| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianyu Wu, Chao Sheng, Zhongfeng Liu, Weili Jia, Bin Wang, Mo Li, Linlin Fu, Zhenhua Ren, Jing An, Lisi Sang, Gongru Song, Yanchuan Wu, Yanling Xu, Shuyan Wang, Zhiguo Chen, Qi Zhou, Y Alex Zhan. Lmx1a enhances the effect of iNSCs in a PD model. Stem cell research. vol 14. issue 1. 2015-09-25. PMID:25460246. |
inscs that over-expressed lmx1a (insc-lmx1a) gave rise to an increased yield of dopaminergic neurons and secreted a higher level of dopamine in vitro. |
2015-09-25 |
2023-08-13 |
mouse |
| Yasuko Kitagishi, Akari Minami, Atsuko Nakanishi, Yasunori Ogura, Satoru Matsud. Neuron membrane trafficking and protein kinases involved in autism and ADHD. International journal of molecular sciences. vol 16. issue 2. 2015-09-25. PMID:25647412. |
attention deficit hyperactivity disorder (adhd) is documented to dopaminergic insufficiencies, which is attributed to synaptic dysfunction of dopamine transporter (dat). |
2015-09-25 |
2023-08-13 |
Not clear |
| Julia Kraemmer, Gabor G Kovacs, Laura Perju-Dumbrava, Susanne Pirker, Tatiana Traub-Weidinger, Walter Pirke. Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 14. 2015-09-21. PMID:25048738. |
only limited data are available on the relationship between striatal dopamine transporter binding and dopaminergic cell loss in the substantia nigra (sn). |
2015-09-21 |
2023-08-13 |
human |
| Julia Kraemmer, Gabor G Kovacs, Laura Perju-Dumbrava, Susanne Pirker, Tatiana Traub-Weidinger, Walter Pirke. Correlation of striatal dopamine transporter imaging with post mortem substantia nigra cell counts. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 14. 2015-09-21. PMID:25048738. |
striatal dopamine transporter binding highly correlated with postmortem sn cell counts, confirming the validity of dopamine transporter imaging as an excellent in vivo marker of nigrostriatal dopaminergic degeneration. |
2015-09-21 |
2023-08-13 |
human |
| Jang-Won Lee, Victor Tapias, Roberto Di Maio, J Timothy Greenamyre, Jason R Canno. Behavioral, neurochemical, and pathologic alterations in bacterial artificial chromosome transgenic G2019S leucine-rich repeated kinase 2 rats. Neurobiology of aging. vol 36. issue 1. 2015-09-21. PMID:25174649. |
at ages of 4, 8, and 12 months, our characterization showed that expression of g2019s lrrk2 induced oxidative stress in striatum and substantia nigra, increased inducible nitric oxide synthase expression in nigral dopamine neurons, and abnormal morphology of nigral dopaminergic neurons in transgenic rats compared with wild-type, without inducing overt neurodegeneration in nigrostriatal dopaminergic neurons. |
2015-09-21 |
2023-08-13 |
human |
| Alberto J Espay, Peter A LeWitt, Horacio Kaufman. Norepinephrine deficiency in Parkinson's disease: the case for noradrenergic enhancement. Movement disorders : official journal of the Movement Disorder Society. vol 29. issue 14. 2015-09-21. PMID:25297066. |
the dramatic response of most motor and some nonmotor symptoms to dopaminergic therapies has contributed to maintaining the long-established identity of parkinson's disease (pd) as primarily a nigrostriatal dopamine (da) deficiency syndrome. |
2015-09-21 |
2023-08-13 |
Not clear |
| Ian D Blum, Lei Zhu, Luc Moquin, Maia V Kokoeva, Alain Gratton, Bruno Giros, Kai-Florian Storc. A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal. eLife. vol 3. 2015-09-21. PMID:25546305. |
we further reveal that striatal dopamine levels fluctuate in synchrony with ultradian activity cycles and that dopaminergic tone strongly predicts ultradian period. |
2015-09-21 |
2023-08-13 |
mouse |
| Ian D Blum, Lei Zhu, Luc Moquin, Maia V Kokoeva, Alain Gratton, Bruno Giros, Kai-Florian Storc. A highly tunable dopaminergic oscillator generates ultradian rhythms of behavioral arousal. eLife. vol 3. 2015-09-21. PMID:25546305. |
our data indicate that an arousal regulating, dopaminergic ultradian oscillator (duo) operates in the mammalian brain, which normally cycles in harmony with the circadian clock, but can desynchronize when dopamine tone is elevated, thereby producing aberrant patterns of arousal which are strikingly similar to perturbed sleep-wake cycles comorbid with psychopathology. |
2015-09-21 |
2023-08-13 |
mouse |
| Devin P Merullo, Melissa A Cordes, Sharon A Stevenson, Lauren V Riter. Neurotensin immunolabeling relates to sexually-motivated song and other social behaviors in male European starlings (Sturnus vulgaris). Behavioural brain research. vol 282. 2015-09-21. PMID:25595421. |
neurotensin (nt) is a neuropeptide that strongly modulates dopamine activity, co-localizes with dopamine in vta, and is found in regions where dopaminergic cells project from vta. |
2015-09-21 |
2023-08-13 |
Not clear |
| Pantelis Stathis, Spiridon Konitsiotis, Angelo Antonin. Dopamine agonists early monotherapy for the delay of development of levodopa-induced dyskinesias. Expert review of neurotherapeutics. vol 15. issue 2. 2015-09-18. PMID:25578445. |
thus, according to continuous dopaminergic stimulation theory, dopamine agonists having half-lifes longer than levodopa would minimize the risk of the development of dyskinesias. |
2015-09-18 |
2023-08-13 |
Not clear |
| Monica Colamartino, Massimo Santoro, Guglielmo Duranti, Stefania Sabatini, Roberta Ceci, Antonella Testa, Luca Padua, Renata Cozz. Evaluation of levodopa and carbidopa antioxidant activity in normal human lymphocytes in vitro: implication for oxidative stress in Parkinson's disease. Neurotoxicity research. vol 27. issue 2. 2015-09-14. PMID:25355370. |
the main pathochemical hallmark of parkinson's disease (pd) is the loss of dopamine in the striatum of the brain, and the oral administration of levodopa (l-dopa) is a treatment that partially restores the dopaminergic transmission. |
2015-09-14 |
2023-08-13 |
human |
| X Jing, H Shi, C Zhang, M Ren, M Han, X Wei, X Zhang, H Lo. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. vol 286. 2015-09-14. PMID:25449120. |
moreover, dmf ameliorated dopaminergic neurotoxicity in 6-ohda-induced pd animal models as evidenced by amelioration of locomotor dysfunction, loss in striatal dopamine, and reductions in dopaminergic neurons in the substantia nigra and striatum. |
2015-09-14 |
2023-08-13 |
mouse |
| Domenico De Berardis, Michele Fornaro, Nicola Serroni, Daniela Campanella, Gabriella Rapini, Luigi Olivieri, Venkataramanujam Srinivasan, Felice Iasevoli, Carmine Tomasetti, Andrea De Bartolomeis, Alessandro Valchera, Giampaolo Perna, Monica Mazza, Marco Di Nicola, Giovanni Martinotti, Massimo Di Giannantoni. Agomelatine beyond borders: current evidences of its efficacy in disorders other than major depression. International journal of molecular sciences. vol 16. issue 1. 2015-09-14. PMID:25569089. |
blockade of 5-ht2c receptors causes release of both noradrenaline and dopamine at the fronto-cortical dopaminergic and noradrenergic pathways. |
2015-09-14 |
2023-08-13 |
Not clear |
| Yu-Qing Pan, Lin Qiao, Xin-Dong Xue, Jian-Hua F. Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: a meta-analysis. Neuroscience letters. vol 590. 2015-09-14. PMID:25641135. |
many molecular studies focusing on dopamine receptors have attempted to analyze the gene polymorphisms involved in dopaminergic transmission. |
2015-09-14 |
2023-08-13 |
Not clear |
| Eugene V Mosharov, Anders Borgkvist, David Sulze. Presynaptic effects of levodopa and their possible role in dyskinesia. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 1. 2015-09-11. PMID:25450307. |
we review how this dopamine (da) precursor enhances dopaminergic transmission by providing a greater sphere of neurotransmitter influence as a result of the confluence of increased quantal size and decreased da reuptake, as well as loading da as a false transmitter into surviving serotonin neuron synaptic vesicles. |
2015-09-11 |
2023-08-13 |
Not clear |
| C Warren Olano. Levodopa: effect on cell death and the natural history of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 1. 2015-09-11. PMID:25502620. |
in vitro, l-dopa can induce degeneration of dopaminergic neurons, but it is not clear that the effects of the drug on cultured dopamine neurons reflect what happens in the pd brain. |
2015-09-11 |
2023-08-13 |
Not clear |
| C Warren Olano. Levodopa: effect on cell death and the natural history of Parkinson's disease. Movement disorders : official journal of the Movement Disorder Society. vol 30. issue 1. 2015-09-11. PMID:25502620. |
furthermore, l-dopa induces a greater decline in imaging measures of dopaminergic function than placebo or dopamine agonists, consistent with toxicity. |
2015-09-11 |
2023-08-13 |
Not clear |
| Tamara Boto, Thierry Louis, Kantiya Jindachomthong, Kees Jalink, Seth M Tomchi. Dopaminergic modulation of cAMP drives nonlinear plasticity across the Drosophila mushroom body lobes. Current biology : CB. vol 24. issue 8. 2015-09-10. PMID:24684937. |
during olfactory classical conditioning, large subsets of dopaminergic neurons are activated, releasing dopamine across broad sets of postsynaptic neurons. |
2015-09-10 |
2023-08-12 |
drosophila_melanogaster |
| Ashley A Vena, Rueben A Gonzale. Temporal profiles dissociate regional extracellular ethanol versus dopamine concentrations. ACS chemical neuroscience. vol 6. issue 1. 2015-09-10. PMID:25537116. |
in vivo monitoring of dopamine via microdialysis has demonstrated that acute, systemic ethanol increases extracellular dopamine in regions innervated by dopaminergic neurons originating in the ventral tegmental area and substantia nigra. |
2015-09-10 |
2023-08-13 |
Not clear |
| J Joutsa, V Voon, J Johansson, S Niemelä, J Bergman, V Kaasine. Dopaminergic function and intertemporal choice. Translational psychiatry. vol 5. 2015-09-09. PMID:25562841. |
finally, in subjects with parkinson's disease and dopamine medication-induced behavioral addictions, temporal discounting is further correlated with greater dopaminergic terminal function in the anterior putamen. |
2015-09-09 |
2023-08-13 |
human |