| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Polina Zozulinsky, Lior Greenbaum, Noa Brande-Eilat, Yair Braun, Idan Shalev, Rachel Tome. Dopamine system genes are associated with orienting bias among healthy individuals. Neuropsychologia. vol 62. 2015-05-19. PMID:25038551. |
the current study examined the hypothesis that functional genetic variants within dopaminergic genes (dat1 3' vntr, dopamine d2 receptor taq1a (rs1800497) and comt val158met (rs4680)) contribute to individual differences in orienting bias, as measured by the greyscales paradigm, in a sample of 197 young healthy israeli jewish participants. |
2015-05-19 |
2023-08-13 |
human |
| J Schomaker, H W Berendse, E M J Foncke, Y D van der Werf, O A van den Heuvel, J Theeuwes, M Meete. Novelty processing and memory formation in Parkinson's disease. Neuropsychologia. vol 62. 2015-05-19. PMID:25065495. |
parkinson's disease (pd) is characterized by a degeneration of nigrostriatal dopaminergic cells, resulting in dopamine depletion. |
2015-05-19 |
2023-08-13 |
Not clear |
| Thomas Goschke, Annette Bolt. Emotional modulation of control dilemmas: the role of positive affect, reward, and dopamine in cognitive stability and flexibility. Neuropsychologia. vol 62. 2015-05-19. PMID:25068705. |
finally, we critically review evidence for the popular hypothesis that effects of positive affect may be mediated by dopaminergic modulations of neural processing in prefrontal and striatal brain circuits, and we refine this "dopamine hypothesis of positive affect" by specifying distinct mechanisms by which dopamine may mediate effects of positive affect and reward on cognitive control. |
2015-05-19 |
2023-08-13 |
Not clear |
| John M Burkhardt, Louise Adermar. Locus of onset and subpopulation specificity of in vivo ethanol effect in the reciprocal ventral tegmental area-nucleus accumbens circuit. Neurochemistry international. vol 76. 2015-05-15. PMID:25058792. |
elevated levels of dopamine in the nucleus accumbens (nac) as a consequence of increased activation of dopaminergic neurons in the vta are associated with the reinforcing properties of ethanol consumption, but whether the initiation of drug-response is connected to a direct activation of dopaminergic cell bodies in the vta region or involves gabaergic neurons in vta and/or the nac is unclear. |
2015-05-15 |
2023-08-13 |
mouse |
| John M Burkhardt, Louise Adermar. Locus of onset and subpopulation specificity of in vivo ethanol effect in the reciprocal ventral tegmental area-nucleus accumbens circuit. Neurochemistry international. vol 76. 2015-05-15. PMID:25058792. |
recorded units were classified based on electrophysiological properties and the pharmacological response to the dopamine d2 receptor agonist quinpirole into putative dopaminergic (da) neurons and fast-spiking or slow-spiking putative gabaergic neurons. |
2015-05-15 |
2023-08-13 |
mouse |
| L F Berro, R Santos, A W Hollais, R Wuo-Silva, D F Fukushiro, E Mári-Kawamoto, J M Costa, T F Trombin, C L Patti, S B Grapiglia, S Tufik, M L Andersen, R Frussa-Filh. Acute total sleep deprivation potentiates cocaine-induced hyperlocomotion in mice. Neuroscience letters. vol 579. 2015-05-12. PMID:25067829. |
physiologically, all of these drugs induce an increase in dopamine release in the mesolimbic dopaminergic system, which leads to hyperlocomotion in rodents. |
2015-05-12 |
2023-08-13 |
mouse |
| Tomoyuki Kanda, Shin-ichi Uchid. Clinical/pharmacological aspect of adenosine A2A receptor antagonist for dyskinesia. International review of neurobiology. vol 119. 2015-05-12. PMID:25175964. |
however, when dyskinesia is already established, the increase in dopaminergic load produced by the addition of a dopamine agonist can result in an increase in the severity and duration of dyskinesia. |
2015-05-12 |
2023-08-13 |
Not clear |
| Jun-Shiao Chou, Chu-Yu Chen, Ying-Ling Chen, Yi-Hsin Weng, Tu-Hsueh Yeh, Chin-Song Lu, Ya-Ming Chang, Hung-Li Wan. (G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse. Neurobiology of disease. vol 68. 2015-05-11. PMID:24830390. |
our study provides the evidence that mutant (g2019s) lrrk2 causes early-phase dysfunctions of snpc dopaminergic neurons, including a decrease in spontaneous firing rate and a reduction in evoked dopamine release, and impairment of corticostriatal ltd in the (g2019s) lrrk2 transgenic mouse. |
2015-05-11 |
2023-08-13 |
mouse |
| Ning Xiao, Eve Privman, B Jill Vento. Optogenetic control of serotonin and dopamine release in Drosophila larvae. ACS chemical neuroscience. vol 5. issue 8. 2015-05-11. PMID:24849718. |
pulsed stimulations were also used to evoke dopamine release in flies expressing chr2 in dopaminergic neurons and similar frequency dependence was observed. |
2015-05-11 |
2023-08-13 |
drosophila_melanogaster |
| Jiyue Zheng, Zhaohui Yang, Xuan Li, Linlang Li, Haikuo Ma, Meiyu Wang, Hongjian Zhang, Xuechu Zhen, Xiaohu Zhan. Optimization of 6-heterocyclic-2-(1H-pyrazol-1-yl)-N-(pyridin-2-yl)pyrimidin-4-amine as potent adenosine A2A receptor antagonists for the treatment of Parkinson's disease. ACS chemical neuroscience. vol 5. issue 8. 2015-05-11. PMID:24922583. |
current therapies are based mainly on dopaminergic replacement strategies by administration of either dopamine agonists or dopamine precursor levodopa (l-dopa). |
2015-05-11 |
2023-08-13 |
Not clear |
| Marcelo Roberto Choi, Nicolás Martín Kouyoumdzian, Natalia Lucía Rukavina Mikusic, María Cecilia Kravetz, María Inés Rosón, Martín Rodríguez Fermepin, Belisario Enrique Fernánde. Renal dopaminergic system: Pathophysiological implications and clinical perspectives. World journal of nephrology. vol 4. issue 2. 2015-05-07. PMID:25949933. |
the aim of this review is to update and discuss on the most recent findings about renal dopaminergic system and its role in several diseases involving the kidneys and the potential use of dopamine as a nephroprotective agent. |
2015-05-07 |
2023-08-13 |
Not clear |
| Thorsten Kahnt, Susanna C Weber, Helene Haker, Trevor W Robbins, Philippe N Toble. Dopamine D2-receptor blockade enhances decoding of prefrontal signals in humans. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 9. 2015-05-01. PMID:25740537. |
these findings are in line with a dual-state model of prefrontal dopamine, and provide new insights into the potential mechanism of action of dopaminergic drugs. |
2015-05-01 |
2023-08-13 |
human |
| Maria Cecilia Ramirez, Ana Maria Ornstein, Guillermina Maria Luque, Maria Ines Perez Millan, Isabel Garcia-Tornadu, Marcelo Rubinstein, Damasia Becu-Villalobo. Pituitary and brain dopamine D2 receptors regulate liver gene sexual dimorphism. Endocrinology. vol 156. issue 3. 2015-04-29. PMID:25545383. |
because gh and prolactin secretion are regulated by dopaminergic pathways, we studied the participation of brain and lactotrope dopamine 2 receptors (d2rs) on liver gene sexual dimorphism, to explore a link between the brain and liver gene expression. |
2015-04-29 |
2023-08-13 |
mouse |
| Kayo Takahashi, Kei Mizuno, Akihiro T Sasaki, Yasuhiro Wada, Masaaki Tanaka, Akira Ishii, Kanako Tajima, Naohiro Tsuyuguchi, Kyosuke Watanabe, Semir Zeki, Yasuyoshi Watanab. Imaging the passionate stage of romantic love by dopamine dynamics. Frontiers in human neuroscience. vol 9. 2015-04-27. PMID:25914637. |
using [(11)c]raclopride, a dopamine d2/d3 receptor antagonist, we undertook a positron emission tomography (pet) study to investigate the involvement of the dopaminergic neurotransmitter system when subjects viewed the pictures of partners to whom they were romantically attached. |
2015-04-27 |
2023-08-13 |
human |
| Marisela Agudelo, Pradnya Khatavkar, Adriana Yndart, Changwon Yoo, Rhonda Rosenberg, Jessy G Devieux, Robert M Malow, Madhavan Nai. Alcohol abuse and HIV infection: role of DRD2. Current HIV research. vol 12. issue 4. 2015-04-22. PMID:25053368. |
to date, the effects of dopamine on hiv neuroimmune pathogenesis are not well understood; however, dopaminergic neural degeneration due to hiv is known to occur by viral invasion into the brain via immune cells, and modulation of dopamine in the cns may be a common mechanism by which different types of substances of abuse impact hiv disease progression. |
2015-04-22 |
2023-08-13 |
Not clear |
| Sudhakar Raja Subramaniam, Laurent Vergnes, Nicholas R Franich, Karen Reue, Marie-Francoise Chessele. Region specific mitochondrial impairment in mice with widespread overexpression of alpha-synuclein. Neurobiology of disease. vol 70. 2015-04-21. PMID:25016198. |
thus, in mice over-expressing alpha-synuclein, mitochondrial dysfunction occurred preferentially in nigrostriatal dopaminergic neurons many months before striatal dopamine loss occurs at 14months of age. |
2015-04-21 |
2023-08-13 |
mouse |
| Madeleine W Cunningha. Rheumatic fever, autoimmunity, and molecular mimicry: the streptococcal connection. International reviews of immunology. vol 33. issue 4. 2015-04-16. PMID:24892819. |
in sydenham chorea, human mabs and their expression in transgenic mice have linked autoimmunity to central dopamine pathways as well as dopamine receptors and dopaminergic neurons in basal ganglia. |
2015-04-16 |
2023-08-13 |
mouse |
| Laura M Vecchio, M Kristel Bermejo, Pieter Beerepoot, Amy J Ramsey, Ali Salahpou. N-terminal tagging of the dopamine transporter impairs protein expression and trafficking in vivo. Molecular and cellular neurosciences. vol 61. 2015-04-15. PMID:24886986. |
as such, it plays an important role in the cessation of dopaminergic neurotransmission and in the maintenance of extracellular dopamine homeostasis. |
2015-04-15 |
2023-08-13 |
mouse |
| Eduard Bentea, Anke Van der Perren, Joeri Van Liefferinge, Anissa El Arfani, Giulia Albertini, Thomas Demuyser, Ellen Merckx, Yvette Michotte, Ilse Smolders, Veerle Baekelandt, Ann Massi. Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein. Frontiers in behavioral neuroscience. vol 9. 2015-04-15. PMID:25873870. |
we report that unilateral administration of 3 μg lactacystin to the substantia nigra of mice leads to partial (~40%) dopaminergic cell loss and concurrent striatal dopamine depletion, accompanied by increased expression of ser129-phosphorylated α-synuclein. |
2015-04-15 |
2023-08-13 |
mouse |
| Hitoshi Shinoto. [Neuroimaging in corticobasal syndrome]. Rinsho shinkeigaku = Clinical neurology. vol 53. issue 11. 2015-04-13. PMID:24291869. |
[(18)f]6-fluorodopa pet and dopamine transporter spect studies demonstrated dysfunction of nigrostriatal dopaminergic function in cbs. |
2015-04-13 |
2023-08-12 |
Not clear |