| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michele Poletti, Ubaldo Bonuccell. Acute and chronic cognitive effects of levodopa and dopamine agonists on patients with Parkinson's disease: a review. Therapeutic advances in psychopharmacology. vol 3. issue 2. 2014-06-24. PMID:24167681. |
the paucity of empirical evidence suggests that no meaningful conclusions can be actually drawn and further research is needed in relation to: (1) other cognitive domains; (2) the acute cognitive effects of dopamine agonists, as compared with levodopa; (3) possible differences between cognitive effects of different dopamine agonists; (4) the cognitive effects of chronic dopaminergic therapies. |
2014-06-24 |
2023-08-12 |
Not clear |
| P J Hamilton, N G Campbell, S Sharma, K Erreger, F Herborg Hansen, C Saunders, A N Belovich, M A Sahai, E H Cook, U Gether, H S McHaourab, H J G Matthies, J S Sutcliffe, A Gall. De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Molecular psychiatry. vol 18. issue 12. 2014-06-23. PMID:23979605. |
the dopamine transporter (dat) is a presynaptic membrane protein that regulates dopaminergic tone in the central nervous system by mediating the high-affinity reuptake of synaptically released da, making it a crucial regulator of da homeostasis. |
2014-06-23 |
2023-08-12 |
human |
| Peng Zhong, Xiaojie Liu, Zhen Zhang, Ying Hu, Sarah J Liu, Martha Lezama-Ruiz, Milan Joksimovic, Qing-song Li. Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 18. 2014-06-23. PMID:24790206. |
dopamine neurons in the ventral tegmental area (vta) govern reward and motivation and dysregulated dopaminergic transmission may account for anhedonia and other symptoms of depression. |
2014-06-23 |
2023-08-13 |
mouse |
| Christopher J Earle. Latest guidelines and advances for treatment of restless legs syndrome. The Journal of clinical psychiatry. vol 75. issue 4. 2014-06-23. PMID:24813409. |
dopaminergic augmentation, which exacerbates rls symptoms, is the most common and challenging side effect of long-term rls treatment with dopamine agonists and requires special clinical consideration. |
2014-06-23 |
2023-08-13 |
Not clear |
| Tyler W Dunn, Wayne S Sossi. Inhibition of the Aplysia sensory neuron calcium current with dopamine and serotonin. Journal of neurophysiology. vol 110. issue 9. 2014-06-20. PMID:23926036. |
the inhibition of aplysia pleural mechanosensory neuron synapses by dopamine and serotonin through activation of endogenous dopaminergic and expressed 5-ht1apl(a)/b receptors, respectively, involves a reduction in action potential-associated calcium influx. |
2014-06-20 |
2023-08-12 |
aplysia |
| Alice Manson, Paola Stirpe, Anette Schra. Levodopa-induced-dyskinesias clinical features, incidence, risk factors, management and impact on quality of life. Journal of Parkinson's disease. vol 2. issue 3. 2014-06-20. PMID:23938226. |
the important aetiological role of non-physiological pulsatile stimulation of dopaminergic receptors is increasingly recognized and more continuous dopaminergic stimulation with the longer acting dopamine agonists has been shown to reduce and delay the onset of dyskinesias. |
2014-06-20 |
2023-08-12 |
Not clear |
| Karen L Eskow Jaunarajs, David G Standaert, Tacey X Viegas, Michael D Bentley, Zhihao Fang, Bekir Dizman, Kunsang Yoon, Rebecca Weimer, Paula Ravenscroft, Tom H Johnston, Michael P Hill, Jonathan M Brotchie, Randall W Moreadit. Rotigotine polyoxazoline conjugate SER-214 provides robust and sustained antiparkinsonian benefit. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 12. 2014-06-20. PMID:24014074. |
currently available dopaminergic drugs such as levodopa and dopamine (da) receptor agonists impart considerable improvement in parkinson's disease (pd) motor symptoms but often lead to significant motor complications including "wearing-off" and dyskinesia. |
2014-06-20 |
2023-08-12 |
rat |
| Zuzanna Kurowska, Elisabet Englund, Håkan Widner, Olle Lindvall, Jia-Yi Li, Patrik Brundi. Signs of degeneration in 12-22-year old grafts of mesencephalic dopamine neurons in patients with Parkinson's disease. Journal of Parkinson's disease. vol 1. issue 1. 2014-06-18. PMID:23939259. |
in the case with the 22-year-old transplant, a high proportion (up to 38%) of the grafted dopaminergic (pigment-granule containing) neurons do not express tyrosine hydroxylase and dopamine transporter and their perikarya appear atrophic. |
2014-06-18 |
2023-08-12 |
human |
| Fabiana da Silva Alves, Geor Bakker, Nicole Schmitz, Nico Abeling, Gregor Hasler, Johan van der Meer, Aart Nederveen, Lieuwe de Haan, Don Linszen, Therese van Amelsvoor. Dopaminergic modulation of the reward system in schizophrenia: a placebo-controlled dopamine depletion fMRI study. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 11. 2014-06-17. PMID:23978392. |
dopaminergic modulation of the reward system in schizophrenia: a placebo-controlled dopamine depletion fmri study. |
2014-06-17 |
2023-08-12 |
Not clear |
| Christopher O Boyson, Elizabeth N Holly, Akiko Shimamoto, Lucas Albrechet-Souza, Lindsay A Weiner, Joseph F DeBold, Klaus A Micze. Social stress and CRF-dopamine interactions in the VTA: role in long-term escalation of cocaine self-administration. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 19. 2014-06-17. PMID:24806691. |
and assessed for either locomotor sensitization, measured by walking activity, or dopaminergic sensitization, measured by extracellular dopamine (da) in the nucleus accumbens shell (nacsh) through in vivo microdialysis. |
2014-06-17 |
2023-08-13 |
rat |
| Bianca C Wittmann, Geoffrey C Tan, John E Lisman, Raymond J Dolan, Emrah Düze. Reprint of: DAT genotype modulates striatal processing and long-term memory for items associated with reward and punishment. Neuropsychologia. vol 51. issue 12. 2014-06-15. PMID:24139823. |
these findings suggest that processing of appetitive and aversive motivation in the human striatum involve the dopaminergic system and that dopamine plays a role in memory for both types of motivational information. |
2014-06-15 |
2023-08-12 |
human |
| L C Jellen, L Lu, X Wang, E L Unger, C J Earley, R P Allen, R W Williams, B C Jone. Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice. Neuroscience. vol 252. 2014-06-11. PMID:23911809. |
these were stromal cell-derived factor 1 (cxcl12, or sdf-1), a ferritin regulator and potent dopamine neuromodulator, and hemoglobin, beta adult chain 1 (hbb-b1), a gene recently shown to play a functional role in dopaminergic neurons. |
2014-06-11 |
2023-08-12 |
mouse |
| M Federici, E C Latagliata, F R Rizzo, A Ledonne, H H Gu, A Romigi, R Nisticò, S Puglisi-Allegra, N B Mercur. Electrophysiological and amperometric evidence that modafinil blocks the dopamine uptake transporter to induce behavioral activation. Neuroscience. vol 252. 2014-06-11. PMID:23933217. |
although the wake-promoting drug modafinil has been shown to bind quite exclusively to the dopamine transporter (dat), its action in the brain has been thought to be partially independent from the facilitation of the dopaminergic signals. |
2014-06-11 |
2023-08-12 |
mouse |
| M Federici, E C Latagliata, F R Rizzo, A Ledonne, H H Gu, A Romigi, R Nisticò, S Puglisi-Allegra, N B Mercur. Electrophysiological and amperometric evidence that modafinil blocks the dopamine uptake transporter to induce behavioral activation. Neuroscience. vol 252. 2014-06-11. PMID:23933217. |
here we used electrophysiological and amperometric techniques to investigate the effects of modafinil on the dopaminergic neurons of the substantia nigra pars compacta (snpc) and on the synaptic overflow of dopamine in the dorsal striatum from the sliced tissue of wild-type and cocaine-insensitive genetically modified mice (dat-ci). |
2014-06-11 |
2023-08-12 |
mouse |
| S Maranis, S Tsouli, S Konitsioti. Treatment of motor symptoms in advanced Parkinson's disease: a practical approach. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 8. 2014-06-09. PMID:21645577. |
motor fluctuations develop with increasing severity of the disease, owing to loss of dopaminergic neurons and loss of the buffering capacity of the neurons to fluctuating dopamine levels. |
2014-06-09 |
2023-08-12 |
Not clear |
| Helder Cardoso-Cruz, Margarida Dourado, Clara Monteiro, Mariana R Matos, Vasco Galhard. Activation of dopaminergic D2/D3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 17. 2014-06-09. PMID:24760846. |
together with our finding of changes in gene expression of dopamine receptors and modulators after the onset of the nerve injury model, these results suggest that disruption of the dopaminergic balance in the hippocampus may be crucial for the clinical neurological and cognitive deficits observed in patients with painful syndromes. |
2014-06-09 |
2023-08-13 |
rat |
| Antonio Dominguez-Meijide, Begoña Villar-Cheda, Pablo Garrido-Gil, German Sierrra-Paredes, Maria J Guerra, Jose L Labandeira-Garci. Effect of chronic treatment with angiotensin type 1 receptor antagonists on striatal dopamine levels in normal rats and in a rat model of Parkinson's disease treated with L-DOPA. Neuropharmacology. vol 76 Pt A. 2014-06-05. PMID:23973568. |
the present experiments involving rats with normal dopaminergic innervation indicate that chronic treatment with the at1 antagonist candesartan does not significantly affect striatal levels of dopamine, serotonin or metabolites, as does not significantly affect motor behavior, as evaluated by the rotarod test. |
2014-06-05 |
2023-08-12 |
rat |
| F S Hall, K Itokawa, A Schmitt, R Moessner, I Sora, K P Lesch, G R Uh. Decreased vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) function in knockout mice affects aging of dopaminergic systems. Neuropharmacology. vol 76 Pt A. 2014-06-05. PMID:23978383. |
decreased vesicular monoamine transporter 2 (vmat2) and dopamine transporter (dat) function in knockout mice affects aging of dopaminergic systems. |
2014-06-05 |
2023-08-12 |
mouse |
| Soyoung Jin, Minyoung Oh, Seung Jun Oh, Jungsu S Oh, Sang Ju Lee, Sun Ju Chung, Chong Sik Lee, Jae Seung Ki. Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging. Nuclear medicine and molecular imaging. vol 47. issue 1. 2014-06-04. PMID:24895507. |
dopamine transporter (dat) imaging can demonstrate presynaptic dopaminergic neuronal loss in parkinson's disease (pd). |
2014-06-04 |
2023-08-13 |
Not clear |
| Giulio Perugi, Michele Poletti, Chiara Logi, Caterina Berti, Anna Romano, Paolo Del Dotto, Claudio Lucetti, Roberto Ceravolo, Liliana Dell'Osso, Ubaldo Bonuccell. Diagnosis, assessment and management of delusional jealousy in Parkinson's disease with and without dementia. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 9. 2014-06-02. PMID:23274831. |
a subgroup of five cognitively preserved patients developed dj after a short period of treatment of therapy with dopamine agonists, while other patients developed dj after a longer period of dopaminergic treatment. |
2014-06-02 |
2023-08-12 |
Not clear |