| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chelsea L Robertson, Kenji Ishibashi, Mark A Mandelkern, Amira K Brown, Dara G Ghahremani, Fred Sabb, Robert Bilder, Tyrone Cannon, Jacqueline Borg, Edythe D Londo. Striatal D1- and D2-type dopamine receptors are linked to motor response inhibition in human subjects. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 15. 2015-06-18. PMID:25878272. |
the results indicate that dopamine d1- and d2-type receptors are associated with response inhibition, and identify the dorsal striatum as an important locus of dopaminergic control in stopping. |
2015-06-18 |
2023-08-13 |
human |
| Arunkumar Asaithambi, Muhammet Ay, Huajun Jin, Anamitra Gosh, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G Kanthasam. Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. PloS one. vol 9. issue 5. 2015-06-16. PMID:24806360. |
dopaminergic neurotoxicant 6-hydroxy dopamine (6-ohda) was used to induce oxidative stress in the n27 dopaminergic cell model and in primary mesencephalic neurons. |
2015-06-16 |
2023-08-13 |
Not clear |
| Christine M Sandiego, Jean-Dominique Gallezot, Keunpoong Lim, Jim Ropchan, Shu-fei Lin, Hong Gao, Evan D Morris, Kelly P Cosgrov. Reference region modeling approaches for amphetamine challenge studies with [11C]FLB 457 and PET. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 4. 2015-06-16. PMID:25564239. |
detecting fluctuations in synaptic dopamine levels in extrastriatal brain regions with [(11)c]flb 457 and positron emission tomography (pet) is a valuable tool for studying dopaminergic dysfunction in psychiatric disorders. |
2015-06-16 |
2023-08-13 |
Not clear |
| Giacomo Koch, Francesco Di Lorenzo, Sonia Bonnì, Viola Giacobbe, Marco Bozzali, Carlo Caltagirone, Alessandro Martoran. Dopaminergic modulation of cortical plasticity in Alzheimer's disease patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 11. 2015-06-15. PMID:24859851. |
our findings reveal that dopamine agonists may restore the altered mechanisms of ltp-like cortical plasticity in ad patients, thus providing novel implications for therapies based on dopaminergic stimulation. |
2015-06-15 |
2023-08-13 |
Not clear |
| KyoungWon Baik, Jungho Cha, Jee Hyun Ham, Gwang-Min Baek, Mun Kyung Sunwoo, Jin Yong Hong, Na-Young Shin, Jae Seung Kim, Jong-Min Lee, Seung-Koo Lee, Young Ho Sohn, Phil Hyu Le. Dopaminergic modulation of resting-state functional connectivity in de novo patients with Parkinson's disease. Human brain mapping. vol 35. issue 11. 2015-06-15. PMID:24938993. |
parkinson's disease (pd) is characterized by degenerative changes of nigral dopamine neurons, resulting in the dopaminergic denervation of the striatum. |
2015-06-15 |
2023-08-13 |
Not clear |
| Karl Friston, Philipp Schwartenbeck, Thomas FitzGerald, Michael Moutoussis, Timothy Behrens, Raymond J Dola. The anatomy of choice: dopamine and decision-making. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1655. 2015-06-15. PMID:25267823. |
the changes in precision during variational updates are remarkably reminiscent of empirical dopaminergic responses-and they may provide a new perspective on the role of dopamine in assimilating reward prediction errors to optimize decision-making. |
2015-06-15 |
2023-08-13 |
Not clear |
| N Krogsgaard-Larsen, K Harpsøe, J Kehler, C T Christoffersen, P Brøsen, T Ball. Revision of the classical dopamine D2 agonist pharmacophore based on an integrated medicinal chemistry, homology modelling and computational docking approach. Neurochemical research. vol 39. issue 10. 2015-06-08. PMID:25056287. |
the scientific advances during the 1970ies and 1980ies within the field of dopaminergic neurotransmission enabled the development of a pharmacophore that became the template for design and synthesis of dopamine d2 agonists during the following four decades. |
2015-06-08 |
2023-08-13 |
Not clear |
| Miklós Sárvári, Levente Deli, Pál Kocsis, László Márk, Gábor Maász, Erik Hrabovszky, Imre Kalló, Dávid Gajári, Csaba Vastagh, Balázs Sümegi, Károly Tihanyi, Zsolt Liposit. Estradiol and isotype-selective estrogen receptor agonists modulate the mesocortical dopaminergic system in gonadectomized female rats. Brain research. vol 1583. 2015-06-05. PMID:24976584. |
collectively, the results indicate that e2 and isotype-selective er agonists can powerfully modulate the responsiveness of the mesocortical dopaminergic system, increase the expression of key genes related to dopaminergic neurotransmission and augment the dopamine content of the pfc. |
2015-06-05 |
2023-08-13 |
rat |
| Vincent D Costa, Valery L Tran, Janita Turchi, Bruno B Averbec. Dopamine modulates novelty seeking behavior during decision making. Behavioral neuroscience. vol 128. issue 5. 2015-06-04. PMID:24911320. |
the idea that dopamine modulates novelty seeking is supported by evidence that novel stimuli excite dopamine neurons and activate brain regions receiving dopaminergic input. |
2015-06-04 |
2023-08-13 |
monkey |
| Elpida Tsika, Meghna Kannan, Caroline Shi-Yan Foo, Dustin Dikeman, Liliane Glauser, Sandra Gellhaar, Dagmar Galter, Graham W Knott, Ted M Dawson, Valina L Dawson, Darren J Moor. Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration. Neurobiology of disease. vol 71. 2015-06-02. PMID:25174890. |
the expression of r1441c lrrk2 does not induce the degeneration of substantia nigra dopaminergic neurons or striatal dopamine deficits in mice up to 2years of age, and fails to precipitate abnormal protein inclusions containing alpha-synuclein, tau, ubiquitin or autophagy markers (lc3 and p62). |
2015-06-02 |
2023-08-13 |
mouse |
| K Yu Sarkisova, M A Kulikov, V S Kudrin, I S Midzyanovskaya, L M Birioukov. [Age-related changes in behavior, in monoamines and their metabolites content, and in density of D1 and D2 dopamine receptors in the brain structures of WAG/Rij rats with depression-like pathology]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 64. issue 6. 2015-06-02. PMID:25975143. |
at age of 36 days, when phenotypic expression of absence epilepsy in wag/rij rats is absent, neurochemical alterations in the brain suggesting a hypo-function of the mesolimbic dopaminergic system (deficit of dopamine in the nucleus accumbens), as well as symptoms of depression-like behavior, are not detected. |
2015-06-02 |
2023-08-13 |
rat |
| K Yu Sarkisova, M A Kulikov, V S Kudrin, I S Midzyanovskaya, L M Birioukov. [Age-related changes in behavior, in monoamines and their metabolites content, and in density of D1 and D2 dopamine receptors in the brain structures of WAG/Rij rats with depression-like pathology]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 64. issue 6. 2015-06-02. PMID:25975143. |
higher density of d2-like dopamine receptors was observed in wag/rij rats compared with controls only at age of 6 months when a hypo-function of the mesolimbic dopaminergic bran system was extremely pronounced indicating that this increase is a compensatory response to a deficit of dopamine. |
2015-06-02 |
2023-08-13 |
rat |
| Tertia D Purves-Tyson, Samantha J Owens, Kay L Double, Reena Desai, David J Handelsman, Cynthia Shannon Weicker. Testosterone induces molecular changes in dopamine signaling pathway molecules in the adolescent male rat nigrostriatal pathway. PloS one. vol 9. issue 3. 2015-05-29. PMID:24618531. |
gene expression changes in the dopaminergic cell body region may serve to modulate both dendritic dopamine feedback inhibition and reuptake in the dopaminergic somatodendritic field as well as dopamine release and re-uptake dynamics at the presynaptic terminals in the striatum. |
2015-05-29 |
2023-08-12 |
rat |
| Rosa Giráldez-Pérez, Mónica Antolín-Vallespín, María Muñoz, Amelia Sánchez-Capel. Models of α-synuclein aggregation in Parkinson's disease. Acta neuropathologica communications. vol 2. 2015-05-29. PMID:25497491. |
indeed, evidences show that dopamine (da) metabolism may be related to α-syn and its conformational plasticity, suggesting an interesting link between the two pathological hallmarks of pd: dopaminergic neurodegeneration and lewy body (lb) formation. |
2015-05-29 |
2023-08-13 |
mouse |
| Se Joon Choi, Anne Panhelainen, Yvonne Schmitz, Kristin E Larsen, Ellen Kanter, Min Wu, David Sulzer, Eugene V Mosharo. Changes in neuronal dopamine homeostasis following 1-methyl-4-phenylpyridinium (MPP+) exposure. The Journal of biological chemistry. vol 290. issue 11. 2015-05-29. PMID:25596531. |
1-methyl-4-phenylpyridinium (mpp(+)), the active metabolite of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, selectively kills dopaminergic neurons in vivo and in vitro via a variety of toxic mechanisms, including mitochondrial dysfunction, generation of peroxynitrite, induction of apoptosis, and oxidative stress due to disruption of vesicular dopamine (da) storage. |
2015-05-29 |
2023-08-13 |
mouse |
| S Little, P Brow. Focusing brain therapeutic interventions in space and time for Parkinson's disease. Current biology : CB. vol 24. issue 18. 2015-05-28. PMID:25247369. |
pharmacogenetics genetically re-engineers neurons to produce neurotrophins that are neuroprotective to vulnerable dopaminergic cells or to directly replace dopamine through enzyme transduction. |
2015-05-28 |
2023-08-13 |
Not clear |
| Iqbal Ahmad, Xing Zhao, Sowmya Parameswaran, Christopher J Destache, Jorge Rodriguez-Sierra, Wallace B Thoreson, Hiba Ahmad, John Sorrentino, Sudha Balasubramania. Direct differentiation of adult ocular progenitors into striatal dopaminergic neurons. International journal of stem cells. vol 8. issue 1. 2015-05-28. PMID:26019760. |
when the limbus-derived neural progenitors were subjected to a well-established protocol of directed differentiation under the influence of shh and fgf8, they acquired the biochemical and functional phenotype of dopaminergic neurons that included the ability to synthesize dopamine. |
2015-05-28 |
2023-08-13 |
rat |
| W Wyatt Wilson, Lauren P Shapiro, Joshua M Bradner, W Michael Caudl. Developmental exposure to the organochlorine insecticide endosulfan damages the nigrostriatal dopamine system in male offspring. Neurotoxicology. vol 44. 2015-05-27. PMID:25092410. |
in contrast, exposure of adult mice to endosulfan did not elicit dopaminergic damage and did not appear to increase the vulnerability of the dopamine neurons to mptp. |
2015-05-27 |
2023-08-13 |
mouse |
| Dietmar Weichert, Ashutosh Banerjee, Christine Hiller, Ralf C Kling, Harald Hübner, Peter Gmeine. Molecular determinants of biased agonism at the dopamine D₂ receptor. Journal of medicinal chemistry. vol 58. issue 6. 2015-05-26. PMID:25734236. |
in an effort to learn to design functionally selective molecular tools for the highly therapeutically relevant dopamine d2 receptor, we synthesized a collection of agonists based on structurally distinct head groups derived from canonical or atypical dopaminergic pharmacophores. |
2015-05-26 |
2023-08-13 |
Not clear |
| Dietmar Weichert, Ashutosh Banerjee, Christine Hiller, Ralf C Kling, Harald Hübner, Peter Gmeine. Molecular determinants of biased agonism at the dopamine D₂ receptor. Journal of medicinal chemistry. vol 58. issue 6. 2015-05-26. PMID:25734236. |
by employing functional assays and molecular dynamics simulations, we could show that atypical dopamine surrogates of type 1 and 2 promote biased signaling, while ligands built from classical dopaminergic head groups (type 3 and 4) typically elicit more balanced signaling profiles. |
2015-05-26 |
2023-08-13 |
Not clear |