| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cristian Follmer, Eduardo Coelho-Cerqueira, Danilo Y Yatabe-Franco, Gabriel D T Araujo, Anderson S Pinheiro, Gilberto B Domont, David Elieze. Oligomerization and Membrane-binding Properties of Covalent Adducts Formed by the Interaction of α-Synuclein with the Toxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde (DOPAL). The Journal of biological chemistry. vol 290. issue 46. 2016-03-07. PMID:26381411. |
when injected into the substantia nigra of rat brains, dopal causes the loss of dopaminergic neurons accompanied by the accumulation of potentially toxic oligomers of the presynaptic protein α-synuclein (as), potentially explaining the synergistic toxicity described for dopamine metabolism and as aggregation. |
2016-03-07 |
2023-08-13 |
rat |
| Mojtaba Golpich, Elham Amini, Fatemeh Hemmati, Norlinah Mohamed Ibrahim, Behrouz Rahmani, Zahurin Mohamed, Azman Ali Raymond, Leila Dargahi, Rasoul Ghasemi, Abolhassan Ahmadian. Glycogen synthase kinase-3 beta (GSK-3β) signaling: Implications for Parkinson's disease. Pharmacological research. vol 97. 2016-03-01. PMID:25829335. |
parkinson's disease (pd) is a chronic neurodegenerative movement disorder characterized by the progressive and massive loss of dopaminergic neurons by neuronal apoptosis in the substantia nigra pars compacta and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. |
2016-03-01 |
2023-08-13 |
Not clear |
| S Sarkar, B Gough, J Raymick, M A Beaudoin, S F Ali, A Virmani, Z K Biniend. Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. Neuroscience letters. vol 606. 2016-03-01. PMID:26321151. |
rats were perfused immediately after testing with 4% paraformaldehyde and immunohistochemical analysis of dopamine transporter (dat), tyrosine hydroxylase (th), glial fibrillary acidic protein (gfap), and microglial cd11b marker was performed in the caudate-putamen (cpu) and the substantia nigra pars compacta (snc) in order to estimate dopaminergic neuronal and transporter damage. |
2016-03-01 |
2023-08-13 |
rat |
| Giovanni Camardese, Luisa De Risio, Marco Di Nicola, Lorella Pucci, Fabrizio Cocciolillo, Pietro Bria, Alessandro Giordano, Luigi Janiri, Daniela Di Giud. Changes of dopamine transporter availability in depressed patients with and without anhedonia: a 123I-N-ω-fluoropropyl-carbomethoxy-3β- (4-Iodophenyl)tropane SPECT study. Neuropsychobiology. vol 70. issue 4. 2016-02-29. PMID:25613182. |
dopamine transporters (dat) may play a crucial role in the pathophysiology of dopaminergic transmission. |
2016-02-29 |
2023-08-13 |
Not clear |
| Jin Ma, Li-Hong Long, Zhuang-Li Hu, Hai Zhang, Jun Han, Lan Ni, Fang Wang, Jian-Guo Chen, Peng-Fei W. Activation of D1-like receptor-dependent phosphatidylinositol signal pathway by SKF83959 inhibits voltage-gated sodium channels in cultured striatal neurons. Brain research. vol 1615. 2016-02-29. PMID:25912434. |
a d1-like dopamine receptor-dependent phosphatidylinositol signal pathway exists in the striatum, however little is known about its role in the dopaminergic modulation of striatal neuronal excitability. |
2016-02-29 |
2023-08-13 |
Not clear |
| Chun-feng Shang, Xiao-quan Li, Chen Yin, Bing Liu, Yu-fan Wang, Zhuan Zhou, Jiu-lin D. Amperometric Monitoring of Sensory-Evoked Dopamine Release in Awake Larval Zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 46. 2016-02-29. PMID:26586817. |
dopamine plays crucial roles in a broad spectrum of brain functions, and neural circuit mechanisms underlying dopaminergic regulation have been intensively studied in the past decade. |
2016-02-29 |
2023-08-13 |
zebrafish |
| Chun-feng Shang, Xiao-quan Li, Chen Yin, Bing Liu, Yu-fan Wang, Zhuan Zhou, Jiu-lin D. Amperometric Monitoring of Sensory-Evoked Dopamine Release in Awake Larval Zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 46. 2016-02-29. PMID:26586817. |
as an example for application, we combined this method with genetic tools and in vivo calcium imaging and found that food extract can activate pretectal dopaminergic neurons, which in turn release dopamine at the visual center through their projection, providing a dopaminergic circuit mechanism for olfactory modulation of visual functions. |
2016-02-29 |
2023-08-13 |
zebrafish |
| M Zucconi, M Manconi, L Ferini Stramb. Aetiopathogenesis of restless legs syndrome. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 28 Suppl 1. 2016-02-23. PMID:17235431. |
all these theories may have a final common pathway in the dopaminergic system, reinforcing the empirical results of benefit with dopamine or dopamine-agonist treatments in rls. |
2016-02-23 |
2023-08-12 |
Not clear |
| Yoshajandith Aguirre-Vidal, Sergio Montes, Luis Tristan-López, Laura Anaya-Ramos, John Teiber, Camilo Ríos, Verónica Baron-Flores, Antonio Monroy-Noyol. The neuroprotective effect of lovastatin on MPP(+)-induced neurotoxicity is not mediated by PON2. Neurotoxicology. vol 48. 2016-02-23. PMID:25842176. |
parkinson's disease (pd) is a neurodegenerative disorder characterized by loss of the pigmented dopaminergic neurons in the substantia nigra pars compacta with subsequent striatal dopamine (da) deficiency and increased lipid peroxidation. |
2016-02-23 |
2023-08-13 |
rat |
| Tina Mitchell Martin Phd, Hamed Benghuzzi Ph D, Michelle Tucci Ph . The effect of acetylcholine administration to sh-sy5y cells in the presence of levodopa (L-dopa) using conventional and sustained drug delivery - biomed 2010. Biomedical sciences instrumentation. vol 46. 2016-02-18. PMID:20467118. |
the loss of dopaminergic neurons resulting in an imbalance between dopamine and acetylcholine is a hallmark feature of parkinson disease. |
2016-02-18 |
2023-08-12 |
Not clear |
| Gaynor A Smith, Emily M Rocha, Thomas Rooney, Pascal Barneoud, Jesse R McLean, Jonathan Beagan, Teresia Osborn, Madeleine Coimbra, Yongyi Luo, Penelope J Hallett, Ole Isacso. A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). PloS one. vol 10. issue 3. 2016-02-18. PMID:25815475. |
dopaminergic neurons in the substantia nigra pars compacta (snpc) are characterized by the expression of genes required for dopamine synthesis, handling and reuptake and the expression of these genes is largely controlled by nuclear receptor related 1 (nurr1). |
2016-02-18 |
2023-08-13 |
rat |
| Hiromi Fujii, Kohki Matsubara, Kiyoshi Sakai, Mikako Ito, Kinji Ohno, Minoru Ueda, Akihito Yamamot. Dopaminergic differentiation of stem cells from human deciduous teeth and their therapeutic benefits for Parkinsonian rats. Brain research. vol 1613. 2016-02-18. PMID:25863132. |
parkinson's disease (pd) is a progressive neurodegenerative disorder caused by the loss of nigrostriatal dopaminergic (daergic) neurons and the depletion of striatal dopamine. |
2016-02-18 |
2023-08-13 |
human |
| Gonzalo Arrondo, Maite Aznárez-Sanado, Maria A Fernández-Seara, Joaquín Goñi, Francis R Loayza, Ewa Salamon-Klobut, Franz H Heukamp, Maria A Pasto. Dopaminergic modulation of the trade-off between probability and time in economic decision-making. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 6. 2016-02-16. PMID:25840742. |
in this work, we have tested dopaminergic modulation of economic decision-making and its neural correlates by administering either placebo or metoclopramide, a dopamine d2-receptor antagonist, to healthy subjects, during a functional mri study. |
2016-02-16 |
2023-08-13 |
human |
| Hajime Hirasawa, Massimo Contini, Elio Raviol. Extrasynaptic release of GABA and dopamine by retinal dopaminergic neurons. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 370. issue 1672. 2016-02-16. PMID:26009765. |
extrasynaptic release of gaba and dopamine by retinal dopaminergic neurons. |
2016-02-16 |
2023-08-13 |
mouse |
| Hajime Hirasawa, Massimo Contini, Elio Raviol. Extrasynaptic release of GABA and dopamine by retinal dopaminergic neurons. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 370. issue 1672. 2016-02-16. PMID:26009765. |
in the mouse retina, dopaminergic amacrine (da) cells synthesize both dopamine and gaba. |
2016-02-16 |
2023-08-13 |
mouse |
| Chamila C Kadigamuwa, Viet Q Le, Kandatege Wimalasen. 2, 2'- and 4, 4'-Cyanines are transporter-independent in vitro dopaminergic toxins with the specificity and mechanism of toxicity similar to MPP⁺. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26094622. |
specific uptake through dopamine transporter followed by the inhibition of the mitochondrial complex-i have been accepted as the cause of the specific dopaminergic toxicity of 1-methyl-4-phenylpyridinium (mpp(+) ). |
2016-02-16 |
2023-08-13 |
Not clear |
| Marcus Lira Brandão, Amanda Ribeiro de Oliveira, Sangu Muthuraju, Ana Caroline Colombo, Viviane Mitsuko Saito, Teddy Talbo. Dual role of dopamine D(2)-like receptors in the mediation of conditioned and unconditioned fear. FEBS letters. vol 589. issue 22. 2016-02-15. PMID:25783771. |
however, the implications of the interplay between opposing actions of dopamine in the rostral and caudal segments of the dopaminergic system are still unclear. |
2016-02-15 |
2023-08-13 |
rat |
| J Meinel, K Radad, W-D Rausch, H Reichmann, G Gill. Cabergoline protects dopaminergic neurons against rotenone-induced cell death in primary mesencephalic cell culture. Folia neuropathologica. vol 53. issue 1. 2016-02-12. PMID:25909873. |
the neuroprotective effects afforded by cabergoline were independent of dopaminergic stimulation as blocking of dopamine receptors by the dopamine receptor antagonist sulpiride did not prevent them. |
2016-02-12 |
2023-08-13 |
mouse |
| Hiroya Abe, Kosuke Ino, Chen-Zhong Li, Yusuke Kanno, Kumi Y Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsu. Electrochemical Imaging of Dopamine Release from Three-Dimensional-Cultured PC12 Cells Using Large-Scale Integration-Based Amperometric Sensors. Analytical chemistry. vol 87. issue 12. 2016-02-12. PMID:25971414. |
bio-lsi clearly showed the effects of the dopaminergic drugs l-3,4-dihydroxyphenylalanine (l-dopa) and reserpine on k(+)-stimulated dopamine release from pc12 spheroids. |
2016-02-12 |
2023-08-13 |
Not clear |
| Hiroya Abe, Kosuke Ino, Chen-Zhong Li, Yusuke Kanno, Kumi Y Inoue, Atsushi Suda, Ryota Kunikata, Masahki Matsudaira, Yasufumi Takahashi, Hitoshi Shiku, Tomokazu Matsu. Electrochemical Imaging of Dopamine Release from Three-Dimensional-Cultured PC12 Cells Using Large-Scale Integration-Based Amperometric Sensors. Analytical chemistry. vol 87. issue 12. 2016-02-12. PMID:25971414. |
our results demonstrate that dopamine release from pc12 spheroids can be monitored using the device, suggesting that the bio-lsi is a promising tool for use in evaluating 3d-cultured dopaminergic cells and the effects of dopaminergic drugs. |
2016-02-12 |
2023-08-13 |
Not clear |