 2016-07-20. PMID:26286107. |
a novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. |
2016-07-20 |
2023-08-13 |
mouse |
| Sandra Noble, Rafael Godoy, Pierre Affaticati, Marc Ekke. Transgenic Zebrafish Expressing mCherry in the Mitochondria of Dopaminergic Neurons. Zebrafish. vol 12. issue 5. 2016-07-19. PMID:26355474. |
to visualize mitochondria in dopaminergic neurons of live zebrafish, we used the regulatory elements of the dopamine transporter (dat) gene to target a reporter, mcherry, after fusion with the mitochondrial localizing signal (mls) of tom20. |
2016-07-19 |
2023-08-13 |
zebrafish |
| Fernando Caravaggio, Margaret Hahn, Shinichiro Nakajima, Philip Gerretsen, Gary Remington, Ariel Graff-Guerrer. Reduced insulin-receptor mediated modulation of striatal dopamine release by basal insulin as a possible contributing factor to hyperdopaminergia in schizophrenia. Medical hypotheses. vol 85. issue 4. 2016-07-12. PMID:26118462. |
we hypothesize that, (i) insulin receptor expression and/or function is reduced in midbrain dopamine neurons in persons with schizophrenia, (ii) basal insulin should reduce dopaminergic transmission in the striatum via these receptors, and (iii) this modulation of dopaminergic transmission by basal insulin is reduced in the brains of persons with schizophrenia. |
2016-07-12 |
2023-08-13 |
Not clear |
| Tian Tian, Zhaoming Li, Hong L. Common pathophysiology affecting diabetic retinopathy and Parkinson's disease. Medical hypotheses. vol 85. issue 4. 2016-07-12. PMID:26141638. |
it is reported that retinal dopamine and tyrosine hydroxylase protein levels are downregulated, and dopaminergic amacrine cells appear to be degenerating in the animal models of dr. further, injecting the diabetic mice with dopamine-restoring or dopamine-activating drugs already used to treat pd can restore dopamine levels and significantly improve diabetes-associated visual dysfunction in the early stage. |
2016-07-12 |
2023-08-13 |
mouse |
| Michael Fritz, Anna M Klawonn, Anna Nilsson, Anand Kumar Singh, Joanna Zajdel, Daniel Björk Wilhelms, Michael Lazarus, Andreas Löfberg, Maarit Jaarola, Unn Örtegren Kugelberg, Timothy R Billiar, David J Hackam, Chhinder P Sodhi, Matthew D Breyer, Johan Jakobsson, Markus Schwaninger, Günther Schütz, Jan Rodriguez Parkitna, Clifford B Saper, Anders Blomqvist, David Engblo. Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. The Journal of clinical investigation. vol 126. issue 2. 2016-07-08. PMID:26690700. |
further, we showed that inflammation-induced pge2 targeted ep1 receptors on striatal dopamine d1 receptor–expressing neurons and that this signaling sequence induced aversion through gaba-mediated inhibition of dopaminergic cells. |
2016-07-08 |
2023-08-13 |
mouse |
| H Ding, R Underwood, N Lavalley, T A Yacoubia. 14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson's disease. Neuroscience. vol 307. 2016-07-06. PMID:26314634. |
14-3-3θ overexpression using this approach did not reduce mptp-induced dopaminergic cell loss in the substantia nigra nor the depletion of dopamine (da) and its metabolites in the striatum at three weeks after mptp administration. |
2016-07-06 |
2023-08-13 |
mouse |
| Stefan M Brudzynsk. Pharmacology of Ultrasonic Vocalizations in adult Rats: Significance, Call Classification and Neural Substrate. Current neuropharmacology. vol 13. issue 2. 2016-07-06. PMID:26411761. |
positive emotional states are associated with emission of 50 khz vocalizations that could be induced by rewarding situations and dopaminergic activation of the nucleus accumbens and are mediated by d1, d2, and partially d3 dopamine receptors. |
2016-07-06 |
2023-08-13 |
rat |
| Eric M Merzetti, Brian E Stavele. spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster. BMC neuroscience. vol 16. 2016-07-06. PMID:26502946. |
these symptoms arise from a decrease of available dopamine in the striatum of the brain resulting from the breakdown and death of dopaminergic (da) neurons. |
2016-07-06 |
2023-08-13 |
drosophila_melanogaster |