| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana M Espinosa-Oliva, Rocío M de Pablos, Manuel Sarmiento, Ruth F Villarán, Alejandro Carrillo-Jiménez, Marti Santiago, José L Venero, Antonio J Herrera, Josefina Cano, Alberto Machad. Role of dopamine in the recruitment of immune cells to the nigro-striatal dopaminergic structures. Neurotoxicology. vol 41. 2014-11-14. PMID:24486959. |
role of dopamine in the recruitment of immune cells to the nigro-striatal dopaminergic structures. |
2014-11-14 |
2023-08-12 |
Not clear |
| Julia Tereshchenko, Andrea Maddalena, Mathias Bähr, Sebastian Kügle. Pharmacologically controlled, discontinuous GDNF gene therapy restores motor function in a rat model of Parkinson's disease. Neurobiology of disease. vol 65. 2014-11-13. PMID:24440408. |
we demonstrate that short-term induced expression of glial cell line derived neurotrophic factor (gdnf) is sufficient to provide i) substantial protection of nigral dopaminergic neurons from degeneration and ii) restoration of dopamine supply and motor behaviour in the partial striatal 6-ohda model pd. |
2014-11-13 |
2023-08-12 |
rat |
| Niccolò E Mencacci, Ioannis U Isaias, Martin M Reich, Christos Ganos, Vincent Plagnol, James M Polke, Jose Bras, Joshua Hersheson, Maria Stamelou, Alan M Pittman, Alastair J Noyce, Kin Y Mok, Thomas Opladen, Erdmute Kunstmann, Sybille Hodecker, Alexander Münchau, Jens Volkmann, Samuel Samnick, Katie Sidle, Tina Nanji, Mary G Sweeney, Henry Houlden, Amit Batla, Anna L Zecchinelli, Gianni Pezzoli, Giorgio Marotta, Andrew Lees, Paulo Alegria, Paul Krack, Florence Cormier-Dequaire, Suzanne Lesage, Alexis Brice, Peter Heutink, Thomas Gasser, Steven J Lubbe, Huw R Morris, Pille Taba, Sulev Koks, Elisa Majounie, J Raphael Gibbs, Andrew Singleton, John Hardy, Stephan Klebe, Kailash P Bhatia, Nicholas W Woo. Parkinson's disease in GTP cyclohydrolase 1 mutation carriers. Brain : a journal of neurology. vol 137. issue Pt 9. 2014-11-06. PMID:24993959. |
dopamine transporter imaging was abnormal in all parkinsonian patients, indicating parkinson's disease-like nigrostriatal dopaminergic denervation. |
2014-11-06 |
2023-08-13 |
human |
| Carlos D Silva, Ana F Neves, Ana I Dias, Hugo J Freitas, Sheena M Mendes, Inês Pita, Sofia D Viana, Paulo A de Oliveira, Rodrigo A Cunha, Carlos A Fontes Ribeiro, Rui D Prediger, Frederico C Pereir. A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice. Neurotoxicity research. vol 25. issue 3. 2014-11-05. PMID:24072398. |
this depressive-like profile induced by meth was accompanied by a marked depletion of frontostriatal dopaminergic and serotonergic neurotransmission, indicated by a reduction in the levels of dopamine, dopac and hva, tyrosine hydroxylase and serotonin, observed at both 3 and 49 days post-administration. |
2014-11-05 |
2023-08-12 |
mouse |
| Dawn M Eagle, Cristie Noschang, Laure-Sophie Camilla d'Angelo, Christie A Noble, Jacob O Day, Marie Louise Dongelmans, David E Theobald, Adam C Mar, Gonzalo P Urcelay, Sharon Morein-Zamir, Trevor W Robbin. The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: a novel possible model of OCD. Behavioural brain research. vol 264. 2014-11-05. PMID:24406720. |
in an established rodent model of ocd checking behaviour, quinpirole (dopamine d2/3-receptor agonist) increased checking in open-field tests, indicating dopaminergic modulation of checking-like behaviours. |
2014-11-05 |
2023-08-12 |
rat |
| Ann-Kathrin Stock, Evelyn Heintschel von Heinegg, Hedda-Luise Köhling, Christian Best. Latent Toxoplasma gondii infection leads to improved action control. Brain, behavior, and immunity. vol 37. 2014-11-04. PMID:24231154. |
since a dopamine plus does not necessarily bear exclusively negative consequences in humans, we investigated potential positive consequences of latent toxoplasmosis (and the presumed boosting of dopaminergic neurotransmission) on human cognition and behavior. |
2014-11-04 |
2023-08-12 |
human |
| Damian M Herz, Hartwig R Siebner, Oliver J Hulme, Esther Florin, Mark S Christensen, Lars Timmerman. Levodopa reinstates connectivity from prefrontal to premotor cortex during externally paced movement in Parkinson's disease. NeuroImage. vol 90. 2014-11-04. PMID:24269570. |
patients were studied after at least 12-hour withdrawal of dopaminergic medication (off state) and after intake of the dopamine precursor levodopa (on state) in order to examine oscillatory coupling between prefrontal and premotor areas during respectively low and high levels of dopamine. |
2014-11-04 |
2023-08-12 |
human |
| Frederico Velasco Costa Sanguedo, Flávia Regina Cruz Dias, Enrrico Bloise, Isabel Cristina Cespedes, Arthur Giraldi-Guimarães, Richard Ian Samuels, Robert J Carey, Marinete Pinheiro Carrer. Increase in medial frontal cortex ERK activation following the induction of apomorphine sensitization. Pharmacology, biochemistry, and behavior. vol 118. 2014-11-04. PMID:24380761. |
the selective increase in erk activity in the pfc associated with behavioral sensitization, points to a possible pivotal role of the dopamine projection to the medial frontal cortex in the mediation of neural plasticity, considered to underlie the sensitization processes induced by dopaminergic drugs. |
2014-11-04 |
2023-08-12 |
rat |
| Michael Nguyen, Andrew Roth, Evan J Kyzar, Manoj K Poudel, Keith Wong, Adam Michael Stewart, Allan V Kaluef. Decoding the contribution of dopaminergic genes and pathways to autism spectrum disorder (ASD). Neurochemistry international. vol 66. 2014-10-31. PMID:24412511. |
here, we comprehensively evaluate known molecular interactors of dopaminergic genes, and identify their potential molecular partners within up/down-steam signaling pathways associated with dopamine. |
2014-10-31 |
2023-08-12 |
Not clear |
| Jee-Young Lee, Beom Seok Jeo. Maladaptive reward-learning and impulse control disorders in patients with Parkinson's disease: a clinical overview and pathophysiology update. Journal of movement disorders. vol 7. issue 2. 2014-10-31. PMID:25360230. |
icd in pd is strongly associated with dopaminergic drug use, especially non-ergot dopamine agonists (da). |
2014-10-31 |
2023-08-13 |
Not clear |
| Hong-Bin Zhao, Hui Ma, Xiao-Qin Ha, Ping Zheng, Xiao-Yun Li, Ming Zhang, Ju-Zi Dong, Yin-Shu Yan. Salidroside induces rat mesenchymal stem cells to differentiate into dopaminergic neurons. Cell biology international. vol 38. issue 4. 2014-10-30. PMID:24323403. |
parkinson's disease (pd) is a neurodegenerative disorder characterised by the loss of substantia nigra dopaminergic neurons that leads to a reduction in striatal dopamine (da) levels. |
2014-10-30 |
2023-08-12 |
rat |
| Hyo Geun Kim, Gunhyuk Park, Ying Piao, Min Seo Kang, Youngmi Kim Pak, Seon-Pyo Hong, Myung Sook O. Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson's disease. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 65. 2014-10-28. PMID:24389454. |
mce increased dopamine availability and protected against mptp-induced dopaminergic neuronal damage. |
2014-10-28 |
2023-08-12 |
mouse |
| Hidetoshi Komatsu, Minoru Maruyama, Shuuhei Yao, Tokuyuki Shinohara, Kensuke Sakuma, Sachiko Imaichi, Tomoko Chikatsu, Kanako Kuniyeda, Foo Kok Siu, Lam Sock Peng, Katherine Zhuo, Lay Sock Mun, Tan Min Han, Yoshio Matsumoto, Tadatoshi Hashimoto, Nobuyuki Miyajima, Yasuaki Itoh, Kazuhiro Ogi, Yugo Habata, Masaaki Mor. Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders. PloS one. vol 9. issue 2. 2014-10-28. PMID:24587241. |
the striatum, in which dopamine d1 and d2 receptors are enriched, is strongly innervated by the ventral tegmental area (vta), which is the origin of dopaminergic cell bodies of the mesocorticolimbic dopamine system_enref_3 and plays a central role in the development of psychiatric disorders_enref_4. |
2014-10-28 |
2023-08-12 |
mouse |
| Olaoluwa O Okusag. 6R-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4): a potential treatment for all symptom domains of schizophrenia. Medical hypotheses. vol 82. issue 3. 2014-10-27. PMID:24491428. |
bh4 may potentiate dopaminergic neurotransmission via mechanisms independent of dopamine biosynthesis. |
2014-10-27 |
2023-08-12 |
Not clear |
| Olaoluwa O Okusag. 6R-l-erythro-5,6,7,8-tetrahydrobiopterin (BH4): a potential treatment for all symptom domains of schizophrenia. Medical hypotheses. vol 82. issue 3. 2014-10-27. PMID:24491428. |
the hypothesis is based on the findings of: (1) reduced bh4 levels in schizophrenia patients; (2) negative and cognitive symptoms of schizophrenia are related to reduced dopamine neurotransmission in some parts of the brain and bh4 may correct this abnormality by potentiating dopaminergic neurotransmission in these brain regions; (3) there is reduced cellular expression of neuronal nos in certain brain regions of schizophrenia patients relative to healthy controls, an abnormality which may be corrected via bh4 cofactor effect on nos; (4) there is increased neuroinflammation in schizophrenia, and bh4 may be anti-inflammatory; (5) schizophrenia is associated with hyperphenyalaninemia (which maybe neurotoxic) and bh4 has clinical utility in normalizing phenylalanine levels. |
2014-10-27 |
2023-08-12 |
Not clear |
| Annadurai Anandhan, Kuppusamy Tamilselvam, Dhanraj Vijayraja, Nataraj Ashokkumar, Srinivasagam Rajasankar, Thamilarasan Manivasaga. Resveratrol attenuates oxidative stress and improves behaviour in 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) challenged mice. Annals of neurosciences. vol 17. issue 3. 2014-10-24. PMID:25205886. |
parkinson's disease (pd) is the most common neurodegenerative disorder, characterized by loss of dopaminergic neurons in substantia nigra and depletion of dopamine in striatum due to mitochondrial dysfunction, oxidative stress, excitotoxicity, apoptosis, inflammation and proteasome failure. |
2014-10-24 |
2023-08-13 |
mouse |
| Sho Yagishita, Akiko Hayashi-Takagi, Graham C R Ellis-Davies, Hidetoshi Urakubo, Shin Ishii, Haruo Kasa. A critical time window for dopamine actions on the structural plasticity of dendritic spines. Science (New York, N.Y.). vol 345. issue 6204. 2014-10-23. PMID:25258080. |
here, we optically stimulated dopaminergic and glutamatergic inputs separately and found that dopamine promoted spine enlargement only during a narrow time window (0.3 to 2 seconds) after the glutamatergic inputs. |
2014-10-23 |
2023-08-13 |
Not clear |
| Matteo Colomb. Deep and beautiful. The reward prediction error hypothesis of dopamine. Studies in history and philosophy of biological and biomedical sciences. vol 45. 2014-10-22. PMID:24252364. |
according to the reward-prediction error hypothesis (rpeh) of dopamine, the phasic activity of dopaminergic neurons in the midbrain signals a discrepancy between the predicted and currently experienced reward of a particular event. |
2014-10-22 |
2023-08-12 |
Not clear |
| Lieuwe Appel, Mats Bergström, Jørgen Buus Lassen, Bengt Långströ. Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: dopamine transporter occupancy as measured by PET. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 2. 2014-10-21. PMID:24239329. |
further, these results suggest that the previously reported dose-dependent weight loss, in te treated subjects, was in part mediated by an up-regulation of dopaminergic pathways due to enhanced amounts of synaptic dopamine after blockade of dat. |
2014-10-21 |
2023-08-12 |
human |
| Zhi Dong Zhou, Fathima Shaffra Refai, Shao Ping Xie, Shin Hui Ng, Christine Hui Shan Chan, Patrick Ghim Hoe Ho, Xiao Dong Zhang, Tit Meng Lim, Eng King Ta. Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. Free radical biology & medicine. vol 68. 2014-10-21. PMID:24374372. |
mutant pink1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons. |
2014-10-21 |
2023-08-12 |
Not clear |