| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenda Jiang, Zhejian Wang, Yiyang Jiang, Meili Lu, Xin L. Ginsenoside Rg1 Ameliorates Motor Function in an Animal Model of Parkinson's Disease. Pharmacology. vol 96. issue 1-2. 2016-05-23. PMID:26065578. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra (sn) and diminished dopamine levels in the striatum. |
2016-05-23 |
2023-08-13 |
rat |
| Tomoteru Yamasaki, Masayuki Fujinaga, Kazunori Kawamura, Kenji Furutsuka, Nobuki Nengaki, Yoko Shimoda, Satoshi Shiomi, Makoto Takei, Hiroki Hashimoto, Joji Yui, Hidekatsu Wakizaka, Akiko Hatori, Lin Xie, Katsushi Kumata, Ming-Rong Zhan. Dynamic Changes in Striatal mGluR1 But Not mGluR5 during Pathological Progression of Parkinson's Disease in Human Alpha-Synuclein A53T Transgenic Rats: A Multi-PET Imaging Study. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 2. 2016-05-17. PMID:26758830. |
furthermore, declines in mglur1 bpnd values were correlated with decreases in bpnd values for [(18)f]fe-pe2i [(e)-n-(3-iodoprop-2e-enyl)-2β-carbo-[(18)f]fluoroethoxy-3β-(4-methylphenyl) nortropane], a specific pet ligand for the dopamine transporter, a biomarker for dopaminergic neurons. |
2016-05-17 |
2023-08-13 |
human |
| Aruna R Natarajan, Gilbert M Eisner, Ines Armando, Shaunagh Browning, John C Pezzullo, Lauren Rhee, Mustafa Dajani, Robert M Carey, Pedro A Jos. The Renin-Angiotensin and Renal Dopaminergic Systems Interact in Normotensive Humans. Journal of the American Society of Nephrology : JASN. vol 27. issue 1. 2016-05-16. PMID:25977313. |
high nacl intake increases renal synthesis of dopamine and dopaminergic receptor activity, decreasing epithelial sodium transport, whereas sodium deficit activates the raas, increasing epithelial sodium transport. |
2016-05-16 |
2023-08-13 |
human |
| Francesco Porta, Alberto Ponzone, Marco Spad. Target Prolactin Range in Treatment of Tetrahydrobiopterin Deficiency. The Journal of pediatrics. vol 168. 2016-05-16. PMID:26515614. |
the introduction of dopamine agonists for treating tetrahydrobiopterin deficiency imposes the evaluation of peripheral prolactin as the sole reliable biochemical marker of dopaminergic homeostasis. |
2016-05-16 |
2023-08-13 |
Not clear |
| Yu-Ting Huang, Dejan Georgiev, Tom Foltynie, Patricia Limousin, Maarten Speekenbrink, Marjan Jahanshah. Different effects of dopaminergic medication on perceptual decision-making in Parkinson's disease as a function of task difficulty and speed-accuracy instructions. Neuropsychologia. vol 75. 2016-05-12. PMID:26184442. |
interestingly, the current results suggest opposite effects of dopaminergic medication on the levels of difficulty and speed-accuracy versions of the moving dots task, possibly reflecting the differential effect of dopamine on modulating drift rate (levels of difficulty task) and non-decision time (speed-accuracy task) in the process of perceptual decision making. |
2016-05-12 |
2023-08-13 |
human |
| Beryl Luk, Mohinuddin Mohammed, Fang Liu, Frank J S Le. A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake. PloS one. vol 10. issue 8. 2016-05-11. PMID:26305376. |
the regulation of the dopamine transporter (dat) impacts extracellular dopamine levels after release from dopaminergic neurons. |
2016-05-11 |
2023-08-13 |
Not clear |
| Robin J Tyacke, David J Nut. Optimising PET approaches to measuring 5-HT release in human brain. Synapse (New York, N.Y.). vol 69. issue 10. 2016-05-10. PMID:26089243. |
the use of this technique has greatly advanced our understanding of dopamine and the dopaminergic system in normal and abnormal brain function. |
2016-05-10 |
2023-08-13 |
human |
| Dor Mohammad Kordi-Tamandani, Shahrad Tajoddini, Farzaneh Salim. Promoter Methylation and BDNF and DAT1 Gene Expression Profiles in Patients with Drug Addiction. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 82. issue 2. 2016-05-09. PMID:26160290. |
because the dopaminergic system has a significant role in drug abuse, the purpose of this study was to analyze the methylation and expression profile of brain-derived neurotrophic factor (bdnf) and dopamine transporter (dat1) genes in individuals with drug addiction. |
2016-05-09 |
2023-08-13 |
Not clear |
| Paulina Janeczek, Corinne Brooker, Peter R Dodd, Joanne M Lewoh. Differential expression of α-synuclein splice variants in the brain of alcohol misusers: Influence of genotype. Drug and alcohol dependence. vol 155. 2016-05-09. PMID:26297298. |
α-synuclein is involved in the dopaminergic reward pathway, where it regulates dopamine synthesis and release. |
2016-05-09 |
2023-08-13 |
Not clear |
| Michael P Saddoris, Xuefei Wang, Jonathan A Sugam, Regina M Carell. Cocaine Self-Administration Experience Induces Pathological Phasic Accumbens Dopamine Signals and Abnormal Incentive Behaviors in Drug-Abstinent Rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 1. 2016-05-09. PMID:26740664. |
although cocaine acts via dopaminergic mechanisms within the nac, less is known about whether phasic dopamine (da) signaling in the nac is altered in animals with cocaine self-administration experience or if these animals learn and interact normally with stimuli in their environment. |
2016-05-09 |
2023-08-13 |
human |
| Cody A Siciliano, Mark J Ferris, Sara R Jone. Cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. The European journal of neuroscience. vol 42. issue 4. 2016-05-06. PMID:26037018. |
cocaine self-administration disrupts mesolimbic dopamine circuit function and attenuates dopaminergic responsiveness to cocaine. |
2016-05-06 |
2023-08-13 |
rat |
| David S Goldstein, Yunden Jinsmaa, Patti Sullivan, Courtney Holmes, Irwin J Kopin, Yehonatan Sharab. Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells. The Journal of pharmacology and experimental therapeutics. vol 356. issue 2. 2016-05-06. PMID:26574516. |
according to the catecholaldehyde hypothesis, the toxic dopamine metabolite 3,4-dihydroxyphenylacetaldehyde (dopal) contributes to the loss of nigrostriatal dopaminergic neurons in parkinson's disease. |
2016-05-06 |
2023-08-13 |
rat |
| Hamed Shafaroodi, Simin Oveisi, Mahsa Hosseini, Hossein Niknahad, Leila Moez. The effect of acute aripiprazole treatment on chemically and electrically induced seizures in mice: The role of nitric oxide. Epilepsy & behavior : E&B. vol 48. 2016-05-05. PMID:26037847. |
dopaminergic and serotonergic systems relate to nitric oxide, and aripiprazole also has effects on dopamine and serotonin receptors. |
2016-05-05 |
2023-08-13 |
mouse |
| David S Goldstein, Patricia Sullivan, Courtney Holmes, Irwin J Kopin, Yehonatan Sharabi, Deborah C Mas. Decreased vesicular storage and aldehyde dehydrogenase activity in multiple system atrophy. Parkinsonism & related disorders. vol 21. issue 6. 2016-05-02. PMID:25829070. |
in pd evidence has accrued for a vesicular storage defect and decreased aldehyde dehydrogenase (aldh) activity in residual dopaminergic terminals, resulting in accumulation of the toxic dopamine (da) metabolite 3,4-dihydroxyphenylacetaldehyde (dopal). |
2016-05-02 |
2023-08-13 |
Not clear |
| Yohei Mukai, Miho Murat. [Scans without Evidence of Dopamine Deficit (SWEDDs)]. Brain and nerve = Shinkei kenkyu no shinpo. vol 68. issue 1. 2016-05-02. PMID:26764301. |
dopamine transporter (dat) single-photon emission computed tomography (spect) and [18f]fluoro-l-dopa ([18f]dopa) positron emission tomography (pet) facilitate the investigation of dopaminergic hypofunction in neurodegenerative diseases. |
2016-05-02 |
2023-08-13 |
human |
| Daniele Tomassoni, Enea Traini, Manuele Mancini, Vincenzo Bramanti, Syed Sarosh Mahdi, Francesco Ament. Dopamine, vesicular transporters, and dopamine receptor expression in rat major salivary glands. American journal of physiology. Regulatory, integrative and comparative physiology. vol 309. issue 5. 2016-04-26. PMID:26136535. |
the above localization of dopamine and dopaminergic markers investigated did not correspond closely with neuron-specific enolase (nse) localization. |
2016-04-26 |
2023-08-13 |
rat |
| Daniele Tomassoni, Enea Traini, Manuele Mancini, Vincenzo Bramanti, Syed Sarosh Mahdi, Francesco Ament. Dopamine, vesicular transporters, and dopamine receptor expression in rat major salivary glands. American journal of physiology. Regulatory, integrative and comparative physiology. vol 309. issue 5. 2016-04-26. PMID:26136535. |
the stronger immunoreactivity for dopamine transporters and receptors in striated duct cells suggests that the dopaminergic system could regulate not only quality, but also volume and ionic concentration of saliva. |
2016-04-26 |
2023-08-13 |
rat |
| Hyung-Wook Kim, Won-Seok Choi, Noah Sorscher, Hyung Joon Park, François Tronche, Richard D Palmiter, Zhengui Xi. Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo. Neurobiology of aging. vol 36. issue 9. 2016-04-25. PMID:26070241. |
however, compared with control mice, ndufs4 cko mice exhibited an age-dependent reduction of dopamine in the striatum and increased α-synuclein phosphorylation in dopaminergic neurons of the substantia nigra pars compacta. |
2016-04-25 |
2023-08-13 |
mouse |
| Hyung-Wook Kim, Won-Seok Choi, Noah Sorscher, Hyung Joon Park, François Tronche, Richard D Palmiter, Zhengui Xi. Genetic reduction of mitochondrial complex I function does not lead to loss of dopamine neurons in vivo. Neurobiology of aging. vol 36. issue 9. 2016-04-25. PMID:26070241. |
these data suggest that mitochondrial complex i inhibition in dopaminergic neurons does contribute to dopamine loss and the development of α-synuclein pathology. |
2016-04-25 |
2023-08-13 |
mouse |
| Ikuko Miyazaki, Shinki Murakami, Nao Torigoe, Yoshihisa Kitamura, Masato Asanum. Neuroprotective effects of levetiracetam target xCT in astrocytes in parkinsonian mice. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26485447. |
gsh derived from astrocytes protects dopamine neurons against neurotoxicity induced by dopaminergic neurotoxin 6-hydroxydopamine (6-ohda). |
2016-04-25 |
2023-08-13 |
mouse |