| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| LinLin Tian, Morvarid Karimi, Chris A Brown, Susan K Loftin, Joel S Perlmutte. In vivo measures of nigrostriatal neuronal response to unilateral MPTP treatment. Brain research. vol 1571. 2015-02-02. PMID:24845719. |
we then calculated the terminal arbor size and compared these measures with previously published data of quantified in vivo positron emission tomography (pet) measures of presynaptic dopaminergic neurons, autoradiographic measures of dat and vesicular monoamine transporter type 2 (vmat2), striatal dopamine, nigral cell counts, and parkinsonian motor ratings in the same animals. |
2015-02-02 |
2023-08-13 |
Not clear |
| Claudia Rangel-Barajas, Maninder Malik, Suwanna Vangveravong, Robert H Mach, Robert R Luedtk. Pharmacological modulation of abnormal involuntary DOI-induced head twitch response in male DBA/2J mice: I. Effects of D2/D3 and D2 dopamine receptor selective compounds. Neuropharmacology. vol 83. 2015-01-29. PMID:24680675. |
this observation suggests a functional interaction between dopaminergic and serotonergic systems through d2 dopamine receptors and the 5-ht2a serotonin receptors in vivo. |
2015-01-29 |
2023-08-12 |
mouse |
| Wen-Tai Chiu, Che-Ming Lin, Tien-Chun Tsai, Chun-Wei Wu, Ching-Lin Tsai, Sheng-Hsiang Lin, Jia-Jin Jason Che. Real-time electrochemical recording of dopamine release under optogenetic stimulation. PloS one. vol 9. issue 2. 2015-01-27. PMID:24586667. |
dopaminergic pc12 cells can synthesize and release dopamine, providing a good cellular model for investigating dopamine regulation. |
2015-01-27 |
2023-08-12 |
Not clear |
| Wen-Tai Chiu, Che-Ming Lin, Tien-Chun Tsai, Chun-Wei Wu, Ching-Lin Tsai, Sheng-Hsiang Lin, Jia-Jin Jason Che. Real-time electrochemical recording of dopamine release under optogenetic stimulation. PloS one. vol 9. issue 2. 2015-01-27. PMID:24586667. |
the aim of this study is to measure dopamine release from dopaminergic pc12 cells under optogenetic stimulation using electrochemical recording of self-assembled monolayers modified microelectrode with amperometric measurement in real time. |
2015-01-27 |
2023-08-12 |
Not clear |
| Wen-Tai Chiu, Che-Ming Lin, Tien-Chun Tsai, Chun-Wei Wu, Ching-Lin Tsai, Sheng-Hsiang Lin, Jia-Jin Jason Che. Real-time electrochemical recording of dopamine release under optogenetic stimulation. PloS one. vol 9. issue 2. 2015-01-27. PMID:24586667. |
this proposed dopamine recording system can be developed to be a good cell model for dopamine regulation and drug screening in vitro, or dopaminergic cell implantation therapy in vivo using optogenetic stimulation in a precise and convenient way. |
2015-01-27 |
2023-08-12 |
Not clear |
| Liqin Jiang, Keli Long, Frank Schaeffel, Xiangtian Zhou, Yibo Zheng, Huangfang Ying, Fan Lu, William K Stell, Jia Q. Effects of dopaminergic agents on progression of naturally occurring myopia in albino guinea pigs (Cavia porcellus). Investigative ophthalmology & visual science. vol 55. issue 11. 2015-01-27. PMID:25270191. |
disruption of dopaminergic signaling has been implicated in the abnormalities of ocular development in albinism, and many experiments have shown that retinal dopamine is a major regulator of postnatal eye growth and myopia in animal models. |
2015-01-27 |
2023-08-13 |
Not clear |
| G Cruz, R Riquelme, P Espinosa, P Jara, A Dagnino-Subiabre, G M Renard, R Sotomayor-Zárat. Neonatal exposure to estradiol valerate increases dopamine content in nigrostriatal pathway during adulthood in the rat. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 46. issue 5. 2015-01-26. PMID:24323410. |
this might imply that estrogenized rats could have changes in the expression of key proteins in dopaminergic regulation, as tyrosine hydroxylase and dopamine transporter. |
2015-01-26 |
2023-08-12 |
rat |
| Christian Brabant, Douglas J Guarnieri, Etienne Quertemon. Stimulant and motivational effects of alcohol: lessons from rodent and primate models. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24632178. |
additionally, the role of dopamine in alcohol-induced hyperactivity is well established since blocking dopaminergic activity suppresses the stimulant effects of alcohol. |
2015-01-26 |
2023-08-12 |
Not clear |
| Elizabeth E Steinberg, Josiah R Boivin, Benjamin T Saunders, Ilana B Witten, Karl Deisseroth, Patricia H Jana. Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens. PloS one. vol 9. issue 4. 2015-01-19. PMID:24733061. |
we find that optogenetic activation of dopaminergic terminals innervating the nac is sufficient to drive icss, and that icss driven by optical activation of dopamine neuron somata in the vta is significantly attenuated by intra-nac injections of d1 or d2 receptor antagonists. |
2015-01-19 |
2023-08-13 |
human |
| Emilio Domínguez-Salazar, Hishan F Naser, Javier Velázquez-Moctezum. D1-like antagonist blocks conditioned place preference induced by ejaculation in male rats. Behavioural brain research. vol 269. 2015-01-15. PMID:24768642. |
dopamine has been implicated in sexual motivation, coital behavior and sexual reward, however, some experiments show that d2-like or non-specific dopaminergic antagonists are not capable of blocking the conditioned place preference induced by ejaculation; therefore, the role of dopamine on sexual reward has not been demonstrated, or has been frequently discarded. |
2015-01-15 |
2023-08-13 |
rat |
| Chen Lu, Jin Zhang, Xiaopeng Shi, Shan Miao, Linlin Bi, Song Zhang, Qian Yang, Xuanxuan Zhou, Meng Zhang, Yanhua Xie, Qing Miao, Siwang Wan. Neuroprotective effects of tetramethylpyrazine against dopaminergic neuron injury in a rat model of Parkinson's disease induced by MPTP. International journal of biological sciences. vol 10. issue 4. 2015-01-14. PMID:24719552. |
the results showed that tmp could notably prevent mptp-induced dopaminergic neurons damage, reflected by improvement of motor deficits, enhancement of th expression and the content of dopamine and its metabolite, dopac. |
2015-01-14 |
2023-08-13 |
rat |
| Cristian Follme. Monoamine oxidase and α-synuclein as targets in Parkinson's disease therapy. Expert review of neurotherapeutics. vol 14. issue 6. 2015-01-13. PMID:24852232. |
the degeneration of dopaminergic neurons in parkinson's disease (pd) is suggested to be associated with the generation of cytotoxic products from dopamine (da) metabolism and the formation of fibrillar inclusions of the protein α-synuclein (as). |
2015-01-13 |
2023-08-13 |
Not clear |
| Brent J Ryan, Lara L Lourenço-Venda, Mark J Crabtree, Ashley B Hale, Keith M Channon, Richard Wade-Martin. α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease. Free radical biology & medicine. vol 67. 2015-01-06. PMID:24148766. |
we have previously demonstrated that sirna-mediated knockdown of α-syn lowers the activity of both dopamine transporter and nos activity and protects dopaminergic neuron-like cells from mpp(+) toxicity. |
2015-01-06 |
2023-08-12 |
human |
| M R Williams, K Galvin, B O'Sullivan, C D MacDonald, E W K Ching, F Turkheimer, O D Howes, R K B Pearce, S R Hirsch, M Maie. Neuropathological changes in the substantia nigra in schizophrenia but not depression. European archives of psychiatry and clinical neuroscience. vol 264. issue 4. 2015-01-05. PMID:24374935. |
the substantia nigra is a basal ganglia nucleus responsible for the production of dopamine and projection of dopaminergic neurons to the striatum. |
2015-01-05 |
2023-08-12 |
Not clear |
| Elizabeth M Hartfield, Michiko Yamasaki-Mann, Hugo J Ribeiro Fernandes, Jane Vowles, William S James, Sally A Cowley, Richard Wade-Martin. Physiological characterisation of human iPS-derived dopaminergic neurons. PloS one. vol 9. issue 2. 2015-01-02. PMID:24586273. |
we first generated and differentiated hipsc lines into midbrain dopaminergic neurons and performed a comprehensive characterisation to confirm dopaminergic functionality by demonstrating dopamine synthesis, release, and re-uptake. |
2015-01-02 |
2023-08-12 |
human |
| Natalie Kaplan, Aya Vituri, Amos D Korczyn, Oren S Cohen, Rivka Inzelberg, Gilad Yahalom, Evgenia Kozlova, Roni Milgrom, Yael Laitman, Eitan Friedman, Saharon Rosset, Sharon Hassin-Bae. Sequence variants in SLC6A3, DRD2, and BDNF genes and time to levodopa-induced dyskinesias in Parkinson's disease. Journal of molecular neuroscience : MN. vol 53. issue 2. 2015-01-02. PMID:24633632. |
in order to identify genetic factors associated with lid, 352 (213 males) levodopa-treated israeli pd patients were genotyped for 34 polymorphisms within three candidate genes affecting dopaminergic activity and synaptic plasticity: dopamine transporter gene (dat1 or slc6a3) [14 single nucleotide polymorphisms (snps) and 40-bp variable number tandem repeat (vntr)], drd2 [11 snps and dinucleotide ca short tandem repeat (str)], and bdnf (7 snps). |
2015-01-02 |
2023-08-12 |
human |
| David O'Tousa, Nicholas Graham. Habit formation: implications for alcoholism research. Alcohol (Fayetteville, N.Y.). vol 48. issue 4. 2014-12-31. PMID:24835007. |
dopaminergic signaling is necessary for the neurological adaptations involved in stimulus-response action, and drugs of abuse appear to facilitate habitual behavior through high levels of dopamine release. |
2014-12-31 |
2023-08-13 |
Not clear |
| Sverker Sikström, Göran Söderlun. Stimulus-dependent dopamine release in attention-deficit/hyperactivity disorder. Psychological review. vol 114. issue 4. 2014-12-30. PMID:17907872. |
normally, a high extracellular dopamine level yields a tonic dopaminergic input that down-regulates stimuli-evoked phasic dopamine responses through autoreceptors. |
2014-12-30 |
2023-08-12 |
Not clear |
| Bidyut Sarkar, Arkarup Banerjee, Anand Kant Das, Suman Nag, Sanjeev Kumar Kaushalya, Umakanta Tripathy, Mohammad Shameem, Shubha Shukla, Sudipta Mait. Label-free dopamine imaging in live rat brain slices. ACS chemical neuroscience. vol 5. issue 5. 2014-12-30. PMID:24661118. |
dopaminergic neurotransmission has been investigated extensively, yet direct optical probing of dopamine has not been possible in live cells. |
2014-12-30 |
2023-08-12 |
rat |
| Bidyut Sarkar, Arkarup Banerjee, Anand Kant Das, Suman Nag, Sanjeev Kumar Kaushalya, Umakanta Tripathy, Mohammad Shameem, Shubha Shukla, Sudipta Mait. Label-free dopamine imaging in live rat brain slices. ACS chemical neuroscience. vol 5. issue 5. 2014-12-30. PMID:24661118. |
the method is established by imaging dopamine in a dopaminergic cell line and in control cells (glia), and is validated by mass spectrometry. |
2014-12-30 |
2023-08-12 |
rat |