| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maximiliano Rapanelli, Luciana Romina Frick, Anabel M M Miguelez Fernández, B Silvano Zanutt. Dopamine bioavailability in the mPFC modulates operant learning performance in rats: an experimental study with a computational interpretation. Behavioural brain research. vol 280. 2015-07-24. PMID:25435314. |
these data have been interpreted through a computational model where the phasic firing of dopaminergic neurons was computed by means of a temporal difference algorithm and dopamine bioavailability in the mpfc was simulated with a gating window. |
2015-07-24 |
2023-08-13 |
rat |
| Lucy G Chastain, Hongyan Qu, Chase H Bourke, P Michael Iuvone, Paul R Dobner, Charles B Nemeroff, Becky Kinkea. Striatal dopamine receptor plasticity in neurotensin deficient mice. Behavioural brain research. vol 280. 2015-07-24. PMID:25449842. |
utilizing male mice lacking the nt gene (nt(-/-)), these studies examined the consequences of nt deficiency on dopaminergic tone and function, investigating (1) dopamine concentrations and dopamine receptor and transporter expression and binding in dopaminergic terminal regions, and (2) the behavioral effects of selective dopamine receptor agonists on locomotion and sensorimotor gating in adult nt(-/-) mice compared to wildtype (nt(+/+)) mice. |
2015-07-24 |
2023-08-13 |
mouse |
| Gael Le Douaron, Fanny Schmidt, Majid Amar, Hanane Kadar, Lucila Debortoli, Alexandra Latini, Blandine Séon-Méniel, Laurent Ferrié, Patrick Pierre Michel, David Touboul, Alain Brunelle, Rita Raisman-Vozari, Bruno Figadèr. Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease. European journal of medicinal chemistry. vol 89. 2015-07-24. PMID:25462259. |
parkinson disease is a neurodegenerative disorder of aging, characterized by disabling motor symptoms resulting from the loss of midbrain dopaminergic neurons and the decrease of dopamine in the striatum. |
2015-07-24 |
2023-08-13 |
mouse |
| Sandy Siegert, Maria Herrojo Ruiz, Christof Brücke, Julius Huebl, Gerd-Helge Schneider, Markus Ullsperger, Andrea A Küh. Error signals in the subthalamic nucleus are related to post-error slowing in patients with Parkinson's disease. Cortex; a journal devoted to the study of the nervous system and behavior. vol 60. 2015-07-23. PMID:24525245. |
further, the modulation of behavioral performance by dopaminergic therapy depending on patients' age may suggest a dopamine overdose effect in patients with earlier onset of pd. |
2015-07-23 |
2023-08-12 |
human |
| Sara Bonzano, Serena Bovetti, Aldo Fasolo, Paolo Peretto, Silvia De Marchi. Odour enrichment increases adult-born dopaminergic neurons in the mouse olfactory bulb. The European journal of neuroscience. vol 40. issue 10. 2015-07-23. PMID:25216299. |
odour deprivation induces down-regulation of tyrosine hydroxylase (th) expression in ob dopaminergic interneurons located in the glomerular layer (gl), resulting in decreased dopamine in the ob. |
2015-07-23 |
2023-08-13 |
mouse |
| Kimberley A Pitman, Ernest Puil, Stephanie L Borglan. GABA(B) modulation of dopamine release in the nucleus accumbens core. The European journal of neuroscience. vol 40. issue 10. 2015-07-23. PMID:25229321. |
modulation of the concentration of dopamine (da) released from dopaminergic terminals in the nucleus accumbens (nac) influences behaviours such as the motivation to obtain drugs of abuse. |
2015-07-23 |
2023-08-13 |
mouse |
| David S Goldstein, Irwin J Kopin, Yehonatan Sharab. Catecholamine autotoxicity. Implications for pharmacology and therapeutics of Parkinson disease and related disorders. Pharmacology & therapeutics. vol 144. issue 3. 2015-07-20. PMID:24945828. |
according to the "catecholaldehyde hypothesis" for the pathogenesis of parkinson disease, long-term increased build-up of 3,4-dihydroxyphenylacetaldehyde (dopal), the catecholaldehyde metabolite of dopamine, causes or contributes to the eventual death of dopaminergic neurons. |
2015-07-20 |
2023-08-13 |
Not clear |
| Allan H Youn. The effects of HPA axis function on cognition and its implications for the pathophysiology of bipolar disorder. Harvard review of psychiatry. vol 22. issue 6. 2015-07-20. PMID:25377604. |
manic states are associated with enhanced dopaminergic transmission, and experimental stress enhances dopamine neurotransmission and impairs cognition. |
2015-07-20 |
2023-08-13 |
Not clear |
| Xiaoqi Pan, Xiongxiong Guo, Fei Xiong, Guihong Cheng, Qing Lu, Hong Ya. Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system. Toxicology letters. vol 236. issue 1. 2015-07-20. PMID:25943760. |
acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system. |
2015-07-20 |
2023-08-13 |
rat |
| Xiaoqi Pan, Xiongxiong Guo, Fei Xiong, Guihong Cheng, Qing Lu, Hong Ya. Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system. Toxicology letters. vol 236. issue 1. 2015-07-20. PMID:25943760. |
the neurotransmitter dopamine (da) has an increasingly important role in the dopaminergic system. |
2015-07-20 |
2023-08-13 |
rat |
| Xiaoqi Pan, Xiongxiong Guo, Fei Xiong, Guihong Cheng, Qing Lu, Hong Ya. Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system. Toxicology letters. vol 236. issue 1. 2015-07-20. PMID:25943760. |
thus, the goal of this study is to evaluate effects of acr on dopamine and its metabolite levels, dopamine transport and metabolic gene expression in dopaminergic neurons. |
2015-07-20 |
2023-08-13 |
rat |
| Xiaoqi Pan, Xiongxiong Guo, Fei Xiong, Guihong Cheng, Qing Lu, Hong Ya. Acrylamide increases dopamine levels by affecting dopamine transport and metabolism related genes in the striatal dopaminergic system. Toxicology letters. vol 236. issue 1. 2015-07-20. PMID:25943760. |
these results suggest that dopamine levels increase significantly in response to acr, presumably due to changes in the dopamine transport and metabolism related genes expression in the striatal dopaminergic neurons. |
2015-07-20 |
2023-08-13 |
rat |
| Pratibha Tripathi, Ashish Singh, Sonal Agrawal, Om Prakash, Mahendra Pratap Sing. Cypermethrin alters the status of oxidative stress in the peripheral blood: relevance to Parkinsonism. Journal of physiology and biochemistry. vol 70. issue 4. 2015-07-17. PMID:25270427. |
parkinson's disease (pd) is a motor scarcity disorder characterized by the striatal dopamine deficiency owing to the selective degeneration of the nigrostriatal dopaminergic neurons. |
2015-07-17 |
2023-08-13 |
rat |
| Caroline Moreau, Sayah Meguig, Jean-Christophe Corvol, Julien Labreuche, Francis Vasseur, Alain Duhamel, Arnaud Delval, Thomas Bardyn, Jean-Christophe Devedjian, Nathalie Rouaix, Gregory Petyt, Christine Brefel-Courbon, Fabienne Ory-Magne, Dominique Guehl, Alexandre Eusebio, Valérie Fraix, Pierre-Jean Saulnier, Ouhaid Lagha-Boukbiza, Frank Durif, Mirela Faighel, Caroline Giordana, Sophie Drapier, David Maltête, Christine Tranchant, Jean-Luc Houeto, Bettina Debû, Jean-Philippe Azulay, François Tison, Alain Destée, Marie Vidailhet, Olivier Rascol, Kathy Dujardin, Luc Defebvre, Régis Bordet, Bernard Sablonnière, David Devo. Polymorphism of the dopamine transporter type 1 gene modifies the treatment response in Parkinson's disease. Brain : a journal of neurology. vol 138. issue Pt 5. 2015-07-17. PMID:25805645. |
the objective of the present study was to determine whether genetic variants of the dopamine transporter type 1-encoding gene (slc6a3) are associated with differences in the response to treatment of motor symptoms and gait disorders with l-dopa and methylphenidate (with respect to the demographic, the disease and the treatment parameters and the other genes involved in the dopaminergic neurotransmission). |
2015-07-17 |
2023-08-13 |
human |
| Harry S Xenias, Osvaldo Ibáñez-Sandoval, Tibor Koós, James M Teppe. Are striatal tyrosine hydroxylase interneurons dopaminergic? The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 16. 2015-07-16. PMID:25904808. |
although generally assumed to be dopaminergic, possibly serving as a compensatory source of dopamine (da) in parkinson's disease, this assumption has never been tested directly. |
2015-07-16 |
2023-08-13 |
mouse |
| Thierry Paillard, Yves Rolland, Philipe de Souto Barret. Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review. Journal of clinical neurology (Seoul, Korea). vol 11. issue 3. 2015-07-16. PMID:26174783. |
exercise limits the alteration in dopaminergic neurons in the substantia nigra and contributes to optimal functioning of the basal ganglia involved in motor commands and control by adaptive mechanisms involving dopamine and glutamate neurotransmission. |
2015-07-16 |
2023-08-13 |
Not clear |
| Kevin J Black, Marilyn L Piccirillo, Jonathan M Koller, Tiffany Hseih, Lei Wang, Mark A Mintu. Levodopa effects on [ (11)C]raclopride binding in the resting human brain. F1000Research. vol 4. 2015-07-16. PMID:26180632. |
we hypothesized that exogenous levodopa might increase dopamine release at striatal synapses under some conditions but not others, allowing a more naturalistic assessment of presynaptic dopaminergic function. |
2015-07-16 |
2023-08-13 |
human |
| P N McCormick, P J Fletcher, V S Wilson, J D C Browne, J N Nobrega, G J Remingto. Low dose pramipexole causes D3 receptor-independent reduction of locomotion and responding for a conditioned reinforcer. Neuropharmacology. vol 89. 2015-07-15. PMID:25283483. |
pramipexole is a clinically important dopamine receptor agonist with reported selectivity for dopamine d3 receptors over other dopaminergic and non-dopaminergic sites. |
2015-07-15 |
2023-08-13 |
mouse |
| Kathryn D Luderman, Rong Chen, Mark J Ferris, Sara R Jones, Margaret E Gneg. Protein kinase C beta regulates the D₂-like dopamine autoreceptor. Neuropharmacology. vol 89. 2015-07-15. PMID:25446677. |
together with the dopamine transporter, the d2 autoreceptor regulates the level of extracellular dopamine and thus dopaminergic signaling. |
2015-07-15 |
2023-08-13 |
mouse |
| Kathryn D Luderman, Rong Chen, Mark J Ferris, Sara R Jones, Margaret E Gneg. Protein kinase C beta regulates the D₂-like dopamine autoreceptor. Neuropharmacology. vol 89. 2015-07-15. PMID:25446677. |
we propose that in the absence of pkcβ activity, surface d2 autoreceptor localization and thus d2 autoreceptor signaling is increased, leading to less dopamine in the extracellular space and attenuated dopaminergic signaling. |
2015-07-15 |
2023-08-13 |
mouse |