| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shinobu Nomura, Maud Bouhadana, Carole Morel, Philippe Faure, Bruno Cauli, Bertrand Lambolez, Régine Hep. Noradrenalin and dopamine receptors both control cAMP-PKA signaling throughout the cerebral cortex. Frontiers in cellular neuroscience. vol 8. 2014-09-05. PMID:25191229. |
imaging of a genetically encoded sensor revealed that noradrenalin and dopamine widely activate pka in cortical pyramidal neurons of frontal, parietal and occipital regions with scarce dopaminergic fibers. |
2014-09-05 |
2023-08-13 |
Not clear |
| Shinobu Nomura, Maud Bouhadana, Carole Morel, Philippe Faure, Bruno Cauli, Bertrand Lambolez, Régine Hep. Noradrenalin and dopamine receptors both control cAMP-PKA signaling throughout the cerebral cortex. Frontiers in cellular neuroscience. vol 8. 2014-09-05. PMID:25191229. |
the pharmacology of these responses was consistent with the involvement of gs-coupled beta1 adrenergic and d1/d5 dopaminergic receptors, but the inhibition of both noradrenalin and dopamine responses by beta adrenergic antagonists was suggestive of the existence of beta1-d1/d5 heteromeric receptors. |
2014-09-05 |
2023-08-13 |
Not clear |
| Meghan R Hennis, Marian A Marvin, Charles M Taylor, Matthew S Goldber. Surprising behavioral and neurochemical enhancements in mice with combined mutations linked to Parkinson's disease. Neurobiology of disease. vol 62. 2014-09-03. PMID:24075852. |
the results of our behavioral, neurochemical and immunohistochemical analyses reveal that pd-linked mutations in parkin and dj-1 cause dysregulation of neurotransmitter systems beyond the nigrostriatal dopaminergic circuit and that loss-of-function mutations in parkin and dj-1 lead to adaptive changes in dopamine and serotonin especially in the context of gpx1 deficiency. |
2014-09-03 |
2023-08-12 |
mouse |
| Nadine Schweizer, Stéfano Pupe, Emma Arvidsson, Karin Nordenankar, Casey J A Smith-Anttila, Souha Mahmoudi, Anna Andrén, Sylvie Dumas, Aparna Rajagopalan, Daniel Lévesque, Richardson N Leão, Åsa Wallén-Mackenzi. Limiting glutamate transmission in a Vglut2-expressing subpopulation of the subthalamic nucleus is sufficient to cause hyperlocomotion. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 21. 2014-09-02. PMID:24821804. |
furthermore, these mice showed reduced dopamine transporter binding and slower dopamine clearance in vivo, suggesting that vglut2-expressing cells in the stn regulate dopaminergic transmission. |
2014-09-02 |
2023-08-13 |
mouse |
| Kun-Han Lue, Hsin-Hon Lin, Chih-Hao K Kao, Hung-Jen Hsieh, Shu-Hsin Liu, Keh-Shih Chuan. A simple algorithm for subregional striatal uptake analysis with partial volume correction in dopaminergic PET imaging. Annals of nuclear medicine. vol 28. issue 1. 2014-08-31. PMID:24135967. |
in positron emission tomography (pet) of the dopaminergic system, quantitative measurements of nigrostriatal dopamine function are useful for differential diagnosis. |
2014-08-31 |
2023-08-12 |
Not clear |
| Hanane Kadar, Gael Le Douaron, Majid Amar, Laurent Ferrié, Bruno Figadère, David Touboul, Alain Brunelle, Rita Raisman-Vozar. MALDI mass spectrometry imaging of 1-methyl-4-phenylpyridinium (MPP+) in mouse brain. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24347373. |
mptp administration displayed a significant decrease of striatal dopamine (da) and a loss of dopaminergic (da) neurons in the substantia nigra pars compacta. |
2014-08-28 |
2023-08-12 |
mouse |
| N Daviaud, E Garbayo, N Lautram, F Franconi, L Lemaire, M Perez-Pinzon, C N Montero-Mene. Modeling nigrostriatal degeneration in organotypic cultures, a new ex vivo model of Parkinson's disease. Neuroscience. vol 256. 2014-08-27. PMID:24161279. |
a substantia nigra dopaminergic cell number decrease was observed by immunohistochemistry against rat tyrosine hydroxylase (th) reaching 80% after 2 days in culture associated with a 30% decrease of striatal th-positive fiber density, a 15% loss of striatal dopamine content quantified by mass spectrometry and a 70% reduction of nigrostriatal fiber fractional anisotropy quantified by dt-rmi. |
2014-08-27 |
2023-08-12 |
rat |
| Andres Urrutia, Noelia Granado, Maria Dolores Gutierrez-Lopez, Rosario Moratalla, Esther O'Shea, Maria Isabel Colad. The JNK inhibitor, SP600125, potentiates the glial response and cell death induced by methamphetamine in the mouse striatum. The international journal of neuropsychopharmacology. vol 17. issue 2. 2014-08-26. PMID:24103647. |
results indicate that meth produced dopaminergic axonal neurotoxicity reflected as a marked decrease in the striatal density of tyrosine hydroxylase-immunoreactive (th-ir) fibres and dopamine transporter-immunoreactivity (dat-ir) 24 h after dosing. |
2014-08-26 |
2023-08-12 |
mouse |
| Juan Segura-Aguilar, Irmgard Paris, Patricia Muñoz, Emanuele Ferrari, Luigi Zecca, Fabio A Zucc. Protective and toxic roles of dopamine in Parkinson's disease. Journal of neurochemistry. vol 129. issue 6. 2014-08-26. PMID:24548101. |
the neurotoxic effects of aminochrome in dopaminergic neurons can be inhibited by: (i) preventing dopamine oxidation of the transporter that takes up dopamine into monoaminergic vesicles with low ph and dopamine oxidative deamination catalyzed by monoamino oxidase (ii) dopamine o-quinone, aminochrome and 5,6-indolequinone polymerization to neuromelanin and (iii) two-electron reduction of aminochrome catalyzed by dt-diaphorase. |
2014-08-26 |
2023-08-12 |
Not clear |
| Daniel P Czech, Joohyung Lee, Jeanne Correia, Hannah Loke, Eva K Möller, Vincent R Harle. Transient neuroprotection by SRY upregulation in dopamine cells following injury in males. Endocrinology. vol 155. issue 7. 2014-08-25. PMID:24708242. |
treatment with the dopaminergic toxin, 6-hydroxydopamine (6-ohda), significantly elevated sry mrna expression (9-fold) in human male dopamine m17 cells. |
2014-08-25 |
2023-08-13 |
human |
| Veronica Francardo, Francesco Bez, Tadeusz Wieloch, Hans Nissbrandt, Karsten Ruscher, M Angela Cenc. Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism. Brain : a journal of neurology. vol 137. issue Pt 7. 2014-08-25. PMID:24755275. |
the behavioural recovery was paralleled by an increased density of dopaminergic fibres in the most denervated striatal regions, by a modest recovery of dopamine levels, and by an upregulation of neurotrophic factors (bdnf and gdnf) and their downstream effector pathways (extracellular signal regulated kinases 1/2 and akt). |
2014-08-25 |
2023-08-13 |
mouse |
| Biswarup Ghosh, Chen Zhang, George M Smit. Bridging between transplantation therapy and neurotrophic factors in Parkinson's disease. Frontiers in bioscience (Elite edition). vol 6. 2014-08-25. PMID:24896204. |
with increased understanding of growth and guidance molecule effecting dopaminergic neurons, it may be feasible to place transplants in the damaged substantia nigra and direct the growth of axons into target regions to reconstruction of midbrain dopamine (da) circuitry. |
2014-08-25 |
2023-08-13 |
Not clear |
| Javier Pagonabarraga, Jaume Kulisevsk. [Dopaminergic treatment in Parkinson's disease: what has each therapeutic family got to offer?]. Revista de neurologia. vol 58. issue 1. 2014-08-18. PMID:24343538. |
different families of dopaminergic agents have allowed to increase the availability of dopamine within the central nervous system by different mechanisms of action. |
2014-08-18 |
2023-08-12 |
Not clear |
| Sunayana B Banerjee, Brian G Dias, David Crews, Elizabeth Adkins-Rega. Newly paired zebra finches have higher dopamine levels and immediate early gene Fos expression in dopaminergic neurons. The European journal of neuroscience. vol 38. issue 12. 2014-08-15. PMID:24329731. |
newly paired zebra finches have higher dopamine levels and immediate early gene fos expression in dopaminergic neurons. |
2014-08-15 |
2023-08-12 |
Not clear |
| Lindsey G Soll, Sharon R Grady, Outi Salminen, Michael J Marks, Andrew R Tappe. A role for α4(non-α6)* nicotinic acetylcholine receptors in motor behavior. Neuropharmacology. vol 73. 2014-08-13. PMID:23688922. |
nicotinic acetylcholine receptors (nachrs) containing either the α4 and/or α6 subunit are robustly expressed in dopaminergic nerve terminals in dorsal striatum where they are hypothesized to modulate dopamine (da) release via acetylcholine (ach) stimulation from cholinergic interneurons. |
2014-08-13 |
2023-08-12 |
mouse |
| Sekar Sathiya, Vijayan Ranju, Periyathambi Kalaivani, Raju Jyothi Priya, Haridass Sumathy, Adoor Gopalan Sunil, Chidambaram Saravana Bab. Telmisartan attenuates MPTP induced dopaminergic degeneration and motor dysfunction through regulation of α-synuclein and neurotrophic factors (BDNF and GDNF) expression in C57BL/6J mice. Neuropharmacology. vol 73. 2014-08-13. PMID:23747572. |
in the present study, the effect of tel on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) induced motor dysfunctions and dopaminergic degeneration was ascertained through investigating the alterations in protein expression of dopamine transporter (dat), tyrosine hydroxylase (th) and syn in c57bl/6j mouse. |
2014-08-13 |
2023-08-12 |
mouse |
| Hiroyoshi Ariga, Kazuko Takahashi-Niki, Izumi Kato, Hiroshi Maita, Takeshi Niki, Sanae M M Iguchi-Arig. Neuroprotective function of DJ-1 in Parkinson's disease. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23766857. |
parkinson's disease (pd) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. |
2014-08-13 |
2023-08-12 |
Not clear |
| Javier Párraga, Nuria Cabedo, Sebastián Andujar, Laura Piqueras, Laura Moreno, Abraham Galán, Emilio Angelina, Ricardo D Enriz, María Dolores Ivorra, María Jesús Sanz, Diego Corte. 2,3,9- and 2,3,11-trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands. European journal of medicinal chemistry. vol 68. 2014-08-12. PMID:23974015. |
previous studies have revealed that isoquinoline compounds such as tetrahydroisoquinolines (thiqs) and tetrahydroprotoberberines (thpbs) can behave as selective d2 dopaminergic alkaloids since they share structural similarities with dopamine. |
2014-08-12 |
2023-08-12 |
human |
| Andrey E Ryabinin, Davelle L Cocking, Simranjit Kau. Inhibition of VTA neurons activates the centrally projecting Edinger-Westphal nucleus: evidence of a stress-reward link? Journal of chemical neuroanatomy. vol 54. 2014-08-11. PMID:23792226. |
to investigate whether inhibition of dopaminergic neurons was responsible for induction of fos, a second experiment was performed where the dopamine agonist quinpirole was unilaterally injected targeting the vta. |
2014-08-11 |
2023-08-12 |
mouse |
| Milene Leivas Vieira, Alice Hartmann Dos Santos, Luiza Sienna Silva, Glaura Scantamburlo Alves Fernandes, Ana Carolina Inhasz Kiss, Estefânia Gastaldello Moreira, Suzana de Fátima Paccola Mesquita, Daniela Cristina Ceccatto Gerardi. Lactational exposure to sulpiride: assessment of maternal care and reproductive and behavioral parameters of male rat pups. Physiology & behavior. vol 122. 2014-08-11. PMID:24021925. |
dopaminergic receptor antagonists may be used as galactagogues because they increase serum prolactin (prl) by counteracting the inhibitory influence of dopamine on prl secretion. |
2014-08-11 |
2023-08-12 |
rat |