| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J Sun, N J Cairns, J S Perlmutter, R H Mach, J X. Regulation of dopamine D₃ receptor in the striatal regions and substantia nigra in diffuse Lewy body disease. Neuroscience. vol 248. 2015-10-20. PMID:23732230. |
the decrease of dopamine pre-synaptic markers implies neuronal loss in the substantia nigra pars compacta (snpc) in these dlb/pdd cases, while the increase of d₃ receptors in striatal regions could be attributed to dopaminergic medication history and psychiatric states such as hallucinations. |
2015-10-20 |
2023-08-12 |
Not clear |
| Mojtaba Golpich, Behrouz Rahmani, Norlinah Mohamed Ibrahim, Leila Dargahi, Zahurin Mohamed, Azman Ali Raymond, Abolhassan Ahmadian. Preconditioning as a potential strategy for the prevention of Parkinson's disease. Molecular neurobiology. vol 51. issue 1. 2015-10-20. PMID:24696268. |
parkinson's disease (pd) is a chronic neurodegenerative movement disorder characterized by the progressive and massive loss of dopaminergic neurons by neuronal apoptosis in the substantia nigra pars compacta and depletion of dopamine in the striatum, which lead to pathological and clinical abnormalities. |
2015-10-20 |
2023-08-13 |
Not clear |
| Bianca C Wittmann, Mark D'Esposit. Levodopa administration modulates striatal processing of punishment-associated items in healthy participants. Psychopharmacology. vol 232. issue 1. 2015-10-16. PMID:24923987. |
on a neural level, reward and its predictors are associated with increased firing of dopaminergic neurons, whereas punishment processing has been linked to the serotonergic system and to decreases in dopamine transmission. |
2015-10-16 |
2023-08-13 |
human |
| Juha T Järvelä, Juha O Rinne, Olli Eskola, Valtteri Kaasine. Mortality in Parkinson's disease is not associated with the severity of early dopaminergic defect. Parkinsonism & related disorders. vol 20. issue 8. 2015-10-16. PMID:24928032. |
although there is a relationship between the extent of striatal dopaminergic defect and the severity of motor symptoms in parkinson's disease (pd), studies investigating associations between dopamine and mortality in pd have been scarce. |
2015-10-16 |
2023-08-13 |
Not clear |
| Xianfeng Wang, Lihua Yang, Yuanyuan Wu, Changjiang Huang, Qiangwei Wang, Jian Han, Yongyong Guo, Xiongjie Shi, Bingsheng Zho. The developmental neurotoxicity of polybrominated diphenyl ethers: Effect of DE-71 on dopamine in zebrafish larvae. Environmental toxicology and chemistry. vol 34. issue 5. 2015-10-16. PMID:25651517. |
also, de-71 resulted in a significant decrease of tyrosine hydroxylase and dopamine transporter protein levels in dopaminergic neurons. |
2015-10-16 |
2023-08-13 |
zebrafish |
| Xianfeng Wang, Lihua Yang, Yuanyuan Wu, Changjiang Huang, Qiangwei Wang, Jian Han, Yongyong Guo, Xiongjie Shi, Bingsheng Zho. The developmental neurotoxicity of polybrominated diphenyl ethers: Effect of DE-71 on dopamine in zebrafish larvae. Environmental toxicology and chemistry. vol 34. issue 5. 2015-10-16. PMID:25651517. |
taken together, the results of the present study demonstrate that acute exposure to pbdes can affect dopaminergic signaling by disrupting the synthesis and transportation of dopamine in zebrafish, thereby disrupting normal neurodevelopment. |
2015-10-16 |
2023-08-13 |
zebrafish |
| Haigang Gu, Roman M Lazarenko, Dmitry Koktysh, Lorraine Iacovitti, Qi Zhan. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Stem cells translational medicine. vol 4. issue 8. 2015-10-16. PMID:26025981. |
the exocytotic release of dopamine is one of the most characteristic but also one of the least appreciated processes in dopaminergic neurotransmission. |
2015-10-16 |
2023-08-13 |
Not clear |
| Haigang Gu, Roman M Lazarenko, Dmitry Koktysh, Lorraine Iacovitti, Qi Zhan. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Stem cells translational medicine. vol 4. issue 8. 2015-10-16. PMID:26025981. |
although the dopaminergic identity of these stem cell-derived neurons has been characterized in different ways, vesicle-mediated dopamine release from their axonal terminals has been barely assessed. |
2015-10-16 |
2023-08-13 |
Not clear |
| Haigang Gu, Roman M Lazarenko, Dmitry Koktysh, Lorraine Iacovitti, Qi Zhan. A Stem Cell-Derived Platform for Studying Single Synaptic Vesicles in Dopaminergic Synapses. Stem cells translational medicine. vol 4. issue 8. 2015-10-16. PMID:26025981. |
we report a more efficient procedure to reliably generate dopamine neurons from embryonic stem cells, and it yields more dopamine neurons with more dopaminergic axon projections than midbrain culture does. |
2015-10-16 |
2023-08-13 |
Not clear |
| Alex S James, Zachary T Pennington, Phu Tran, James David Jentsc. Compromised NMDA/Glutamate Receptor Expression in Dopaminergic Neurons Impairs Instrumental Learning, But Not Pavlovian Goal Tracking or Sign Tracking eNeuro. vol 2. issue 3. 2015-10-14. PMID:26464985. |
compromised nmda/glutamate receptor expression in dopaminergic neurons impairs instrumental learning, but not pavlovian goal tracking or sign tracking two theories regarding the role for dopamine neurons in learning include the concepts that their activity serves as a (1) mechanism that confers incentive salience onto rewards and associated cues and/or (2) contingency teaching signal reflecting reward prediction error. |
2015-10-14 |
2023-08-13 |
mouse |
| Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Małgorzata Kajta, Lucyna Antkiewicz-Michalu. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous neurotoxic compound, disturbs the behavioral and biochemical effects of L-DOPA: in vivo and ex vivo studies in the rat. Neurotoxicity research. vol 26. issue 3. 2015-10-13. PMID:24842650. |
an ex vivo neurochemical study indicated that both acute and chronic 1bntiq injections strongly inhibited l-dopa-induced increases in the concentration of dopamine and all of its metabolites in dopaminergic structures. |
2015-10-13 |
2023-08-13 |
rat |
| Jolanta Konieczny, Danuta Jantas, Tomasz Lenda, Helena Domin, Anna Czarnecka, Katarzyna Kuter, Maria Śmiałowska, Władysław Lasoń, Elżbieta Lorenc-Koc. Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease. Neurotoxicity research. vol 26. issue 3. 2015-10-13. PMID:24842651. |
in the in vivo study, none of the celastrol doses (0.3-3 mg/kg) attenuated the lactacystin-induced decrease in the level of dopamine (da) and its metabolites or protected nigral dopaminergic neurons against the lactacystin-induced degeneration. |
2015-10-13 |
2023-08-13 |
mouse |
| Wojciech Bobela, Lu Zheng, Bernard L Schneide. Overview of mouse models of Parkinson's disease. Current protocols in mouse biology. vol 4. issue 3. 2015-10-09. PMID:25723963. |
pharmacological approaches targeting dopamine signaling and toxins leading to selective degeneration of nigral neurons are used to validate symptomatic treatments that aim at restoring effective dopaminergic function for motor control. |
2015-10-09 |
2023-08-13 |
mouse |
| Gábor Debertin, Orsolya Kántor, Tamás Kovács-Öller, Lajos Balogh, Edina Szabó-Meleg, József Orbán, Miklós Nyitrai, Béla Völgy. Tyrosine hydroxylase positive perisomatic rings are formed around various amacrine cell types in the mammalian retina. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25940543. |
aii amacrine cells have been considered as the main targets of dopamine signaling in the mammalian retina owing to a characteristic ring-like innervation from dopaminergic (th(+) ) amacrine cells (green) to somata of aii cells (red). |
2015-10-09 |
2023-08-13 |
mouse |
| Ning Xiao, B Jill Vento. Characterization of dopamine releasable and reserve pools in Drosophila larvae using ATP/P2X2 -mediated stimulation. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25951875. |
dopaminergic signaling pathways are conserved between mammals and drosophila, but the factors important for maintaining the functional pool of synaptic dopamine are not fully understood in drosophila. |
2015-10-09 |
2023-08-13 |
drosophila_melanogaster |
| Ning Xiao, B Jill Vento. Characterization of dopamine releasable and reserve pools in Drosophila larvae using ATP/P2X2 -mediated stimulation. Journal of neurochemistry. vol 134. issue 3. 2015-10-09. PMID:25951875. |
dopamine release was stimulated by applying atp which activated p2x2 channels specifically expressed in dopaminergic neurons. |
2015-10-09 |
2023-08-13 |
drosophila_melanogaster |
| Brittany Butler, Shawn Goodwin, Kaustuv Saha, Jonas Becker, Danielle Sambo, Paran Davari, Habibeh Khoshboue. Dopamine Transporter Activity Is Modulated by α-synuclein. The Journal of biological chemistry. 2015-10-08. PMID:26048988. |
the duration and strength of the dopaminergic signal is regulated by the dopamine transporter (dat). |
2015-10-08 |
2023-08-13 |
Not clear |
| Briana R De Miranda, Katriana A Popichak, Sean L Hammond, James A Miller, Stephen Safe, Ronald B Tjalken. Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. Toxicological sciences : an official journal of the Society of Toxicology. vol 143. issue 2. 2015-10-01. PMID:25406165. |
c-dim12 prevented nuclear export of nurr1 in dopaminergic neurons and enhanced expression of the nurr1-regulated proteins tyrosine hydroxylase and the dopamine transporter. |
2015-10-01 |
2023-08-13 |
mouse |
| Briana R De Miranda, Katriana A Popichak, Sean L Hammond, James A Miller, Stephen Safe, Ronald B Tjalken. Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. Toxicological sciences : an official journal of the Society of Toxicology. vol 143. issue 2. 2015-10-01. PMID:25406165. |
these data indicate that nr4a-active c-dim compounds protect against loss of dopamine neurons in the mptpp model of pd by preventing glial-mediated neuronal injury and by supporting a dopaminergic phenotype in th-positive neurons in the snpc. |
2015-10-01 |
2023-08-13 |
mouse |
| T M Jeitner, M Kalogiannis, P A Patrick, I Gomolin, T Palaia, L Ragolia, D Brand, E J Delikatn. Inflaming the diseased brain: a role for tainted melanins. Biochimica et biophysica acta. vol 1852. issue 5. 2015-10-01. PMID:25585261. |
a second-order rate constant for the reaction of hocl and dopamine of 2.5 × 10(4)m(-1)s(-1) was obtained by measuring loss of dopaminergic fluorescence due to hocl. |
2015-10-01 |
2023-08-13 |
Not clear |