| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karolina Pytka, Małgorzata Zygmunt, Barbara Filipe. [Pharmacotherapy of Parkinson's disease: progress or regress?]. Postepy higieny i medycyny doswiadczalnej (Online). vol 67. 2014-04-29. PMID:24018435. |
parkinson's disease (pd) is a chronic, progressive disease of the central nervous system (cns), characterized by a slow loss of dopaminergic neurons in the substantia nigra, leading to significant decrease in dopamine (da) levels in the striatum. |
2014-04-29 |
2023-08-12 |
Not clear |
| Natalia Gass, Adam James Schwarz, Alexander Sartorius, Dirk Cleppien, Lei Zheng, Esther Schenker, Celine Risterucci, Andreas Meyer-Lindenberg, Wolfgang Weber-Fah. Haloperidol modulates midbrain-prefrontal functional connectivity in the rat brain. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23165219. |
dopamine d₂ receptor antagonists effectively reduce positive symptoms in schizophrenia, implicating abnormal dopaminergic neurotransmission as an underlying mechanism of psychosis. |
2014-04-24 |
2023-08-12 |
rat |
| Guoqi Zhu, Xuncui Wang, Shengbing Wu, Xiaoxiang Li, Qinglin L. Neuroprotective effects of puerarin on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson's disease model in mice. Phytotherapy research : PTR. vol 28. issue 2. 2014-04-24. PMID:23512787. |
in this study, we addressed that puerarin attenuated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced behavioral deficits, dopaminergic neuronal degeneration and dopamine depletion. |
2014-04-24 |
2023-08-12 |
mouse |
| Nao Chuhma, Susana Mingote, Holly Moore, Stephen Raypor. Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling. Neuron. vol 81. issue 4. 2014-04-23. PMID:24559678. |
here, we show that dopamine neurons make direct fast dopaminergic and glutamatergic connections with cholinergic interneurons, with regional heterogeneity. |
2014-04-23 |
2023-08-12 |
Not clear |
| M A Fahim, S Shehab, A Nemmar, A Adem, S Dhanasekaran, M Y Hasa. Daily subacute paraquat exposure decreases muscle function and substantia nigra dopamine level. Physiological research. vol 62. issue 3. 2014-04-21. PMID:23489189. |
dopamine concentrations in the ventral mesencephalon were measured by high performance liquid chromatography and the number of dopaminergic neurons in substantia nigra pars compacta was estimated by tyrosine hydroxylase immunohistochemistry. |
2014-04-21 |
2023-08-12 |
rat |
| Wout Duthoo, Senne Braem, Femke Houtman, Nathalie Schouppe, Patrick Santens, Wim Notebaer. Dopaminergic medication counteracts conflict adaptation in patients with Parkinson's disease. Neuropsychology. vol 27. issue 5. 2014-04-18. PMID:23815093. |
we tested the role of dopamine in conflict-induced behavioral adjustments by evaluating the effect of dopaminergic medication on conflict adaptation in parkinson's disease (pd) patients. |
2014-04-18 |
2023-08-12 |
Not clear |
| Yuri Aono, Tadashi Saigusa, Hiroko Taguchi, Takuya Uchida, Koji Takada, Noriaki Koshikawa, Alexander R Cool. Synergistic, but not separate, stimulation of accumbal β1- and β2-adrenoceptors alters the accumbal dopamine efflux in freely moving rats. European journal of pharmacology. vol 715. issue 1-3. 2014-04-14. PMID:23665498. |
the present results support our previously reported conclusion that stimulation of accumbal β-adrenoceptors which are suggested to be postsynaptically located on accumbal dopaminergic terminals, can enhance the dopamine efflux in the nucleus accumbens. |
2014-04-14 |
2023-08-12 |
rat |
| Dianlu Jiang, Shuyun Shi, Lin Zhang, Lin Liu, Bingrong Ding, Bingqing Zhao, Gargey Yagnik, Feimeng Zho. Inhibition of the Fe(III)-catalyzed dopamine oxidation by ATP and its relevance to oxidative stress in Parkinson's disease. ACS chemical neuroscience. vol 4. issue 9. 2014-04-14. PMID:23823941. |
parkinson's disease (pd) is characterized by the progressive degeneration of dopaminergic cells, which implicates a role of dopamine (da) in the etiology of pd. |
2014-04-14 |
2023-08-12 |
rat |
| Morteza Piri, Elham Ayazi, Mohammad Reza Zarrindas. Involvement of the dorsal hippocampal dopamine D2 receptors in histamine-induced anxiogenic-like effects in mice. Neuroscience letters. vol 550. 2014-04-11. PMID:23872092. |
histamine can decrease dopaminergic tone in the dorsal hippocampus through decreasing the endogenous dopamine release, whereas quinpirole does the same via the postsynaptic da receptors' activation. |
2014-04-11 |
2023-08-12 |
mouse |
| Leigh Christopher, Connie Marras, Sarah Duff-Canning, Yuko Koshimori, Robert Chen, Isabelle Boileau, Barbara Segura, Oury Monchi, Anthony E Lang, Pablo Rusjan, Sylvain Houle, Antonio P Strafell. Combined insular and striatal dopamine dysfunction are associated with executive deficits in Parkinson's disease with mild cognitive impairment. Brain : a journal of neurology. vol 137. issue Pt 2. 2014-04-11. PMID:24334314. |
we used positron emission tomography imaging with dopaminergic ligands (11)c-dihydrotetrabenazine, to investigate striatal dopamine neuron integrity in the associative subdivision and (11)c-flb 457, to investigate cortical d2 receptor availability in patients with parkinson's disease (55-80 years of age) with mild cognitive impairment (n = 11), cognitively normal patients with parkinson's disease (n = 11) and age-matched healthy control subjects (n = 14). |
2014-04-11 |
2023-08-12 |
human |
| Maria D Rubio, Jana B Drummond, James H Meador-Woodruf. Glutamate receptor abnormalities in schizophrenia: implications for innovative treatments. Biomolecules & therapeutics. vol 20. issue 1. 2014-04-09. PMID:24116269. |
although numerous studies point to dopaminergic abnormalities in schizophrenia, dopamine dysfunction cannot completely account for all of the symptoms seen in schizophrenia, and dopamine-based treatments are often inadequate and can be associated with serious side effects. |
2014-04-09 |
2023-08-12 |
Not clear |
| Ja-Hyun Bai. Dopamine signaling in reward-related behaviors. Frontiers in neural circuits. vol 7. 2014-04-08. PMID:24130517. |
dopamine (da) regulates emotional and motivational behavior through the mesolimbic dopaminergic pathway. |
2014-04-08 |
2023-08-12 |
Not clear |
| Roberto Cilia, Chiara Siri, Margherita Canesi, Anna Lena Zecchinelli, Danilo De Gaspari, Francesca Natuzzi, Silvana Tesei, Nicoletta Meucci, Claudio Bruno Mariani, Giorgio Sacilotto, Michela Zini, Claudio Ruffmann, Gianni Pezzol. Dopamine dysregulation syndrome in Parkinson's disease: from clinical and neuropsychological characterisation to management and long-term outcome. Journal of neurology, neurosurgery, and psychiatry. vol 85. issue 3. 2014-04-03. PMID:23591553. |
dopamine dysregulation syndrome (dds) refers to a compulsive pattern of dopaminergic drug misuse complicating parkinson's disease (pd). |
2014-04-03 |
2023-08-12 |
Not clear |
| b' Mikl\\xc3\\xb3s Palotai, Zsolt Bagosi, Mikl\\xc3\\xb3s J\\xc3\\xa1szber\\xc3\\xa9nyi, Krisztina Csabafi, Roberta Dochnal, M\\xc3\\xa1t\\xc3\\xa9 Manczinger, Gyula Telegdy, Gyula Szab\\xc3\\xb. Ghrelin amplifies the nicotine-induced dopamine release in the rat striatum. Neurochemistry international. vol 63. issue 4. 2014-04-02. PMID:23831084.' |
ghrelin stimulates the dopaminergic neurons via growth hormone secretagogue receptors (ghs-r1a) in the ventral tegmental area and the substantia nigra pars compacta resulting in the release of dopamine in the ventral and dorsal striatum, respectively. |
2014-04-02 |
2023-08-12 |
rat |
| Fukie Niijima-Yaoita, Masahiro Tsuchiya, Hiroko Saito, Yuka Nagasawa, Shigeo Murai, Yuichiro Arai, Osamu Nakagawasai, Wataru Nemoto, Takeshi Tadano, Koichi Tan-N. Influence of a long-term powdered diet on the social interaction test and dopaminergic systems in mice. Neurochemistry international. vol 63. issue 4. 2014-04-02. PMID:23871718. |
these results suggest that the masticatory dysfunction induced by long-term powdered diet feeding may cause the increased si time and the changes in the dopaminergic system, especially dopamine d4 receptor subtype in the frontal cortex. |
2014-04-02 |
2023-08-12 |
mouse |
| Maja Zivković, Alma Mihaljević-Peles, Nada Bozina, Marina Sagud, Matea Nikolac-Perkovic, Bjanka Vuksan-Cusa, Dorotea Muck-Sele. The association study of polymorphisms in DAT, DRD2, and COMT genes and acute extrapyramidal adverse effects in male schizophrenic patients treated with haloperidol. Journal of clinical psychopharmacology. vol 33. issue 5. 2014-04-01. PMID:23963056. |
the aim of this study was to determine the association between dopaminergic type 2 receptor (drd2) dopamine transporter (slc6a3) and catechol-o-methyltransferase (comt) gene polymorphisms and acute epss in 240 male schizophrenic patients treated with haloperidol (15-mg/d) over a period of 2 weeks. |
2014-04-01 |
2023-08-12 |
Not clear |
| Petra Amchova, Jana Kucerova, Valentina Giugliano, Zuzana Babinska, Mary T Zanda, Maria Scherma, Ladislav Dusek, Paola Fadda, Vincenzo Micale, Alexandra Sulcova, Walter Fratta, Liana Fattor. Enhanced self-administration of the CB1 receptor agonist WIN55,212-2 in olfactory bulbectomized rats: evaluation of possible serotonergic and dopaminergic underlying mechanisms. Frontiers in pharmacology. vol 5. 2014-04-01. PMID:24688470. |
finally, dopamine levels in the nucleus accumbens (nac) of obx rats did not increase in response to a win challenge, as in sham rats, indicating a dopaminergic dysfunction in bulbectomized rats. |
2014-04-01 |
2023-08-12 |
rat |
| J G Ramaekers, E A Evers, E L Theunissen, K P C Kuypers, A Goulas, P Stier. Methylphenidate reduces functional connectivity of nucleus accumbens in brain reward circuit. Psychopharmacology. vol 229. issue 2. 2014-03-31. PMID:23604336. |
the present study was designed to trace the reinforcing effect of dopamine release by measuring the functional connectivity (fc) between the nacc and brain regions involved in a limbic cortical-subcortical circuit during a dopaminergic challenge. |
2014-03-31 |
2023-08-12 |
human |
| Alessandro Ustione, David W Piston, Paul E Harri. Minireview: Dopaminergic regulation of insulin secretion from the pancreatic islet. Molecular endocrinology (Baltimore, Md.). vol 27. issue 8. 2014-03-31. PMID:23744894. |
exogenous dopamine inhibits insulin secretion from pancreatic β-cells, but the lack of dopaminergic neurons in pancreatic islets has led to controversy regarding the importance of this effect. |
2014-03-31 |
2023-08-12 |
Not clear |
| b' Mikl\\xc3\\xb3s Palotai, Zsolt Bagosi, Mikl\\xc3\\xb3s J\\xc3\\xa1szber\\xc3\\xa9nyi, Krisztina Csabafi, Roberta Dochnal, M\\xc3\\xa1t\\xc3\\xa9 Manczinger, Gyula Telegdy, Gyula Szab\\xc3\\xb. Ghrelin and nicotine stimulate equally the dopamine release in the rat amygdala. Neurochemical research. vol 38. issue 10. 2014-03-28. PMID:23836294.' |
ghrelin and nicotine activates the mesolimbicocortical dopaminergic pathways via growth hormone secretagogue receptors (ghs-r1a) and nicotinic acetylcholine receptors (nachr), respectively, resulting in the release of dopamine in the nucleus accumbens, the amygdala and the prefrontal cortex. |
2014-03-28 |
2023-08-12 |
rat |