| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A S C França, B Lobão-Soares, L Muratori, G Nascimento, J Winne, C M Pereira, S M B Jeronimo, S Ribeir. D2 dopamine receptor regulation of learning, sleep and plasticity. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 4. 2016-01-11. PMID:25778861. |
since d2 dopaminergic transmission is required for the occurrence of rapid-eye-movement (rem) sleep, it is possible that dopamine affects learning by way of changes in post-acquisition rem sleep. |
2016-01-11 |
2023-08-13 |
mouse |
| Rafael Godoy, Sandra Noble, Kevin Yoon, Hymie Anisman, Marc Ekke. Chemogenetic ablation of dopaminergic neurons leads to transient locomotor impairments in zebrafish larvae. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26118896. |
to determine the impact of a controlled loss of dopaminergic neurons on locomotor function, we generated transgenic zebrafish, tg(dat:cfp-ntr), expressing a cyan fluorescent protein-nitroreductase fusion protein (cfp-ntr) under the control of dopamine transporter (dat) cis-regulatory elements. |
2016-01-11 |
2023-08-13 |
zebrafish |
| Javier Castro-Hernández, Domingo Afonso-Oramas, Ignacio Cruz-Muros, Josmar Salas-Hernández, Pedro Barroso-Chinea, Rosario Moratalla, Mark J Millan, Tomás González-Hernánde. Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake. Neurobiology of disease. vol 74. 2016-01-06. PMID:25511804. |
the dopamine (da) transporter (dat), a membrane glycoprotein expressed in dopaminergic neurons, clears da from extracellular space and is regulated by diverse presynaptic proteins like protein kinases, α-synuclein, d2 and d3 autoreceptors. |
2016-01-06 |
2023-08-13 |
mouse |
| Arturo Avalos-Fuentes, Sacnité Albarrán-Bravo, Santiago Loya-Lopéz, Hernán Cortés, Sergio Recillas-Morales, Jonathan J Magaña, Francisco Paz-Bermúdez, Claudia Rangel-Barajas, Jorge Aceves, David Erlij, Benjamín Florá. Dopaminergic denervation switches dopamine D3 receptor signaling and disrupts its Ca(2+) dependent modulation by CaMKII and calmodulin in striatonigral projections of the rat. Neurobiology of disease. vol 74. 2016-01-06. PMID:25517101. |
dopaminergic denervation switches dopamine d3 receptor signaling and disrupts its ca(2+) dependent modulation by camkii and calmodulin in striatonigral projections of the rat. |
2016-01-06 |
2023-08-13 |
rat |
| Francisco Molinet-Dronda, Belén Gago, Ana Quiroga-Varela, Carlos Juri, María Collantes, Mercedes Delgado, Elena Prieto, Margarita Ecay, Elena Iglesias, Concepció Marín, Iván Peñuelas, José A Obes. Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study. Neurobiology of disease. vol 77. 2016-01-06. PMID:25681534. |
behavior was characterized by rotational, catalepsy and limb-use asymmetry tests and dopaminergic striatal denervation was validated post-mortem by immunostaining of the dopamine transporter (dat). |
2016-01-06 |
2023-08-13 |
rat |
| Arman Rahimmi, Farnoosh Khosrobakhsh, Esmael Izadpanah, Mohammad Raman Moloudi, Kambiz Hassanzade. N-acetylcysteine prevents rotenone-induced Parkinson's disease in rat: An investigation into the interaction of parkin and Drp1 proteins. Brain research bulletin. vol 113. 2016-01-04. PMID:25732239. |
dopamine levels of dopaminergic areas in rat brain including substantia nigra (sn) and striatum (st) were assessed using high performance liquid chromatography analysis to measure the loss of dopamine. |
2016-01-04 |
2023-08-13 |
rat |
| Alessandro Pristerà, Wei Lin, Anna-Kristin Kaufmann, Katherine R Brimblecombe, Sarah Threlfell, Paul D Dodson, Peter J Magill, Cathy Fernandes, Stephanie J Cragg, Siew-Lan An. Transcription factors FOXA1 and FOXA2 maintain dopaminergic neuronal properties and control feeding behavior in adult mice. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 35. 2016-01-04. PMID:26283356. |
we show that deletion of foxa1/2 results in down-regulation of tyrosine hydroxylase, the rate-limiting enzyme of dopamine (da) biosynthesis, specifically in dopaminergic neurons of the substantia nigra pars compacta (snc). |
2016-01-04 |
2023-08-13 |
mouse |
| Ethan R Block, Jacob Nuttle, Judith Joyce Balcita-Pedicino, John Caltagarone, Simon C Watkins, Susan R Sesack, Alexander Sorki. Brain Region-Specific Trafficking of the Dopamine Transporter. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 37. 2016-01-04. PMID:26377471. |
the dopamine (da) transporter (dat) controls dopaminergic neurotransmission by removing extracellular da. |
2016-01-04 |
2023-08-13 |
mouse |
| L Barros-Miñones, B Goñi-Allo, V Suquia, G Beitia, N Aguirre, E Puert. Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice. Neuropharmacology. vol 93. 2016-01-01. PMID:25666033. |
contribution of dopamine to mitochondrial complex i inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice. |
2016-01-01 |
2023-08-13 |
mouse |
| L Barros-Miñones, B Goñi-Allo, V Suquia, G Beitia, N Aguirre, E Puert. Contribution of dopamine to mitochondrial complex I inhibition and dopaminergic deficits caused by methylenedioxymethamphetamine in mice. Neuropharmacology. vol 93. 2016-01-01. PMID:25666033. |
on the other hand, dopamine uptake blockade using gbr 12909, inhibited both, the acute inhibition of complex i activity and the long-term dopaminergic toxicity caused by mdma. |
2016-01-01 |
2023-08-13 |
mouse |
| Stefano Espinoza, Valentina Ghisi, Marco Emanuele, Damiana Leo, Ilya Sukhanov, Tatiana D Sotnikova, Evelina Chieregatti, Raul R Gainetdino. Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1. Neuropharmacology. vol 93. 2016-01-01. PMID:25721394. |
mice lacking this receptor show a higher sensitivity to dopaminergic stimuli, such as amphetamine; however, it is not clear whether d1 or d2 dopamine receptors and which associated intracellular signaling events are involved in this modulation. |
2016-01-01 |
2023-08-13 |
mouse |
| Aleksandar Rakovic, Philip Seibler, Christine Klei. iPS models of Parkin and PINK1. Biochemical Society transactions. vol 43. issue 2. 2016-01-01. PMID:25849934. |
recessively inherited parkin and pten-induced putative kinase 1 (pink1) mutations have been investigated in this context and the present review describes the first insights gained from studies in ipsc-derived dopaminergic neurons, which comprise abnormalities in mitochondrial and dopamine homoeostasis, microtubular stability and axonal outgrowth. |
2016-01-01 |
2023-08-13 |
human |
| Yoko Hagino, Shinya Kasai, Masayo Fujita, Susumu Setogawa, Hiroshi Yamaura, Dai Yanagihara, Makoto Hashimoto, Kazuto Kobayashi, Herbert Y Meltzer, Kazutaka Iked. Involvement of cholinergic system in hyperactivity in dopamine-deficient mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 5. 2015-12-31. PMID:25367503. |
however, the observations that some parkinson's disease patients can move effectively under appropriate conditions despite low dopamine levels (eg, kinesia paradoxia) and that several psychotic symptoms are typical antipsychotic resistant and atypical antipsychotic sensitive indicate that other systems beyond the dopaminergic system may also affect locomotor activity and psychosis. |
2015-12-31 |
2023-08-13 |
mouse |
| Hikaru Takeuchi, Yasuyuki Taki, Atsushi Sekiguchi, Hiroshi Hashizume, Rui Nouchi, Yuko Sassa, Yuka Kotozaki, Carlos Makoto Miyauchi, Ryoichi Yokoyama, Kunio Iizuka, Seishu Nakagawa, Tomomi Nagase, Keiko Kunitoki, Ryuta Kawashim. Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity-related temperaments in young healthy adults. Human brain mapping. vol 36. issue 5. 2015-12-31. PMID:25627674. |
the globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. |
2015-12-31 |
2023-08-13 |
human |
| Jiaming Mei, Chaoshi Ni. Protective and reversal effects of conserved dopamine neurotrophic factor on PC12 cells following 6-hydroxydopamine administration. Molecular medicine reports. vol 12. issue 1. 2015-12-31. PMID:25738732. |
conserved dopamine neurotrophic factor (cdnf), a member of the mammalian mesencephalic astrocyte-derived neurotrophic factor family of conserved secreted factors, has been reported to protect and rescue dopaminergic neurons in vivo. |
2015-12-31 |
2023-08-13 |
Not clear |
| J T Yorgason, J H Rose, J M McIntosh, M J Ferris, S R Jone. Greater ethanol inhibition of presynaptic dopamine release in C57BL/6J than DBA/2J mice: Role of nicotinic acetylcholine receptors. Neuroscience. vol 284. 2015-12-30. PMID:25451295. |
previous electrophysiology and microdialysis studies have demonstrated greater ethanol-induced vta dopaminergic firing and nac dopamine elevations in dba compared to c57 mice. |
2015-12-30 |
2023-08-13 |
mouse |
| Toshikatsu Okumura, Tsukasa Nozu, Shima Kumei, Kaoru Takakusaki, Saori Miyagishi, Masumi Ohhir. Involvement of the dopaminergic system in the central orexin-induced antinociceptive action against colonic distension in conscious rats. Neuroscience letters. vol 605. 2015-12-30. PMID:26275349. |
these results suggest for the first time that dopaminergic signaling via d1 and d2 dopamine receptors in the brain may induce visceral antinociception and that the dopaminergic signaling may be involved in the central orexin-induced antinociceptive action against colonic distension. |
2015-12-30 |
2023-08-13 |
rat |
| Ana B Fagundo, Fernando Fernández-Aranda, Rafael de la Torre, Antonio Verdejo-García, Roser Granero, Eva Penelo, Manel Gené, Carme Barrot, Cristina Sánchez, Eva Alvarez-Moya, Cristian Ochoa, Maria Neus Aymamí, Mónica Gómez-Peña, Jose M Menchón, Susana Jiménez-Murci. Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers. Journal of psychopharmacology (Oxford, England). vol 28. issue 12. 2015-12-23. PMID:25237117. |
like drug addiction, pathological gambling (pg) has been associated with impairments in executive functions and alterations in dopaminergic functioning; however, the role of dopamine (da) in the executive profile of pg remains unclear. |
2015-12-23 |
2023-08-13 |
Not clear |
| Carmelo Sgobio, David A Kupferschmidt, Guohong Cui, Lixin Sun, Zheng Li, Huaibin Cai, David M Lovinge. Optogenetic measurement of presynaptic calcium transients using conditional genetically encoded calcium indicator expression in dopaminergic neurons. PloS one. vol 9. issue 10. 2015-12-22. PMID:25360513. |
calcium triggers dopamine release from presynaptic terminals of midbrain dopaminergic (mda) neurons in the striatum. |
2015-12-22 |
2023-08-13 |
mouse |
| Bart P de Kwaasteniet, Chedwa Pinto, Henricus G Ruhé, Eric H G Ruhé, Guido A van Wingen, Jan Booij, Damiaan Deny. Striatal dopamine D2/3 receptor availability in treatment resistant depression. PloS one. vol 9. issue 11. 2015-12-22. PMID:25411966. |
several studies demonstrated improvement of depressive symptoms in treatment resistant depression (trd) after administering dopamine agonists which suggest abnormal dopaminergic neurotransmission in trd. |
2015-12-22 |
2023-08-13 |
human |